Cdca7l (cell division cycle associated 7 like) - Rat Genome Database

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Gene: Cdca7l (cell division cycle associated 7 like) Mus musculus
Analyze
Symbol: Cdca7l
Name: cell division cycle associated 7 like
RGD ID: 1617380
MGI Page MGI
Description: Predicted to be involved in regulation of DNA-templated transcription. Predicted to act upstream of or within positive regulation of cell population proliferation. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; genitourinary system; gut; respiratory system; and sensory organ. Orthologous to human CDCA7L (cell division cycle associated 7 like).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BC006933; cell division cycle-associated 7-like protein; JP; JPO2; MGC11998; transcription factor RAM2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912117,807,209 - 117,842,441 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12117,768,024 - 117,842,441 (+)EnsemblGRCm39 Ensembl
GRCm3812117,843,475 - 117,878,712 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12117,804,289 - 117,878,706 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712119,082,334 - 119,117,179 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612112,046,157 - 112,082,644 (+)NCBIMGSCv36mm8
MGSCv3612118,285,870 - 118,322,812 (+)NCBIMGSCv36mm8
Cytogenetic Map12F2NCBI
cM Map1263.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
3,7-dihydropurine-6-thione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
CGP 52608  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
Cuprizon  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP,ISO)
dibutyl phthalate  (EXP)
dorsomorphin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
gentamycin  (ISO)
hypochlorous acid  (EXP)
indometacin  (ISO)
lead(0)  (ISO)
lidocaine  (ISO)
mercaptopurine  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
ozone  (EXP,ISO)
PCB138  (EXP)
pirinixic acid  (EXP)
potassium chromate  (ISO)
pravastatin  (EXP,ISO)
propiconazole  (EXP)
purine-6-thiol  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
tamoxifen  (EXP)
testosterone  (ISO)
thapsigargin  (ISO)
thioacetamide  (ISO)
Tributyltin oxide  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (ISO)
fibrillar center  (ISO)
nucleolus  (ISO)
nucleoplasm  (ISO)
nucleus  (IBA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15489334   PMID:15994933   PMID:16141072   PMID:16141073   PMID:16829576   PMID:21267068  
PMID:21440680   PMID:21677750   PMID:21873635   PMID:22234937   PMID:22922362   PMID:28705898   PMID:32325033   PMID:34321999   PMID:36893788  


Genomics

Comparative Map Data
Cdca7l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912117,807,209 - 117,842,441 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12117,768,024 - 117,842,441 (+)EnsemblGRCm39 Ensembl
GRCm3812117,843,475 - 117,878,712 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12117,804,289 - 117,878,706 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712119,082,334 - 119,117,179 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612112,046,157 - 112,082,644 (+)NCBIMGSCv36mm8
MGSCv3612118,285,870 - 118,322,812 (+)NCBIMGSCv36mm8
Cytogenetic Map12F2NCBI
cM Map1263.2NCBI
CDCA7L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38721,900,899 - 21,945,899 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl721,900,899 - 21,945,903 (-)EnsemblGRCh38hg38GRCh38
GRCh37721,940,517 - 21,985,517 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36721,907,044 - 21,952,031 (-)NCBINCBI36Build 36hg18NCBI36
Celera721,926,218 - 21,971,211 (-)NCBICelera
Cytogenetic Map7p15.3NCBI
HuRef721,826,171 - 21,871,060 (-)NCBIHuRef
CHM1_1721,941,227 - 21,986,281 (-)NCBICHM1_1
T2T-CHM13v2.0722,037,210 - 22,082,187 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2721,991,889 - 22,036,870 (-)NCBI
Cdca7l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86144,936,885 - 144,982,844 (+)NCBIGRCr8
mRatBN7.26138,793,953 - 138,839,889 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6138,794,228 - 138,839,888 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6142,236,179 - 142,281,814 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06138,853,594 - 138,899,230 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06139,401,964 - 139,447,548 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06145,739,570 - 145,785,607 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6145,740,035 - 145,785,606 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06154,626,049 - 154,699,231 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46145,146,073 - 145,191,663 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera6136,447,403 - 136,493,195 (+)NCBICelera
Cytogenetic Map6q33NCBI
Cdca7l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541024,353,128 - 24,366,987 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541024,353,024 - 24,366,987 (-)NCBIChiLan1.0ChiLan1.0
CDCA7L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2626,680,097 - 26,811,822 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1775,004,823 - 75,136,548 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0722,501,225 - 22,632,357 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1721,898,007 - 21,944,329 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl721,897,798 - 21,944,329 (-)Ensemblpanpan1.1panPan2
CDCA7L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11435,784,991 - 35,835,548 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1435,785,129 - 35,835,454 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1435,326,643 - 35,377,210 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01435,710,363 - 35,760,778 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1435,709,677 - 35,760,796 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11435,830,057 - 35,880,485 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01435,527,978 - 35,578,330 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01435,863,270 - 35,913,641 (-)NCBIUU_Cfam_GSD_1.0
Cdca7l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511880,005,571 - 80,050,984 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365467,680,353 - 7,726,118 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365467,681,731 - 7,726,053 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDCA7L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl990,766,795 - 90,806,865 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1990,766,767 - 90,807,287 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29100,217,610 - 100,257,482 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CDCA7L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12136,304,723 - 36,349,801 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2136,305,383 - 36,351,035 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604268,229,588 - 68,274,053 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdca7l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247398,770,483 - 8,810,070 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247398,770,463 - 8,810,165 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cdca7l
1610 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:638
Count of miRNA genes:473
Interacting mature miRNAs:535
Transcripts:ENSMUST00000021592, ENSMUST00000176499, ENSMUST00000176735, ENSMUST00000177339
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300883Ath21_matherosclerosis 21 (mouse)Not determined1285961579119961683Mouse
4142007Chlq17_mcirculating hormone level QTL 17 (mouse)Not determined1288052874120092757Mouse
1300545Lifespan3_mlife span 3 (mouse)Not determined1288052874120092757Mouse
1301308Prdt4_mprion disease incubation time 4 (mouse)Not determined1288308354120092757Mouse
5491194Mobq3_mmultigenic obesity QTL 3 (mouse)Not determined1289664071120092757Mouse
1301836Heal5_mwound healing/regeneration 5 (mouse)Not determined1289939031120092757Mouse
1301922Bbaa6_mB.burgdorferi-associated arthritis 6 (mouse)Not determined1290308268120092757Mouse
10402491Dipa4_mdrug induced psychomotor activation 4 (mouse)Not determined1291222515120092757Mouse
12910532Nrq10a_mnoise-induced hearing loss resistant QTL 10a (mouse)1292750025120092757Mouse
12910533Nrq10_mnoise-induced hearing loss resistant QTL 10 (mouse)1292750025120092757Mouse
1357463Vtbt14_mvertebral trabecular bone trait 14 (mouse)Not determined1292936097120092757Mouse
1300973Abmm_mantibody mediated myocarditis (mouse)Not determined1293264461120092757Mouse
1302177Dps2_mdelta power in slow-wave sleep 2 (mouse)Not determined1294146064120092757Mouse
1302138Im6_mimmunoregulatory 6 (mouse)Not determined1296860337120092757Mouse
1301269Sluc12_msusceptibility to lung cancer 12 (mouse)Not determined1296860337120092757Mouse
10412075Nils1_mneointima lesion size 1 (mouse)Not determined12102024665120092757Mouse
1558957Igan4_mIgA nephropathy 4 (mouse)Not determined12109750025119024949Mouse
15092085Igly2_mIgG glycosylation 2, GP14 (mouse)12111737297119992757Mouse
15092083Igly5_mIgG glycosylation 5, GP20 (mouse)12113373605117830647Mouse
15092084Igly1_mIgG glycosylation 1, GP1 (mouse)12114429496117830647Mouse
15092086Igly3_mIgG glycosylation 3, GP16 (mouse)12114429496117830647Mouse
15092087Igly4_mIgG glycosylation 4, GP17a (mouse)12114429496118423781Mouse

Markers in Region
RH140935  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3812117,873,746 - 117,874,033UniSTSGRCm38
MGSCv3712119,112,219 - 119,112,506UniSTSGRCm37
Cytogenetic Map12F2UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000021592   ⟹   ENSMUSP00000021592
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12117,807,250 - 117,842,441 (+)Ensembl
GRCm38.p6 Ensembl12117,843,515 - 117,878,706 (+)Ensembl
RefSeq Acc Id: ENSMUST00000176499
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12117,768,024 - 117,833,782 (+)Ensembl
GRCm38.p6 Ensembl12117,804,289 - 117,870,047 (+)Ensembl
RefSeq Acc Id: ENSMUST00000176735   ⟹   ENSMUSP00000135142
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12117,807,619 - 117,837,492 (+)Ensembl
GRCm38.p6 Ensembl12117,843,884 - 117,873,757 (+)Ensembl
RefSeq Acc Id: ENSMUST00000177339   ⟹   ENSMUSP00000135053
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12117,807,623 - 117,839,362 (+)Ensembl
GRCm38.p6 Ensembl12117,843,888 - 117,875,627 (+)Ensembl
RefSeq Acc Id: NM_001412933   ⟹   NP_001399862
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912117,807,616 - 117,842,441 (+)NCBI
RefSeq Acc Id: NM_001412934   ⟹   NP_001399863
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912117,807,616 - 117,842,441 (+)NCBI
RefSeq Acc Id: NM_001412935   ⟹   NP_001399864
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912117,807,616 - 117,842,441 (+)NCBI
RefSeq Acc Id: NM_146040   ⟹   NP_666152
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912117,807,616 - 117,842,441 (+)NCBI
GRCm3812117,843,861 - 117,878,706 (+)NCBI
MGSCv3712119,082,334 - 119,117,179 (+)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_182072
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912117,807,616 - 117,842,441 (+)NCBI
RefSeq Acc Id: NR_182073
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912117,807,616 - 117,842,441 (+)NCBI
RefSeq Acc Id: XM_011244100   ⟹   XP_011242402
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912117,807,209 - 117,840,570 (+)NCBI
GRCm3812117,851,763 - 117,876,240 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_666152   ⟸   NM_146040
- Peptide Label: isoform 3
- UniProtKB: Q922M5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011242402   ⟸   XM_011244100
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSMUSP00000135053   ⟸   ENSMUST00000177339
RefSeq Acc Id: ENSMUSP00000021592   ⟸   ENSMUST00000021592
RefSeq Acc Id: ENSMUSP00000135142   ⟸   ENSMUST00000176735
RefSeq Acc Id: NP_001399862   ⟸   NM_001412933
- Peptide Label: isoform 1
RefSeq Acc Id: NP_001399863   ⟸   NM_001412934
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001399864   ⟸   NM_001412935
- Peptide Label: isoform 4

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q922M5-F1-model_v2 AlphaFold Q922M5 1-438 view protein structure

Promoters
RGD ID:8679476
Promoter ID:EPDNEW_M17768
Type:multiple initiation site
Name:Cdca7l_1
Description:Mus musculus cell division cycle associated 7 like , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3812117,843,881 - 117,843,941EPDNEW
RGD ID:6822798
Promoter ID:MM_KWN:13098
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   ES_Cell,   Lung
Transcripts:NM_146040
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3612119,081,991 - 119,082,491 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2384982 AgrOrtholog
Ensembl Genes ENSMUSG00000021175 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000021592 ENTREZGENE
  ENSMUST00000021592.16 UniProtKB/Swiss-Prot
  ENSMUST00000176735.8 UniProtKB/TrEMBL
  ENSMUST00000177339.2 UniProtKB/TrEMBL
InterPro CDCA7/CDA7L UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf-4CXXC_R1 UniProtKB/Swiss-Prot
KEGG Report mmu:217946 UniProtKB/Swiss-Prot
MGD MGI:2384982 ENTREZGENE
NCBI Gene 217946 ENTREZGENE
PANTHER PTHR31169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR31169:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam zf-4CXXC_R1 UniProtKB/Swiss-Prot
PhenoGen Cdca7l PhenoGen
UniProt CDA7L_MOUSE UniProtKB/Swiss-Prot
  H3BJN2_MOUSE UniProtKB/TrEMBL
  H3BJV7_MOUSE UniProtKB/TrEMBL
  Q922M5 ENTREZGENE