Cks1brt (CDC28 protein kinase 1b, retrogene) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Cks1brt (CDC28 protein kinase 1b, retrogene) Mus musculus
Analyze
No known orthologs.
Symbol: Cks1brt
Name: CDC28 protein kinase 1b, retrogene
RGD ID: 1617079
MGI Page MGI
Description: Predicted to enable several functions, including cyclin-dependent protein serine/threonine kinase activator activity; histone binding activity; and ubiquitin binding activity. Predicted to be involved in regulation of mitotic cell cycle. Predicted to be part of SCF ubiquitin ligase complex and cyclin-dependent protein kinase holoenzyme complex.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: EG624855; Gm6531; predicted gene 6531; uncharacterized protein LOC624855
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,878,553 - 85,900,251 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl885,878,553 - 85,900,251 (+)EnsemblGRCm39 Ensembl
GRCm38885,151,924 - 85,173,622 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl885,151,924 - 85,173,622 (+)EnsemblGRCm38mm10GRCm38
MGSCv37887,675,823 - 87,697,521 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36888,042,029 - 88,063,727 (+)NCBIMGSCv36mm8
Celera889,440,026 - 89,465,858 (+)NCBICelera
Cytogenetic Map8C3NCBI
cM Map841.55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cks1brtMousecarbon nanotube increases expressionEXP 6480464Nanotubes and Carbon results in increased expression of CKS1BRT mRNACTDPMID:25554681


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cks1brtMouseregulation of mitotic cell cycle involved_inIBAPANTHER:PTN000602176 more ...2290270 GO_CentralGO_REF:0000033

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cks1brtMousecyclin-dependent protein kinase holoenzyme complex part_ofIBAPANTHER:PTN000602176 more ...2290270 GO_CentralGO_REF:0000033
Cks1brtMouseSCF ubiquitin ligase complex part_ofIBAPANTHER:PTN000602176 and FB:FBgn00376132290270 GO_CentralGO_REF:0000033

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cks1brtMousecyclin-dependent protein serine/threonine kinase activator activity enablesIBAPANTHER:PTN000602176 and PomBase:SPBC1734.14c2290270 GO_CentralGO_REF:0000033
Cks1brtMousehistone binding enablesIBAPANTHER:PTN000602176 and SGD:S0000003392290270 GO_CentralGO_REF:0000033
Cks1brtMouseprotein kinase binding enablesIBAPANTHER:PTN000602176 and WB:WBGene000010512290270 GO_CentralGO_REF:0000033
Cks1brtMouseubiquitin binding enablesIBAPANTHER:PTN000602176 and SGD:S0000003392290270 GO_CentralGO_REF:0000033


#
Reference Title
Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:21873635  



.

.
Variants in Cks1brt
2187 total Variants

Predicted Target Of
Summary Value
Count of predictions:427
Count of miRNA genes:328
Interacting mature miRNAs:361
Transcripts:ENSMUST00000076896
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 35 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined866326836100326976Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83663015493455280Mouse
12904012Cfq10_mconditioned fear QTL 10 (mouse)88079340489740987Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85892810792928107Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined876411976110412125Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined866084397100084549Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85474046188740637Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85515925889159407Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined871032003105032123Mouse

1 to 10 of 35 rows






Ensembl Acc Id: ENSMUST00000076896   ⟹   ENSMUSP00000076162
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl885,897,951 - 85,900,251 (+)Ensembl
GRCm38.p6 Ensembl885,171,322 - 85,173,622 (+)Ensembl
Ensembl Acc Id: ENSMUST00000211617   ⟹   ENSMUSP00000147685
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl885,878,553 - 85,900,251 (+)Ensembl
GRCm38.p6 Ensembl885,151,924 - 85,173,622 (+)Ensembl
RefSeq Acc Id: NM_001037922   ⟹   NP_001033011
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39885,878,553 - 85,900,251 (+)NCBI
GRCm38885,151,924 - 85,173,622 (+)ENTREZGENE
MGSCv37887,675,823 - 87,697,521 (+)RGD
Celera889,440,026 - 89,465,858 (+)RGD
cM Map8 ENTREZGENE
Sequence:
Protein RefSeqs NP_001033011 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI47101 (Get FASTA)   NCBI Sequence Viewer  
  AAI47102 (Get FASTA)   NCBI Sequence Viewer  
  BAE25818 (Get FASTA)   NCBI Sequence Viewer  
  EDL11002 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000076162.6
  ENSMUSP00000147685
  ENSMUSP00000147685.2
RefSeq Acc Id: NP_001033011   ⟸   NM_001037922
- UniProtKB: Q3UNC9 (UniProtKB/TrEMBL),   Q9D0L3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000147685   ⟸   ENSMUST00000211617
Ensembl Acc Id: ENSMUSP00000076162   ⟸   ENSMUST00000076896

Name Modeler Protein Id AA Range Protein Structure
AF-Q3UNC9-F1-model_v2 AlphaFold Q3UNC9 1-96 view protein structure

RGD ID:8667751
Promoter ID:EPDNEW_M11907
Type:multiple initiation site
Name:Cks1brt_1
Description:Mus musculus CDC28 protein kinase 1b, retrogene , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38885,171,526 - 85,171,586EPDNEW


1 to 19 of 19 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000062687 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000076896.6 UniProtKB/TrEMBL
  ENSMUST00000211617 ENTREZGENE
  ENSMUST00000211617.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.170.10 UniProtKB/TrEMBL
InterPro Cyclin-dep_kinase_reg-sub UniProtKB/TrEMBL
  Cyclin-dep_kinase_reg-sub_sf UniProtKB/TrEMBL
KEGG Report mmu:624855 UniProtKB/TrEMBL
MGD MGI:3643620 ENTREZGENE
NCBI Gene 624855 ENTREZGENE
PANTHER CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7 UniProtKB/TrEMBL
Pfam CKS UniProtKB/TrEMBL
PhenoGen Cks1brt PhenoGen
PRINTS CYCLINKINASE UniProtKB/TrEMBL
PROSITE CKS_1 UniProtKB/TrEMBL
SMART CKS UniProtKB/TrEMBL
Superfamily-SCOP Cyc_dep_kin_rsub UniProtKB/TrEMBL
UniProt Q3UNC9 ENTREZGENE, UniProtKB/TrEMBL
  Q9D0L3 ENTREZGENE
1 to 19 of 19 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-05-21 Cks1brt  CDC28 protein kinase 1b, retrogene  Gm6531  predicted gene 6531  Symbol and/or name change 5135510 APPROVED