Foxd4 (forkhead box D4) - Rat Genome Database

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Gene: Foxd4 (forkhead box D4) Mus musculus
Analyze
Symbol: Foxd4
Name: forkhead box D4
RGD ID: 1614459
MGI Page MGI
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; embryo endoderm; embryo mesoderm; lung; and neural ectoderm. Orthologous to several human genes including FOXD4 (forkhead box D4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fkh2; forkhead box protein D4; forkhead homolog 2; forkhead-related protein FKHL9; forkhead-related transcription factor 5; FREA; FREAC-5; FREAC5; transcription factor FKH-2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391924,876,307 - 24,878,380 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1924,876,600 - 24,878,561 (-)EnsemblGRCm39 Ensembl
GRCm381924,898,943 - 24,901,016 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1924,899,236 - 24,901,197 (-)EnsemblGRCm38mm10GRCm38
MGSCv371924,973,455 - 24,975,799 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361924,966,062 - 24,968,406 (-)NCBIMGSCv36mm8
Celera1925,674,165 - 25,676,509 (-)NCBICelera
Cytogenetic Map19BNCBI
cM Map1919.86NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IEA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7689224   PMID:7957066   PMID:8530406   PMID:8861101   PMID:9449667   PMID:9895322   PMID:10208738   PMID:11820816   PMID:12412011   PMID:12477932   PMID:12812790   PMID:15618518  
PMID:15857913   PMID:16602821   PMID:16884697   PMID:17389379   PMID:18287559   PMID:18973680   PMID:20932939   PMID:21267068   PMID:21873635   PMID:22045912   PMID:22711520   PMID:22972626  
PMID:22988430   PMID:24952961   PMID:27092474   PMID:29992973   PMID:38355793  


Genomics

Comparative Map Data
Foxd4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391924,876,307 - 24,878,380 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1924,876,600 - 24,878,561 (-)EnsemblGRCm39 Ensembl
GRCm381924,898,943 - 24,901,016 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1924,899,236 - 24,901,197 (-)EnsemblGRCm38mm10GRCm38
MGSCv371924,973,455 - 24,975,799 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361924,966,062 - 24,968,406 (-)NCBIMGSCv36mm8
Celera1925,674,165 - 25,676,509 (-)NCBICelera
Cytogenetic Map19BNCBI
cM Map1919.86NCBI
FOXD4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389116,231 - 118,417 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9116,231 - 118,417 (-)EnsemblGRCh38hg38GRCh38
GRCh379116,231 - 118,417 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369106,234 - 108,419 (-)NCBINCBI36Build 36hg18NCBI36
Build 349106,055 - 108,204NCBI
Cytogenetic Map9p24.3NCBI
HuRef958,001 - 60,188 (-)NCBIHuRef
CHM1_19116,562 - 118,749 (-)NCBICHM1_1
T2T-CHM13v2.09110,353 - 112,540 (-)NCBIT2T-CHM13v2.0
Foxd4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81231,983,872 - 231,985,565 (-)NCBIGRCr8
mRatBN7.21222,557,494 - 222,559,189 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1222,557,360 - 222,559,159 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01242,808,886 - 242,810,186 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1242,808,965 - 242,810,186 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01250,082,104 - 250,083,404 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41228,348,202 - 228,349,654 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11228,512,922 - 228,513,225 (-)NCBI
Celera1219,761,312 - 219,762,612 (-)NCBICelera
Cytogenetic Map1q51NCBI
Foxd4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554344,723,198 - 4,725,013 (-)NCBIChiLan1.0ChiLan1.0
FOXD4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211124,531,633 - 124,558,349 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19124,538,385 - 124,560,226 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B129,258,299 - 129,277,210 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
Foxd4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947136,512,355 - 136,514,796 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365034,658,802 - 4,660,203 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOXD4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11221,577,685 - 221,580,452 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21247,834,116 - 247,835,450 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Foxd4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247364,872,270 - 4,874,153 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Foxd4
55 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:147
Count of miRNA genes:134
Interacting mature miRNAs:143
Transcripts:ENSMUST00000058600
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301271Datd_mdopamine transporter density (mouse)Not determined19132340234Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192137870555378928Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192023431454234461Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191492301648923138Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191829516252295381Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19332321637323348Mouse
1357596Tgct3_mtesticular germ cell tumor 3 (mouse)Not determined192198409132912719Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19531332639313470Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191591260749912719Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192231332653911504Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191591260749912719Mouse
14928311Manh85_mmandible shape 85 (mouse)191191478945914789Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192023431454234461Mouse
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132875174Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19165376435653927Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19325000035877400Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19332321637323348Mouse
12801464Rta2_mretinal aging 2 (mouse)141230287425302874Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19332321637323348Mouse
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191829516252295381Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19332321637323348Mouse
1301197Tlyr1_mthymic lymphoma resistance 1 (mouse)Not determined192053952825313796Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19930571543305821Mouse

Markers in Region
X86368  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381924,899,133 - 24,899,331UniSTSGRCm38
MGSCv371924,973,623 - 24,973,821UniSTSGRCm37
Celera1925,674,333 - 25,674,531UniSTS
Cytogenetic Map19BUniSTS
cM Map1917.5UniSTS
Whitehead/MRC_RH19259.68UniSTS
RH139093  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381924,900,485 - 24,900,693UniSTSGRCm38
MGSCv371924,974,975 - 24,975,183UniSTSGRCm37
Celera1925,675,685 - 25,675,893UniSTS
Cytogenetic Map19BUniSTS
cM Map1917.5UniSTS
Foxd4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381924,901,109 - 24,901,895UniSTSGRCm38
MGSCv371924,975,599 - 24,976,385UniSTSGRCm37
Celera1925,676,309 - 25,677,094UniSTS
Cytogenetic Map8E1UniSTS
Cytogenetic Map19BUniSTS
cM Map865.5UniSTS
cM Map1917.5UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000058600   ⟹   ENSMUSP00000058575
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1924,876,600 - 24,878,561 (-)Ensembl
GRCm38.p6 Ensembl1924,899,236 - 24,901,197 (-)Ensembl
RefSeq Acc Id: NM_008022   ⟹   NP_032048
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391924,876,307 - 24,878,380 (-)NCBI
GRCm381924,898,943 - 24,901,016 (-)NCBI
MGSCv371924,973,455 - 24,975,799 (-)RGD
Celera1925,674,165 - 25,676,509 (-)RGD
cM Map19 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_032048 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI38433 (Get FASTA)   NCBI Sequence Viewer  
  AAI38435 (Get FASTA)   NCBI Sequence Viewer  
  CAA50742 (Get FASTA)   NCBI Sequence Viewer  
  CAA60128 (Get FASTA)   NCBI Sequence Viewer  
  EDL41622 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000058575
  ENSMUSP00000058575.3
GenBank Protein Q60688 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_032048   ⟸   NM_008022
- UniProtKB: B2RRJ0 (UniProtKB/Swiss-Prot),   Q61573 (UniProtKB/Swiss-Prot),   Q60688 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000058575   ⟸   ENSMUST00000058600

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q60688-F1-model_v2 AlphaFold Q60688 1-444 view protein structure

Promoters
RGD ID:6830042
Promoter ID:MM_KWN:26708
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Lung
Transcripts:NM_008022
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361924,973,734 - 24,974,234 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1347467 AgrOrtholog
Ensembl Genes ENSMUSG00000051490 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000058600 ENTREZGENE
  ENSMUST00000058600.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot
InterPro Fork_head_dom UniProtKB/Swiss-Prot
  FOX_domain-containing UniProtKB/Swiss-Prot
  TF_fork_head_CS_1 UniProtKB/Swiss-Prot
  TF_fork_head_CS_2 UniProtKB/Swiss-Prot
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot
  WH_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report mmu:14237 UniProtKB/Swiss-Prot
MGD MGI:1347467 ENTREZGENE
NCBI Gene 14237 ENTREZGENE
PANTHER FORKHEAD BOX PROTEIN UniProtKB/Swiss-Prot
  FORKHEAD BOX PROTEIN D4-RELATED UniProtKB/Swiss-Prot
Pfam Forkhead UniProtKB/Swiss-Prot
PhenoGen Foxd4 PhenoGen
PRINTS FORKHEAD UniProtKB/Swiss-Prot
PROSITE FORK_HEAD_1 UniProtKB/Swiss-Prot
  FORK_HEAD_2 UniProtKB/Swiss-Prot
  FORK_HEAD_3 UniProtKB/Swiss-Prot
SMART SM00339 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot
UniProt B2RRJ0 ENTREZGENE
  FOXD4_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q61573 ENTREZGENE
UniProt Secondary B2RRJ0 UniProtKB/Swiss-Prot
  Q61573 UniProtKB/Swiss-Prot