Nrm (nurim (nuclear envelope membrane protein)) - Rat Genome Database

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Gene: Nrm (nurim (nuclear envelope membrane protein)) Mus musculus
Analyze
Symbol: Nrm
Name: nurim (nuclear envelope membrane protein)
RGD ID: 1614232
MGI Page MGI
Description: Predicted to be located in nuclear envelope. Predicted to be active in nuclear membrane. Is expressed in several structures, including brain ventricular layer; cranium; heart; metanephros; and nasal capsule. Orthologous to human NRM (nurim).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 2610307M02Rik; AI429796; nuclear envelope membrane protein; nuclear rim protein; nurim; RIKEN cDNA 2610307M02 gene
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391736,171,987 - 36,176,292 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1736,172,210 - 36,176,294 (+)EnsemblGRCm39 Ensembl
GRCm381735,860,311 - 35,865,400 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1735,861,318 - 35,865,402 (+)EnsemblGRCm38mm10GRCm38
MGSCv371735,998,263 - 36,002,345 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361735,469,371 - 35,473,453 (+)NCBIMGSCv36mm8
Celera1739,371,141 - 39,375,224 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. An association study revealed substantial effects of dominance, epistasis and substance dependence co-morbidity on alcohol dependence symptom count. Chen G, etal., Addict Biol. 2017 Nov;22(6):1475-1485. doi: 10.1111/adb.12402. Epub 2016 May 5.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11125038   PMID:11217851   PMID:11591818   PMID:12466851   PMID:12477932   PMID:12904583   PMID:14610273  
PMID:16141072   PMID:16141073   PMID:18799693   PMID:21267068   PMID:21873635   PMID:24457600   PMID:28600179   PMID:32554809  


Genomics

Comparative Map Data
Nrm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391736,171,987 - 36,176,292 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1736,172,210 - 36,176,294 (+)EnsemblGRCm39 Ensembl
GRCm381735,860,311 - 35,865,400 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1735,861,318 - 35,865,402 (+)EnsemblGRCm38mm10GRCm38
MGSCv371735,998,263 - 36,002,345 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361735,469,371 - 35,473,453 (+)NCBIMGSCv36mm8
Celera1739,371,141 - 39,375,224 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.72NCBI
NRM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38630,688,049 - 30,691,420 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl630,688,047 - 30,691,420 (-)EnsemblGRCh38hg38GRCh38
GRCh37630,655,826 - 30,659,197 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36630,763,805 - 30,766,748 (-)NCBINCBI36Build 36hg18NCBI36
Build 34630,763,805 - 30,766,748NCBI
Celera632,253,963 - 32,256,906 (-)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef630,455,762 - 30,459,135 (-)NCBIHuRef
CHM1_1630,657,931 - 30,661,304 (-)NCBICHM1_1
T2T-CHM13v2.0630,552,255 - 30,555,626 (-)NCBIT2T-CHM13v2.0
Nrm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8202,893,126 - 2,897,725 (-)NCBIGRCr8
mRatBN7.2202,888,321 - 2,892,804 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl202,877,567 - 2,891,802 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx202,939,808 - 2,943,295 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0202,944,781 - 2,948,268 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0202,970,921 - 2,974,397 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0203,397,834 - 3,402,264 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl203,397,834 - 3,401,315 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0205,494,939 - 5,498,418 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,035,770 - 3,039,251 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1203,035,990 - 3,039,486 (-)NCBI
Celera20314,246 - 317,724 (-)NCBICelera
Cytogenetic Map20p12NCBI
Nrm
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955583681,302 - 683,658 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955583681,543 - 683,629 (-)NCBIChiLan1.0ChiLan1.0
NRM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2545,248,247 - 45,253,160 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1641,211,455 - 41,214,901 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0630,432,800 - 30,436,272 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1631,302,302 - 31,305,536 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl631,302,302 - 31,305,536 (-)Ensemblpanpan1.1panPan2
Nrm
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494633,991,746 - 33,995,403 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936837357,086 - 359,947 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936837357,005 - 359,956 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NRM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl723,222,307 - 23,225,522 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1723,222,305 - 23,225,506 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2726,944,259 - 26,947,458 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NRM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11741,762,420 - 41,765,757 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1741,762,829 - 41,765,867 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604430,385,194 - 30,388,248 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nrm
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475425,025,292 - 25,027,638 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475425,024,961 - 25,027,689 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nrm
172 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1109
Count of miRNA genes:541
Interacting mature miRNAs:601
Transcripts:ENSMUST00000074259, ENSMUST00000172931, ENSMUST00000174873
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10412276Leci2_mleukocyte endothelial cell interactions 2 (mouse)Not determined17334817537348299Mouse
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17397489048866091Mouse
4141215Mnic1_mmacronutrient intake, carbohydrate 1 (mouse)Not determined485475245670266Mouse
1300706Alan1_malloantigen response 1 (mouse)Not determined17485475246469702Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17485475247885665Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined485475265637357Mouse
10043949Pbft7_mpercent body fat 7 (mouse)Not determined17689393640893936Mouse
1301935Skull24_mskull morphology 24 (mouse)Not determined17858491442585149Mouse
1300787Cd8mts5_mCD8 memory T cell subset 5 (mouse)Not determined17858491442585149Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined171008134086996400Mouse
1302028Asbb3_mautoimmune susceptibility in C57BL/6J and BALB/c 3 (mouse)Not determined171087811944878219Mouse
4142342Lfnq4_mlung function QTL 4 (mouse)Not determined1120648439364059Mouse
4141067Hbnr2_mHeligmosomoides bakeri nematode resistance 2 (mouse)Not determined1188597145886119Mouse
14747010Mancz14_mmandible centroid size 14 (mouse)171199818445998184Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171228621183361768Mouse
12904946Tammq8_mtibialis anterior muscle mass QTL 8 (mouse)171245178746451787Mouse
13524847Asrq8a_macoustic startle response 8a (mouse)171264696146646961Mouse
11081168Tir7_mtrypanosome infection response 7 (mouse)171412337248123496Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171506165249061760Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171506165249061760Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171506165249061760Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171506165249061760Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171681972150819843Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171681972150819843Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171702994351030078Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171746220851462345Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171746220851462345Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171746220851462345Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171746220851462345Mouse
1301840Ssial4_msusceptibility to sialadenitiss 4 (mouse)Not determined171817541252178214Mouse
1301331Lbw1_mlupus NZB x NZW 1 (mouse)Not determined171841835752420983Mouse
1301056Pas2_mpulmonary adenoma susceptibility 2 (mouse)Not determined171842214152424327Mouse
15039354Nmrs36_mNAFLD-associated magnetic resonance shift 36 (mouse)171914502553145025Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172461275058612864Mouse
10412198Sst5_msusceptibility to tuberculosis 5 (mouse)Not determined172507658355712970Mouse
10412196Bbaa28_mB.burgdorferi-associated arthritis 28 (mouse)Not determined172558491443976235Mouse
10412204Bbaa29_mB.burgdorferi-associated arthritis 29 (mouse)Not determined172605118560051352Mouse
1558758Kcal2_mkilocalorie 2 (mouse)Not determined172640101252911704Mouse
1300602Eye2_meye weight 2 (mouse)Not determined172650533741105037Mouse
1302005Loco2_mlocomotor activity 2 (mouse)Not determined172688497260885114Mouse
11075105Modc1_mmodifier of Odc1 (mouse)172771579245622654Mouse
15039348Nmrs37_mNAFLD-associated magnetic resonance shift 37 (mouse)172781520961815209Mouse
10045977Tir9_mtrypanosome infection response 9 (mouse)Not determined172787811943885114Mouse
1300703Uvbi2_mUVB induced immunosuppression 2 (mouse)Not determined172862240662622654Mouse
1300589Myaa2_mmodifier of Yaa 2 (mouse)Not determined173013255564132666Mouse
4141357Mrdq1_mmodifier of retinal degeneration QTL 1 (mouse)Not determined3098790348039703Mouse
4140955Plgr1_mplague resistance locus 1 (mouse)Not determined3103350065033630Mouse
1300692Blmpf1_mbleomycin-induced pulmonary fibrosis 1 (mouse)Not determined173206165237644775Mouse
26884379Skwq5_mskull length QTL 5, 5 week (mouse)173311897454107028Mouse
1302189Dps3_mdelta power in slow-wave sleep 3 (mouse)Not determined173381972136250180Mouse
1300885Mbis4_mMycobacterium bovis-induced systemic lupus erythematosus 4 (mouse)Not determined173517581770165926Mouse
10755514Amzn2_manatomical modifier of Zfp423 2 (mouse)173596629469966424Mouse

Markers in Region
AI429796  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381735,865,131 - 35,865,297UniSTSGRCm38
MGSCv371736,002,076 - 36,002,242UniSTSGRCm37
Celera1739,374,955 - 39,375,121UniSTS
Cytogenetic Map17B1UniSTS
Whitehead/MRC_RH17487.93UniSTS
RH139928  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381735,864,510 - 35,864,696UniSTSGRCm38
MGSCv371736,001,455 - 36,001,641UniSTSGRCm37
Celera1739,374,334 - 39,374,520UniSTS
Cytogenetic Map17B1UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000074259   ⟹   ENSMUSP00000073873
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1736,172,210 - 36,176,294 (+)Ensembl
GRCm38.p6 Ensembl1735,861,318 - 35,865,402 (+)Ensembl
RefSeq Acc Id: ENSMUST00000172931   ⟹   ENSMUSP00000134569
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1736,172,378 - 36,175,495 (+)Ensembl
GRCm38.p6 Ensembl1735,861,486 - 35,864,603 (+)Ensembl
RefSeq Acc Id: ENSMUST00000174873   ⟹   ENSMUSP00000133355
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1736,172,230 - 36,175,555 (+)Ensembl
GRCm38.p6 Ensembl1735,861,338 - 35,864,663 (+)Ensembl
RefSeq Acc Id: NM_134122   ⟹   NP_598883
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391736,172,210 - 36,176,292 (+)NCBI
GRCm381735,861,318 - 35,865,400 (+)NCBI
MGSCv371735,998,263 - 36,002,345 (+)RGD
Celera1739,371,141 - 39,375,224 (+)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030249416   ⟹   XP_030105276
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391736,171,987 - 36,175,599 (+)NCBI
GRCm381735,860,311 - 35,864,707 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_598883   ⟸   NM_134122
- UniProtKB: Q8VC65 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030105276   ⟸   XM_030249416
- Peptide Label: isoform X1
- UniProtKB: G3UWN3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000134569   ⟸   ENSMUST00000172931
RefSeq Acc Id: ENSMUSP00000073873   ⟸   ENSMUST00000074259
RefSeq Acc Id: ENSMUSP00000133355   ⟸   ENSMUST00000174873

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VC65-F1-model_v2 AlphaFold Q8VC65 1-262 view protein structure

Promoters
RGD ID:13675924
Promoter ID:EPDNEW_M22111
Type:initiation region
Name:Nrm_1
Description:Mus musculus nurim , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381735,861,357 - 35,861,417EPDNEW
RGD ID:6828420
Promoter ID:MM_KWN:23345
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   Brain,   ES_Cell,   Lung
Transcripts:NM_134122
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361735,998,056 - 35,998,556 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2146855 AgrOrtholog
Ensembl Genes ENSMUSG00000059791 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000074259 ENTREZGENE
  ENSMUST00000074259.15 UniProtKB/Swiss-Prot
  ENSMUST00000172931.2 UniProtKB/TrEMBL
  ENSMUST00000174873 ENTREZGENE
  ENSMUST00000174873.2 UniProtKB/TrEMBL
InterPro Nurim-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:106582 UniProtKB/Swiss-Prot
MGD MGI:2146855 ENTREZGENE
NCBI Gene 106582 ENTREZGENE
PANTHER NURIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR31040 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nrm PhenoGen
UniProt A0A1W6AWH1_MOUSE UniProtKB/TrEMBL
  G3UWN3 ENTREZGENE, UniProtKB/TrEMBL
  G3UZN7_MOUSE UniProtKB/TrEMBL
  NRM_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 Nrm  nurim (nuclear envelope membrane protein)  2610307M02Rik  RIKEN cDNA 2610307M02 gene  Data merged from RGD:1608457 737654 PROVISIONAL