ASTE1 (asteroid homolog 1) - Rat Genome Database

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Gene: ASTE1 (asteroid homolog 1) Homo sapiens
Analyze
Symbol: ASTE1
Name: asteroid homolog 1
RGD ID: 1606299
HGNC Page HGNC:25021
Description: Enables 3' overhang single-stranded DNA endodeoxyribonuclease activity. Involved in double-strand break repair via homologous recombination and double-strand break repair via nonhomologous end joining. Implicated in Lynch syndrome and mismatch repair cancer syndrome.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: asteroid homolog 1 (Drosophila); HT001; MGC129980; protein asteroid homolog 1; single-strand DNA endonuclease ASTE1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383131,013,875 - 131,026,825 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3131,013,875 - 131,027,649 (-)EnsemblGRCh38hg38GRCh38
GRCh373130,732,719 - 130,745,669 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363132,215,411 - 132,228,336 (-)NCBINCBI36Build 36hg18NCBI36
Celera3129,157,968 - 129,170,892 (-)NCBICelera
Cytogenetic Map3q22.1NCBI
HuRef3128,116,859 - 128,129,780 (-)NCBIHuRef
CHM1_13130,696,245 - 130,709,170 (-)NCBICHM1_1
T2T-CHM13v2.03133,757,625 - 133,770,598 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ASTE1HumanLynch syndrome  IAGP 153297765DNA:mutations:cds: (human)RGD 
ASTE1Humanmismatch repair cancer syndrome  IAGP 153297765DNA:mutations:cds: (human)RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ASTE1Humanalkaptonuria  IAGPRGD:1518693628554872ClinVar Annotator: match by term: AlkaptonuriaClinVarPMID:12501223|PMID:19862842|PMID:28492532
ASTE1Humangenetic disease  IAGPRGD:5976994018554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVar 
ASTE1HumanPrimary Lymphedema with Myelodysplasia  IAGPRGD:1503379228554872ClinVar Annotator: match by term: Emberger syndromeClinVarPMID:22147895|PMID:25741868

1 to 20 of 30 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ASTE1Human17beta-estradiol multiple interactionsISORGD:13046436480464[bisphenol A co-treated with Estradiol] results in increased expression of ASTE1 mRNACTDPMID:26496021
ASTE1Human2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:13122026480464Tetrachlorodibenzodioxin affects the expression of ASTE1 mRNACTDPMID:21570461
ASTE1Human2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISORGD:13122026480464[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression more ...CTDPMID:25975270
ASTE1Humanaflatoxin B1 decreases methylationEXP 6480464Aflatoxin B1 results in decreased methylation of ASTE1 geneCTDPMID:27153756
ASTE1Humanall-trans-retinoic acid decreases expressionEXP 6480464Tretinoin results in decreased expression of ASTE1 mRNACTDPMID:33167477
ASTE1Humanbenzo[a]pyrene increases expressionISORGD:13046436480464Benzo(a)pyrene results in increased expression of ASTE1 mRNACTDPMID:21839799
ASTE1Humanbisphenol A multiple interactionsISORGD:13046436480464[bisphenol A co-treated with Estradiol] results in increased expression of ASTE1 mRNACTDPMID:26496021
ASTE1Humanbisphenol A decreases methylationISORGD:13122026480464bisphenol A results in decreased methylation of ASTE1 promoterCTDPMID:27312807
ASTE1Humanbisphenol A increases methylationISORGD:13046436480464bisphenol A results in increased methylation of ASTE1 geneCTDPMID:28505145
ASTE1Humanbisphenol A decreases expressionISORGD:13046436480464bisphenol A results in decreased expression of ASTE1 mRNACTDPMID:25181051
ASTE1Humanbutanal decreases expressionEXP 6480464butyraldehyde results in decreased expression of ASTE1 mRNACTDPMID:26079696
ASTE1Humancalcium silicate increases expressionISORGD:13122026480464calcium silicate results in increased expression of ASTE1 mRNACTDPMID:29279043
ASTE1HumanCGP 52608 multiple interactionsEXP 6480464CGP 52608 promotes the reaction [RORA protein binds to ASTE1 gene]CTDPMID:28238834
ASTE1Humancopper(II) sulfate decreases expressionEXP 6480464Copper Sulfate results in decreased expression of ASTE1 mRNACTDPMID:19549813
ASTE1Humancyclosporin A decreases expressionEXP 6480464Cyclosporine results in decreased expression of ASTE1 mRNACTDPMID:25562108
ASTE1HumanDibutyl phosphate affects expressionEXP 6480464di-n-butylphosphoric acid affects the expression of ASTE1 mRNACTDPMID:37042841
ASTE1Humandicrotophos decreases expressionEXP 6480464dicrotophos results in decreased expression of ASTE1 mRNACTDPMID:28302478
ASTE1HumanGSK-J4 decreases expressionEXP 6480464GSK-J4 results in decreased expression of ASTE1 mRNACTDPMID:29301935
ASTE1Humanmanganese(II) chloride increases expressionISORGD:13046436480464manganese chloride results in increased expression of ASTE1 mRNACTDPMID:28801915
ASTE1Humanmethyl methanesulfonate increases expressionEXP 6480464Methyl Methanesulfonate results in increased expression of ASTE1 mRNACTDPMID:23649840

1 to 20 of 30 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ASTE1HumanDNA recombination involved_inIEAARBA:ARBA00028026150520179 UniProtGO_REF:0000117
ASTE1Humandouble-strand break repair via homologous recombination involved_inIMP 150520179 PMID:34354233UniProtPMID:34354233
ASTE1Humandouble-strand break repair via homologous recombination involved_inIEAUniProtKB:Q8BIR2|ensembl:ENSMUSP00000035181150520179 EnsemblGO_REF:0000107
ASTE1Humandouble-strand break repair via nonhomologous end joining involved_inIMP 150520179 PMID:34354233UniProtPMID:34354233
ASTE1Humandouble-strand break repair via nonhomologous end joining involved_inIEAUniProtKB:Q8BIR2|ensembl:ENSMUSP00000035181150520179 EnsemblGO_REF:0000107

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ASTE1Human3' overhang single-stranded DNA endodeoxyribonuclease activity enablesIDA 150520179 PMID:34354233UniProtPMID:34354233
ASTE1HumanDNA endonuclease activity enablesIEAARBA:ARBA00029205150520179 UniProtGO_REF:0000117
ASTE1Humanhydrolase activity enablesIEAUniProtKB-KW:KW-0378150520179 UniProtGO_REF:0000043
ASTE1Humannuclease activity enablesIEAInterPro:IPR006085150520179 InterProGO_REF:0000002
ASTE1Humanprotein binding enablesIPIUniProtKB:Q5UIP0|UniProtKB:Q6ZNX1|UniProtKB:Q86V20|UniProtKB:Q8IYI0|UniProtKB:Q9UI95150520179 PMID:34354233UniProtPMID:34354233
ASTE1Humanprotein binding enablesIPIUniProtKB:Q13426150520179 PMID:25416956IntActPMID:25416956
ASTE1Humansingle-stranded DNA endodeoxyribonuclease activity enablesIDA 150520179 PMID:34354233UniProtPMID:34354233


#
Reference Title
Reference Citation
1. Frameshift mutational target gene analysis identifies similarities and differences in constitutional mismatch repair-deficiency and Lynch syndrome. Maletzki C, etal., Mol Carcinog. 2017 Jul;56(7):1753-1764. doi: 10.1002/mc.22632. Epub 2017 Mar 30.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:12477932   PMID:14702039   PMID:19503063   PMID:23344038   PMID:24163370   PMID:25416956   PMID:26496610   PMID:28514442   PMID:33961781   PMID:34354233   PMID:34983924  



ASTE1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383131,013,875 - 131,026,825 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3131,013,875 - 131,027,649 (-)EnsemblGRCh38hg38GRCh38
GRCh373130,732,719 - 130,745,669 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363132,215,411 - 132,228,336 (-)NCBINCBI36Build 36hg18NCBI36
Celera3129,157,968 - 129,170,892 (-)NCBICelera
Cytogenetic Map3q22.1NCBI
HuRef3128,116,859 - 128,129,780 (-)NCBIHuRef
CHM1_13130,696,245 - 130,709,170 (-)NCBICHM1_1
T2T-CHM13v2.03133,757,625 - 133,770,598 (-)NCBIT2T-CHM13v2.0
Aste1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399105,272,533 - 105,285,497 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9105,272,591 - 105,289,428 (+)EnsemblGRCm39 Ensembl
GRCm389105,395,294 - 105,408,299 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9105,395,392 - 105,412,229 (+)EnsemblGRCm38mm10GRCm38
MGSCv379105,297,722 - 105,308,088 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369105,253,622 - 105,263,561 (+)NCBIMGSCv36mm8
Celera9104,992,887 - 105,003,207 (+)NCBICelera
Cytogenetic Map9F1NCBI
cM Map956.61NCBI
Aste1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88114,905,349 - 114,923,775 (+)NCBIGRCr8
mRatBN7.28106,026,570 - 106,044,694 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8106,026,515 - 106,044,430 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8111,655,122 - 111,665,629 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08109,854,373 - 109,864,880 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08107,697,077 - 107,707,584 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08113,936,991 - 113,954,833 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8113,936,991 - 113,954,832 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08113,322,462 - 113,342,413 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48110,501,422 - 110,516,965 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18110,519,628 - 110,528,378 (+)NCBI
Celera8105,359,298 - 105,369,824 (+)NCBICelera
Cytogenetic Map8q32NCBI
Aste1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555017,373,713 - 7,383,092 (+)NCBIChiLan1.0ChiLan1.0
ASTE1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22128,972,825 - 128,983,442 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13128,977,552 - 128,987,990 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03128,098,219 - 128,111,196 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13135,420,860 - 135,433,827 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3135,421,044 - 135,432,284 (-)Ensemblpanpan1.1panPan2
ASTE1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12328,233,165 - 28,244,036 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2328,231,032 - 28,243,768 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2328,205,872 - 28,216,831 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02328,740,377 - 28,751,279 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12328,436,690 - 28,447,583 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02328,495,397 - 28,506,344 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02328,745,248 - 28,756,015 (-)NCBIUU_Cfam_GSD_1.0
Aste1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560267,711,919 - 67,723,819 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365294,470,347 - 4,484,590 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365294,472,157 - 4,484,319 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASTE1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl131,435,678 - 1,449,855 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1131,435,714 - 1,457,733 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2131,093,040 - 1,113,028 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ASTE1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11559,178,704 - 59,186,556 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604132,196,726 - 32,205,222 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aste1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247306,998,274 - 7,008,828 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247306,998,194 - 7,010,284 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in ASTE1
52 total Variants

Predicted Target Of
Summary Value
Count of predictions:984
Count of miRNA genes:604
Interacting mature miRNAs:674
Transcripts:ENST00000264992, ENST00000504725, ENST00000504964, ENST00000505290, ENST00000505545, ENST00000507978, ENST00000509060, ENST00000514044
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

HT001__6609  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373130,732,644 - 130,733,180UniSTSGRCh37
Build 363132,215,334 - 132,215,870RGDNCBI36
Celera3129,157,891 - 129,158,427RGD
HuRef3128,116,782 - 128,117,318UniSTS
RH78727  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373130,734,960 - 130,735,136UniSTSGRCh37
Build 363132,217,650 - 132,217,826RGDNCBI36
Celera3129,160,207 - 129,160,383RGD
Cytogenetic Map3q22.1UniSTS
HuRef3128,119,097 - 128,119,273UniSTS
GeneMap99-GB4 RH Map3461.18UniSTS
RH11935  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373130,735,030 - 130,735,179UniSTSGRCh37
Build 363132,217,720 - 132,217,869RGDNCBI36
Celera3129,160,277 - 129,160,426RGD
Cytogenetic Map3q22.1UniSTS
HuRef3128,119,167 - 128,119,316UniSTS
GeneMap99-GB4 RH Map3461.23UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2253 4974 1726 2351 6 624 1951 465 2270 7306 6472 52 3733 1 852 1744 1617 174 1


1 to 24 of 24 rows
RefSeq Transcripts NM_001288950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_014065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_110229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017006266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017006267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017006268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017006269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024453486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054346363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054346364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC055733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF113539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK027258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK027806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK294156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC030274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC103709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC110616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM992874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HF583927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 24 of 24 rows

Ensembl Acc Id: ENST00000264992   ⟹   ENSP00000264992
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3131,013,875 - 131,026,825 (-)Ensembl
Ensembl Acc Id: ENST00000504725   ⟹   ENSP00000422851
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3131,025,162 - 131,026,586 (-)Ensembl
Ensembl Acc Id: ENST00000504964   ⟹   ENSP00000426363
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3131,018,505 - 131,025,539 (-)Ensembl
Ensembl Acc Id: ENST00000505290   ⟹   ENSP00000423347
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3131,016,291 - 131,024,450 (-)Ensembl
Ensembl Acc Id: ENST00000505545   ⟹   ENSP00000425683
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3131,025,158 - 131,027,649 (-)Ensembl
Ensembl Acc Id: ENST00000507978   ⟹   ENSP00000421019
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3131,013,982 - 131,026,854 (-)Ensembl
Ensembl Acc Id: ENST00000509060   ⟹   ENSP00000427303
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3131,025,286 - 131,026,609 (-)Ensembl
Ensembl Acc Id: ENST00000514044   ⟹   ENSP00000426421
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3131,013,875 - 131,026,792 (-)Ensembl
RefSeq Acc Id: NM_001288950   ⟹   NP_001275879
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383131,013,875 - 131,026,825 (-)NCBI
HuRef3128,116,855 - 128,129,832 (-)NCBI
CHM1_13130,696,241 - 130,709,222 (-)NCBI
T2T-CHM13v2.03133,757,625 - 133,770,574 (-)NCBI
Sequence:
RefSeq Acc Id: NM_014065   ⟹   NP_054784
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383131,013,875 - 131,026,825 (-)NCBI
GRCh373130,732,721 - 130,745,698 (-)NCBI
Build 363132,215,411 - 132,228,336 (-)NCBI Archive
Celera3129,157,968 - 129,170,892 (-)RGD
HuRef3128,116,855 - 128,129,832 (-)NCBI
CHM1_13130,696,241 - 130,709,222 (-)NCBI
T2T-CHM13v2.03133,757,625 - 133,770,574 (-)NCBI
Sequence:
RefSeq Acc Id: NR_110229
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383131,013,875 - 131,026,825 (-)NCBI
HuRef3128,116,855 - 128,129,832 (-)NCBI
CHM1_13130,696,241 - 130,709,222 (-)NCBI
T2T-CHM13v2.03133,757,625 - 133,770,574 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017006266   ⟹   XP_016861755
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383131,016,144 - 131,026,825 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024453486   ⟹   XP_024309254
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383131,016,144 - 131,026,825 (-)NCBI
Sequence:
RefSeq Acc Id: XM_054346363   ⟹   XP_054202338
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.03133,759,894 - 133,770,569 (-)NCBI
RefSeq Acc Id: XM_054346364   ⟹   XP_054202339
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.03133,759,894 - 133,770,598 (-)NCBI
1 to 5 of 14 rows
1 to 5 of 14 rows
RefSeq Acc Id: NP_054784   ⟸   NM_014065
- Peptide Label: isoform 2
- UniProtKB: Q96JY1 (UniProtKB/Swiss-Prot),   Q8N6G4 (UniProtKB/Swiss-Prot),   Q3MIB6 (UniProtKB/Swiss-Prot),   B4DFL9 (UniProtKB/Swiss-Prot),   Q9UHX6 (UniProtKB/Swiss-Prot),   Q2TB18 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001275879   ⟸   NM_001288950
- Peptide Label: isoform 1
- UniProtKB: D6RG30 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016861755   ⟸   XM_017006266
- Peptide Label: isoform X1
- UniProtKB: Q2TB18 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_024309254   ⟸   XM_024453486
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSP00000422851   ⟸   ENST00000504725
XPG N-terminal

Name Modeler Protein Id AA Range Protein Structure
AF-Q2TB18-F1-model_v2 AlphaFold Q2TB18 1-679 view protein structure

RGD ID:6865746
Promoter ID:EPDNEW_H6002
Type:initiation region
Name:ASTE1_1
Description:asteroid homolog 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H6004  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh383131,026,764 - 131,026,824EPDNEW
RGD ID:6814703
Promoter ID:HG_XEF:5642
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:NM_001164828
Position:
Human AssemblyChrPosition (strand)Source
Build 363132,219,586 - 132,220,086 (-)MPROMDB
RGD ID:6801352
Promoter ID:HG_KWN:46214
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001146003,   NM_014065,   NM_024800,   NM_145910,   UC003ENW.1,   UC003ENZ.1,   UC010HTM.1,   UC010HTN.1
Position:
Human AssemblyChrPosition (strand)Source
Build 363132,227,436 - 132,228,392 (+)MPROMDB


1 to 40 of 41 rows
Database
Acc Id
Source(s)
COSMIC ASTE1 COSMIC
Ensembl Genes ENSG00000034533 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000264992 ENTREZGENE
  ENST00000264992.8 UniProtKB/Swiss-Prot
  ENST00000507978 ENTREZGENE
  ENST00000507978.5 UniProtKB/Swiss-Prot
  ENST00000514044 ENTREZGENE
Gene3D-CATH 5'-nuclease UniProtKB/Swiss-Prot
GTEx ENSG00000034533 GTEx
HGNC ID HGNC:25021 ENTREZGENE
Human Proteome Map ASTE1 Human Proteome Map
InterPro Asteroid UniProtKB/Swiss-Prot
  PIN-like_dom_sf UniProtKB/Swiss-Prot
  XPG_DNA_repair_N UniProtKB/Swiss-Prot
KEGG Report hsa:28990 UniProtKB/Swiss-Prot
NCBI Gene 28990 ENTREZGENE
OMIM 620693 OMIM
PANTHER PROTEIN ASTEROID HOMOLOG 1 UniProtKB/Swiss-Prot
  PTHR15665 UniProtKB/Swiss-Prot
Pfam XPG_N UniProtKB/Swiss-Prot
PharmGKB PA142672577 PharmGKB
Superfamily-SCOP SSF88723 UniProtKB/Swiss-Prot
UniProt A0A1Y8EM16_HUMAN UniProtKB/TrEMBL
  ASTE1_HUMAN UniProtKB/Swiss-Prot
  B4DFL9 ENTREZGENE
  D6R9W5_HUMAN UniProtKB/TrEMBL
  D6RG30 ENTREZGENE, UniProtKB/TrEMBL
  D6RGH3_HUMAN UniProtKB/TrEMBL
  D6RJF1_HUMAN UniProtKB/TrEMBL
  H0Y982_HUMAN UniProtKB/TrEMBL
  L8E8G8_HUMAN UniProtKB/TrEMBL
  Q2TB18 ENTREZGENE
  Q3MIB6 ENTREZGENE
  Q8N6G4 ENTREZGENE
  Q96JY1 ENTREZGENE
  Q9UHX6 ENTREZGENE
UniProt Secondary B4DFL9 UniProtKB/Swiss-Prot
  Q3MIB6 UniProtKB/Swiss-Prot
  Q8N6G4 UniProtKB/Swiss-Prot
  Q96JY1 UniProtKB/Swiss-Prot
1 to 40 of 41 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-05-30 ASTE1  asteroid homolog 1    asteroid homolog 1 (Drosophila)  Symbol and/or name change 5135510 APPROVED