VSIG8 (V-set and immunoglobulin domain containing 8)

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Gene: VSIG8 (V-set and immunoglobulin domain containing 8) Homo sapiens

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Symbol:

VSIG8

Name:

V-set and immunoglobulin domain containing 8

RGD ID:

1603819

HGNC Page

HGNC:32063

Description:

Enables RNA binding activity. Predicted to be located in membrane.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

V-set and immunoglobulin domain-containing protein 8

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	159,854,316 - 159,862,657 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	159,854,316 - 159,862,657 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	159,824,106 - 159,832,447 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	158,090,730 - 158,099,071 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	132,892,533 - 132,900,874 (-)	NCBI		Celera
Cytogenetic Map	1	q23.2	NCBI
HuRef	1	131,180,790 - 131,189,134 (-)	NCBI		HuRef
CHM1_1	1	161,219,446 - 161,227,779 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	158,991,321 - 158,999,665 (-)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autoimmune interstitial lung, joint, and kidney disease (IAGP)

gastrointestinal stromal tumor (IAGP)

parathyroid carcinoma (IAGP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

4,4'-sulfonyldiphenol (EXP,ISO)

6-propyl-2-thiouracil (ISO)

alpha-Zearalanol (ISO)

arsane (EXP)

arsenic atom (EXP)

benzo[a]pyrene (EXP)

bisphenol A (ISO)

carbon nanotube (ISO)

CGP 52608 (EXP)

Cuprizon (ISO)

decabromodiphenyl ether (ISO)

epoxiconazole (ISO)

fenvalerate (ISO)

perfluorooctanoic acid (ISO)

sodium arsenate (EXP)

sodium arsenite (ISO)

titanium dioxide (ISO)

trichloroethene (ISO)

trovafloxacin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

membrane (IEA)

Molecular Function

protein binding (IPI)

RNA binding (HDA)

Phenotype Annotations Click to see Annotation Detail View

Human Phenotype

Gastrointestinal stroma tumor (IAGP)

Parathyroid carcinoma (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:19380743	PMID:19615732	PMID:21873635	PMID:22681889	PMID:22990118	PMID:25332235	PMID:25963833	PMID:26186194	PMID:27173435	PMID:28514442	PMID:29507755
PMID:29509190	PMID:31586073	PMID:32687490	PMID:33961781	PMID:35516420	PMID:35864588

Genomics

Comparative Map Data

VSIG8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	159,854,316 - 159,862,657 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	159,854,316 - 159,862,657 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	159,824,106 - 159,832,447 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	158,090,730 - 158,099,071 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	132,892,533 - 132,900,874 (-)	NCBI		Celera
Cytogenetic Map	1	q23.2	NCBI
HuRef	1	131,180,790 - 131,189,134 (-)	NCBI		HuRef
CHM1_1	1	161,219,446 - 161,227,779 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	158,991,321 - 158,999,665 (-)	NCBI		T2T-CHM13v2.0

Vsig8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	172,383,505 - 172,391,284 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	172,383,505 - 172,391,284 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	172,555,938 - 172,563,717 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	172,555,938 - 172,563,717 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	174,486,069 - 174,493,848 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	174,392,613 - 174,400,391 (+)	NCBI		MGSCv36	mm8
Celera	1	175,410,068 - 175,418,089 (+)	NCBI		Celera
Cytogenetic Map	1	H3	NCBI
cM Map	1	79.95	NCBI

Vsig8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	87,555,533 - 87,563,720 (+)	NCBI		GRCr8
mRatBN7.2	13	85,023,177 - 85,031,364 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	85,023,177 - 85,031,364 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	87,526,386 - 87,534,524 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	88,926,659 - 88,934,797 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	86,111,397 - 86,119,535 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	90,943,255 - 90,951,443 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	90,943,255 - 90,951,443 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	95,462,572 - 95,470,761 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	88,561,388 - 88,569,578 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	13	84,632,209 - 84,640,242 (+)	NCBI		Celera
Cytogenetic Map	13	q24	NCBI

VSIG8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	89,995,386 - 90,020,025 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	89,735,562 - 89,739,801 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	135,185,990 - 135,221,407 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	139,126,959 - 139,134,922 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	139,126,959 - 139,135,206 (-)	Ensembl	panpan1.1		panPan2

VSIG8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	38	22,278,668 - 22,285,444 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	38	22,278,807 - 22,285,444 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	38	22,356,485 - 22,363,024 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	38	22,401,958 - 22,408,499 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	38	22,401,956 - 22,408,086 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.0	38	22,701,347 - 22,707,882 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	38	23,112,192 - 23,118,737 (+)	NCBI		UU_Cfam_GSD_1.0

Vsig8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	5,998,083 - 6,005,935 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936740	748,581 - 756,424 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936740	752,134 - 756,428 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

VSIG8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	90,637,077 - 90,645,388 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	90,636,983 - 90,644,818 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	98,638,510 - 98,646,086 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

VSIG8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	4,091,971 - 4,096,947 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	4,088,450 - 4,096,212 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	3,150,252 - 3,155,311 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Vsig8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624794	1,396,009 - 1,403,567 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624794	1,389,093 - 1,403,574 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in VSIG8
23 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 1q23.2-24.1(chr1:159479887-166895086)x1	copy number loss	See cases [RCV000051172]	Chr1:159479887..166895086 [GRCh38] Chr1:159449677..166864323 [GRCh37] Chr1:157716301..165130947 [NCBI36] Chr1:1q23.2-24.1	pathogenic
GRCh38/hg38 1q23.1-23.3(chr1:156664483-160727411)x3	copy number gain	Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051851]\|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051851]\|See cases [RCV000051851]	Chr1:156664483..160727411 [GRCh38] Chr1:156634275..160697201 [GRCh37] Chr1:154900899..158963825 [NCBI36] Chr1:1q23.1-23.3	pathogenic
GRCh38/hg38 1q23.1-25.1(chr1:157747246-176021247)x3	copy number gain	See cases [RCV000051854]	Chr1:157747246..176021247 [GRCh38] Chr1:157717036..175990383 [GRCh37] Chr1:155983660..174257006 [NCBI36] Chr1:1q23.1-25.1	pathogenic
GRCh38/hg38 1q21.2-25.2(chr1:149854269-180267197)x3	copy number gain	See cases [RCV000143515]	Chr1:149854269..180267197 [GRCh38] Chr1:149825831..180236332 [GRCh37] Chr1:148092455..178502955 [NCBI36] Chr1:1q21.2-25.2	pathogenic
GRCh37/hg19 1q23.2(chr1:159824090-159857739)x1	copy number loss	See cases [RCV000448554]	Chr1:159824090..159857739 [GRCh37] Chr1:1q23.2	likely benign
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3	copy number gain	See cases [RCV000510383]	Chr1:849467..249224684 [GRCh37] Chr1:1p36.33-q44	pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)	copy number gain	See cases [RCV000510926]	Chr1:849467..249224684 [GRCh37] Chr1:1p36.33-q44	pathogenic
NM_001013661.1(VSIG8):c.68G>A (p.Arg23Gln)	single nucleotide variant	not specified [RCV004330669]	Chr1:159858894 [GRCh38] Chr1:159828684 [GRCh37] Chr1:1q23.2	uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3	copy number gain	not provided [RCV000736295]	Chr1:47851..249228449 [GRCh37] Chr1:1p36.33-q44	pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3	copy number gain	not provided [RCV000736305]	Chr1:82154..249218992 [GRCh37] Chr1:1p36.33-q44	pathogenic
GRCh37/hg19 1q23.2-25.2(chr1:159815642-177026983)x1	copy number loss	not provided [RCV000736717]	Chr1:159815642..177026983 [GRCh37] Chr1:1q23.2-25.2	pathogenic
GRCh37/hg19 1q23.2-23.3(chr1:159808188-161011163)x3	copy number gain	not provided [RCV000846649]	Chr1:159808188..161011163 [GRCh37] Chr1:1q23.2-23.3	uncertain significance
NM_001013661.1(VSIG8):c.1100G>A (p.Gly367Asp)	single nucleotide variant	not specified [RCV004683323]	Chr1:159854898 [GRCh38] Chr1:159824688 [GRCh37] Chr1:1q23.2	uncertain significance
GRCh37/hg19 1q23.1-24.2(chr1:157321299-167391423)x1	copy number loss	not provided [RCV000848773]	Chr1:157321299..167391423 [GRCh37] Chr1:1q23.1-24.2	pathogenic
NM_001013661.1(VSIG8):c.805G>A (p.Val269Ile)	single nucleotide variant	not specified [RCV004326342]	Chr1:159856049 [GRCh38] Chr1:159825839 [GRCh37] Chr1:1q23.2	likely benign
NM_001013661.1(VSIG8):c.556C>T (p.His186Tyr)	single nucleotide variant	not specified [RCV004683322]	Chr1:159857841 [GRCh38] Chr1:159827631 [GRCh37] Chr1:1q23.2	uncertain significance
NC_000001.10:g.(?_130980840)_(248900000_?)dup	duplication	Gastrointestinal stromal tumor [RCV001300221]\|Parathyroid carcinoma [RCV001341077]	Chr1:130980840..248900000 [GRCh37] Chr1:1q12-44	uncertain significance
NC_000001.10:g.(?_158581054)_(162750036_?)dup	duplication	Autoimmune interstitial lung disease-arthritis syndrome [RCV001918952]\|not provided [RCV001918953]	Chr1:158581054..162750036 [GRCh37] Chr1:1q23.1-23.3	uncertain significance\|no classifications from unflagged records
NM_001013661.1(VSIG8):c.275A>G (p.His92Arg)	single nucleotide variant	not specified [RCV004299333]	Chr1:159858245 [GRCh38] Chr1:159828035 [GRCh37] Chr1:1q23.2	uncertain significance
GRCh37/hg19 1q23.2-23.3(chr1:159778364-160770515)x3	copy number gain	not provided [RCV002474924]	Chr1:159778364..160770515 [GRCh37] Chr1:1q23.2-23.3	uncertain significance
NM_001013661.1(VSIG8):c.916G>A (p.Gly306Ser)	single nucleotide variant	not specified [RCV004204236]	Chr1:159855938 [GRCh38] Chr1:159825728 [GRCh37] Chr1:1q23.2	likely benign
NM_001013661.1(VSIG8):c.1138G>A (p.Ala380Thr)	single nucleotide variant	not specified [RCV004126410]	Chr1:159854860 [GRCh38] Chr1:159824650 [GRCh37] Chr1:1q23.2	uncertain significance
NM_001013661.1(VSIG8):c.668A>T (p.Asp223Val)	single nucleotide variant	not specified [RCV004159919]	Chr1:159856628 [GRCh38] Chr1:159826418 [GRCh37] Chr1:1q23.2	uncertain significance
NM_001013661.1(VSIG8):c.1073G>T (p.Arg358Leu)	single nucleotide variant	not specified [RCV004197572]	Chr1:159854925 [GRCh38] Chr1:159824715 [GRCh37] Chr1:1q23.2	uncertain significance
NM_001013661.1(VSIG8):c.1091C>G (p.Pro364Arg)	single nucleotide variant	not specified [RCV004186554]	Chr1:159854907 [GRCh38] Chr1:159824697 [GRCh37] Chr1:1q23.2	uncertain significance
NM_001013661.1(VSIG8):c.484G>A (p.Asp162Asn)	single nucleotide variant	not specified [RCV004099737]	Chr1:159857913 [GRCh38] Chr1:159827703 [GRCh37] Chr1:1q23.2	uncertain significance
NM_001013661.1(VSIG8):c.841G>A (p.Val281Ile)	single nucleotide variant	not specified [RCV004076126]	Chr1:159856013 [GRCh38] Chr1:159825803 [GRCh37] Chr1:1q23.2	uncertain significance
NM_001013661.1(VSIG8):c.791T>A (p.Val264Glu)	single nucleotide variant	not specified [RCV004096942]	Chr1:159856063 [GRCh38] Chr1:159825853 [GRCh37] Chr1:1q23.2	uncertain significance
NM_001013661.1(VSIG8):c.505G>A (p.Ala169Thr)	single nucleotide variant	not specified [RCV004124955]	Chr1:159857892 [GRCh38] Chr1:159827682 [GRCh37] Chr1:1q23.2	uncertain significance
NM_001013661.1(VSIG8):c.100C>G (p.Leu34Val)	single nucleotide variant	not specified [RCV004158276]	Chr1:159858862 [GRCh38] Chr1:159828652 [GRCh37] Chr1:1q23.2	uncertain significance
NM_001013661.1(VSIG8):c.1042C>T (p.Pro348Ser)	single nucleotide variant	not specified [RCV004260617]	Chr1:159854956 [GRCh38] Chr1:159824746 [GRCh37] Chr1:1q23.2	uncertain significance
NM_001013661.1(VSIG8):c.1078T>A (p.Tyr360Asn)	single nucleotide variant	not specified [RCV004331527]	Chr1:159854920 [GRCh38] Chr1:159824710 [GRCh37] Chr1:1q23.2	uncertain significance
NM_001013661.1(VSIG8):c.782G>A (p.Arg261His)	single nucleotide variant	not specified [RCV004248708]	Chr1:159856072 [GRCh38] Chr1:159825862 [GRCh37] Chr1:1q23.2	uncertain significance
NM_001013661.1(VSIG8):c.163C>T (p.Pro55Ser)	single nucleotide variant	not specified [RCV004264828]	Chr1:159858799 [GRCh38] Chr1:159828589 [GRCh37] Chr1:1q23.2	uncertain significance
NM_001013661.1(VSIG8):c.1160C>T (p.Ser387Phe)	single nucleotide variant	not specified [RCV004306860]	Chr1:159854838 [GRCh38] Chr1:159824628 [GRCh37] Chr1:1q23.2	uncertain significance
NM_001013661.1(VSIG8):c.76G>A (p.Gly26Arg)	single nucleotide variant	not specified [RCV004341783]	Chr1:159858886 [GRCh38] Chr1:159828676 [GRCh37] Chr1:1q23.2	uncertain significance
NM_001013661.1(VSIG8):c.886G>A (p.Ala296Thr)	single nucleotide variant	not specified [RCV004344425]	Chr1:159855968 [GRCh38] Chr1:159825758 [GRCh37] Chr1:1q23.2	uncertain significance
GRCh37/hg19 1q23.1-23.3(chr1:158001058-162858285)x1	copy number loss	not provided [RCV003483944]	Chr1:158001058..162858285 [GRCh37] Chr1:1q23.1-23.3	likely pathogenic
NM_001013661.1(VSIG8):c.572G>A (p.Arg191Gln)	single nucleotide variant	not specified [RCV004485013]	Chr1:159857825 [GRCh38] Chr1:159827615 [GRCh37] Chr1:1q23.2	uncertain significance

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	365
Count of miRNA genes:	291
Interacting mature miRNAs:	316
Transcripts:	ENST00000368100
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCh38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1357381	BW57_H	Body weight QTL 57 (human)	1	0.0001	Body weight	fat free mass after exercise training	1	140630236	166630236	Human
407365794	GWAS1014770_H	abdominal fat cell number QTL GWAS1014770 (human)		0.000001	abdominal fat cell number		1	159855045	159855046	Human
407222786	GWAS871762_H	red blood cell density measurement QTL GWAS871762 (human)		0.000002	red blood cell density measurement		1	159855400	159855401	Human

Markers in Region

RH70397

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	1	159,833,691 - 159,833,841	UniSTS	GRCh37
Build 36	1	158,100,315 - 158,100,465	RGD	NCBI36
Celera	1	132,902,118 - 132,902,268	RGD
Cytogenetic Map	1	q23.2	UniSTS
GeneMap99-GB4 RH Map	1	575.02	UniSTS
NCBI RH Map	1	1436.5	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	entire extraembryonic component	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system
1196	2386	2706	2198	4728	1539	2127	4	442	1453	284	2098	6456	5923	43	3653	812	1692	1580	172

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001013661	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AL590560	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC132893	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC132895	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068277	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENST00000368100 ⟹ ENSP00000357080

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	1	159,854,316 - 159,862,657 (-)	Ensembl

RefSeq Acc Id:

NM_001013661 ⟹ NP_001013683

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	1	159,854,316 - 159,862,657 (-)	NCBI
GRCh37	1	159,824,106 - 159,832,447 (-)	RGD
Build 36	1	158,090,730 - 158,099,071 (-)	NCBI Archive
Celera	1	132,892,533 - 132,900,874 (-)	RGD
HuRef	1	131,180,790 - 131,189,134 (-)	ENTREZGENE
CHM1_1	1	161,219,446 - 161,227,779 (-)	NCBI
T2T-CHM13v2.0	1	158,991,321 - 158,999,665 (-)	NCBI

Sequence:

show sequence

ACTCATTGCACCTTCCTGCCACCCCAGGCAGTGTCTGGGCCCTCAGCTCCCCCTCCCTCCACCT
ACCCCCTCACACCCACCACTACGACCCCACGGGATACCCAGCCCAGACGGAGGAAACACCGAGC
CTAGAGACATGAGAGTTGGAGGAGCATTCCACCTTCTACTCGTGTGCCTGAGCCCAGCACTGCT
GTCTGCTGTGCGGATCAACGGGGATGGACAGGAGGTCCTGTACCTGGCAGAAGGTGATAATGTG
AGGCTGGGCTGCCCCTACGTCCTGGACCCTGAGGACTATGGTCCCAATGGGCTGGACATCGAGT
GGATGCAGGTCAACTCAGACCCCGCCCACCACCGAGAGAACGTGTTCCTTAGTTACCAGGACAA
GAGGATCAACCATGGCAGCCTTCCCCATCTGCAGCAGAGGGTCCGCTTTGCAGCCTCAGACCCA
AGCCAGTACGATGCCTCCATCAACCTCATGAACCTGCAGGTATCTGATACAGCCACTTATGAGT
GCCGGGTGAAGAAGACCACCATGGCCACCCGGAAGGTCATTGTCACTGTCCAAGCACGACCTGC
AGTGCCCATGTGCTGGACAGAGGGCCACATGACATATGGCAACGATGTGGTGCTGAAGTGCTAT
GCCAGTGGGGGCTCCCAGCCCCTCTCCTACAAGTGGGCCAAGATCAGTGGGCACCATTACCCCT
ATCGAGCTGGGTCTTACACCTCCCAGCACAGCTACCACTCAGAGCTGTCCTACCAGGAGTCCTT
CCACAGCTCCATAAACCAAGGCCTGAACAATGGGGACCTGGTGTTGAAGGATATCTCCAGAGCA
GATGATGGGCTGTATCAGTGCACAGTGGCCAACAACGTGGGCTACAGTGTTTGTGTGGTGGAGG
TGAAGGTCTCAGACTCCCGGCGTATAGGCGTGATCATCGGCATCGTCCTGGGCTCTCTGCTCGC
GCTGGGCTGCCTGGCCGTAGGCATCTGGGGGCTCGTCTGCTGCTGCTGCGGGGGCTCCGGGGCT
GGCGGCGCCCGCGGTGCCTTCGGCTACGGCAACGGCGGCGGGGTCGGCGGAGGGGCCTGCGGCG
ACTTGGCTAGTGAGATCAGAGAGGACGCCGTGGCGCCCGGGTGCAAGGCCAGCGGGCGCGGCAG
CCGCGTCACCCACCTCCTGGGGTACCCGACGCAGAACGTCAGCCGCTCCCTGCGCCGCAAGTAC
GCGCCTCCCCCCTGCGGCGGCCCCGAGGACGTGGCCCTGGCGCCCTGCACCGCCGCCGCCGCCT
GCGAAGCGGGCCCCTCCCCGGTCTACGTCAAGGTCAAGAGCGCGGAGCCGGCTGACTGCGCCGA
GGGGCCGGTGCAGTGCAAGAACGGCCTCTTGGTGTGAGCGCGCGCGCCGGGCCGGGCTGCGCCC
CAGCCAGGAGGAGGGCGCGGGGCTCTCTGTCTGCAGCTGGGGACACGTCGGGGCTGGGGACGAC
CTCGCTCGCCCCAGGCTGCCAGGCGGCTGGGGGTGAAGGCATTTCCCTAAGGAAATGCGTAGGG
AGGCAGAGCCTCCTCCCCAAAAGTGGGAAGGGGCGGGCGAGGGCGGAGGAAGGCGATCCTGAGC
CTTCTCCGCACCCCCGGGACCGAAGGCTTGGGGGAGAGGGAGGGAGGAGGAGGCTGAGTGTCCT
AGAGCGGCTGAGGCCGGAGGCCTGGTGTCCCCAGCCTAAGCAGAGGGCCCCGGGGGCCGGGTGG
GTGGGGGTCTGTCTGGACGAATTGTTCTGTGTGTGAGGTCTGAGCTCTGAGGCAGCAGTGTTAG
CACAATAAAGAAACATTGAGACGTGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001013683	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI32894	(Get FASTA)	NCBI Sequence Viewer
	AAI32896	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000357080
	ENSP00000357080.1
GenBank Protein	P0DPA2	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001013683 ⟸ NM_001013661
- Peptide Label:	precursor
- UniProtKB:	P0DPA2 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MRVGGAFHLLLVCLSPALLSAVRINGDGQEVLYLAEGDNVRLGCPYVLDPEDYGPNGLDIEWMQ VNSDPAHHRENVFLSYQDKRINHGSLPHLQQRVRFAASDPSQYDASINLMNLQVSDTATYECRV KKTTMATRKVIVTVQARPAVPMCWTEGHMTYGNDVVLKCYASGGSQPLSYKWAKISGHHYPYRA GSYTSQHSYHSELSYQESFHSSINQGLNNGDLVLKDISRADDGLYQCTVANNVGYSVCVVEVKV SDSRRIGVIIGIVLGSLLALGCLAVGIWGLVCCCCGGSGAGGARGAFGYGNGGGVGGGACGDLA SEIREDAVAPGCKASGRGSRVTHLLGYPTQNVSRSLRRKYAPPPCGGPEDVALAPCTAAAACEA GPSPVYVKVKSAEPADCAEGPVQCKNGLLV hide sequence

Ensembl Acc Id:

ENSP00000357080 ⟸ ENST00000368100

Protein Domains

Ig-like V-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P0DPA2-F1-model_v2	AlphaFold	P0DPA2	1-414	view protein structure

Promoters

RGD ID:

6857734

Promoter ID:

EPDNEW_H2032

Type:

initiation region

Name:

VSIG8_3

Description:

V-set and immunoglobulin domain containing 8

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H2033 EPDNEW_H2034

Experiment Methods:

Single-end sequencing.; Paired-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	1	159,854,778 - 159,854,838	EPDNEW

RGD ID:

6857736

Promoter ID:

EPDNEW_H2033

Type:

multiple initiation site

Name:

VSIG8_1

Description:

V-set and immunoglobulin domain containing 8

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H2032 EPDNEW_H2034

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	1	159,862,657 - 159,862,717	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:32063	AgrOrtholog
COSMIC	VSIG8	COSMIC
Ensembl Genes	ENSG00000243284	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000368100	ENTREZGENE
	ENST00000368100.1	UniProtKB/Swiss-Prot
Gene3D-CATH	2.60.40.10	UniProtKB/Swiss-Prot
GTEx	ENSG00000243284	GTEx
HGNC ID	HGNC:32063	ENTREZGENE
Human Proteome Map	VSIG8	Human Proteome Map
InterPro	Ig-like_dom	UniProtKB/Swiss-Prot
	Ig-like_dom_sf	UniProtKB/Swiss-Prot
	Ig-like_fold	UniProtKB/Swiss-Prot
	Ig_sub	UniProtKB/Swiss-Prot
	Ig_sub2	UniProtKB/Swiss-Prot
	Ig_V-set	UniProtKB/Swiss-Prot
	V-set/Ig_domain	UniProtKB/Swiss-Prot
KEGG Report	hsa:391123	UniProtKB/Swiss-Prot
NCBI Gene	391123	ENTREZGENE
PANTHER	V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 8	UniProtKB/Swiss-Prot
	V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 8	UniProtKB/Swiss-Prot
Pfam	Ig_3	UniProtKB/Swiss-Prot
	V-set	UniProtKB/Swiss-Prot
PharmGKB	PA142670610	PharmGKB
PROSITE	IG_LIKE	UniProtKB/Swiss-Prot
SMART	IGc2	UniProtKB/Swiss-Prot
	IGv	UniProtKB/Swiss-Prot
	SM00409	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF48726	UniProtKB/Swiss-Prot
UniProt	P0DPA2	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	Q5VU13	UniProtKB/Swiss-Prot
	Q5VU14	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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