MIR629 (microRNA 629) - Rat Genome Database

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Gene: MIR629 (microRNA 629) Homo sapiens
Analyze
Symbol: MIR629
Name: microRNA 629
RGD ID: 1602924
HGNC Page HGNC:32885
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-629; mir-629; MIRN629
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381570,079,372 - 70,079,468 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1570,079,372 - 70,079,468 (-)EnsemblGRCh38hg38GRCh38
GRCh371570,371,711 - 70,371,807 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361568,158,764 - 68,158,860 (-)NCBINCBI36Build 36hg18NCBI36
Celera1547,261,117 - 47,261,174 (-)NCBICelera
Cytogenetic Map15q23NCBI
CHM1_11570,489,566 - 70,489,662 (-)NCBICHM1_1
T2T-CHM13v2.01567,901,600 - 67,901,696 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:16505370   PMID:17604727   PMID:21037258   PMID:22114071   PMID:24687380   PMID:25381221   PMID:27155035   PMID:28629464   PMID:28972400   PMID:29072689   PMID:30042169  
PMID:30178840   PMID:30657562   PMID:30954576   PMID:31240850   PMID:31379200   PMID:32108166   PMID:32457332   PMID:32716350   PMID:33763157   PMID:33886809   PMID:34373436   PMID:35776288  
PMID:36990459   PMID:37602452   PMID:39056503  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 15q23-25.1(chr15:70025300-78705993)x1 copy number loss See cases [RCV000141666] Chr15:70025300..78705993 [GRCh38]
Chr15:70317639..78998335 [GRCh37]
Chr15:68104693..76785390 [NCBI36]
Chr15:15q23-25.1		 pathogenic
GRCh38/hg38 15q22.2-26.3(chr15:59828460-101920998)x3 copy number gain See cases [RCV000142915] Chr15:59828460..101920998 [GRCh38]
Chr15:60120659..102461201 [GRCh37]
Chr15:57907951..100278724 [NCBI36]
Chr15:15q22.2-26.3		 pathogenic
GRCh38/hg38 15q23-24.1(chr15:68830574-73823337)x1 copy number loss See cases [RCV000050780] Chr15:68830574..73823337 [GRCh38]
Chr15:69122913..74115678 [GRCh37]
Chr15:66909967..71902731 [NCBI36]
Chr15:15q23-24.1		 pathogenic
GRCh38/hg38 15q23(chr15:69765212-70293917)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051970]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051970]|See cases [RCV000051970] Chr15:69765212..70293917 [GRCh38]
Chr15:70057551..70586256 [GRCh37]
Chr15:67844605..68373310 [NCBI36]
Chr15:15q23		 uncertain significance
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
DDX3Xhsa-miR-629-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
HNF4Ahsa-miR-629-5pMirtarbaseexternal_infoELISA//Flow//Immunohistochemistry//ImmunoprecipitaFunctional MTI22153071
H2AC6hsa-miR-629-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
HNF4Ahsa-miR-629-5pOncomiRDBexternal_infoNANA22153071

Predicted Targets
Summary Value
Count of predictions:47166
Count of gene targets:17898
Count of transcripts:37925
Interacting mature miRNAs:hsa-miR-629-3p, hsa-miR-629-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
21 34 66 44 95 26 68 2 11 176 10 81 267 251 8 38 15 40 54 4

Sequence


Ensembl Acc Id: ENST00000385230
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1570,079,372 - 70,079,468 (-)Ensembl
RefSeq Acc Id: NR_030714
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381570,079,372 - 70,079,468 (-)NCBI
GRCh371570,371,711 - 70,371,807 (-)RGD
Celera1547,261,117 - 47,261,174 (-)RGD
CHM1_11570,489,566 - 70,489,662 (-)NCBI
T2T-CHM13v2.01567,901,600 - 67,901,696 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR629 COSMIC
Ensembl Genes ENSG00000207965 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000385230 ENTREZGENE
GTEx ENSG00000207965 GTEx
HGNC ID HGNC:32885 ENTREZGENE
Human Proteome Map MIR629 Human Proteome Map
miRBase MI0003643 ENTREZGENE
NCBI Gene 693214 ENTREZGENE
PharmGKB PA164722925 PharmGKB
RNAcentral URS00002F3336 RNACentral
  URS00004065BA RNACentral
  URS000075CA16 RNACentral