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Gene: DDX3X (DEAD-box helicase 3 X-linked) Homo sapiens
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Symbol: DDX3X
Name: DEAD-box helicase 3 X-linked
Description: Exhibits several functions, including eukaryotic initiation factor 4E binding activity; nucleic acid binding activity; and nucleoside-triphosphatase activity. Involved in several processes, including apoptotic signaling pathway; regulation of cell growth; and regulation of cellular protein metabolic process. Localizes to the cytoplasmic stress granule; cytosol; and nucleoplasm. Colocalizes with the cytosolic small ribosomal subunit and eukaryotic translation initiation factor 3 complex. Implicated in non-syndromic X-linked intellectual disability.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ATP-dependent RNA helicase DDX3X; CAP-Rf; DBX; DDX14; DDX3; DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked; DEAD box protein 3, X-chromosomal; DEAD box, X isoform; DEAD-box helicase 3, X-linked; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3; DEAD/H box-3; helicase like protein 2; helicase-like protein 2; HLP2; MRX102
Orthologs:
Mus musculus (house mouse) : Ddx3x (DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ddx3x (DEAD-box helicase 3, X-linked)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ddx3x (DEAD-box helicase 3 X-linked)
Pan paniscus (bonobo/pygmy chimpanzee) : DDX3X (DEAD-box helicase 3, X-linked)
Canis lupus familiaris (dog) : DDX3X (DEAD-box helicase 3 X-linked)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ddx3x (DEAD-box helicase 3 X-linked)
Sus scrofa (pig) : DDX3X (DEAD-box helicase 3 X-linked)
more info ...
Related Pseudogenes: DDX3P3  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X41,333,308 - 41,364,472 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X41,192,561 - 41,209,527 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X41,077,595 - 41,094,471 (+)NCBINCBI36hg18NCBI36
Build 34X40,948,904 - 40,979,978NCBI
CeleraX45,333,407 - 45,350,283 (+)NCBI
Cytogenetic MapXp11.4NCBI
HuRefX38,924,970 - 38,941,587 (+)NCBIHuRef
CHM1_1X41,225,277 - 41,256,447 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on DDX3X
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1352934
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.