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Gene: DDX3X (DEAD-box helicase 3 X-linked) Homo sapiens
Symbol: DDX3X
Name: DEAD-box helicase 3 X-linked
Description: Exhibits several functions, including eukaryotic initiation factor 4E binding activity; nucleic acid binding activity; and nucleoside-triphosphatase activity. Involved in several processes, including apoptotic signaling pathway; regulation of cell growth; and regulation of cellular protein metabolic process. Localizes to the cytoplasmic stress granule; cytosol; and nucleoplasm. Colocalizes with the cytosolic small ribosomal subunit and eukaryotic translation initiation factor 3 complex. Implicated in non-syndromic X-linked intellectual disability.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ATP-dependent RNA helicase DDX3X; CAP-Rf; DBX; DDX14; DDX3; DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked; DEAD box protein 3, X-chromosomal; DEAD box, X isoform; DEAD-box helicase 3, X-linked; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3; DEAD/H box-3; helicase like protein 2; helicase-like protein 2; HLP2; MRX102
Mus musculus (house mouse) : Ddx3x (DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ddx3x (DEAD-box helicase 3, X-linked)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ddx3x (DEAD-box helicase 3 X-linked)
Pan paniscus (bonobo/pygmy chimpanzee) : DDX3X (DEAD-box helicase 3, X-linked)
Canis lupus familiaris (dog) : DDX3X (DEAD-box helicase 3 X-linked)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ddx3x (DEAD-box helicase 3 X-linked)
Sus scrofa (pig) : DDX3X (DEAD-box helicase 3 X-linked)
more info ...
Related Pseudogenes: DDX3P3  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X41,333,308 - 41,364,472 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X41,192,561 - 41,209,527 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X41,077,595 - 41,094,471 (+)NCBINCBI36hg18NCBI36
Build 34X40,948,904 - 40,979,978NCBI
CeleraX45,333,407 - 45,350,283 (+)NCBI
Cytogenetic MapXp11.4NCBI
HuRefX38,924,970 - 38,941,587 (+)NCBIHuRef
CHM1_1X41,225,277 - 41,256,447 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on DDX3X
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1352934
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.