Pnma5 (PNMA family member 5) - Rat Genome Database

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Gene: Pnma5 (PNMA family member 5) Rattus norvegicus
Analyze
Symbol: Pnma5
Name: PNMA family member 5
RGD ID: 1565857
Description: Predicted to enable identical protein binding activity. Predicted to be involved in meiosis I. Predicted to be located in nucleus. Predicted to be active in cell cortex and meiotic spindle. Orthologous to human PNMA5 (PNMA family member 5); INTERACTS WITH bisphenol A; C60 fullerene; aflatoxin B1 (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC309266; paraneoplastic antigen like 5; paraneoplastic antigen-like protein 5; paraneoplastic Ma antigen family member 5; RGD1565857; similar to paraneoplastic antigen like 5
RGD Orthologs
Human
Mouse
Bonobo
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X155,923,131 - 155,925,055 (-)NCBIGRCr8
mRatBN7.2X150,880,865 - 150,882,789 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX150,880,865 - 150,882,789 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX153,072,910 - 153,074,834 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X156,605,250 - 156,607,174 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X154,148,364 - 154,150,288 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X153,037,448 - 153,039,372 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX153,037,448 - 153,039,372 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01148,767,026 - 148,768,950 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,030,480 - 159,032,404 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1131,845,146 - 131,847,070 (-)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 12 of 12 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pnma5Ratadrenoleukodystrophy  ISOPNMA5 (Homo sapiens)8554872ClinVar Annotator: match by term: AdrenoleukodystrophyClinVarPMID:10480214 more ...
Pnma5Ratautistic disorder  ISOPNMA5 (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311
Pnma5Ratautosomal hemophilia A  ISOPNMA5 (Homo sapiens)8554872ClinVar Annotator: match by term: AUTOSOMAL HEMOPHILIA AClinVarPMID:31690835
Pnma5RatBarth syndrome  ISOPNMA5 (Homo sapiens)8554872ClinVar Annotator: match by term: 3-Methylglutaconic aciduria type 2ClinVarPMID:10480214 more ...
Pnma5Ratcerebral creatine deficiency syndrome 1  ISOPNMA5 (Homo sapiens)8554872ClinVar Annotator: match by term: Creatine transporter deficiencyClinVarPMID:10480214 more ...
Pnma5Ratdyskeratosis congenita  ISOPNMA5 (Homo sapiens)8554872ClinVar Annotator: match by term: Dyskeratosis congenitaClinVarPMID:18177777 and PMID:28492532
Pnma5RatEmery-Dreifuss muscular dystrophy  ISOPNMA5 (Homo sapiens)8554872ClinVar Annotator: match by term: X-linked Emery-Dreifuss muscular dystrophyClinVarPMID:10480214 more ...
Pnma5Ratfactor VIII deficiency  ISOPNMA5 (Homo sapiens)8554872ClinVar Annotator: match by term: Factor 8 deficiency and congenitalClinVarPMID:31690835
Pnma5Ratfavism  ISOPNMA5 (Homo sapiens)8554872ClinVar Annotator: match by term: Anemia more ...ClinVarPMID:18177777 and PMID:28492532
Pnma5Ratparaplegia  ISOPNMA5 (Homo sapiens)8554872ClinVar Annotator: match by term: Spastic paraplegiaClinVarPMID:10480214 more ...
Pnma5Ratperiventricular nodular heterotopia  ISOPNMA5 (Homo sapiens)8554872ClinVar Annotator: match by term: Heterotopia more ...ClinVarPMID:10480214 more ...
Pnma5Ratsyndromic X-linked intellectual disability Lubs type  ISOPNMA5 (Homo sapiens)8554872ClinVar Annotator: match by term: Syndromic X-linked intellectual disability Lubs typeClinVarPMID:22679399 more ...
1 to 12 of 12 rows

1 to 12 of 12 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pnma5Rataflatoxin B1 decreases expressionISOPNMA5 (Homo sapiens)6480464Aflatoxin B1 results in decreased expression of PNMA5 mRNACTDPMID:22100608
Pnma5Ratbenzo[a]pyrene decreases methylationISOPNMA5 (Homo sapiens)6480464Benzo(a)pyrene results in decreased methylation of PNMA5 5' UTRCTDPMID:27901495
Pnma5Ratbis(2-ethylhexyl) phthalate decreases expressionISOPnma5 (Mus musculus)6480464Diethylhexyl Phthalate results in decreased expression of PNMA5 mRNACTDPMID:34319233
Pnma5Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of PNMA5 mRNACTDPMID:25181051
Pnma5Ratbisphenol A increases methylationEXP 6480464bisphenol A results in increased methylation of PNMA5 geneCTDPMID:28505145
Pnma5RatC60 fullerene decreases expressionEXP 6480464fullerene C60 results in decreased expression of PNMA5 mRNACTDPMID:19167457
Pnma5Ratchlorpyrifos increases expressionISOPnma5 (Mus musculus)6480464Chlorpyrifos results in increased expression of PNMA5 mRNACTDPMID:32715474
Pnma5Ratfolic acid decreases expressionISOPnma5 (Mus musculus)6480464Folic Acid results in decreased expression of PNMA5 mRNACTDPMID:25629700
Pnma5Ratlead(0) affects expressionISOPNMA5 (Homo sapiens)6480464Lead affects the expression of PNMA5 mRNACTDPMID:28903495
Pnma5Ratsilicon dioxide increases expressionISOPNMA5 (Homo sapiens)6480464Silicon Dioxide analog results in increased expression of PNMA5 mRNACTDPMID:25895662
Pnma5Rattitanium dioxide decreases expressionISOPnma5 (Mus musculus)6480464titanium dioxide results in decreased expression of PNMA5 mRNACTDPMID:35295148
Pnma5Ratvalproic acid increases methylationISOPNMA5 (Homo sapiens)6480464Valproic Acid results in increased methylation of PNMA5 geneCTDPMID:29154799

1 to 12 of 12 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pnma5Ratmeiosis I involved_inISOPnma5 (Mus musculus)1624291 PMID:29228573RGDPMID:29228573
Pnma5Ratphosphatidylinositol 3-kinase/protein kinase B signal transduction acts_upstream_of_or_withinISOPnma5 (Mus musculus)1624291 PMID:29228573RGDPMID:29228573

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pnma5Ratcell cortex is_active_inISOPnma5 (Mus musculus)1624291 PMID:29228573RGDPMID:29228573
Pnma5Ratmeiotic spindle is_active_inISOPnma5 (Mus musculus)1624291 PMID:29228573RGDPMID:29228573
Pnma5Ratnucleus located_inISOPNMA5 (Homo sapiens)1624291 PMID:31429579RGDPMID:31429579
Pnma5Ratnucleus located_inIEAUniProtKB:Q96PV4 and ensembl:ENSP000004457751600115GO_REF:0000107EnsemblGO_REF:0000107

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pnma5Ratidentical protein binding enablesISOPNMA5 (Homo sapiens)1624291UniProtKB:Q96PV4 more ...RGDPMID:25416956 and PMID:32296183
Pnma5Ratidentical protein binding enablesIEAUniProtKB:Q96PV4 and ensembl:ENSP000004457751600115GO_REF:0000107EnsemblGO_REF:0000107
Pnma5Ratprotein binding enablesISOPNMA5 (Homo sapiens)1624291UniProtKB:A1L4K1 more ...RGDPMID:25416956 more ...


#
Reference Title
Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:25416956  



Pnma5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X155,923,131 - 155,925,055 (-)NCBIGRCr8
mRatBN7.2X150,880,865 - 150,882,789 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX150,880,865 - 150,882,789 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX153,072,910 - 153,074,834 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X156,605,250 - 156,607,174 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X154,148,364 - 154,150,288 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X153,037,448 - 153,039,372 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX153,037,448 - 153,039,372 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01148,767,026 - 148,768,950 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,030,480 - 159,032,404 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1131,845,146 - 131,847,070 (-)NCBICelera
Cytogenetic MapXq37NCBI
PNMA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X152,988,824 - 152,994,116 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX152,988,824 - 152,994,116 (-)EnsemblGRCh38hg38GRCh38
GRCh37X152,157,368 - 152,162,660 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X151,908,024 - 151,911,417 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X151,827,938 - 151,831,326NCBI
CeleraX152,491,524 - 152,496,827 (-)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX140,957,736 - 140,961,176 (-)NCBIHuRef
CHM1_1X152,032,328 - 152,037,631 (-)NCBICHM1_1
T2T-CHM13v2.0X151,255,263 - 151,260,555 (-)NCBIT2T-CHM13v2.0
Pnma5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X72,077,587 - 72,083,315 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX72,077,587 - 72,080,709 (-)EnsemblGRCm39 Ensembl
GRCm38X73,033,981 - 73,039,721 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX73,033,981 - 73,037,103 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X70,279,327 - 70,282,442 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X70,279,322 - 70,282,442 (-)NCBIMGSCv36mm8
CeleraX63,958,163 - 63,961,281 (-)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX37.29NCBI
PNMA5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X153,053,179 - 153,059,368 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X153,056,782 - 153,062,686 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X142,564,200 - 142,566,785 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X152,483,324 - 152,487,740 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX152,483,930 - 152,485,276 (-)Ensemblpanpan1.1panPan2
Pnma5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X118,097,358 - 118,101,500 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936714155,618 - 157,563 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936714155,618 - 156,955 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PNMA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX123,999,037 - 124,000,974 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X123,998,935 - 124,001,201 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PNMA5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X127,511,081 - 127,517,052 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX127,512,502 - 127,513,848 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606565,334,322 - 65,337,737 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

.

Predicted Target Of
Summary Value
Count of predictions:55
Count of miRNA genes:52
Interacting mature miRNAs:55
Transcripts:ENSRNOT00000037851
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat

RH143166  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X150,881,755 - 150,881,971 (+)MAPPERmRatBN7.2
Rnor_6.0X153,038,339 - 153,038,554NCBIRnor6.0
Rnor_5.01148,767,917 - 148,768,132UniSTSRnor5.0
RGSC_v3.4X159,031,371 - 159,031,586UniSTSRGSC3.4
Celera1131,846,037 - 131,846,252UniSTS
Cytogenetic MapXq37UniSTS
RH139174  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X150,881,785 - 150,881,969 (+)MAPPERmRatBN7.2
Rnor_6.0X153,038,369 - 153,038,552NCBIRnor6.0
Rnor_5.01148,767,947 - 148,768,130UniSTSRnor5.0
RGSC_v3.4X159,031,401 - 159,031,584UniSTSRGSC3.4
Celera1131,846,067 - 131,846,250UniSTS
Cytogenetic MapXq37UniSTS
UniSTS:496785  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X150,880,736 - 150,880,962 (+)MAPPERmRatBN7.2
mRatBN7.2X150,908,926 - 150,909,152 (-)MAPPERmRatBN7.2
mRatBN7.2X150,880,736 - 150,880,962 (-)MAPPERmRatBN7.2
mRatBN7.2X150,908,926 - 150,909,152 (+)MAPPERmRatBN7.2
Rnor_6.0X153,037,320 - 153,037,545NCBIRnor6.0
Rnor_6.0X153,066,466 - 153,066,691NCBIRnor6.0
Rnor_5.01148,795,491 - 148,795,716UniSTSRnor5.0
Rnor_5.01148,766,898 - 148,767,123UniSTSRnor5.0
RGSC_v3.4X159,060,178 - 159,060,403UniSTSRGSC3.4
RGSC_v3.4X159,030,352 - 159,030,577UniSTSRGSC3.4
Celera1131,845,018 - 131,845,243UniSTS
Celera1131,872,931 - 131,873,156UniSTS
Cytogenetic MapXq37UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 1 3 22 10 17 2 8 2 6 29 11 16 12 45 15


RefSeq Transcripts NM_001107579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH474110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000085250   ⟹   ENSRNOP00000074335
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX150,880,865 - 150,882,789 (-)Ensembl
Rnor_6.0 EnsemblX153,037,448 - 153,039,372 (-)Ensembl
RefSeq Acc Id: NM_001107579   ⟹   NP_001101049
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X155,923,131 - 155,925,055 (-)NCBI
mRatBN7.2X150,880,865 - 150,882,789 (-)NCBI
Rnor_6.0X153,037,448 - 153,039,372 (-)NCBI
Rnor_5.01148,767,026 - 148,768,950 (-)NCBI
RGSC_v3.4X159,030,480 - 159,032,404 (-)RGD
Celera1131,845,146 - 131,847,070 (-)NCBI
Sequence:
Protein RefSeqs NP_001101049 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL82842 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000074335
  ENSRNOP00000074335.1
RefSeq Acc Id: NP_001101049   ⟸   NM_001107579
- UniProtKB: D4AEL1 (UniProtKB/TrEMBL),   A6KSY9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074335   ⟸   ENSRNOT00000085250
Name Modeler Protein Id AA Range Protein Structure
AF-D4AEL1-F1-model_v2 AlphaFold D4AEL1 1-436 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 17 of 17 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-690 BioCyc
Ensembl Genes ENSRNOG00000058423 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000085250 ENTREZGENE
  ENSRNOT00000085250.2 UniProtKB/TrEMBL
InterPro PNMA UniProtKB/TrEMBL
  PNMA_C UniProtKB/TrEMBL
  PNMA_N UniProtKB/TrEMBL
KEGG Report rno:309266 UniProtKB/TrEMBL
NCBI Gene 309266 ENTREZGENE
PANTHER PTHR23095 UniProtKB/TrEMBL
  PTHR23095:SF4 UniProtKB/TrEMBL
Pfam PNMA UniProtKB/TrEMBL
  PNMA_N UniProtKB/TrEMBL
PhenoGen Pnma5 PhenoGen
RatGTEx ENSRNOG00000058423 RatGTEx
UniProt A6KSY9 ENTREZGENE, UniProtKB/TrEMBL
  D4AEL1 ENTREZGENE, UniProtKB/TrEMBL
1 to 17 of 17 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-09-28 Pnma5  PNMA family member 5  Pnma5  paraneoplastic Ma antigen family member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-10 Pnma5  paraneoplastic Ma antigen family member 5  Pnma5  paraneoplastic antigen like 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-01-23 Pnma5  paraneoplastic antigen like 5  RGD1565857  similar to paraneoplastic antigen like 5   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1565857  similar to paraneoplastic antigen like 5   RGD1565857_predicted  similar to paraneoplastic antigen like 5 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1565857_predicted  similar to paraneoplastic antigen like 5 (predicted)  LOC309266  similar to paraneoplastic antigen like 5  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC309266  similar to paraneoplastic antigen like 5      Symbol and Name status set to provisional 70820 PROVISIONAL