C10h16orf89 (similar to human chromosome 16 open reading frame 89) - Rat Genome Database

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Gene: C10h16orf89 (similar to human chromosome 16 open reading frame 89) Rattus norvegicus
Analyze
Symbol: C10h16orf89 (Ensembl: RGD1565166)
Name: similar to human chromosome 16 open reading frame 89 (Ensembl:similar to MGC45438 protein)
RGD ID: 1565166
Description: Predicted to enable protein homodimerization activity. Predicted to be active in cytosol and membrane. Orthologous to human C16orf89 (chromosome 16 open reading frame 89); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC287059; LOC287059; RGD1565166; similar to MGC45438 protein; uncharacterized protein LOC287059; UPF0764 protein C16orf89 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81010,856,320 - 10,877,515 (+)NCBIGRCr8
mRatBN7.21010,361,909 - 10,371,046 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1010,361,948 - 10,371,046 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1015,068,671 - 15,077,802 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01014,557,481 - 14,566,612 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01010,226,421 - 10,235,585 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01010,555,337 - 10,564,433 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1010,555,337 - 10,564,433 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0109,313,103 - 9,334,297 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41010,476,014 - 10,485,110 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera109,327,992 - 9,337,089 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA,ISO)
membrane  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19056867   PMID:20578903   PMID:23376485   PMID:23533145  


Genomics

Comparative Map Data
C10h16orf89
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81010,856,320 - 10,877,515 (+)NCBIGRCr8
mRatBN7.21010,361,909 - 10,371,046 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1010,361,948 - 10,371,046 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1015,068,671 - 15,077,802 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01014,557,481 - 14,566,612 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01010,226,421 - 10,235,585 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01010,555,337 - 10,564,433 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1010,555,337 - 10,564,433 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0109,313,103 - 9,334,297 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41010,476,014 - 10,485,110 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera109,327,992 - 9,337,089 (+)NCBICelera
Cytogenetic Map10q12NCBI
C16orf89
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38165,042,772 - 5,065,956 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl165,044,122 - 5,066,110 (-)EnsemblGRCh38hg38GRCh38
GRCh37165,094,123 - 5,115,957 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36165,034,124 - 5,056,112 (-)NCBINCBI36Build 36hg18NCBI36
Celera165,303,508 - 5,325,498 (-)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef165,060,189 - 5,082,211 (-)NCBIHuRef
CHM1_1165,095,334 - 5,117,334 (-)NCBICHM1_1
T2T-CHM13v2.0165,072,272 - 5,095,444 (-)NCBIT2T-CHM13v2.0
AU021092
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39165,029,677 - 5,040,170 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl165,029,687 - 5,040,163 (-)EnsemblGRCm39 Ensembl
GRCm38165,211,814 - 5,222,308 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl165,211,823 - 5,222,299 (-)EnsemblGRCm38mm10GRCm38
MGSCv37165,211,912 - 5,222,392 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36165,127,147 - 5,137,601 (-)NCBIMGSCv36mm8
Celera165,844,837 - 5,855,314 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map162.51NCBI
CUNH16orf89
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544212,496,527 - 12,508,802 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544212,496,862 - 12,507,655 (+)NCBIChiLan1.0ChiLan1.0
C18H16orf89
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2185,571,392 - 5,594,001 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1169,361,729 - 9,384,330 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0163,967,203 - 3,990,077 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1165,131,629 - 5,153,316 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl165,132,090 - 5,153,079 (-)Ensemblpanpan1.1panPan2
C6H16orf89
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1636,388,221 - 36,402,847 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl636,388,165 - 36,402,860 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha637,778,562 - 37,794,456 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0636,590,239 - 36,604,802 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl636,590,156 - 36,604,815 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1636,388,880 - 36,403,412 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0636,280,052 - 36,294,599 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0636,680,313 - 36,694,835 (+)NCBIUU_Cfam_GSD_1.0
CUNH16orf89
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344107,083,493 - 107,102,698 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365304,936,064 - 4,948,079 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365304,936,034 - 4,948,076 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C3H16orf89
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl337,346,532 - 37,365,357 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1337,346,530 - 37,365,367 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2338,352,463 - 38,371,273 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CUNH16orf89
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.154,714,323 - 4,735,290 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl54,714,313 - 4,734,915 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606825,918,962 - 25,940,342 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CUNH16orf89
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248242,842,238 - 2,852,027 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248242,838,681 - 2,854,521 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in C10h16orf89
35 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:57
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000032495
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10615418215990232Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10129497586Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 6 40 105 40 45 15 16 15 6 141 71 91 41 60 30

Sequence


Ensembl Acc Id: ENSRNOT00000032495   ⟹   ENSRNOP00000031136
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1010,361,948 - 10,371,046 (+)Ensembl
Rnor_6.0 Ensembl1010,555,337 - 10,564,433 (+)Ensembl
RefSeq Acc Id: NM_001105762   ⟹   NP_001099232
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81010,868,419 - 10,877,515 (+)NCBI
mRatBN7.21010,361,948 - 10,371,046 (+)NCBI
Rnor_6.01010,555,337 - 10,564,433 (+)NCBI
Rnor_5.0109,313,103 - 9,334,297 (+)NCBI
RGSC_v3.41010,476,014 - 10,485,110 (+)RGD
Celera109,327,992 - 9,337,089 (+)RGD
Sequence:
RefSeq Acc Id: XM_063268523   ⟹   XP_063124593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81010,856,320 - 10,877,323 (+)NCBI
RefSeq Acc Id: XM_063268524   ⟹   XP_063124594
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81010,868,373 - 10,876,540 (+)NCBI
RefSeq Acc Id: XR_005489707
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81010,868,377 - 10,874,481 (+)NCBI
mRatBN7.21010,361,909 - 10,370,047 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001099232 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124593 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124594 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL96260 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000031136.4
RefSeq Acc Id: NP_001099232   ⟸   NM_001105762
- Peptide Label: precursor
- UniProtKB: D3ZFA0 (UniProtKB/TrEMBL),   A6K4N8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000031136   ⟸   ENSRNOT00000032495
RefSeq Acc Id: XP_063124593   ⟸   XM_063268523
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063124594   ⟸   XM_063268524
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZFA0-F1-model_v2 AlphaFold D3ZFA0 1-375 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565166 AgrOrtholog
BioCyc Gene G2FUF-26063 BioCyc
Ensembl Genes ENSRNOG00000021796 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000032495.5 UniProtKB/TrEMBL
InterPro DUF4735 UniProtKB/TrEMBL
KEGG Report rno:287059 UniProtKB/TrEMBL
NCBI Gene 287059 ENTREZGENE
PANTHER PTHR33539 UniProtKB/TrEMBL
  UPF0764 PROTEIN C16ORF89 UniProtKB/TrEMBL
Pfam DUF4735 UniProtKB/TrEMBL
PhenoGen C10h16orf89 PhenoGen
RatGTEx ENSRNOG00000021796 RatGTEx
UniProt A6K4N8 ENTREZGENE, UniProtKB/TrEMBL
  D3ZFA0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 C10h16orf89  similar to human chromosome 16 open reading frame 89  RGD1565166  similar to MGC45438 protein  Symbol and Name Changed 1299863 APPROVED
2008-04-30 RGD1565166  similar to MGC45438 protein   RGD1565166_predicted  similar to MGC45438 protein (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1565166_predicted  similar to MGC45438 protein (predicted)  LOC287059  similar to MGC45438 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC287059  similar to MGC45438 protein      Symbol and Name status set to provisional 70820 PROVISIONAL