Magec2 (MAGE family member C2) - Rat Genome Database

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Gene: Magec2 (MAGE family member C2) Rattus norvegicus
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Symbol: Magec2
Name: MAGE family member C2
RGD ID: 1563272
Description: Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; positive regulation of ubiquitin-protein transferase activity; and protein catabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human MAGEC2 (MAGE family member C2); INTERACTS WITH trichloroethene; 2,3,7,8-tetrachlorodibenzodioxine (ortholog); aflatoxin B1 (ortholog).
Type: protein-coding
RefSeq Status: PREDICTED
Previously known as: hypothetical protein LOC317590; melanoma antigen family C, 2; MGC114529; similar to melanoma antigen family A, 10; uncharacterized protein LOC317590
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X145,646,856 - 145,651,730 (+)NCBIGRCr8
mRatBN7.2X140,610,610 - 140,615,484 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX140,606,825 - 140,615,471 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX142,795,973 - 142,800,847 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X146,336,948 - 146,341,822 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X143,892,668 - 143,897,542 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X145,353,959 - 145,362,427 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX145,357,553 - 145,362,426 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X145,374,410 - 145,385,537 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X147,899,671 - 147,904,545 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX136,622,663 - 136,627,537 (+)NCBICelera
Cytogenetic MapXq36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (ISO)
nucleoplasm  (ISO)
nucleus  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:12920247   PMID:20864041  


Genomics

Comparative Map Data
Magec2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X145,646,856 - 145,651,730 (+)NCBIGRCr8
mRatBN7.2X140,610,610 - 140,615,484 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX140,606,825 - 140,615,471 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX142,795,973 - 142,800,847 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X146,336,948 - 146,341,822 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X143,892,668 - 143,897,542 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X145,353,959 - 145,362,427 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX145,357,553 - 145,362,426 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X145,374,410 - 145,385,537 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X147,899,671 - 147,904,545 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX136,622,663 - 136,627,537 (+)NCBICelera
Cytogenetic MapXq36NCBI
MAGEC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X142,202,342 - 142,205,290 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX142,202,342 - 142,205,290 (-)EnsemblGRCh38hg38GRCh38
GRCh37X141,290,128 - 141,293,076 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X141,117,796 - 141,120,742 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X141,015,649 - 141,018,596NCBI
CeleraX141,577,705 - 141,580,653 (-)NCBICelera
Cytogenetic MapXq27.2NCBI
HuRefX130,393,491 - 130,396,267 (-)NCBIHuRef
CHM1_1X141,201,271 - 141,204,219 (-)NCBICHM1_1
T2T-CHM13v2.0X140,511,041 - 140,513,989 (-)NCBIT2T-CHM13v2.0
Magec2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X61,326,566 - 61,335,690 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX61,327,105 - 61,335,684 (+)EnsemblGRCm39 Ensembl
GRCm38X62,282,960 - 62,292,084 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX62,283,499 - 62,292,078 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X59,536,674 - 59,545,257 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X58,551,041 - 58,552,746 (+)NCBIMGSCv36mm8
CeleraX48,697,643 - 48,706,210 (+)NCBICelera
Cytogenetic MapXA6NCBI
cM MapX34.57NCBI

Variants

.
Variants in Magec2
7 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:97
Count of miRNA genes:87
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000033723
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat

Markers in Region
BI288264  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X140,615,060 - 140,615,266 (+)MAPPERmRatBN7.2
Rnor_6.0X145,362,004 - 145,362,209NCBIRnor6.0
Rnor_5.0X145,385,114 - 145,385,319UniSTSRnor5.0
RGSC_v3.4X147,904,122 - 147,904,327UniSTSRGSC3.4
CeleraX136,627,114 - 136,627,319UniSTS
RH 3.4 Map11619.71UniSTS
Cytogenetic MapXq36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 3 10 21 18 19 9 7 9 3 60 25 15 21 48 10

Sequence


Ensembl Acc Id: ENSRNOT00000033723   ⟹   ENSRNOP00000034773
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX140,610,583 - 140,615,471 (+)Ensembl
Rnor_6.0 EnsemblX145,357,553 - 145,362,426 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093770   ⟹   ENSRNOP00000076874
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX140,606,825 - 140,615,471 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106815   ⟹   ENSRNOP00000088622
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX140,610,705 - 140,615,471 (+)Ensembl
RefSeq Acc Id: NM_001025713   ⟹   NP_001020884
RefSeq Status: PREDICTED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X145,646,856 - 145,651,730 (+)NCBI
mRatBN7.2X140,610,610 - 140,615,484 (+)NCBI
Rnor_6.0X145,357,553 - 145,362,427 (+)NCBI
Rnor_5.0X145,374,410 - 145,385,537 (+)NCBI
RGSC_v3.4X147,899,671 - 147,904,545 (+)RGD
CeleraX136,622,663 - 136,627,537 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001020884 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH97464 (Get FASTA)   NCBI Sequence Viewer  
  EDL86181 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000034773.4
  ENSRNOP00000076874.1
  ENSRNOP00000088622.1
RefSeq Acc Id: NP_001020884   ⟸   NM_001025713
- UniProtKB: Q4QR72 (UniProtKB/TrEMBL),   A6K513 (UniProtKB/TrEMBL),   A0A8I5YBY6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000034773   ⟸   ENSRNOT00000033723
Ensembl Acc Id: ENSRNOP00000088622   ⟸   ENSRNOT00000106815
Ensembl Acc Id: ENSRNOP00000076874   ⟸   ENSRNOT00000093770
Protein Domains
MAGE

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4QR72-F1-model_v2 AlphaFold Q4QR72 1-429 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13702022
Promoter ID:EPDNEW_R12546
Type:single initiation site
Name:Magec2_1
Description:MAGE family member C2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X145,357,535 - 145,357,595EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563272 AgrOrtholog
BioCyc Gene G2FUF-856 BioCyc
Ensembl Genes ENSRNOG00000026265 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033723.5 UniProtKB/TrEMBL
  ENSRNOT00000093770.1 UniProtKB/TrEMBL
  ENSRNOT00000106815.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.1200 UniProtKB/TrEMBL
  1.10.10.1210 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7457620 IMAGE-MGC_LOAD
InterPro MAGE UniProtKB/TrEMBL
  MAGE UniProtKB/TrEMBL
  MAGE_WH1 UniProtKB/TrEMBL
  MAGE_WH2 UniProtKB/TrEMBL
KEGG Report rno:317590 UniProtKB/TrEMBL
MGC_CLONE MGC:114529 IMAGE-MGC_LOAD
NCBI Gene 317590 ENTREZGENE
PANTHER MELANOMA-ASSOCIATED ANTIGEN C2 UniProtKB/TrEMBL
  PTHR11736 UniProtKB/TrEMBL
Pfam MAGE UniProtKB/TrEMBL
PhenoGen Magec2 PhenoGen
PROSITE MAGE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000026265 RatGTEx
SMART MAGE UniProtKB/TrEMBL
UniProt A0A8I5YBY6 ENTREZGENE, UniProtKB/TrEMBL
  A6K513 ENTREZGENE
  Q4QR72 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A6K513 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-10 Magec2  MAGE family member C2  Magec2  melanoma antigen family C, 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-15 Magec2  melanoma antigen family C, 2  MGC114529  similar to melanoma antigen family A, 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 MGC114529  similar to melanoma antigen family A, 10      Symbol and Name status set to provisional 70820 PROVISIONAL