Mageb18 (MAGE family member B18) - Rat Genome Database

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Gene: Mageb18 (MAGE family member B18) Rattus norvegicus
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Symbol: Mageb18
Name: MAGE family member B18
RGD ID: 1560369
Description: Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human MAGEB18 (MAGE family member B18); INTERACTS WITH 17alpha-ethynylestradiol; atrazine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC317270; melanoma antigen family B, 18; melanoma-associated antigen B18; MGC114496; RGD1560369; similar to hypothetical protein B430216B18
RGD Orthologs
Human
Mouse
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X60,861,961 - 61,456,154 (-)NCBIGRCr8
mRatBN7.2X56,885,991 - 56,888,245 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX56,885,991 - 56,888,245 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX58,269,851 - 58,272,105 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X61,772,150 - 61,774,404 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X59,365,686 - 59,367,940 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X61,229,831 - 61,232,133 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX61,229,831 - 61,232,085 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X61,812,677 - 61,814,931 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X79,444,746 - 79,447,000 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX57,313,054 - 57,315,308 (-)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (ISO)
nucleus  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:22332604  


Genomics

Comparative Map Data
Mageb18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X60,861,961 - 61,456,154 (-)NCBIGRCr8
mRatBN7.2X56,885,991 - 56,888,245 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX56,885,991 - 56,888,245 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX58,269,851 - 58,272,105 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X61,772,150 - 61,774,404 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X59,365,686 - 59,367,940 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X61,229,831 - 61,232,133 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX61,229,831 - 61,232,085 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X61,812,677 - 61,814,931 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X79,444,746 - 79,447,000 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX57,313,054 - 57,315,308 (-)NCBICelera
Cytogenetic MapXq22NCBI
MAGEB18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X26,138,343 - 26,140,736 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX26,138,343 - 26,140,736 (+)EnsemblGRCh38hg38GRCh38
GRCh37X26,156,460 - 26,158,853 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X26,066,381 - 26,068,773 (+)NCBINCBI36Build 36hg18NCBI36
CeleraX30,283,735 - 30,286,128 (+)NCBICelera
Cytogenetic MapXp21.3NCBI
HuRefX23,893,758 - 23,896,151 (+)NCBIHuRef
CHM1_1X26,188,119 - 26,190,512 (+)NCBICHM1_1
T2T-CHM13v2.0X25,725,680 - 25,728,073 (+)NCBIT2T-CHM13v2.0
Mageb18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X91,162,485 - 91,643,178 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX91,162,485 - 91,643,178 (-)EnsemblGRCm39 Ensembl
GRCm38X92,118,879 - 92,599,572 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX92,118,879 - 92,599,572 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X89,364,218 - 89,844,911 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X88,371,598 - 88,852,291 (-)NCBIMGSCv36mm8
CeleraX79,058,805 - 79,544,266 (-)NCBICelera
Cytogenetic MapXC2- C3NCBI
cM MapX40.62NCBI
LOC111094768
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X23,027,346 - 23,029,856 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX27,991,370 - 27,993,859 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X23,047,980 - 23,050,469 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X23,083,528 - 23,086,017 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X23,097,538 - 23,100,027 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X23,160,836 - 23,163,324 (+)NCBIUU_Cfam_GSD_1.0
LOC100737023
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX22,083,012 - 22,084,040 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X22,082,917 - 22,084,040 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X23,660,138 - 23,662,803 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAGEB18
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X24,611,324 - 24,614,095 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX24,612,338 - 24,613,372 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605626,511,366 - 26,513,725 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:296
Count of miRNA genes:210
Interacting mature miRNAs:238
Transcripts:ENSRNOT00000039605
Prediction methods:Microtar, Miranda, Pita, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
1 1 4 32 4 3 4 5 16 9 26 5 49 3

Sequence


Ensembl Acc Id: ENSRNOT00000039605   ⟹   ENSRNOP00000034674
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX56,885,991 - 56,888,245 (-)Ensembl
Rnor_6.0 EnsemblX61,229,831 - 61,232,085 (-)Ensembl
RefSeq Acc Id: NM_001044246   ⟹   NP_001037711
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X60,861,961 - 60,864,215 (-)NCBI
mRatBN7.2X56,885,991 - 56,888,245 (-)NCBI
Rnor_6.0X61,229,831 - 61,232,085 (-)NCBI
Rnor_5.0X61,812,677 - 61,814,931 (-)NCBI
RGSC_v3.4X79,444,746 - 79,447,000 (-)RGD
CeleraX57,313,054 - 57,315,308 (-)RGD
Sequence:
RefSeq Acc Id: XM_063280032   ⟹   XP_063136102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X60,861,965 - 61,456,154 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001037711 (Get FASTA)   NCBI Sequence Viewer  
  NP_001421016 (Get FASTA)   NCBI Sequence Viewer  
  XP_063136102 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH97441 (Get FASTA)   NCBI Sequence Viewer  
  EDL96020 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000034674.3
RefSeq Acc Id: NP_001037711   ⟸   NM_001044246
- UniProtKB: A6IPZ3 (UniProtKB/TrEMBL),   G3V932 (UniProtKB/TrEMBL),   Q4V8D2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000034674   ⟸   ENSRNOT00000039605
RefSeq Acc Id: XP_063136102   ⟸   XM_063280032
- Peptide Label: isoform X1
Protein Domains
MAGE

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V932-F1-model_v2 AlphaFold G3V932 1-325 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560369 AgrOrtholog
BioCyc Gene G2FUF-2284 BioCyc
Ensembl Genes ENSRNOG00000038230 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000039605.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.1200 UniProtKB/TrEMBL
  1.10.10.1210 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7456024 IMAGE-MGC_LOAD
InterPro MAGE UniProtKB/TrEMBL
  MAGE UniProtKB/TrEMBL
  MAGE_WH1 UniProtKB/TrEMBL
  MAGE_WH2 UniProtKB/TrEMBL
  Melanoma_ass_antigen_N UniProtKB/TrEMBL
KEGG Report rno:317270 UniProtKB/TrEMBL
MGC_CLONE MGC:114496 IMAGE-MGC_LOAD
NCBI Gene 317270 ENTREZGENE
PANTHER MELANOMA-ASSOCIATED ANTIGEN B18 UniProtKB/TrEMBL
  PTHR11736 UniProtKB/TrEMBL
Pfam MAGE UniProtKB/TrEMBL
  MAGE_N UniProtKB/TrEMBL
PhenoGen Mageb18 PhenoGen
PROSITE MAGE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000038230 RatGTEx
SMART MAGE UniProtKB/TrEMBL
  MAGE_N UniProtKB/TrEMBL
UniProt A6IPZ3 ENTREZGENE, UniProtKB/TrEMBL
  G3V932 ENTREZGENE, UniProtKB/TrEMBL
  Q4V8D2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-10 Mageb18  MAGE family member B18  Mageb18  melanoma antigen family B, 18  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Mageb18  melanoma antigen family B, 18   Mageb18_predicted  melanoma antigen family B, 18 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Mageb18_predicted  melanoma antigen family B, 18 (predicted)  RGD1560369_predicted  similar to hypothetical protein B430216B18 (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1560369_predicted  similar to hypothetical protein B430216B18 (predicted)  LOC317270  similar to hypothetical protein B430216B18  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC317270  similar to hypothetical protein B430216B18      Symbol and Name status set to provisional 70820 PROVISIONAL