Ccdc70 (coiled-coil domain containing 70) - Rat Genome Database

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Gene: Ccdc70 (coiled-coil domain containing 70) Rattus norvegicus
Analyze
Symbol: Ccdc70
Name: coiled-coil domain containing 70
RGD ID: 1559811
Description: Predicted to be located in plasma membrane. Orthologous to human CCDC70 (coiled-coil domain containing 70); INTERACTS WITH bisphenol A; 1,2-dichloroethane (ortholog); 2,2',4,4',5,5'-hexachlorobiphenyl (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: coiled-coil domain-containing protein 70; LOC498657; RGD1559811; similar to RIKEN cDNA 1700112P19
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81676,739,795 - 76,745,019 (-)NCBIGRCr8
mRatBN7.21670,037,309 - 70,042,401 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1670,037,309 - 70,042,339 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1675,311,016 - 75,315,175 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01678,749,909 - 78,754,060 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01673,999,239 - 74,003,390 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01674,958,897 - 74,963,925 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1674,958,897 - 74,963,044 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01674,588,763 - 74,592,932 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41674,694,594 - 74,699,743 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1667,921,841 - 67,926,867 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Ccdc70
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81676,739,795 - 76,745,019 (-)NCBIGRCr8
mRatBN7.21670,037,309 - 70,042,401 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1670,037,309 - 70,042,339 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1675,311,016 - 75,315,175 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01678,749,909 - 78,754,060 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01673,999,239 - 74,003,390 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01674,958,897 - 74,963,925 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1674,958,897 - 74,963,044 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01674,588,763 - 74,592,932 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41674,694,594 - 74,699,743 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1667,921,841 - 67,926,867 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
CCDC70
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381351,861,969 - 51,866,232 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1351,861,969 - 51,866,232 (+)EnsemblGRCh38hg38GRCh38
GRCh371352,436,105 - 52,440,368 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361351,334,118 - 51,338,373 (+)NCBINCBI36Build 36hg18NCBI36
Celera1333,484,752 - 33,489,009 (+)NCBICelera
Cytogenetic Map13q14.3NCBI
HuRef1333,224,665 - 33,228,925 (+)NCBIHuRef
CHM1_11352,402,803 - 52,407,058 (+)NCBICHM1_1
T2T-CHM13v2.01351,076,664 - 51,080,932 (+)NCBIT2T-CHM13v2.0
Ccdc70
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39822,459,791 - 22,464,071 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl822,459,791 - 22,464,057 (+)EnsemblGRCm39 Ensembl
GRCm38821,969,775 - 21,974,055 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl821,969,775 - 21,974,041 (+)EnsemblGRCm38mm10GRCm38
MGSCv37823,081,068 - 23,084,513 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36823,436,141 - 23,439,586 (+)NCBIMGSCv36mm8
Celera823,466,734 - 23,470,179 (+)NCBICelera
Cytogenetic Map8A2NCBI
cM Map810.73NCBI
Ccdc70
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554315,166,451 - 5,170,263 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554315,166,451 - 5,170,263 (+)NCBIChiLan1.0ChiLan1.0
CCDC70
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21453,296,249 - 53,303,786 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11351,940,430 - 51,947,971 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01332,991,931 - 32,997,329 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11351,738,467 - 51,742,786 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1351,741,930 - 51,742,631 (+)Ensemblpanpan1.1panPan2
CCDC70
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.122258,746 - 263,908 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl22258,880 - 259,563 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha22294,401 - 299,601 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.022241,731 - 246,931 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl22241,865 - 242,524 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.122162,936 - 168,137 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.022212,548 - 217,749 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.022230,532 - 235,734 (-)NCBIUU_Cfam_GSD_1.0
CCDC70
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1115,977,289 - 15,977,945 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11115,976,814 - 15,978,050 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21116,336,219 - 16,343,715 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCDC70
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1329,745,345 - 29,749,711 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl329,748,861 - 29,749,559 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605714,065,509 - 14,067,523 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccdc70
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247482,280,239 - 2,280,880 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247482,280,183 - 2,283,892 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ccdc70
13 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:87
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000018362
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat
1298527Arunc2Aerobic running capacity QTL 22.9exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)166853271675029966Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
1 3 1 13 9 11 4 6 4 17 9 12 1 23 7

Sequence


Ensembl Acc Id: ENSRNOT00000018362   ⟹   ENSRNOP00000018362
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1670,037,309 - 70,041,464 (-)Ensembl
Rnor_6.0 Ensembl1674,958,897 - 74,963,044 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113817   ⟹   ENSRNOP00000082354
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1670,038,054 - 70,041,959 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115480   ⟹   ENSRNOP00000081872
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1670,038,054 - 70,042,339 (-)Ensembl
RefSeq Acc Id: NM_001420932   ⟹   NP_001407861
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81676,739,795 - 76,743,951 (-)NCBI
mRatBN7.21670,037,309 - 70,041,465 (-)NCBI
RefSeq Acc Id: XM_056984883   ⟹   XP_056840863
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81676,740,601 - 76,745,019 (-)NCBI
mRatBN7.21670,038,139 - 70,042,401 (-)NCBI
RefSeq Acc Id: XM_063275649   ⟹   XP_063131719
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81676,740,601 - 76,744,479 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001407861 (Get FASTA)   NCBI Sequence Viewer  
  XP_056840863 (Get FASTA)   NCBI Sequence Viewer  
  XP_063131719 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI69046 (Get FASTA)   NCBI Sequence Viewer  
  EDM08981 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018362.2
  ENSRNOP00000081872.1
  ENSRNOP00000082354.1
Ensembl Acc Id: ENSRNOP00000018362   ⟸   ENSRNOT00000018362
Ensembl Acc Id: ENSRNOP00000081872   ⟸   ENSRNOT00000115480
Ensembl Acc Id: ENSRNOP00000082354   ⟸   ENSRNOT00000113817
RefSeq Acc Id: NP_001407861   ⟸   NM_001420932
- UniProtKB: A0A8I5ZTU4 (UniProtKB/TrEMBL),   B5DFG0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_056840863   ⟸   XM_056984883
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZTU4 (UniProtKB/TrEMBL),   B5DFG0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131719   ⟸   XM_063275649
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZTU4 (UniProtKB/TrEMBL),   B5DFG0 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B5DFG0-F1-model_v2 AlphaFold B5DFG0 1-223 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700211
Promoter ID:EPDNEW_R10720
Type:multiple initiation site
Name:Ccdc70_1
Description:coiled-coil domain containing 70
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01674,963,053 - 74,963,113EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559811 AgrOrtholog
BioCyc Gene G2FUF-10855 BioCyc
Ensembl Genes ENSRNOG00000013740 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018362.5 UniProtKB/TrEMBL
  ENSRNOT00000113817.1 UniProtKB/TrEMBL
  ENSRNOT00000115480.1 UniProtKB/TrEMBL
InterPro GOLGA6L UniProtKB/TrEMBL
NCBI Gene 498657 ENTREZGENE
PANTHER SPERMATID-ASSOCIATED-LIKE UniProtKB/TrEMBL
  TRICHOHYALIN-RELATED UniProtKB/TrEMBL
PhenoGen Ccdc70 PhenoGen
RatGTEx ENSRNOG00000013740 RatGTEx
UniProt A0A8I5ZTU4 ENTREZGENE, UniProtKB/TrEMBL
  B5DFG0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-22 Ccdc70  coiled-coil domain containing 70  RGD1559811  similar to RIKEN cDNA 1700112P19  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1559811  similar to RIKEN cDNA 1700112P19   RGD1559811_predicted  similar to RIKEN cDNA 1700112P19 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1559811_predicted  similar to RIKEN cDNA 1700112P19 (predicted)  LOC498657  similar to RIKEN cDNA 1700112P19  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498657  similar to RIKEN cDNA 1700112P19      Symbol and Name status set to provisional 70820 PROVISIONAL