St6galnac1 (ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: St6galnac1 (ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1) Mus musculus
Analyze
Symbol: St6galnac1
Name: ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
RGD ID: 1558378
MGI Page MGI
Description: Enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity. Involved in host-mediated regulation of intestinal microbiota composition. Acts upstream of or within oligosaccharide biosynthetic process. Predicted to be located in membrane. Predicted to be active in Golgi membrane. Is expressed in colon; mammary gland; and salivary gland. Used to study inflammatory bowel disease. Orthologous to human ST6GALNAC1 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; Si; sialyltransferase 7 ((alpha-N-acetylneuraminyl 2,3-beta-galactosyl-1,3)-N-acetyl galactosaminde alpha-2,6-sialyltransferase) A; sialyltransferase 7A; SIAT7-A; Siat7a; ST6GalNAc I; ST6GalNAcI
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911116,655,851 - 116,666,333 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11116,655,851 - 116,666,333 (-)EnsemblGRCm39 Ensembl
GRCm3811116,765,025 - 116,775,507 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11116,765,025 - 116,775,507 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711116,626,339 - 116,636,821 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611116,581,115 - 116,591,597 (-)NCBIMGSCv36mm8
Celera11128,478,824 - 128,520,872 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1181.49NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
Golgi membrane  (ISO,ISS)
membrane  (ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
Additional References at PubMed
PMID:10207017   PMID:10349636   PMID:10381338   PMID:10788794   PMID:11042159   PMID:11076861   PMID:11884638   PMID:12477932   PMID:14681479   PMID:15383613   PMID:16141072   PMID:16141073  
PMID:21267068   PMID:21873635   PMID:22228572   PMID:27235117   PMID:35303419   PMID:38015847  


Genomics

Comparative Map Data
St6galnac1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911116,655,851 - 116,666,333 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11116,655,851 - 116,666,333 (-)EnsemblGRCm39 Ensembl
GRCm3811116,765,025 - 116,775,507 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11116,765,025 - 116,775,507 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711116,626,339 - 116,636,821 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611116,581,115 - 116,591,597 (-)NCBIMGSCv36mm8
Celera11128,478,824 - 128,520,872 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1181.49NCBI
ST6GALNAC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381776,617,407 - 76,643,757 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1776,624,761 - 76,643,786 (-)EnsemblGRCh38hg38GRCh38
GRCh371774,620,845 - 74,639,839 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361772,132,440 - 72,151,489 (-)NCBINCBI36Build 36hg18NCBI36
Build 341772,132,441 - 72,151,327NCBI
Celera1771,213,224 - 71,232,267 (-)NCBICelera
Cytogenetic Map17q25.1NCBI
HuRef1770,048,336 - 70,067,435 (-)NCBIHuRef
CHM1_11774,685,839 - 74,704,894 (-)NCBICHM1_1
T2T-CHM13v2.01777,513,932 - 77,540,529 (-)NCBIT2T-CHM13v2.0
St6galnac1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810102,471,481 - 102,481,876 (-)NCBIGRCr8
mRatBN7.210101,972,656 - 101,983,053 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10101,972,668 - 101,983,053 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10107,079,707 - 107,090,110 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010106,542,789 - 106,553,192 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010101,893,516 - 101,903,911 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010105,713,305 - 105,723,700 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10105,713,317 - 105,723,700 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010105,374,445 - 105,384,844 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410106,837,311 - 106,881,619 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera10100,544,188 - 100,554,583 (-)NCBICelera
Cytogenetic Map10q32.2NCBI
St6galnac1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555065,656,176 - 5,677,614 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555065,656,182 - 5,677,596 (+)NCBIChiLan1.0ChiLan1.0
ST6GALNAC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21992,668,358 - 92,693,706 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11797,493,720 - 97,519,466 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01770,705,223 - 70,721,046 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11776,263,305 - 76,288,115 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1776,263,877 - 76,287,941 (-)Ensemblpanpan1.1panPan2
ST6GALNAC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.194,098,881 - 4,124,417 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl94,101,050 - 4,123,896 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha94,782,442 - 4,805,244 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.094,774,895 - 4,800,385 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl94,777,043 - 4,800,178 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.194,802,574 - 4,825,137 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.094,922,238 - 4,945,012 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.095,003,369 - 5,026,130 (+)NCBIUU_Cfam_GSD_1.0
St6galnac1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056024,698,944 - 4,721,193 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365941,690,769 - 1,711,982 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365941,690,799 - 1,711,940 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ST6GALNAC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl124,890,406 - 4,909,351 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1124,889,852 - 4,909,345 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2124,742,080 - 4,760,387 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ST6GALNAC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11645,020,465 - 45,057,403 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1645,038,943 - 45,057,615 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607715,778,125 - 15,797,400 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
St6galnac1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248016,478,910 - 6,499,959 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248016,478,153 - 6,500,047 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in St6galnac1
406 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:236
Count of miRNA genes:207
Interacting mature miRNAs:221
Transcripts:ENSMUST00000009732
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94437183118022724Mouse
1301012Vispl_mvisual placing (mouse)Not determined11101022590121973369Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194063779118022724Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
11341721Rvfs2_mRift Valley fever susceptibility 2 (mouse)11100254186120887165Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194190826118890826Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199254187121973369Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100058103121973369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse

Markers in Region
Siat7a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11E2UniSTS
cM Map11 UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000009732   ⟹   ENSMUSP00000009732
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11116,655,851 - 116,666,333 (-)Ensembl
GRCm38.p6 Ensembl11116,765,025 - 116,775,507 (-)Ensembl
RefSeq Acc Id: NM_011371   ⟹   NP_035501
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911116,655,851 - 116,666,333 (-)NCBI
GRCm3811116,765,025 - 116,775,507 (-)ENTREZGENE
MGSCv3711116,626,339 - 116,636,821 (-)RGD
Celera11128,478,824 - 128,520,872 (-)NCBI
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_035501   ⟸   NM_011371
- UniProtKB: A2AA23 (UniProtKB/Swiss-Prot),   Q9JJP5 (UniProtKB/Swiss-Prot),   Q9QZ39 (UniProtKB/Swiss-Prot),   B7ZNQ3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000009732   ⟸   ENSMUST00000009732

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QZ39-F1-model_v2 AlphaFold Q9QZ39 1-526 view protein structure

Promoters
RGD ID:8677538
Promoter ID:EPDNEW_M16771
Type:initiation region
Name:St6galnac1_1
Description:Mus musculus ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811116,775,449 - 116,775,509EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1341826 AgrOrtholog
Ensembl Genes ENSMUSG00000009588 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000009732 ENTREZGENE
  ENSMUST00000009732.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.1480.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Glyco_trans_29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GT29-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20445 UniProtKB/Swiss-Prot
MGD MGI:1341826 ENTREZGENE
NCBI Gene 20445 ENTREZGENE
PANTHER ALPHA-N-ACETYLGALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45941 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Glyco_transf_29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen St6galnac1 PhenoGen
UniProt A2AA23 ENTREZGENE
  B7ZNQ3 ENTREZGENE, UniProtKB/TrEMBL
  Q9JJP5 ENTREZGENE
  Q9QZ39 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A2AA23 UniProtKB/Swiss-Prot
  Q9JJP5 UniProtKB/Swiss-Prot