Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | ISO | Hdgfl3 (Rattus norvegicus) | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of HDGFL3 mRNA] | CTD | PMID:31150632 | 1,1-dichloroethene | decreases expression | EXP | | 6480464 | vinylidene chloride results in decreased expression of HDGFL3 mRNA | CTD | PMID:26682919 | 1,2-dichloroethane | decreases expression | EXP | | 6480464 | ethylene dichloride results in decreased expression of HDGFL3 mRNA | CTD | PMID:28960355 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Hdgfl3 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of HDGFL3 mRNA | CTD | PMID:34747641 | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | increases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:18550172 | 4,4'-sulfonyldiphenol | decreases methylation | EXP | | 6480464 | bisphenol S results in decreased methylation of HDGFL3 exon | CTD | PMID:33297965 | 4,4'-sulfonyldiphenol | affects methylation | EXP | | 6480464 | bisphenol S affects the methylation of HDGFL3 gene | CTD | PMID:31683443 | 5-fluorouracil | multiple interactions | ISO | HDGFL3 (Homo sapiens) | 6480464 | TP53 protein affects the reaction [Fluorouracil results in decreased expression of HDGFL3 mRNA] | CTD | PMID:15016801 | 6-propyl-2-thiouracil | increases expression | ISO | Hdgfl3 (Rattus norvegicus) | 6480464 | Propylthiouracil results in increased expression of HDGFRP3 mRNA | CTD | PMID:30047161 | acetamide | increases expression | ISO | Hdgfl3 (Rattus norvegicus) | 6480464 | acetamide results in increased expression of HDGFL3 mRNA | CTD | PMID:31881176 | aconitine | increases expression | ISO | Hdgfl3 (Rattus norvegicus) | 6480464 | Aconitine results in increased expression of HDGFL3 protein | CTD | PMID:33236894 | aflatoxin B1 | increases expression | ISO | HDGFL3 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased expression of HDGFL3 mRNA | CTD | PMID:22100608 | aflatoxin B1 | increases expression | ISO | Hdgfl3 (Rattus norvegicus) | 6480464 | Aflatoxin B1 results in increased expression of HDGFL3 mRNA | CTD | PMID:23630614 more ... | all-trans-retinoic acid | increases expression | ISO | HDGFL3 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of HDGFL3 mRNA | CTD | PMID:23724009 | amitrole | increases expression | ISO | Hdgfl3 (Rattus norvegicus) | 6480464 | Amitrole results in increased expression of HDGFRP3 mRNA | CTD | PMID:30047161 | ammonium chloride | affects expression | ISO | Hdgfl3 (Rattus norvegicus) | 6480464 | Ammonium Chloride affects the expression of HDGFL3 mRNA | CTD | PMID:16483693 | amphetamine | decreases expression | ISO | Hdgfl3 (Rattus norvegicus) | 6480464 | Amphetamine results in decreased expression of HDGFL3 mRNA | CTD | PMID:30779732 | aristolochic acid A | decreases expression | ISO | HDGFL3 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of HDGFL3 mRNA | CTD | PMID:33212167 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of HDGFL3 mRNA | CTD | PMID:32417428 | benzo[a]pyrene | increases expression | ISO | HDGFL3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of HDGFL3 mRNA | CTD | PMID:32234424 | bisphenol A | increases expression | ISO | Hdgfl3 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of HDGFL3 mRNA | CTD | PMID:25181051 more ... | bisphenol A | decreases expression | ISO | HDGFL3 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of HDGFL3 mRNA and bisphenol A results in decreased expression of HDGFL3 protein | CTD | PMID:29275510 and PMID:34186270 | Brodifacoum | increases expression | ISO | Hdgfl3 (Rattus norvegicus) | 6480464 | bromfenacoum results in increased expression of HDGFL3 protein | CTD | PMID:28903499 | capecitabine | decreases response to substance | ISO | HDGFL3 (Homo sapiens) | 6480464 | HDGFL3 protein results in decreased susceptibility to Capecitabine | CTD | PMID:16734730 | carbon nanotube | decreases expression | EXP | | 6480464 | Nanotubes and Carbon analog results in decreased expression of HDGFL3 mRNA | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | HDGFL3 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to HDGFL3 gene] | CTD | PMID:28238834 | cyclosporin A | increases expression | ISO | HDGFL3 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of HDGFL3 mRNA | CTD | PMID:20106945 | dorsomorphin | multiple interactions | ISO | HDGFL3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDGFL3 mRNA | CTD | PMID:27188386 | entinostat | decreases expression | ISO | HDGFL3 (Homo sapiens) | 6480464 | entinostat results in decreased expression of HDGFL3 mRNA | CTD | PMID:27188386 | epoxiconazole | increases expression | EXP | | 6480464 | epoxiconazole results in increased expression of HDGFL3 mRNA | CTD | PMID:35436446 | fenofibrate | increases expression | ISO | Hdgfl3 (Rattus norvegicus) | 6480464 | Fenofibrate results in increased expression of HDGFL3 mRNA | CTD | PMID:17264098 | fenvalerate | increases expression | ISO | Hdgfl3 (Rattus norvegicus) | 6480464 | fenvalerate results in increased expression of HDGFL3 mRNA | CTD | PMID:30307764 | folic acid | decreases expression | EXP | | 6480464 | Folic Acid results in decreased expression of HDGFL3 mRNA | CTD | PMID:25629700 | FR900359 | increases phosphorylation | ISO | HDGFL3 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of HDGFL3 protein | CTD | PMID:37730182 | furan | increases expression | ISO | Hdgfl3 (Rattus norvegicus) | 6480464 | furan results in increased expression of HDGFL3 mRNA | CTD | PMID:27387713 | lithium chloride | decreases expression | ISO | HDGFL3 (Homo sapiens) | 6480464 | Lithium Chloride results in decreased expression of HDGFL3 mRNA | CTD | PMID:15711924 | manganese(II) chloride | increases expression | ISO | Hdgfl3 (Rattus norvegicus) | 6480464 | manganese chloride results in increased expression of HDGFL3 mRNA | CTD | PMID:28801915 | methimazole | increases expression | ISO | Hdgfl3 (Rattus norvegicus) | 6480464 | Methimazole results in increased expression of HDGFRP3 mRNA | CTD | PMID:30047161 | methotrexate | affects response to substance | ISO | HDGFL3 (Homo sapiens) | 6480464 | HDGFL3 protein affects the susceptibility to Methotrexate | CTD | PMID:16217747 | ochratoxin A | increases expression | ISO | Hdgfl3 (Rattus norvegicus) | 6480464 | ochratoxin A results in increased expression of HDGFL3 mRNA | CTD | PMID:22124623 | ozone | increases expression | ISO | Hdgfl3 (Rattus norvegicus) | 6480464 | Ozone results in increased expression of HDGFL3 protein | CTD | PMID:33146391 | ozone | multiple interactions | EXP | | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of HDGFL3 mRNA and [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of HDGFL3 mRNA | CTD | PMID:34911549 | perfluorohexanesulfonic acid | increases expression | EXP | | 6480464 | perfluorohexanesulfonic acid results in increased expression of HDGFL3 mRNA | CTD | PMID:37995155 | phenobarbital | increases expression | ISO | HDGFL3 (Homo sapiens) | 6480464 | Phenobarbital results in increased expression of HDGFL3 mRNA | CTD | PMID:19084549 | picoxystrobin | decreases expression | ISO | HDGFL3 (Homo sapiens) | 6480464 | picoxystrobin results in decreased expression of HDGFL3 mRNA | CTD | PMID:33512557 | rotenone | decreases expression | ISO | HDGFL3 (Homo sapiens) | 6480464 | Rotenone results in decreased expression of HDGFL3 mRNA | CTD | PMID:33512557 | SB 431542 | multiple interactions | ISO | HDGFL3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDGFL3 mRNA | CTD | PMID:27188386 | serpentine asbestos | increases expression | ISO | HDGFL3 (Homo sapiens) | 6480464 | Asbestos and Serpentine results in increased expression of HDGFL3 mRNA | CTD | PMID:21148743 and PMID:33581214 | sodium arsenate | decreases expression | EXP | | 6480464 | sodium arsenate results in decreased expression of HDGFL3 mRNA | CTD | PMID:21795629 | sodium arsenite | affects methylation | ISO | HDGFL3 (Homo sapiens) | 6480464 | sodium arsenite affects the methylation of HDGFL3 gene | CTD | PMID:28589171 | sulfadimethoxine | increases expression | ISO | Hdgfl3 (Rattus norvegicus) | 6480464 | Sulfadimethoxine results in increased expression of HDGFRP3 mRNA | CTD | PMID:30047161 | tetrachloromethane | increases expression | ISO | Hdgfl3 (Rattus norvegicus) | 6480464 | Carbon Tetrachloride results in increased expression of HDGFL3 mRNA | CTD | PMID:31150632 | tetrachloromethane | multiple interactions | ISO | Hdgfl3 (Rattus norvegicus) | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of HDGFL3 mRNA] | CTD | PMID:31150632 | thioacetamide | increases expression | ISO | Hdgfl3 (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of HDGFL3 mRNA | CTD | PMID:23411599 and PMID:34492290 | triadimefon | increases expression | ISO | Hdgfl3 (Rattus norvegicus) | 6480464 | triadimefon results in increased expression of HDGFRP3 mRNA | CTD | PMID:30047161 | trichostatin A | decreases expression | ISO | HDGFL3 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of HDGFL3 mRNA | CTD | PMID:24935251 | valproic acid | increases methylation | ISO | HDGFL3 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of HDGFL3 gene | CTD | PMID:29154799 | valproic acid | affects expression | ISO | HDGFL3 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of HDGFL3 mRNA | CTD | PMID:25979313 | valproic acid | decreases expression | ISO | HDGFL3 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of HDGFL3 mRNA | CTD | PMID:23179753 more ... | valproic acid | multiple interactions | ISO | HDGFL3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDGFL3 mRNA | CTD | PMID:27188386 | |