Tnni3k (TNNI3 interacting kinase) - Rat Genome Database

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Gene: Tnni3k (TNNI3 interacting kinase) Mus musculus
Analyze
Symbol: Tnni3k
Name: TNNI3 interacting kinase
RGD ID: 1557651
MGI Page MGI
Description: Predicted to enable protein serine/threonine kinase activity. Involved in regulation of cardiac conduction and regulation of heart rate. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to several human genes including TNNI3K (TNNI3 interacting kinase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ca; cardiac ankyrin repeat kinase; Cark; D830019J24Rik; serine/threonine-protein kinase TNNI3K; TNNI3-interacting kinase
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393154,491,928 - 154,761,044 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3154,491,928 - 154,761,044 (-)EnsemblGRCm39 Ensembl
GRCm383154,786,291 - 155,055,407 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3154,786,291 - 155,055,407 (-)EnsemblGRCm38mm10GRCm38
MGSCv373154,449,255 - 154,718,371 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363154,721,595 - 154,990,700 (-)NCBIMGSCv36mm8
Celera3161,244,354 - 161,513,160 (-)NCBICelera
Cytogenetic Map3H4NCBI
cM Map379.32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
nucleus  (IEA,ISO)

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:16075368   PMID:16141072   PMID:16141073   PMID:17287827   PMID:19763165   PMID:20059953   PMID:21267068  
PMID:21525387   PMID:21677750   PMID:21873635   PMID:23085512   PMID:23236294   PMID:24132636   PMID:24899531   PMID:25787061   PMID:28783163   PMID:31589606   PMID:33084860   PMID:36382596  
PMID:36912240   PMID:37597489   PMID:37628941   PMID:37769962   PMID:38355793  


Genomics

Comparative Map Data
Tnni3k
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393154,491,928 - 154,761,044 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3154,491,928 - 154,761,044 (-)EnsemblGRCm39 Ensembl
GRCm383154,786,291 - 155,055,407 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3154,786,291 - 155,055,407 (-)EnsemblGRCm38mm10GRCm38
MGSCv373154,449,255 - 154,718,371 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363154,721,595 - 154,990,700 (-)NCBIMGSCv36mm8
Celera3161,244,354 - 161,513,160 (-)NCBICelera
Cytogenetic Map3H4NCBI
cM Map379.32NCBI
TNNI3K
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38174,235,387 - 74,544,428 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl174,235,387 - 74,544,428 (+)EnsemblGRCh38hg38GRCh38
GRCh37174,701,071 - 75,010,112 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36174,473,673 - 74,782,696 (+)NCBINCBI36Build 36hg18NCBI36
Build 34174,413,105 - 74,722,129NCBI
Celera172,909,510 - 73,255,421 (+)NCBICelera
Cytogenetic Map1p31.1NCBI
HuRef172,835,865 - 73,144,630 (+)NCBIHuRef
CHM1_1174,816,721 - 75,125,605 (+)NCBICHM1_1
T2T-CHM13v2.0174,076,908 - 74,385,812 (+)NCBIT2T-CHM13v2.0
Tnni3k
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82246,397,051 - 246,665,000 (-)NCBIGRCr8
mRatBN7.22243,737,346 - 244,005,319 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2243,710,950 - 244,005,268 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2251,567,799 - 251,835,409 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02249,461,629 - 249,729,221 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02244,362,150 - 244,636,856 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02261,069,210 - 261,337,294 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2261,069,203 - 261,337,163 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02279,730,855 - 279,999,134 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42252,627,444 - 252,824,416 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12252,942,037 - 252,962,090 (+)NCBI
Celera2235,659,697 - 235,927,289 (-)NCBICelera
Cytogenetic Map2q45NCBI
LOC100990811
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21152,335,419 - 152,681,099 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11151,495,855 - 151,840,275 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0173,464,364 - 73,772,977 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1175,440,781 - 75,747,682 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl175,403,555 - 75,747,240 (+)Ensemblpanpan1.1panPan2
TNNI3K
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1671,825,853 - 72,107,832 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl671,815,734 - 72,119,476 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha674,489,520 - 74,761,768 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0672,463,781 - 72,703,848 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl672,419,208 - 72,703,805 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1671,913,206 - 72,224,860 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0671,904,267 - 72,144,070 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0672,399,222 - 72,639,531 (-)NCBIUU_Cfam_GSD_1.0
Tnni3k
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505886,154,293 - 86,333,794 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365711,559,956 - 1,843,688 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365711,559,845 - 1,843,985 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNNI3K
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6138,634,274 - 138,914,115 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16138,634,770 - 138,914,194 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26128,498,341 - 128,553,755 (-)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:424
Count of miRNA genes:265
Interacting mature miRNAs:278
Transcripts:ENSMUST00000064076, ENSMUST00000143410, ENSMUST00000146952
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301347Fpli_mfasting plasma insulin (mouse)Not determined3126460514159745316Mouse
1301218Letohc1_mlow ethanol consumption 1 (mouse)Not determined3126352986159745316Mouse
1301222Scc7_mcolon tumor susceptibility 7 (mouse)Not determined3143352986156364108Mouse
1301563Alcp3_malcohol preference locus 3 (mouse)Not determined3130736935159745316Mouse
4142245Pstc1_mperiosteal circumference 1 (mouse)Not determined3126270248159745316Mouse
11039523Tbbr1_mTrypanosoma brucei brucei response 1 (mouse)3130849375159745316Mouse
1301528Loco1_mlocomotor activity 1 (mouse)Not determined3133461893159745316Mouse
10412240Alpq6_malcohol preference QTL 6 (mouse)Not determined3120772078154772078Mouse

Markers in Region
D3Mit115  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383154,936,414 - 154,936,555UniSTSGRCm38
MGSCv373154,599,378 - 154,599,519UniSTSGRCm37
Celera3161,391,880 - 161,392,020UniSTS
Cytogenetic Map3H4UniSTS
cM Map384.9UniSTS
Whitehead Genetic364.5UniSTS
Whitehead/MRC_RH31707.9UniSTS
Whitehead_YAC3 UniSTS
D3Mit219  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383154,979,422 - 154,979,567UniSTSGRCm38
MGSCv373154,642,386 - 154,642,531UniSTSGRCm37
Celera3161,435,007 - 161,435,152UniSTS
Cytogenetic Map3H4UniSTS
cM Map384.9UniSTS
Whitehead Genetic364.5UniSTS
Whitehead/MRC_RH31710.23UniSTS
Whitehead_YAC3 UniSTS
D3Mit234  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383154,946,746 - 154,946,932UniSTSGRCm38
MGSCv373154,609,710 - 154,609,896UniSTSGRCm37
Celera3161,402,386 - 161,402,572UniSTS
Cytogenetic Map3H4UniSTS
cM Map384.1UniSTS
Whitehead Genetic363.4UniSTS
Whitehead/MRC_RH31709.12UniSTS
Whitehead_YAC3 UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000064076   ⟹   ENSMUSP00000070561
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3154,491,936 - 154,761,044 (-)Ensembl
GRCm38.p6 Ensembl3154,786,299 - 155,055,407 (-)Ensembl
Ensembl Acc Id: ENSMUST00000143410   ⟹   ENSMUSP00000122478
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3154,491,928 - 154,761,044 (-)Ensembl
GRCm38.p6 Ensembl3154,786,291 - 155,055,407 (-)Ensembl
Ensembl Acc Id: ENSMUST00000146952
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3154,735,648 - 154,760,987 (-)Ensembl
GRCm38.p6 Ensembl3155,030,011 - 155,055,350 (-)Ensembl
RefSeq Acc Id: NM_177066   ⟹   NP_796040
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393154,491,928 - 154,761,044 (-)NCBI
GRCm383154,786,291 - 155,055,407 (-)ENTREZGENE
MGSCv373154,449,255 - 154,718,371 (-)RGD
Celera3161,244,354 - 161,513,160 (-)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011240154   ⟹   XP_011238456
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393154,533,200 - 154,761,039 (-)NCBI
GRCm383154,827,563 - 155,055,402 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011240155   ⟹   XP_011238457
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393154,498,416 - 154,761,039 (-)NCBI
GRCm383154,792,779 - 155,055,402 (-)NCBI
Sequence:
RefSeq Acc Id: XR_375539
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393154,492,351 - 154,761,039 (-)NCBI
GRCm383154,786,714 - 155,055,402 (-)NCBI
Sequence:
RefSeq Acc Id: NP_796040   ⟸   NM_177066
- UniProtKB: Q5GIG6 (UniProtKB/Swiss-Prot),   Q5GIG5 (UniProtKB/Swiss-Prot),   B2RTJ7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011238457   ⟸   XM_011240155
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011238456   ⟸   XM_011240154
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000122478   ⟸   ENSMUST00000143410
Ensembl Acc Id: ENSMUSP00000070561   ⟸   ENSMUST00000064076
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5GIG6-F1-model_v2 AlphaFold Q5GIG6 1-834 view protein structure

Promoters
RGD ID:6882684
Promoter ID:EPDNEW_M4793
Type:multiple initiation site
Name:Tnni3k_1
Description:Mus musculus TNNI3 interacting kinase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383155,055,349 - 155,055,409EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2443276 AgrOrtholog
Ensembl Genes ENSMUSG00000040086 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000064076 ENTREZGENE
  ENSMUST00000064076.6 UniProtKB/Swiss-Prot
  ENSMUST00000143410 ENTREZGENE
  ENSMUST00000143410.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Ser_Thr_protein_kinase UniProtKB/Swiss-Prot
KEGG Report mmu:435766 UniProtKB/Swiss-Prot
MGD MGI:2443276 ENTREZGENE
NCBI Gene Tnni3k ENTREZGENE
PANTHER ANKYRIN REPEAT FAMILY PROTEIN UniProtKB/TrEMBL
  DIEGO, ISOFORM A UniProtKB/TrEMBL
  DUAL SPECIFICITY PROTEIN KINASE SPLA-RELATED UniProtKB/Swiss-Prot
  SERINE-THREONINE PROTEIN KINASE UniProtKB/Swiss-Prot
Pfam Ank UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ank_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot
PhenoGen Tnni3k PhenoGen
PRINTS ANKYRIN UniProtKB/Swiss-Prot
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
SMART ANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot
UniProt B2RTJ7 ENTREZGENE
  Q5GIG5 ENTREZGENE
  Q5GIG6 ENTREZGENE
  Q8BFR0_MOUSE UniProtKB/TrEMBL
  TNI3K_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary B2RTJ7 UniProtKB/Swiss-Prot
  Q5GIG5 UniProtKB/Swiss-Prot