Tnni3k (TNNI3 interacting kinase) - Rat Genome Database

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Pathways
Gene: Tnni3k (TNNI3 interacting kinase) Rattus norvegicus
Analyze
Symbol: Tnni3k
Name: TNNI3 interacting kinase
RGD ID: 727908
Description: Predicted to enable protein kinase activity. Predicted to be involved in regulation of heart contraction. Predicted to be located in cytoplasm and nucleus. Orthologous to several human genes including TNNI3K (TNNI3 interacting kinase); INTERACTS WITH 6-propyl-2-thiouracil; atrazine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cardiac ankyrin repeat kinase; Cark; serine/threonine-protein kinase TNNI3K; TNNI3-interacting kinase
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22243,737,346 - 244,005,319 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2243,710,950 - 244,005,268 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2251,567,799 - 251,835,409 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02249,461,629 - 249,729,221 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02244,362,150 - 244,636,856 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02261,069,210 - 261,337,294 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2261,069,203 - 261,337,163 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02279,730,855 - 279,999,134 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42252,627,444 - 252,824,416 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12252,942,037 - 252,962,090 (+)NCBI
Celera2235,659,697 - 235,927,289 (-)NCBICelera
Cytogenetic Map2q45NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA,ISO,ISS)
nucleus  (IBA,IEA,ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Cloning and characterization of a novel cardiac-specific kinase that interacts specifically with cardiac troponin I. Zhao Y, etal., J Mol Med 2003 May;81(5):297-304. Epub 2003 Apr 30.
Additional References at PubMed
PMID:12477932   PMID:18205602   PMID:23236294   PMID:23369981   PMID:23472207   PMID:24925317  


Genomics

Comparative Map Data
Tnni3k
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22243,737,346 - 244,005,319 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2243,710,950 - 244,005,268 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2251,567,799 - 251,835,409 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02249,461,629 - 249,729,221 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02244,362,150 - 244,636,856 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02261,069,210 - 261,337,294 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2261,069,203 - 261,337,163 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02279,730,855 - 279,999,134 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42252,627,444 - 252,824,416 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12252,942,037 - 252,962,090 (+)NCBI
Celera2235,659,697 - 235,927,289 (-)NCBICelera
Cytogenetic Map2q45NCBI
TNNI3K
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38174,235,387 - 74,544,428 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl174,235,387 - 74,544,428 (+)EnsemblGRCh38hg38GRCh38
GRCh37174,701,071 - 75,010,112 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36174,473,673 - 74,782,696 (+)NCBINCBI36Build 36hg18NCBI36
Build 34174,413,105 - 74,722,129NCBI
Celera172,909,510 - 73,255,421 (+)NCBICelera
Cytogenetic Map1p31.1NCBI
HuRef172,835,865 - 73,144,630 (+)NCBIHuRef
CHM1_1174,816,721 - 75,125,605 (+)NCBICHM1_1
T2T-CHM13v2.0174,076,908 - 74,385,812 (+)NCBIT2T-CHM13v2.0
Tnni3k
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393154,491,928 - 154,761,044 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3154,491,928 - 154,761,044 (-)EnsemblGRCm39 Ensembl
GRCm383154,786,291 - 155,055,407 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3154,786,291 - 155,055,407 (-)EnsemblGRCm38mm10GRCm38
MGSCv373154,449,255 - 154,718,371 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363154,721,595 - 154,990,700 (-)NCBIMGSCv36mm8
Celera3161,244,354 - 161,513,160 (-)NCBICelera
Cytogenetic Map3H4NCBI
cM Map379.32NCBI
LOC100990811
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11151,495,855 - 151,840,275 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0173,464,364 - 73,772,977 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1175,440,781 - 75,747,682 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl175,403,555 - 75,747,240 (+)Ensemblpanpan1.1panPan2
TNNI3K
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1671,825,853 - 72,107,832 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl671,815,734 - 72,119,476 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha674,489,520 - 74,761,768 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0672,463,781 - 72,703,848 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl672,419,208 - 72,703,805 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1671,913,206 - 72,224,860 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0671,904,267 - 72,144,070 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0672,399,222 - 72,639,531 (-)NCBIUU_Cfam_GSD_1.0
Tnni3k
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505886,154,293 - 86,333,794 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365711,559,956 - 1,843,688 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365711,559,845 - 1,843,985 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNNI3K
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6138,634,274 - 138,914,115 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16138,634,770 - 138,914,194 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26128,498,341 - 128,553,755 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Tnni3k
1636 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:38
Count of miRNA genes:37
Interacting mature miRNAs:37
Transcripts:ENSRNOT00000030341
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
9587428Epfw6Epididymal fat weight QTL 67.470.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)2223389739249053267Rat
7411555Bw132Body weight QTL 1320.001body mass (VT:0001259)body weight gain (CMO:0000420)2223389739249053267Rat
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2229059610249053267Rat

Markers in Region
D2Got363  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22243,780,563 - 243,780,713 (+)MAPPERmRatBN7.2
Rnor_6.02261,112,080 - 261,112,229NCBIRnor6.0
Rnor_5.02279,773,723 - 279,773,872UniSTSRnor5.0
RGSC_v3.42252,671,448 - 252,671,597UniSTSRGSC3.4
Celera2235,702,645 - 235,702,794UniSTS
Cytogenetic Map2q45UniSTS
RH128803  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22243,737,357 - 243,737,549 (+)MAPPERmRatBN7.2
Rnor_6.02261,069,217 - 261,069,408NCBIRnor6.0
Rnor_5.02279,730,860 - 279,731,051UniSTSRnor5.0
RGSC_v3.42252,627,449 - 252,627,640UniSTSRGSC3.4
Celera2235,659,702 - 235,659,893UniSTS
RH 3.4 Map21640.0UniSTS
Cytogenetic Map2q45UniSTS
AU048026  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22243,912,810 - 243,913,009 (+)MAPPERmRatBN7.2
Rnor_6.02261,244,679 - 261,244,877NCBIRnor6.0
Rnor_5.02279,906,322 - 279,906,520UniSTSRnor5.0
RGSC_v3.42252,804,232 - 252,804,430UniSTSRGSC3.4
Celera2235,834,871 - 235,835,069UniSTS
Cytogenetic Map2q45UniSTS
BE100289  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22243,807,263 - 243,807,427 (+)MAPPERmRatBN7.2
Rnor_6.02261,139,064 - 261,139,227NCBIRnor6.0
Rnor_5.02279,800,707 - 279,800,870UniSTSRnor5.0
RGSC_v3.42252,697,346 - 252,697,509UniSTSRGSC3.4
Celera2235,729,322 - 235,729,485UniSTS
RH 3.4 Map21629.7UniSTS
Cytogenetic Map2q45UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 33
Low 10 3 1 5 1 2 20 7 8
Below cutoff 19 6 13 6 8 8 53 11 16 3 8

Sequence


RefSeq Acc Id: ENSRNOT00000030341   ⟹   ENSRNOP00000031479
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2243,737,353 - 244,005,268 (-)Ensembl
Rnor_6.0 Ensembl2261,069,203 - 261,337,163 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102655   ⟹   ENSRNOP00000095720
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2243,737,353 - 244,005,268 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103906   ⟹   ENSRNOP00000091387
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2243,763,384 - 244,005,268 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000120189   ⟹   ENSRNOP00000082900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2243,710,950 - 244,005,268 (-)Ensembl
RefSeq Acc Id: NM_181769   ⟹   NP_861434
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22243,737,353 - 244,005,268 (-)NCBI
Rnor_6.02261,069,212 - 261,337,132 (-)NCBI
Rnor_5.02279,730,855 - 279,999,134 (-)NCBI
RGSC_v3.42252,627,444 - 252,824,416 (-)RGD
Celera2235,659,697 - 235,927,289 (-)RGD
Sequence:
RefSeq Acc Id: XM_008761563   ⟹   XP_008759785
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22243,737,346 - 244,005,319 (-)NCBI
Rnor_6.02261,069,210 - 261,337,291 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039102111   ⟹   XP_038958039
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22243,824,444 - 244,005,319 (-)NCBI
RefSeq Acc Id: NP_861434   ⟸   NM_181769
- UniProtKB: Q7TQP6 (UniProtKB/Swiss-Prot),   F1LPM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759785   ⟸   XM_008761563
- Peptide Label: isoform X1
- UniProtKB: F1LPM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000031479   ⟸   ENSRNOT00000030341
RefSeq Acc Id: XP_038958039   ⟸   XM_039102111
- Peptide Label: isoform X2
- UniProtKB: F1LPM9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000095720   ⟸   ENSRNOT00000102655
RefSeq Acc Id: ENSRNOP00000082900   ⟸   ENSRNOT00000120189
RefSeq Acc Id: ENSRNOP00000091387   ⟸   ENSRNOT00000103906
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TQP6-F1-model_v2 AlphaFold Q7TQP6 1-835 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727908 AgrOrtholog
BioCyc Gene G2FUF-50734 BioCyc
Ensembl Genes ENSRNOG00000028225 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000030341 ENTREZGENE
  ENSRNOT00000030341.7 UniProtKB/TrEMBL
  ENSRNOT00000102655.1 UniProtKB/TrEMBL
  ENSRNOT00000103906.1 UniProtKB/TrEMBL
  ENSRNOT00000120189.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:295531 UniProtKB/Swiss-Prot
NCBI Gene 295531 ENTREZGENE
PANTHER ANK_REP_REGION DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MOLTING PROTEIN MLT-4 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE TNNI3K UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ank_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tnni3k PhenoGen
PRINTS ANKYRIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028225 RatGTEx
SMART ANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZUY2_RAT UniProtKB/TrEMBL
  A0A8I6AED2_RAT UniProtKB/TrEMBL
  A0A8I6AU11_RAT UniProtKB/TrEMBL
  F1LPM9 ENTREZGENE, UniProtKB/TrEMBL
  Q7TQP6 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-03 Tnni3k  TNNI3 interacting kinase  Cark  cardiac ankyrin repeat kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Cark  cardiac ankyrin repeat kinase      Symbol and Name status set to approved 1299863 APPROVED