Krt33b (keratin 33B) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Krt33b (keratin 33B) Mus musculus
Analyze
Symbol: Krt33b
Name: keratin 33B
RGD ID: 1552816
MGI Page MGI
Description: Predicted to enable structural molecule activity. Predicted to be involved in epithelial cell differentiation and intermediate filament organization. Predicted to be located in intermediate filament. Predicted to be active in cytoskeleton. Is expressed in filiform papillae and integumental system. Orthologous to several human genes including KRT31 (keratin 31) and KRT34 (keratin 34).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ha; Ha3; Ha4; hair keratin, type I Ha3; K33B; keratin complex 1, acidic, gene 3; keratin complex 1, gene 3; keratin, type I cuticular Ha3; keratin, type I cuticular Ha3-II; keratin-33B; Krt1-; Krt1-3; mHa; mHa3; ortholog of keratin, hair, acidic, 3B KRTHA3B
RGD Orthologs
Human
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391199,914,460 - 99,920,694 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1199,914,460 - 99,920,694 (-)EnsemblGRCm39 Ensembl
GRCm3811100,023,634 - 100,029,868 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,023,634 - 100,029,868 (-)EnsemblGRCm38mm10GRCm38
MGSCv371199,884,948 - 99,891,182 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361199,839,719 - 99,846,164 (-)NCBIMGSCv36mm8
Celera11110,639,955 - 110,646,187 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1163.37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Differential expression of type I hair keratins. Bertolino AP, etal., J Invest Dermatol 1990 Mar;94(3):297-303.
2. The RAIG family member, GPRC5D, is associated with hard-keratinized structures. Inoue S, etal., J Invest Dermatol 2004 Mar;122(3):565-73.
3. Whn and mHa3 are components of the genetic hierarchy controlling hair follicle differentiation. Meier N, etal., Mech Dev 1999 Dec;89(1-2):215-21.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. BAC contig from a 3-cM region of mouse chromosome 11 surrounding Brca1. Pershouse M, etal., Genomics 2000 Oct 1;69(1):139-42.
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
8. Sequence and expression of murine type I hair keratins mHa2 and mHa3. Winter H, etal., Exp Cell Res 1994 Jun;212(2):190-200.
Additional References at PubMed
PMID:16831889   PMID:21267068   PMID:21565611   PMID:21873635   PMID:28964716   PMID:38355793  


Genomics

Comparative Map Data
Krt33b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391199,914,460 - 99,920,694 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1199,914,460 - 99,920,694 (-)EnsemblGRCm39 Ensembl
GRCm3811100,023,634 - 100,029,868 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,023,634 - 100,029,868 (-)EnsemblGRCm38mm10GRCm38
MGSCv371199,884,948 - 99,891,182 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361199,839,719 - 99,846,164 (-)NCBIMGSCv36mm8
Celera11110,639,955 - 110,646,187 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1163.37NCBI
KRT33B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381741,363,498 - 41,369,813 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1741,363,498 - 41,369,813 (-)EnsemblGRCh38hg38GRCh38
GRCh371739,519,750 - 39,526,065 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361736,773,272 - 36,779,573 (-)NCBINCBI36Build 36hg18NCBI36
Build 341736,773,272 - 36,779,573NCBI
Celera1736,172,962 - 36,179,263 (-)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1735,283,248 - 35,289,554 (-)NCBIHuRef
CHM1_11739,755,090 - 39,761,396 (-)NCBICHM1_1
T2T-CHM13v2.01742,219,031 - 42,225,346 (-)NCBIT2T-CHM13v2.0
LOC100516036
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11221,235,308 - 21,242,550 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21221,376,132 - 21,383,379 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103243461
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11664,862,981 - 64,870,078 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1664,863,785 - 64,869,736 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607735,708,271 - 35,714,829 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Krt33b
209 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:135
Count of miRNA genes:131
Interacting mature miRNAs:132
Transcripts:ENSMUST00000073890
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301535Pas5b_mpulmonary adenoma susceptibility 5b (mouse)Not determined1196176465108806384Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1196897693110603991Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1180890826101890826Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94437183118022724Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1192939373112544554Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
1357631Motr1_mmodifier of tubby retinal degeneration 1 (mouse)Not determined1187691198103274115Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194063779118022724Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
13513918Heal55_mwound healing/ regeneration 55 (mouse)1199672251100232454Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194190826118890826Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199254187121973369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse

Markers in Region
X75650  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811100,023,671 - 100,023,866UniSTSGRCm38
MGSCv371199,884,985 - 99,885,180UniSTSGRCm37
Celera11110,639,992 - 110,640,187UniSTS
Cytogenetic Map11DUniSTS
cM Map1159.0UniSTS
Whitehead_YAC11 UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000073890   ⟹   ENSMUSP00000073552
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1199,914,460 - 99,920,694 (-)Ensembl
GRCm38.p6 Ensembl11100,023,634 - 100,029,868 (-)Ensembl
RefSeq Acc Id: NM_013570   ⟹   NP_038598
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391199,914,460 - 99,920,694 (-)NCBI
GRCm3811100,023,634 - 100,029,868 (-)ENTREZGENE
MGSCv371199,884,948 - 99,891,182 (-)RGD
Celera11110,639,955 - 110,646,187 (-)RGD
cM Map11 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_038598 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA53305 (Get FASTA)   NCBI Sequence Viewer  
  EDL02591 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000073552
  ENSMUSP00000073552.4
GenBank Protein Q61897 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_038598   ⟸   NM_013570
- UniProtKB: A2A5X8 (UniProtKB/Swiss-Prot),   Q61897 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000073552   ⟸   ENSMUST00000073890
Protein Domains
IF rod

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61897-F1-model_v2 AlphaFold Q61897 1-404 view protein structure

Promoters
RGD ID:8676646
Promoter ID:EPDNEW_M16354
Type:single initiation site
Name:Krt33b_1
Description:Mus musculus keratin 33B , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811100,029,885 - 100,029,945EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1309991 AgrOrtholog
Ensembl Genes ENSMUSG00000057723 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000073890 ENTREZGENE
  ENSMUST00000073890.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
  Single helix bin UniProtKB/Swiss-Prot
  Vasodilator-stimulated phosphoprotein UniProtKB/Swiss-Prot
InterPro IF_conserved UniProtKB/Swiss-Prot
  IF_rod_dom UniProtKB/Swiss-Prot
  Keratin_I UniProtKB/Swiss-Prot
KEGG Report mmu:16671 UniProtKB/Swiss-Prot
MGD MGI:1309991 ENTREZGENE
NCBI Gene 16671 ENTREZGENE
PANTHER KERATIN, TYPE I CUTICULAR HA1 UniProtKB/Swiss-Prot
  PTHR23239 UniProtKB/Swiss-Prot
Pfam Filament UniProtKB/Swiss-Prot
PhenoGen Krt33b PhenoGen
PRINTS TYPE1KERATIN UniProtKB/Swiss-Prot
PROSITE IF_ROD_1 UniProtKB/Swiss-Prot
  IF_ROD_2 UniProtKB/Swiss-Prot
SMART Filament UniProtKB/Swiss-Prot
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/Swiss-Prot
  Prefoldin UniProtKB/Swiss-Prot
UniProt A2A5X8 ENTREZGENE
  KT33B_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A2A5X8 UniProtKB/Swiss-Prot