Tas2r123 (taste receptor, type 2, member 123) - Rat Genome Database

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Gene: Tas2r123 (taste receptor, type 2, member 123) Mus musculus
Analyze
No known orthologs.
Symbol: Tas2r123
Name: taste receptor, type 2, member 123
RGD ID: 1552670
MGI Page MGI
Description: Predicted to enable bitter taste receptor activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of bitter taste. Predicted to act upstream of or within sensory perception of taste and signal transduction. Predicted to be active in membrane. Orthologous to human TAS2R14 (taste 2 receptor member 14).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: mGR2; mGR23; mt2r5; mt2r55; STC9-2; T2R123; T2R2; T2R23; t2r55; Tas2; Tas2r23; taste receptor type 2 member 123; taste receptor type 2 member 23
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396132,824,105 - 132,825,106 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6132,824,105 - 132,825,106 (+)EnsemblGRCm39 Ensembl
GRCm386132,847,142 - 132,848,143 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6132,847,142 - 132,848,143 (+)EnsemblGRCm38mm10GRCm38
MGSCv376132,797,160 - 132,798,161 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366132,812,835 - 132,813,836 (+)NCBIMGSCv36mm8
Celera6132,920,255 - 132,921,256 (+)NCBICelera
Cytogenetic Map6G1NCBI
cM Map664.03NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A novel family of mammalian taste receptors. Adler E, etal., Cell 2000 Mar 17;100(6):693-702.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11696554   PMID:11854532   PMID:12139982   PMID:12581520   PMID:12679530   PMID:12734386   PMID:15938754   PMID:21267068   PMID:21873635  


Genomics

Variants

.
Variants in Tas2r123
2 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:70
Interacting mature miRNAs:72
Transcripts:ENSMUST00000071696
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141611Btts_mbitterness tasting (mouse)Not determined6125333609134096586Mouse
10412215Cmv3_mcytomegalovirus resistance 3 (mouse)Not determined6128811857137416927Mouse
1301915Chab3_mcholesterol absorption 3 (mouse)Not determined698908709132916997Mouse
4141151Ath38_matherosclerosis 38 (mouse)Not determined128495857136293176Mouse
1301820Mop1_mmorphine preference 1 (mouse)Not determined6132578005146330736Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
11353842Bmiq4_mbody mass index QTL 4 (mouse)692584287146330736Mouse
1301152Athsq2_matherosclerosis susceptibility QTL 2 (mouse)Not determined6117059949149588044Mouse
13463481Mcvq14_mmean corpuscular volume QTL 14 (mouse)6111142448145142541Mouse
4141889Qui_mquinine sensitivity, taste (mouse)Not determined115546805149549364Mouse
10412134Cmv4_mcytomegalovirus resistance 4 (mouse)Not determined6127815180136022150Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683690851146954059Mouse
1301518Bbaa5_mB.burgdorferi-associated arthritis 5 (mouse)Not determined698483798145881170Mouse
10412207Cypr5_mcytokine production 5 (mouse)Not determined6110815180144815323Mouse
1301804Bulb2_mbulb size 2 (mouse)Not determined6120416806149588044Mouse
1301084Bpq5_mblood pressure QTL 5 (mouse)Not determined6129330484149588044Mouse
1302131Bmd8_mbone mineral density 8 (mouse)Not determined699132089133132228Mouse
11252138Clas1_mcarcinogen-induced lung adenoma susceptibility 1 (mouse)6112246918146954059Mouse
4140980Mvwf2_mmodifier of von Willebrand factor 2 (mouse)Not determined114345693145601739Mouse
4141295Rua_mraffinose acetate tasting (mouse)Not determined115546805149549364Mouse
1302089Wta2_mweight adult 2 (mouse)Not determined6125269523149588044Mouse
1301927Etohcta6_methanol conditioned taste aversion 6 (mouse)Not determined6115578005149578150Mouse
4142079Skmw15_mskeletal muscle weight 15 (mouse)Not determined6116829851149588044Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
1300887Pabr1_mplasma apolipoprotein B (human) regulator 1 (mouse)Not determined6103754405136400690Mouse
10449437Pas15_mpulmonary adenoma susceptibility 15 (mouse)6128180868149588044Mouse
4141974Skmw14_mskeletal muscle weight 14 (mouse)Not determined6129330484149588044Mouse
12879916Shm5_msperm head morphology 5 (mouse)6132266532145601739Mouse
4142416Egq11_mearly growth QTL 11 (mouse)Not determined96632912146535124Mouse
1301620Insq8_minsulin QTL 8 (mouse)Not determined6129534979149588044Mouse
14746990Manh61_mmandible shape 61 (mouse)6130156355149588044Mouse
4141194Cyx_mcycloheximide tasting (mouse)Not determined115546805149549364Mouse
1301027Hdlq12_mHDL QTL 12 (mouse)Not determined6128601582149588044Mouse
1558959Eamcd2_mexperimental autoimmune myocarditis 2 (mouse)Not determined6129953954149588044Mouse
14746999Mancz6_mmandible centroid size 6 (mouse)6130156355149588044Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673476983134676963Mouse
1357555Tesq2_mtestis weight QTL 2 (mouse)Not determined696632912146535124Mouse
10766452Sle23_msystematic lupus erythematosus susceptibility 23 (mouse)6128601582149588044Mouse
1357806Aaj3_manxiety in A/J 3 (mouse)Not determined6104480321136400690Mouse
10053680Lith25_mlithogenic gene 25 (mouse)Not determined6128601582149588044Mouse
1301686Trmq1_mT cell ratio modifier QTL 1 (mouse)Not determined6129330484149588044Mouse
4141940W6q5_mweight 6 weeks QTL 5 (mouse)Not determined96632912146535124Mouse
1301658Radpf3_mradiation pulmonary fibrosis 3 (mouse)Not determined6115219814146330736Mouse
10449436Pas17_mpulmonary adenoma susceptibility 17 (mouse)6124334273145601739Mouse

Markers in Region
UniSTS:491964  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386132,847,077 - 132,848,242UniSTSGRCm38
MGSCv376132,797,095 - 132,798,260UniSTSGRCm37
Celera6132,920,190 - 132,921,355UniSTS
Cytogenetic Map6G1UniSTS
cM Map663.5UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000071696   ⟹   ENSMUSP00000071615
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6132,824,105 - 132,825,106 (+)Ensembl
GRCm38.p6 Ensembl6132,847,142 - 132,848,143 (+)Ensembl
RefSeq Acc Id: NM_207025   ⟹   NP_996908
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396132,824,105 - 132,825,106 (+)NCBI
GRCm386132,847,142 - 132,848,143 (+)ENTREZGENE
MGSCv376132,797,160 - 132,798,161 (+)RGD
Celera6132,920,255 - 132,921,256 (+)RGD
cM Map6 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_996908 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAL85202 (Get FASTA)   NCBI Sequence Viewer  
  DAA01222 (Get FASTA)   NCBI Sequence Viewer  
  EDL29774 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000071615
  ENSMUSP00000071615.2
GenBank Protein P59528 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_996908   ⟸   NM_207025
- UniProtKB: Q7M714 (UniProtKB/Swiss-Prot),   P59528 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000071615   ⟸   ENSMUST00000071696

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P59528-F1-model_v2 AlphaFold P59528 1-333 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2681264 AgrOrtholog
Ensembl Genes ENSMUSG00000057381 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000071696 ENTREZGENE
  ENSMUST00000071696.2 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  T2R UniProtKB/Swiss-Prot
KEGG Report mmu:353167 UniProtKB/Swiss-Prot
MGD MGI:2681264 ENTREZGENE
NCBI Gene 353167 ENTREZGENE
PANTHER TASTE RECEPTOR TYPE 2 UniProtKB/Swiss-Prot
  TASTE RECEPTOR TYPE 2 MEMBER 123 UniProtKB/Swiss-Prot
Pfam TAS2R UniProtKB/Swiss-Prot
PhenoGen Tas2r123 PhenoGen
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt P59528 ENTREZGENE
  Q7M714 ENTREZGENE
  TR123_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q7M714 UniProtKB/Swiss-Prot