MYLK4 (myosin light chain kinase family member 4) - Rat Genome Database

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Gene: MYLK4 (myosin light chain kinase family member 4) Sus scrofa
Analyze
Symbol: MYLK4
Name: myosin light chain kinase family member 4
RGD ID: 14288316
Description: ENCODES a protein that exhibits ATP binding (inferred); myosin light chain kinase activity (inferred); protein kinase activity (inferred); ASSOCIATED WITH genetic disease (ortholog); long QT syndrome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.171,567,816 - 1,656,230 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.271,668,984 - 1,745,594 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MYLK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.171,567,816 - 1,656,230 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.271,668,984 - 1,745,594 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MYLK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3862,663,637 - 2,770,376 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl62,663,629 - 2,770,330 (-)EnsemblGRCh38hg38GRCh38
GRCh3762,663,871 - 2,770,610 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3662,608,870 - 2,696,153 (-)NCBINCBI36Build 36hg18NCBI36
Celera63,892,821 - 3,980,110 (-)NCBICelera
Cytogenetic Map6p25.2NCBI
HuRef62,536,304 - 2,624,297 (-)NCBIHuRef
CHM1_162,665,967 - 2,753,728 (-)NCBICHM1_1
T2T-CHM13v2.062,529,217 - 2,636,238 (-)NCBIT2T-CHM13v2.0
Mylk4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391332,884,807 - 32,967,947 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1332,884,810 - 32,967,937 (-)EnsemblGRCm39 Ensembl
GRCm381332,700,824 - 32,806,773 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1332,700,827 - 32,783,954 (-)EnsemblGRCm38mm10GRCm38
MGSCv371332,792,696 - 32,873,648 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361332,716,344 - 32,791,693 (-)NCBIMGSCv36mm8
Celera1332,909,607 - 32,990,711 (-)NCBICelera
Cytogenetic Map13A3.2NCBI
cM Map1313.72NCBI
Mylk4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81731,877,739 - 31,956,012 (+)NCBIGRCr8
mRatBN7.21731,669,028 - 31,747,250 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1731,661,513 - 31,744,544 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01732,980,753 - 33,056,578 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1732,082,937 - 32,100,166 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1733,028,293 - 33,045,690 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01733,976,723 - 34,004,177 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01734,873,053 - 34,948,155 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1731,231,423 - 31,306,810 (+)NCBICelera
Cytogenetic Map17p12NCBI
Mylk4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546510,613,914 - 10,684,629 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546510,590,235 - 10,690,630 (+)NCBIChiLan1.0ChiLan1.0
MYLK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2517,290,291 - 17,392,601 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1613,281,520 - 13,383,250 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v062,486,235 - 2,587,893 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.162,590,139 - 2,686,737 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl62,597,456 - 2,686,770 (-)Ensemblpanpan1.1panPan2
MYLK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1352,997,595 - 3,107,400 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha353,005,815 - 3,115,572 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0353,057,076 - 3,163,236 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl353,060,336 - 3,138,312 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1352,929,667 - 3,039,085 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0352,951,754 - 3,061,676 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0354,284,818 - 4,394,074 (-)NCBIUU_Cfam_GSD_1.0
Mylk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494622,762,667 - 22,871,807 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366333,759,909 - 3,830,384 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366333,748,867 - 3,832,560 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYLK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11769,398,995 - 69,486,934 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660442,610,927 - 2,696,776 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mylk4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475622,076,307 - 22,142,513 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475622,054,285 - 22,149,819 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MYLK4
3606 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 2 6 1
Below cutoff 3 2 3 4 16 1 1 1

Sequence


Reference Sequences
RefSeq Acc Id: XM_013977395   ⟹   XP_013832849
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.171,567,816 - 1,635,731 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021100109   ⟹   XP_020955768
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.171,567,816 - 1,656,230 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021100110   ⟹   XP_020955769
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.171,567,816 - 1,656,230 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021100111   ⟹   XP_020955770
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.171,567,816 - 1,656,230 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021100112   ⟹   XP_020955771
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.171,567,816 - 1,656,230 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021100113   ⟹   XP_020955772
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.171,567,816 - 1,635,720 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020955769   ⟸   XM_021100110
- Peptide Label: isoform X2
- UniProtKB: A0A8D1H5J2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020955771   ⟸   XM_021100112
- Peptide Label: isoform X5
- UniProtKB: A0A287AC29 (UniProtKB/TrEMBL),   A0A4X1SR14 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020955768   ⟸   XM_021100109
- Peptide Label: isoform X1
- UniProtKB: A0A8D1H5J2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020955770   ⟸   XM_021100111
- Peptide Label: isoform X3
- UniProtKB: A0A8D1H5J2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013832849   ⟸   XM_013977395
- Peptide Label: isoform X4
- UniProtKB: A0A8D1H5I6 (UniProtKB/TrEMBL),   A0A8D1QXE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020955772   ⟸   XM_021100113
- Peptide Label: isoform X6
- UniProtKB: A0A4X1SSK3 (UniProtKB/TrEMBL),   A0A8D1E5B5 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000028777 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025063246 UniProtKB/TrEMBL
  ENSSSCG00030015076 UniProtKB/TrEMBL
  ENSSSCG00035041283 UniProtKB/TrEMBL
  ENSSSCG00040028130 UniProtKB/TrEMBL
  ENSSSCG00045011906 UniProtKB/TrEMBL
  ENSSSCG00055018154 UniProtKB/TrEMBL
  ENSSSCG00065039768 UniProtKB/TrEMBL
  ENSSSCG00070003369 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000031472.4 UniProtKB/TrEMBL
  ENSSSCT00000062868 ENTREZGENE
  ENSSSCT00000062868.3 UniProtKB/TrEMBL
  ENSSSCT00000080077.1 UniProtKB/TrEMBL
  ENSSSCT00000084701 ENTREZGENE
  ENSSSCT00000084701.2 UniProtKB/TrEMBL
  ENSSSCT00025086568.1 UniProtKB/TrEMBL
  ENSSSCT00025086841.1 UniProtKB/TrEMBL
  ENSSSCT00025087066.1 UniProtKB/TrEMBL
  ENSSSCT00025087279.1 UniProtKB/TrEMBL
  ENSSSCT00030020816.1 UniProtKB/TrEMBL
  ENSSSCT00035054847.1 UniProtKB/TrEMBL
  ENSSSCT00035054853.1 UniProtKB/TrEMBL
  ENSSSCT00035054871.1 UniProtKB/TrEMBL
  ENSSSCT00035054883.1 UniProtKB/TrEMBL
  ENSSSCT00040037859.1 UniProtKB/TrEMBL
  ENSSSCT00045020202.1 UniProtKB/TrEMBL
  ENSSSCT00045020262.1 UniProtKB/TrEMBL
  ENSSSCT00045020304.1 UniProtKB/TrEMBL
  ENSSSCT00045020345.1 UniProtKB/TrEMBL
  ENSSSCT00055035529.1 UniProtKB/TrEMBL
  ENSSSCT00055035647.1 UniProtKB/TrEMBL
  ENSSSCT00055035794.1 UniProtKB/TrEMBL
  ENSSSCT00055035895.1 UniProtKB/TrEMBL
  ENSSSCT00065054347.1 UniProtKB/TrEMBL
  ENSSSCT00065054364.1 UniProtKB/TrEMBL
  ENSSSCT00070006349.1 UniProtKB/TrEMBL
  ENSSSCT00070006362.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report ssc:100157526 UniProtKB/TrEMBL
NCBI Gene MYLK4 ENTREZGENE
PANTHER MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A287AC29 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1SR14 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1SSK3 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QP30_PIG UniProtKB/TrEMBL
  A0A5G2QXB9_PIG UniProtKB/TrEMBL
  A0A8D0T9B1_PIG UniProtKB/TrEMBL
  A0A8D1E5B5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1H5I6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1H5J2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1QXE5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1R294_PIG UniProtKB/TrEMBL
  I3L6E0_PIG UniProtKB/TrEMBL
VGNC ID VGNC:90519 ENTREZGENE