INTS8 (integrator complex subunit 8) - Rat Genome Database

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Gene: INTS8 (integrator complex subunit 8) Sus scrofa
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Symbol: INTS8
Name: integrator complex subunit 8
RGD ID: 14282597
Description: INVOLVED IN protein localization to chromatin (inferred); RNA polymerase II transcription initiation surveillance (inferred); snRNA 3'-end processing (inferred); ASSOCIATED WITH long QT syndrome (ortholog); NEURODEVELOPMENTAL DISORDER WITH CEREBELLAR HYPOPLASIA AND SPASTICITY (ortholog); prostate cancer (ortholog); FOUND IN chromatin (inferred); INTAC complex (inferred); integrator complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl441,821,768 - 41,878,690 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1441,820,718 - 41,878,857 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2445,138,933 - 45,206,626 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
INTS8Piglong QT syndrome  ISOINTS8 (Homo sapiens)8554872ClinVar Annotator: match by term: Long QT syndromeClinVarPMID:26132555
INTS8PigNEURODEVELOPMENTAL DISORDER WITH CEREBELLAR HYPOPLASIA AND SPASTICITY  ISOINTS8 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 more ...
INTS8Pigprostate cancer  ISOINTS8 (Homo sapiens)8554872ClinVar Annotator: match by term: Malignant tumor of prostateClinVarPMID:23265383
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
INTS8PigNEURODEVELOPMENTAL DISORDER WITH CEREBELLAR HYPOPLASIA AND SPASTICITY  ISOINTS8 (Homo sapiens)7240710 OMIM 


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
INTS8Pigprotein localization to chromatin involved_inIEAUniProtKB:Q75QN2 and ensembl:ENSP00000430338150520179 EnsemblGO_REF:0000107
INTS8PigRNA polymerase II transcription initiation surveillance involved_inIEAUniProtKB:Q75QN2 and ensembl:ENSP00000430338150520179 EnsemblGO_REF:0000107
INTS8PigsnRNA 3'-end processing involved_inIBAFB:FBgn0025830 and PANTHER:PTN001000619150520179 GO_CentralGO_REF:0000033
INTS8PigsnRNA 3'-end processing involved_inIEAInterPro:IPR038751150520179 InterProGO_REF:0000002
INTS8PigsnRNA processing involved_inIEAUniProtKB:Q75QN2 and ensembl:ENSP00000430338150520179 EnsemblGO_REF:0000107

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
INTS8Pigchromatin is_active_inIEAUniProtKB:Q75QN2 and ensembl:ENSP00000430338150520179 EnsemblGO_REF:0000107
INTS8PigINTAC complex part_ofIEAUniProtKB:Q75QN2 and ensembl:ENSP00000430338150520179 EnsemblGO_REF:0000107
INTS8Pigintegrator complex part_ofIEAUniProtKB:Q75QN2 and ensembl:ENSP00000430338150520179 EnsemblGO_REF:0000107
INTS8Pigintegrator complex part_ofIBAFB:FBgn0025830 more ...150520179 GO_CentralGO_REF:0000033
INTS8Pignucleus located_inIEAUniProtKB-KW:KW-0539150520179 UniProtGO_REF:0000043
INTS8Pignucleus is_active_inIEAUniProtKB:Q75QN2 and ensembl:ENSP00000430338150520179 EnsemblGO_REF:0000107
INTS8Pignucleus located_inIEAUniProtKB-SubCell:SL-0191150520179 UniProtGO_REF:0000044

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
INTS8Pigprotein binding enablesISOUniProtKB:Q6P9B99068941 PMID:33548203 and PMID:33961781IntActPMID:33548203 and PMID:33961781
INTS8Pigprotein binding enablesISOUniProtKB:P249289068941 PMID:16239144UniProtPMID:16239144

PMID:22301074   PMID:30032202  



INTS8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl441,821,768 - 41,878,690 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1441,820,718 - 41,878,857 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2445,138,933 - 45,206,626 (-)NCBISscrofa10.2Sscrofa10.2susScr3
INTS8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38894,823,287 - 94,881,746 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl894,813,311 - 94,881,746 (+)EnsemblGRCh38hg38GRCh38
GRCh37895,835,515 - 95,893,974 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36895,904,710 - 95,961,897 (+)NCBINCBI36Build 36hg18NCBI36
Celera892,020,737 - 92,077,921 (+)NCBICelera
Cytogenetic Map8q22.1NCBI
HuRef891,043,438 - 91,100,696 (+)NCBIHuRef
CHM1_1895,875,841 - 95,933,067 (+)NCBICHM1_1
T2T-CHM13v2.0895,948,260 - 96,006,732 (+)NCBIT2T-CHM13v2.0
Ints8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39411,199,158 - 11,254,264 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl411,199,158 - 11,254,258 (-)EnsemblGRCm39 Ensembl
GRCm38411,199,158 - 11,254,265 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl411,199,158 - 11,254,258 (-)EnsemblGRCm38mm10GRCm38
MGSCv37411,126,305 - 11,181,406 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36411,126,305 - 11,181,376 (-)NCBIMGSCv36mm8
MGSCv36410,682,764 - 10,738,665 (-)NCBIMGSCv36mm8
Celera411,009,643 - 11,064,963 (-)NCBICelera
Cytogenetic Map4A1NCBI
cM Map45.08NCBI
Ints8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8529,094,475 - 29,141,874 (-)NCBIGRCr8
mRatBN7.2524,295,542 - 24,344,642 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl524,297,191 - 24,344,740 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0524,446,002 - 24,493,819 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl524,445,886 - 24,493,670 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0529,171,591 - 29,219,259 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4525,043,872 - 25,091,357 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1525,043,876 - 25,091,436 (-)NCBI
Celera523,515,547 - 23,563,020 (-)NCBICelera
Cytogenetic Map5q13NCBI
Ints8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541710,975,103 - 11,027,697 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541710,975,716 - 11,027,697 (+)NCBIChiLan1.0ChiLan1.0
INTS8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27112,151,701 - 112,208,934 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1887,688,740 - 87,745,976 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0891,442,560 - 91,499,916 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1893,645,053 - 93,702,373 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl893,645,053 - 93,702,373 (+)Ensemblpanpan1.1panPan2
INTS8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12939,482,834 - 39,533,761 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2939,474,640 - 39,533,719 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2939,644,306 - 39,695,236 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02939,687,365 - 39,737,725 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2939,687,359 - 39,737,725 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12939,699,399 - 39,749,982 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02939,695,597 - 39,745,833 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02940,136,118 - 40,187,065 (+)NCBIUU_Cfam_GSD_1.0
Ints8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530339,925,605 - 40,008,627 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365447,784,242 - 7,839,565 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365447,784,093 - 7,839,646 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INTS8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1889,790,758 - 89,846,764 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl889,790,758 - 89,850,755 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603950,986,134 - 51,042,368 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ints8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247632,186,027 - 2,242,393 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247632,185,841 - 2,242,469 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in INTS8
1473 total Variants



alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3



Ensembl Acc Id: ENSSSCT00000006687   ⟹   ENSSSCP00000006507
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl441,821,768 - 41,878,690 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000059483   ⟹   ENSSSCP00000059090
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl441,821,764 - 41,878,868 (-)Ensembl
RefSeq Acc Id: XM_003125559   ⟹   XP_003125607
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1441,820,718 - 41,878,857 (-)NCBI
Sequence:
Protein RefSeqs XP_003125607 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000006507
  ENSSSCP00000006507.4
  ENSSSCP00065010195.1
RefSeq Acc Id: XP_003125607   ⟸   XM_003125559
- UniProtKB: A0A8D1XXY3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000006507   ⟸   ENSSSCT00000006687
Ensembl Acc Id: ENSSSCP00000059090   ⟸   ENSSSCT00000059483



1 to 15 of 15 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSSSCG00000006096 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00065018788 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000006687 ENTREZGENE
  ENSSSCT00000006687.5 UniProtKB/TrEMBL
  ENSSSCT00065024967.1 UniProtKB/TrEMBL
InterPro Int8 UniProtKB/TrEMBL
  TPR-like_helical_dom_sf UniProtKB/TrEMBL
KEGG Report ssc:100511876 UniProtKB/TrEMBL
NCBI Gene INTS8 ENTREZGENE
PANTHER INTEGRATOR COMPLEX SUBUNIT 8 UniProtKB/TrEMBL
  PTHR13350 UniProtKB/TrEMBL
Superfamily-SCOP SSF48452 UniProtKB/TrEMBL
UniProt A0A8D1XXY3 ENTREZGENE, UniProtKB/TrEMBL
  F1RY55_PIG UniProtKB/TrEMBL
VGNC ID VGNC:89168 ENTREZGENE
1 to 15 of 15 rows