MSH5 (mutS homolog 5) - Rat Genome Database

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Gene: MSH5 (mutS homolog 5) Sus scrofa
Analyze
Symbol: MSH5
Name: mutS homolog 5
RGD ID: 14205854
Description: ENCODES a protein that exhibits ATP binding (inferred); ATP-dependent DNA damage sensor activity (inferred); DNA binding (inferred); INVOLVED IN female gamete generation (ortholog); homologous chromosome pairing at meiosis (ortholog); meiosis I (ortholog); ASSOCIATED WITH azoospermia (ortholog); hepatocellular carcinoma (ortholog); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN synaptonemal complex (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: mutS protein homolog 5; mutS-like protein 5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl723,852,918 - 23,872,760 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1723,852,864 - 23,872,760 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MSH5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl723,852,918 - 23,872,760 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1723,852,864 - 23,872,760 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MSH5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38631,740,005 - 31,762,676 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl631,739,677 - 31,762,676 (+)EnsemblGRCh38hg38GRCh38
GRCh37631,707,782 - 31,730,453 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,815,753 - 31,838,432 (+)NCBINCBI36Build 36hg18NCBI36
Build 34631,815,755 - 31,840,601NCBI
Celera633,305,954 - 33,328,700 (+)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef631,493,957 - 31,516,883 (+)NCBIHuRef
CHM1_1631,709,839 - 31,732,578 (+)NCBICHM1_1
T2T-CHM13v2.0631,593,029 - 31,615,723 (+)NCBIT2T-CHM13v2.0
Msh5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,247,581 - 35,267,842 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1735,247,581 - 35,265,721 (-)EnsemblGRCm39 Ensembl
GRCm381735,028,605 - 35,046,997 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1735,028,605 - 35,046,745 (-)EnsemblGRCm38mm10GRCm38
MGSCv371735,165,550 - 35,183,668 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361734,636,661 - 34,654,678 (-)NCBIMGSCv36mm8
Celera1738,124,846 - 38,143,436 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.57NCBI
Msh5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8203,779,180 - 3,797,996 (+)NCBIGRCr8
mRatBN7.2203,773,867 - 3,793,337 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,776,942 - 3,793,336 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,476,493 - 4,492,884 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0203,838,546 - 3,854,939 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,376,404 - 4,392,844 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0205,020,690 - 5,037,125 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,020,667 - 5,037,088 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,093,706 - 7,110,044 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,845,731 - 3,862,011 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1203,846,041 - 3,862,242 (+)NCBI
Celera204,233,160 - 4,249,400 (-)NCBICelera
Cytogenetic Map20p12NCBI
Msh5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955437279,744 - 297,153 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955437275,976 - 297,268 (+)NCBIChiLan1.0ChiLan1.0
MSH5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2546,217,203 - 46,239,558 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1642,178,711 - 42,201,176 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0631,401,343 - 31,424,665 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1632,289,318 - 32,313,411 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl632,290,511 - 32,311,085 (+)Ensemblpanpan1.1panPan2
MSH5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,221,278 - 1,243,042 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,357,836 - 1,379,567 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0121,364,526 - 1,386,294 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl121,364,451 - 1,386,294 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1121,223,762 - 1,245,520 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0121,290,998 - 1,312,682 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0121,358,882 - 1,380,614 (+)NCBIUU_Cfam_GSD_1.0
Msh5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494635,767,176 - 35,785,306 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367271,777,570 - 1,793,711 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367271,776,038 - 1,794,152 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MSH5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11740,260,979 - 40,283,872 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1740,261,125 - 40,282,511 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604431,652,919 - 31,675,016 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Msh5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475424,453,902 - 24,473,051 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475424,453,750 - 24,477,574 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.
Variants

.
Variants in MSH5
347 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000057162   ⟹   ENSSSCP00000034231
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl723,852,918 - 23,872,755 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000069186   ⟹   ENSSSCP00000061304
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl723,852,918 - 23,872,755 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000107852   ⟹   ENSSSCP00000082236
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl723,852,918 - 23,872,755 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000107853   ⟹   ENSSSCP00000082237
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl723,852,918 - 23,872,755 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000107854   ⟹   ENSSSCP00000082238
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl723,852,918 - 23,872,755 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000107855   ⟹   ENSSSCP00000082239
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl723,852,918 - 23,872,755 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000107867   ⟹   ENSSSCP00000082250
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl723,853,351 - 23,872,760 (+)Ensembl
RefSeq Acc Id: NM_001195358   ⟹   NP_001182287
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1723,853,351 - 23,872,756 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021098148   ⟹   XP_020953807
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1723,852,864 - 23,872,760 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021098149   ⟹   XP_020953808
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1723,852,864 - 23,872,760 (+)NCBI
Sequence:
RefSeq Acc Id: XP_020953807   ⟸   XM_021098148
- Peptide Label: isoform X1
- UniProtKB: A0A286ZRM4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020953808   ⟸   XM_021098149
- Peptide Label: isoform X2
- UniProtKB: A0A286ZRM4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001182287   ⟸   NM_001195358
- UniProtKB: B9TSR3 (UniProtKB/TrEMBL),   A0A8D1RJJ5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000034231   ⟸   ENSSSCT00000057162
Ensembl Acc Id: ENSSSCP00000061304   ⟸   ENSSSCT00000069186
Ensembl Acc Id: ENSSSCP00000082237   ⟸   ENSSSCT00000107853
Ensembl Acc Id: ENSSSCP00000082238   ⟸   ENSSSCT00000107854
Ensembl Acc Id: ENSSSCP00000082236   ⟸   ENSSSCT00000107852
Ensembl Acc Id: ENSSSCP00000082239   ⟸   ENSSSCT00000107855
Ensembl Acc Id: ENSSSCP00000082250   ⟸   ENSSSCT00000107867

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000035596 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015080787 UniProtKB/TrEMBL
  ENSSSCG00025076525 UniProtKB/TrEMBL
  ENSSSCG00030058070 UniProtKB/TrEMBL
  ENSSSCG00035021486 UniProtKB/TrEMBL
  ENSSSCG00040050359 UniProtKB/TrEMBL
  ENSSSCG00045039512 UniProtKB/TrEMBL
  ENSSSCG00050011336 UniProtKB/TrEMBL
  ENSSSCG00055020807 UniProtKB/TrEMBL
  ENSSSCG00065044438 UniProtKB/TrEMBL
  ENSSSCG00070023613 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000057162 ENTREZGENE
  ENSSSCT00000057162.3 UniProtKB/TrEMBL
  ENSSSCT00000069186 ENTREZGENE
  ENSSSCT00000069186.1 UniProtKB/TrEMBL
  ENSSSCT00015110085.1 UniProtKB/TrEMBL
  ENSSSCT00015110100.1 UniProtKB/TrEMBL
  ENSSSCT00025106412.1 UniProtKB/TrEMBL
  ENSSSCT00025106449.1 UniProtKB/TrEMBL
  ENSSSCT00030081642.1 UniProtKB/TrEMBL
  ENSSSCT00030081703.1 UniProtKB/TrEMBL
  ENSSSCT00035028176.1 UniProtKB/TrEMBL
  ENSSSCT00035028194.1 UniProtKB/TrEMBL
  ENSSSCT00040070692.1 UniProtKB/TrEMBL
  ENSSSCT00040070920.1 UniProtKB/TrEMBL
  ENSSSCT00045068860.1 UniProtKB/TrEMBL
  ENSSSCT00045068863.1 UniProtKB/TrEMBL
  ENSSSCT00050015505.1 UniProtKB/TrEMBL
  ENSSSCT00050015511.1 UniProtKB/TrEMBL
  ENSSSCT00055042992.1 UniProtKB/TrEMBL
  ENSSSCT00055043230.1 UniProtKB/TrEMBL
  ENSSSCT00065060783.1 UniProtKB/TrEMBL
  ENSSSCT00070047152.1 UniProtKB/TrEMBL
  ENSSSCT00070047164.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1420.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro DNA_mismatch_repair_MutS/MSH UniProtKB/TrEMBL
  DNA_mismatch_repair_MutS_C UniProtKB/TrEMBL
  DNA_mismatch_repair_MutS_clamp UniProtKB/TrEMBL
  DNA_mismatch_repair_MutS_core UniProtKB/TrEMBL
  DNA_mismatch_repair_MutS_sf UniProtKB/TrEMBL
  MutS_family UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report ssc:100270818 UniProtKB/TrEMBL
NCBI Gene MSH5 ENTREZGENE
PANTHER MUTS PROTEIN HOMOLOG 5 UniProtKB/TrEMBL
  PTHR11361 UniProtKB/TrEMBL
Pfam MutS_III UniProtKB/TrEMBL
  MutS_IV UniProtKB/TrEMBL
  MutS_V UniProtKB/TrEMBL
PIRSF DNA_mis_repair_Msh6 UniProtKB/TrEMBL
PROSITE DNA_MISMATCH_REPAIR_2 UniProtKB/TrEMBL
SMART MUTSac UniProtKB/TrEMBL
  MUTSd UniProtKB/TrEMBL
Superfamily-SCOP SSF48334 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A286ZRM4 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1VDK7_PIG UniProtKB/TrEMBL
  A0A4X1VDR3_PIG UniProtKB/TrEMBL
  A0A5G2QB85_PIG UniProtKB/TrEMBL
  A0A8D0QJF0_PIG UniProtKB/TrEMBL
  A0A8D0UFA7_PIG UniProtKB/TrEMBL
  A0A8D0Z0I6_PIG UniProtKB/TrEMBL
  A0A8D0Z6F4_PIG UniProtKB/TrEMBL
  A0A8D1RJJ5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1RJS9_PIG UniProtKB/TrEMBL
  A0A8D1YYN9_PIG UniProtKB/TrEMBL
  B9TSR3 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:110210 ENTREZGENE