ASIC1 (acid sensing ion channel subunit 1) - Rat Genome Database

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Gene: ASIC1 (acid sensing ion channel subunit 1) Sus scrofa
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Symbol: ASIC1
Name: acid sensing ion channel subunit 1
RGD ID: 14195655
Description: ENCODES a protein that exhibits inorganic cation transmembrane transporter activity (ortholog); monoatomic ion channel activity (ortholog); pH-gated monoatomic ion channel activity (ortholog); INVOLVED IN associative learning (ortholog); behavioral fear response (ortholog); calcium ion transmembrane transport (ortholog); ASSOCIATED WITH Brain Injuries (ortholog); brain ischemia (ortholog); epilepsy (ortholog); FOUND IN cell surface (ortholog); glutamatergic synapse (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ACCN2; acid-sensing (proton-gated) ion channel 1; acid-sensing ion channel 1; acid-sensing ion channel 1 pseudogene; amiloride-sensitive cation channel 2, neuronal
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl515,965,084 - 15,991,876 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1515,965,082 - 15,991,291 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2516,354,884 - 16,365,975 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:22421400   PMID:30032202   PMID:32160007  


Genomics

Comparative Map Data
ASIC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl515,965,084 - 15,991,876 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1515,965,082 - 15,991,291 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2516,354,884 - 16,365,975 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ASIC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381250,057,596 - 50,083,622 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1250,057,548 - 50,083,611 (+)EnsemblGRCh38hg38GRCh38
GRCh371250,451,379 - 50,477,394 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361248,737,754 - 48,763,661 (+)NCBINCBI36Build 36hg18NCBI36
Build 341248,737,753 - 48,763,660NCBI
Celera1249,246,955 - 49,272,856 (+)NCBICelera
Cytogenetic Map12q13.12NCBI
HuRef1247,485,455 - 47,510,311 (+)NCBIHuRef
CHM1_11250,417,567 - 50,443,552 (+)NCBICHM1_1
T2T-CHM13v2.01250,020,656 - 50,046,680 (+)NCBIT2T-CHM13v2.0
Asic1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391599,568,090 - 99,599,011 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1599,568,249 - 99,599,011 (+)EnsemblGRCm39 Ensembl
GRCm381599,670,197 - 99,701,130 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1599,670,368 - 99,701,130 (+)EnsemblGRCm38mm10GRCm38
MGSCv371599,501,149 - 99,531,559 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361599,498,752 - 99,529,162 (+)NCBIMGSCv36mm8
Celera15101,826,413 - 101,856,974 (+)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.13NCBI
Asic1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87132,677,158 - 132,707,379 (+)NCBIGRCr8
mRatBN7.27130,798,317 - 130,828,535 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7130,799,917 - 130,828,541 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7132,603,489 - 132,632,142 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07134,829,075 - 134,857,723 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07134,741,599 - 134,770,248 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07141,324,714 - 141,354,937 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7141,326,321 - 141,354,937 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X115,830,166 - 115,859,585 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47138,414,656 - 138,443,272 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17138,491,092 - 138,517,829 (+)NCBI
Celera7127,281,326 - 127,309,938 (+)NCBICelera
Cytogenetic Map7q36NCBI
Asic1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955547635,638 - 658,541 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955547635,714 - 658,541 (+)NCBIChiLan1.0ChiLan1.0
ASIC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21044,105,768 - 44,132,086 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11244,102,536 - 44,128,341 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01238,672,253 - 38,698,247 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11239,569,149 - 39,593,822 (-)NCBIpanpan1.1PanPan1.1panPan2
ASIC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1274,638,826 - 4,663,352 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl274,638,812 - 4,648,038 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2741,594,907 - 41,619,336 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0274,687,973 - 4,712,419 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl274,687,975 - 4,711,469 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1274,652,821 - 4,677,403 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0274,642,373 - 4,667,009 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02741,989,720 - 42,014,370 (+)NCBIUU_Cfam_GSD_1.0
Asic1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494565,418,273 - 65,444,825 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365127,720,523 - 7,746,579 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365127,720,591 - 7,746,557 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASIC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11146,286,665 - 46,313,016 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1146,287,787 - 46,314,177 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037199,808,378 - 199,835,287 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Asic1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248162,228,440 - 2,253,004 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248162,228,440 - 2,253,798 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ASIC1
698 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
8 2 23 3 3 10 6 23 2 4

Sequence


Ensembl Acc Id: ENSSSCT00000000232   ⟹   ENSSSCP00000000229
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl515,965,084 - 15,991,876 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000028934   ⟹   ENSSSCP00000022499
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl515,947,382 - 15,991,877 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000038460   ⟹   ENSSSCP00000046439
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl515,981,961 - 15,990,976 (+)Ensembl
RefSeq Acc Id: XM_021091639   ⟹   XP_020947298
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1515,965,118 - 15,991,291 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021091640   ⟹   XP_020947299
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1515,965,082 - 15,991,291 (+)NCBI
Sequence:
RefSeq Acc Id: XP_020947299   ⟸   XM_021091640
- Peptide Label: isoform X2
- UniProtKB: A0A4X1WDR0 (UniProtKB/TrEMBL),   F1SH99 (UniProtKB/TrEMBL),   A0A4X1WCI5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020947298   ⟸   XM_021091639
- Peptide Label: isoform X1
- UniProtKB: A0A4X1WCI5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000022499   ⟸   ENSSSCT00000028934
Ensembl Acc Id: ENSSSCP00000046439   ⟸   ENSSSCT00000038460
Ensembl Acc Id: ENSSSCP00000000229   ⟸   ENSSSCT00000000232


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000000216 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015080052 UniProtKB/TrEMBL
  ENSSSCG00025071876 UniProtKB/TrEMBL
  ENSSSCG00030055327 UniProtKB/TrEMBL
  ENSSSCG00035072789 UniProtKB/TrEMBL
  ENSSSCG00040025156 UniProtKB/TrEMBL
  ENSSSCG00045006933 UniProtKB/TrEMBL
  ENSSSCG00050063869 UniProtKB/TrEMBL
  ENSSSCG00055023509 UniProtKB/TrEMBL
  ENSSSCG00060016689 UniProtKB/TrEMBL
  ENSSSCG00065043828 UniProtKB/TrEMBL
  ENSSSCG00070030450 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000000232 ENTREZGENE
  ENSSSCT00000000232.5 UniProtKB/TrEMBL
  ENSSSCT00000038460.2 UniProtKB/TrEMBL
  ENSSSCT00015108794.1 UniProtKB/TrEMBL
  ENSSSCT00025098784.1 UniProtKB/TrEMBL
  ENSSSCT00025098970.1 UniProtKB/TrEMBL
  ENSSSCT00025099109.1 UniProtKB/TrEMBL
  ENSSSCT00030077090.1 UniProtKB/TrEMBL
  ENSSSCT00035098541.1 UniProtKB/TrEMBL
  ENSSSCT00040033597.1 UniProtKB/TrEMBL
  ENSSSCT00040033756.1 UniProtKB/TrEMBL
  ENSSSCT00045011521.1 UniProtKB/TrEMBL
  ENSSSCT00045011560.1 UniProtKB/TrEMBL
  ENSSSCT00050086964.1 UniProtKB/TrEMBL
  ENSSSCT00055046263.1 UniProtKB/TrEMBL
  ENSSSCT00055046412.1 UniProtKB/TrEMBL
  ENSSSCT00055046530.1 UniProtKB/TrEMBL
  ENSSSCT00060022277.1 UniProtKB/TrEMBL
  ENSSSCT00060022282.1 UniProtKB/TrEMBL
  ENSSSCT00065059949.1 UniProtKB/TrEMBL
  ENSSSCT00070061299.1 UniProtKB/TrEMBL
  ENSSSCT00070061300.1 UniProtKB/TrEMBL
  ENSSSCT00070061301.1 UniProtKB/TrEMBL
Gene3D-CATH acid-sensing ion channel 1 domain UniProtKB/TrEMBL
  Acid-sensing ion channel domain UniProtKB/TrEMBL
  Acid-sensing ion channels like domains UniProtKB/TrEMBL
  YojJ-like UniProtKB/TrEMBL
InterPro ENaC UniProtKB/TrEMBL
  ENaC_chordates UniProtKB/TrEMBL
  ENaC_CS UniProtKB/TrEMBL
NCBI Gene ASIC1 ENTREZGENE
PANTHER ACID-SENSING ION CHANNEL 1 UniProtKB/TrEMBL
  PTHR11690 UniProtKB/TrEMBL
Pfam ASC UniProtKB/TrEMBL
PRINTS AMINACHANNEL UniProtKB/TrEMBL
PROSITE ASC UniProtKB/TrEMBL
UniProt A0A287AQV5_PIG UniProtKB/TrEMBL
  A0A4X1WCI4_PIG UniProtKB/TrEMBL
  A0A4X1WCI5 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1WDR0 ENTREZGENE, UniProtKB/TrEMBL
  F1SH99 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:85578 ENTREZGENE