DTX1 (deltex E3 ubiquitin ligase 1) - Rat Genome Database

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Gene: DTX1 (deltex E3 ubiquitin ligase 1) Sus scrofa
Analyze
Symbol: DTX1
Name: deltex E3 ubiquitin ligase 1
RGD ID: 14131667
Description: ENCODES a protein that exhibits metal ion binding (inferred); Notch binding (inferred); transferase activity (inferred); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); glial cell differentiation (ortholog); negative regulation of T cell differentiation (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH oligodendroglioma (ortholog); pancreatic ductal carcinoma (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nuclear body (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: deltex homolog 1; E3 ubiquitin-protein ligase DTX1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1438,560,924 - 38,599,787 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11438,559,705 - 38,599,790 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21441,019,609 - 41,058,799 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
nuclear body  (IEA)
nucleoplasm  (IBA,IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DTX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1438,560,924 - 38,599,787 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11438,559,705 - 38,599,790 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21441,019,609 - 41,058,799 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DTX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812113,056,730 - 113,098,025 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12113,056,730 - 113,098,028 (+)EnsemblGRCh38hg38GRCh38
GRCh3712113,494,535 - 113,535,830 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612111,980,045 - 112,020,216 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412111,958,381 - 111,998,553NCBI
Celera12113,122,650 - 113,162,824 (+)NCBICelera
Cytogenetic Map12q24.13NCBI
HuRef12110,508,732 - 110,548,499 (+)NCBIHuRef
CHM1_112113,463,985 - 113,504,150 (+)NCBICHM1_1
T2T-CHM13v2.012113,033,383 - 113,074,667 (+)NCBIT2T-CHM13v2.0
Dtx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395120,818,268 - 120,850,879 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5120,818,267 - 120,849,992 (-)EnsemblGRCm39 Ensembl
GRCm385120,680,203 - 120,711,867 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5120,680,202 - 120,711,927 (-)EnsemblGRCm38mm10GRCm38
MGSCv375121,130,273 - 121,161,678 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365120,940,881 - 120,972,286 (-)NCBIMGSCv36mm8
Celera5117,765,888 - 117,797,400 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map560.64NCBI
Dtx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81241,510,252 - 41,541,433 (+)NCBIGRCr8
mRatBN7.21235,849,647 - 35,880,835 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1235,849,617 - 35,880,838 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01241,383,885 - 41,415,783 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1241,385,241 - 41,414,754 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01243,243,009 - 43,274,204 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1237,511,093 - 37,542,318 (+)NCBICelera
Cytogenetic Map12q16NCBI
Dtx1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554829,417,116 - 9,446,239 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554829,416,456 - 9,447,265 (+)NCBIChiLan1.0ChiLan1.0
DTX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210121,145,431 - 121,186,963 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112121,141,821 - 121,183,360 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012110,661,247 - 110,702,780 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112114,045,961 - 114,086,465 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12114,046,700 - 114,085,372 (+)Ensemblpanpan1.1panPan2
DTX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12610,469,850 - 10,502,682 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2610,587,454 - 10,623,052 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02610,709,514 - 10,745,094 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2610,710,204 - 10,745,091 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12610,683,018 - 10,718,602 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02610,746,204 - 10,781,784 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02610,794,682 - 10,830,404 (+)NCBIUU_Cfam_GSD_1.0
LOC106145247
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118148,509,829 - 148,522,177 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366683,006,539 - 3,021,066 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DTX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111108,299,691 - 108,343,271 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11108,300,193 - 108,342,738 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037136,750,394 - 136,792,825 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dtx1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474719,318,465 - 19,352,473 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474719,321,842 - 19,352,661 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DTX1
1018 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000045618   ⟹   ENSSSCP00000052068
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1438,560,924 - 38,599,787 (+)Ensembl
RefSeq Acc Id: XM_021072393   ⟹   XP_020928052
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11438,559,705 - 38,599,790 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020928052 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000052068
  ENSSSCP00000052068.2
RefSeq Acc Id: XP_020928052   ⟸   XM_021072393
- UniProtKB: A0A287B7L2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000052068   ⟸   ENSSSCT00000045618
Protein Domains
RING-type   WWE


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000009873 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000045618 ENTREZGENE
  ENSSSCT00000045618.3 UniProtKB/TrEMBL
Gene3D-CATH 3.30.390.130 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
  3.30.720.50 UniProtKB/TrEMBL
InterPro Deltex_C UniProtKB/TrEMBL
  Deltex_C_sf UniProtKB/TrEMBL
  Deltex_fam UniProtKB/TrEMBL
  WWE-dom UniProtKB/TrEMBL
  WWE-dom_subgr UniProtKB/TrEMBL
  WWE_dom_sf UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
NCBI Gene DTX1 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE DTX1 UniProtKB/TrEMBL
  PTHR12622 UniProtKB/TrEMBL
Pfam DTC UniProtKB/TrEMBL
  WWE UniProtKB/TrEMBL
PROSITE WWE UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
SMART RING UniProtKB/TrEMBL
  WWE UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
  SSF117839 UniProtKB/TrEMBL
UniProt A0A287B7L2 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:87466 ENTREZGENE