MAP4K1 (mitogen-activated protein kinase kinase kinase kinase 1) - Rat Genome Database

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Gene: MAP4K1 (mitogen-activated protein kinase kinase kinase kinase 1) Sus scrofa
Analyze
Symbol: MAP4K1
Name: mitogen-activated protein kinase kinase kinase kinase 1
RGD ID: 14069211
Description: ENCODES a protein that exhibits 3-phosphoinositide-dependent protein kinase activity (inferred); AMP-activated protein kinase activity (inferred); ATP binding (inferred); INVOLVED IN peptidyl-serine phosphorylation (ortholog); protein autophosphorylation (ortholog); protein phosphorylation (ortholog); ASSOCIATED WITH transient cerebral ischemia (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl647,458,541 - 47,475,815 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1647,458,540 - 47,475,090 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2642,960,191 - 42,969,750 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MAP4K1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl647,458,541 - 47,475,815 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1647,458,540 - 47,475,090 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2642,960,191 - 42,969,750 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAP4K1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381938,587,641 - 38,617,953 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1938,587,641 - 38,618,882 (-)EnsemblGRCh38hg38GRCh38
GRCh371939,078,281 - 39,108,593 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361943,770,121 - 43,800,483 (-)NCBINCBI36Build 36hg18NCBI36
Build 341943,770,120 - 43,800,404NCBI
Celera1935,880,315 - 35,910,669 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1935,526,409 - 35,555,215 (-)NCBIHuRef
CHM1_11939,079,211 - 39,109,466 (-)NCBICHM1_1
T2T-CHM13v2.01941,391,622 - 41,421,931 (-)NCBIT2T-CHM13v2.0
Map4k1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,681,506 - 28,702,704 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl728,681,475 - 28,702,704 (+)EnsemblGRCm39 Ensembl
GRCm38728,982,050 - 29,003,279 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,982,050 - 29,003,279 (+)EnsemblGRCm38mm10GRCm38
MGSCv37729,767,873 - 29,788,298 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36728,691,621 - 28,712,039 (+)NCBIMGSCv36mm8
Celera723,544,299 - 23,565,707 (+)NCBICelera
Cytogenetic Map7B1NCBI
cM Map716.94NCBI
Map4k1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8193,398,460 - 93,419,996 (+)NCBIGRCr8
mRatBN7.2184,270,951 - 84,292,496 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,271,069 - 84,292,493 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx189,680,879 - 89,702,365 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0198,140,702 - 98,162,163 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0191,436,736 - 91,458,226 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0187,937,126 - 87,959,514 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl187,938,042 - 87,959,569 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0189,113,867 - 89,135,540 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4184,094,589 - 84,116,015 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1184,172,706 - 84,194,129 (+)NCBI
Celera178,661,150 - 78,682,606 (+)NCBICelera
Cytogenetic Map1q21NCBI
Map4k1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955468859,126 - 879,727 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955468859,123 - 879,727 (+)NCBIChiLan1.0ChiLan1.0
MAP4K1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22044,882,621 - 44,911,705 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11946,752,952 - 46,782,048 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01935,685,526 - 35,714,300 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11944,256,548 - 44,286,113 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1944,256,655 - 44,285,969 (-)Ensemblpanpan1.1panPan2
MAP4K1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11114,444,231 - 114,461,254 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1114,444,553 - 114,461,254 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1113,849,647 - 113,865,893 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01115,046,954 - 115,063,212 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1114,883,820 - 115,063,219 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11114,619,927 - 114,636,176 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01114,237,646 - 114,253,899 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01115,276,214 - 115,292,470 (+)NCBIUU_Cfam_GSD_1.0
Map4k1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934913,133,139 - 13,150,104 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368011,298,539 - 1,314,465 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049368011,298,495 - 1,315,475 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP4K1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1633,234,559 - 33,262,996 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl633,234,058 - 33,262,550 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607311,181,967 - 11,211,244 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map4k1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479412,004,643 - 12,024,364 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479412,004,536 - 12,025,430 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MAP4K1
222 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 22 3 2 5 14 12 22 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000003286   ⟹   ENSSSCP00000003204
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl647,458,541 - 47,475,815 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000038048   ⟹   ENSSSCP00000049505
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl647,458,541 - 47,475,109 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000078018   ⟹   ENSSSCP00000070329
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl647,458,541 - 47,475,109 (-)Ensembl
RefSeq Acc Id: XM_021094343   ⟹   XP_020950002
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1647,458,540 - 47,475,090 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020950002 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000003204.4
  ENSSSCP00000049505
  ENSSSCP00000049505.2
  ENSSSCP00000070329.1
  ENSSSCP00070010098.1
  ENSSSCP00070010108.1
  ENSSSCP00070010124.1
GenBank Protein JAG69385 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_020950002   ⟸   XM_021094343
- UniProtKB: A0A287AZW8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000070329   ⟸   ENSSSCT00000078018
Ensembl Acc Id: ENSSSCP00000003204   ⟸   ENSSSCT00000003286
Ensembl Acc Id: ENSSSCP00000049505   ⟸   ENSSSCT00000038048
Protein Domains
CNH   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000002962 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070006401 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000003286.5 UniProtKB/TrEMBL
  ENSSSCT00000038048 ENTREZGENE
  ENSSSCT00000038048.3 UniProtKB/TrEMBL
  ENSSSCT00000078018.2 UniProtKB/TrEMBL
  ENSSSCT00070012285.1 UniProtKB/TrEMBL
  ENSSSCT00070012297.1 UniProtKB/TrEMBL
  ENSSSCT00070012314.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro CNH_dom UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  MAPKKKK UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  STE20/SPS1-PAK UniProtKB/TrEMBL
NCBI Gene MAP4K1 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 1 UniProtKB/TrEMBL
  STERILE20-LIKE KINASE, ISOFORM B-RELATED UniProtKB/TrEMBL
Pfam CNH UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PIRSF MAPKKKK UniProtKB/TrEMBL
PROSITE CNH UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
SMART CNH UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A287AZW8 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1T2Y0_PIG UniProtKB/TrEMBL
  A0A4X1T5E9_PIG UniProtKB/TrEMBL
  A0A4X1T5H2_PIG UniProtKB/TrEMBL
  A0A5G2RGI3_PIG UniProtKB/TrEMBL
  F1RI42_PIG UniProtKB/TrEMBL
VGNC ID VGNC:98111 ENTREZGENE