Map4k1 (mitogen-activated protein kinase kinase kinase kinase 1) - Rat Genome Database

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Gene: Map4k1 (mitogen-activated protein kinase kinase kinase kinase 1) Mus musculus
Analyze
Symbol: Map4k1
Name: mitogen-activated protein kinase kinase kinase kinase 1
RGD ID: 1313505
MGI Page MGI
Description: Enables ATP binding activity and protein serine/threonine kinase activity. Involved in intracellular signal transduction and protein phosphorylation. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; liver; and lung. Orthologous to human MAP4K1 (mitogen-activated protein kinase kinase kinase kinase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hematopoietic progenitor kinase 1; HPK; Hpk1; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1; mHPK1; mitogen activated protein kinase kinase kinase kinase 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,681,506 - 28,702,704 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl728,681,475 - 28,702,704 (+)EnsemblGRCm39 Ensembl
GRCm38728,982,050 - 29,003,279 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,982,050 - 29,003,279 (+)EnsemblGRCm38mm10GRCm38
MGSCv37729,767,873 - 29,788,298 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36728,691,621 - 28,712,039 (+)NCBIMGSCv36mm8
Celera723,544,299 - 23,565,707 (+)NCBICelera
Cytogenetic Map7B1NCBI
cM Map716.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (EXP)
2-palmitoylglycerol  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alpha-Zearalanol  (ISO)
antirheumatic drug  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (ISO)
buta-1,3-diene  (EXP)
cadmium dichloride  (EXP)
carbamazepine  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
choline  (EXP)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
cyanocob(III)alamin  (EXP)
dexamethasone  (EXP)
Dibutyl phosphate  (ISO)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (EXP,ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
folic acid  (EXP)
gentamycin  (ISO)
glycine betaine  (EXP)
hydrazine  (EXP)
hypochlorous acid  (EXP)
L-methionine  (EXP)
lead(0)  (ISO)
lidocaine  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (EXP)
methylmercury chloride  (ISO)
monosodium L-glutamate  (ISO)
nickel atom  (ISO)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
quercetin  (ISO)
SB 431542  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP)
sotorasib  (ISO)
starch  (ISO)
sulfates  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trametinib  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Tyrosine phosphorylation of HPK1 by activated Src promotes ischemic brain injury in rat hippocampal CA1 region. Li T, etal., FEBS Lett. 2008 Jun 11;582(13):1894-900. doi: 10.1016/j.febslet.2008.05.009. Epub 2008 May 20.
3. Neuroprotection against ischemic brain injury by knockdown of hematopietic progenitor kinase 1 expression. Li T, etal., Neuroreport. 2008 Apr 16;19(6):647-51. doi: 10.1097/WNR.0b013e3282f942a8.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8702917   PMID:9003777   PMID:9346925   PMID:10349636   PMID:10903746   PMID:11042159   PMID:11076861   PMID:11487585   PMID:12130508   PMID:12477932   PMID:14563325   PMID:14610273  
PMID:14681479   PMID:15100220   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16341093   PMID:17115060   PMID:17712048   PMID:18287559   PMID:18799693   PMID:19414772  
PMID:19706536   PMID:20824186   PMID:20957749   PMID:21267068   PMID:21725061   PMID:21873635   PMID:22334673   PMID:22976002   PMID:23460610   PMID:28378742   PMID:30282040   PMID:30913212  
PMID:32325033   PMID:32631900   PMID:37140994   PMID:38828677  


Genomics

Comparative Map Data
Map4k1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,681,506 - 28,702,704 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl728,681,475 - 28,702,704 (+)EnsemblGRCm39 Ensembl
GRCm38728,982,050 - 29,003,279 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,982,050 - 29,003,279 (+)EnsemblGRCm38mm10GRCm38
MGSCv37729,767,873 - 29,788,298 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36728,691,621 - 28,712,039 (+)NCBIMGSCv36mm8
Celera723,544,299 - 23,565,707 (+)NCBICelera
Cytogenetic Map7B1NCBI
cM Map716.94NCBI
MAP4K1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381938,587,641 - 38,617,953 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1938,587,641 - 38,618,882 (-)EnsemblGRCh38hg38GRCh38
GRCh371939,078,281 - 39,108,593 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361943,770,121 - 43,800,483 (-)NCBINCBI36Build 36hg18NCBI36
Build 341943,770,120 - 43,800,404NCBI
Celera1935,880,315 - 35,910,669 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1935,526,409 - 35,555,215 (-)NCBIHuRef
CHM1_11939,079,211 - 39,109,466 (-)NCBICHM1_1
T2T-CHM13v2.01941,391,622 - 41,421,931 (-)NCBIT2T-CHM13v2.0
Map4k1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8193,398,460 - 93,419,996 (+)NCBIGRCr8
mRatBN7.2184,270,951 - 84,292,496 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,271,069 - 84,292,493 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx189,680,879 - 89,702,365 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0198,140,702 - 98,162,163 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0191,436,736 - 91,458,226 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0187,937,126 - 87,959,514 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl187,938,042 - 87,959,569 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0189,113,867 - 89,135,540 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4184,094,589 - 84,116,015 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1184,172,706 - 84,194,129 (+)NCBI
Celera178,661,150 - 78,682,606 (+)NCBICelera
Cytogenetic Map1q21NCBI
Map4k1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955468859,126 - 879,727 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955468859,123 - 879,727 (+)NCBIChiLan1.0ChiLan1.0
MAP4K1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22044,882,621 - 44,911,705 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11946,752,952 - 46,782,048 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01935,685,526 - 35,714,300 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11944,256,548 - 44,286,113 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1944,256,655 - 44,285,969 (-)Ensemblpanpan1.1panPan2
MAP4K1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11114,444,231 - 114,461,254 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1114,444,553 - 114,461,254 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1113,849,647 - 113,865,893 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01115,046,954 - 115,063,212 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1114,883,820 - 115,063,219 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11114,619,927 - 114,636,176 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01114,237,646 - 114,253,899 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01115,276,214 - 115,292,470 (+)NCBIUU_Cfam_GSD_1.0
Map4k1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934913,133,139 - 13,150,104 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368011,298,539 - 1,314,465 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049368011,298,495 - 1,315,475 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP4K1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl647,458,541 - 47,475,815 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1647,458,540 - 47,475,090 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2642,960,191 - 42,969,750 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAP4K1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1633,234,559 - 33,262,996 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl633,234,058 - 33,262,550 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607311,181,967 - 11,211,244 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map4k1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479412,004,643 - 12,024,364 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479412,004,536 - 12,025,430 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:97
Count of miRNA genes:95
Interacting mature miRNAs:97
Transcripts:ENSMUST00000085835
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
1301041Prnr2_mprion resistance 2 (mouse)Not determined71872879439674033Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72267388756674033Mouse
1301969Lbw5_mlupus NZB x NZW 5 (mouse)Not determined72684761560851775Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71928001553280104Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72306653157066531Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
7394747asp3_maudiogenic seizure prone 3 (mouse)Not determined72730579836842367Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
12790989Tgl6_mtriglyceride 6 (mouse)72754054961540549Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined71984225053842367Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7243169636431844Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined7998886743988984Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71030579844305936Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72288857256888716Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse

Markers in Region
AI528790  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38729,003,373 - 29,003,512UniSTSGRCm38
MGSCv37729,788,392 - 29,788,531UniSTSGRCm37
Celera723,565,801 - 23,565,940UniSTS
Cytogenetic Map7B1UniSTS
Cytogenetic Map7A2-B3UniSTS
Whitehead/MRC_RH7401.22UniSTS
Map4k1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7B1UniSTS
cM Map7 UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001355054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001427163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001427164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001427165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001427166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006539996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006539998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC165142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC166357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC024832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y09010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000085835   ⟹   ENSMUSP00000082995
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl728,682,253 - 28,702,703 (+)Ensembl
GRCm38.p6 Ensembl728,982,828 - 29,003,278 (+)Ensembl
Ensembl Acc Id: ENSMUST00000207185   ⟹   ENSMUSP00000147189
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl728,682,286 - 28,702,704 (+)Ensembl
GRCm38.p6 Ensembl728,982,861 - 29,003,279 (+)Ensembl
Ensembl Acc Id: ENSMUST00000208227   ⟹   ENSMUSP00000146807
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl728,681,475 - 28,702,701 (+)Ensembl
GRCm38.p6 Ensembl728,982,050 - 29,003,276 (+)Ensembl
Ensembl Acc Id: ENSMUST00000208784
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl728,700,967 - 28,702,699 (+)Ensembl
GRCm38.p6 Ensembl729,001,542 - 29,003,274 (+)Ensembl
RefSeq Acc Id: NM_001355054   ⟹   NP_001341983
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39728,681,569 - 28,702,704 (+)NCBI
GRCm38728,982,050 - 29,003,279 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001427163   ⟹   NP_001414092
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39728,682,278 - 28,702,704 (+)NCBI
RefSeq Acc Id: NM_001427164   ⟹   NP_001414093
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39728,682,278 - 28,702,704 (+)NCBI
RefSeq Acc Id: NM_001427165   ⟹   NP_001414094
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39728,681,569 - 28,702,704 (+)NCBI
RefSeq Acc Id: NM_001427166   ⟹   NP_001414095
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39728,682,278 - 28,702,704 (+)NCBI
RefSeq Acc Id: NM_008279   ⟹   NP_032305
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39728,682,278 - 28,702,704 (+)NCBI
GRCm38728,982,854 - 29,003,279 (+)NCBI
MGSCv37729,767,873 - 29,788,298 (+)RGD
Celera723,544,299 - 23,565,707 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006539996   ⟹   XP_006540059
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39728,681,508 - 28,702,704 (+)NCBI
GRCm38728,982,083 - 29,003,279 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006539998   ⟹   XP_006540061
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39728,681,506 - 28,702,704 (+)NCBI
GRCm38728,982,082 - 29,003,279 (+)NCBI
Sequence:
RefSeq Acc Id: NP_032305   ⟸   NM_008279
- Peptide Label: isoform 1
- UniProtKB: Q8R3R0 (UniProtKB/Swiss-Prot),   Q99K62 (UniProtKB/Swiss-Prot),   P70218 (UniProtKB/Swiss-Prot),   Q3UJX3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006540061   ⟸   XM_006539998
- Peptide Label: isoform X5
- UniProtKB: Q3UJX3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006540059   ⟸   XM_006539996
- Peptide Label: isoform X2
- UniProtKB: Q3UJX3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001341983   ⟸   NM_001355054
- Peptide Label: isoform 2
- UniProtKB: Q3UPT4 (UniProtKB/TrEMBL),   Q3UJX3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000082995   ⟸   ENSMUST00000085835
Ensembl Acc Id: ENSMUSP00000146807   ⟸   ENSMUST00000208227
Ensembl Acc Id: ENSMUSP00000147189   ⟸   ENSMUST00000207185
RefSeq Acc Id: NP_001414094   ⟸   NM_001427165
- Peptide Label: isoform 5
RefSeq Acc Id: NP_001414093   ⟸   NM_001427164
- Peptide Label: isoform 4
RefSeq Acc Id: NP_001414095   ⟸   NM_001427166
- Peptide Label: isoform 6
RefSeq Acc Id: NP_001414092   ⟸   NM_001427163
- Peptide Label: isoform 3
Protein Domains
CNH   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70218-F1-model_v2 AlphaFold P70218 1-827 view protein structure

Promoters
RGD ID:6892508
Promoter ID:EPDNEW_M9705
Type:initiation region
Name:Map4k1_1
Description:Mus musculus mitogen-activated protein kinase kinase kinase kinase1 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38728,982,881 - 28,982,941EPDNEW
RGD ID:6841008
Promoter ID:MM_KWN:49690
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000098615,   NM_028659,   UC009GAJ.1,   UC009GAK.1,   UC009GAL.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36729,766,691 - 29,767,277 (-)MPROMDB
RGD ID:6841494
Promoter ID:MM_KWN:49691
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour
Transcripts:NM_008279
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36729,767,794 - 29,768,294 (+)MPROMDB
RGD ID:6841495
Promoter ID:MM_KWN:49692
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   ES_Cell,   Spleen
Transcripts:UC009GAN.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36729,786,104 - 29,786,604 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1346882 AgrOrtholog
Ensembl Genes ENSMUSG00000037337 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000085835 ENTREZGENE
  ENSMUST00000085835.8 UniProtKB/Swiss-Prot
  ENSMUST00000207185 ENTREZGENE
  ENSMUST00000207185.2 UniProtKB/TrEMBL
  ENSMUST00000208227 ENTREZGENE
  ENSMUST00000208227.2 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Citron UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAPKKKK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STE20/SPS1-PAK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:26411 UniProtKB/Swiss-Prot
MGD MGI:1346882 ENTREZGENE
NCBI Gene 26411 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STERILE20-LIKE KINASE, ISOFORM B-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CNH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Map4k1 PhenoGen
PIRSF MAPKKKK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CNH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CNH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140LJF0_MOUSE UniProtKB/TrEMBL
  M4K1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UJX3 ENTREZGENE, UniProtKB/TrEMBL
  Q3UPT4 ENTREZGENE, UniProtKB/TrEMBL
  Q8R3R0 ENTREZGENE
  Q99K62 ENTREZGENE
UniProt Secondary Q8R3R0 UniProtKB/Swiss-Prot
  Q99K62 UniProtKB/Swiss-Prot