TLCD5 (TLC domain containing 5) - Rat Genome Database

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Gene: TLCD5 (TLC domain containing 5) Sus scrofa
Analyze
Symbol: TLCD5
Name: TLC domain containing 5
RGD ID: 14066140
Description: ASSOCIATED WITH CD3epsilon deficiency (ortholog); chromosome 11 partial duplication syndrome (ortholog); Dwarfism (ortholog); FOUND IN membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: TMEM136; transmembrane protein 136
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl947,464,905 - 47,472,764 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1947,464,840 - 47,472,819 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2952,592,116 - 52,594,934 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074  


Genomics

Comparative Map Data
TLCD5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl947,464,905 - 47,472,764 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1947,464,840 - 47,472,819 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2952,592,116 - 52,594,934 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TLCD5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811120,325,299 - 120,333,686 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11120,325,296 - 120,333,686 (+)EnsemblGRCh38hg38GRCh38
GRCh3711120,196,008 - 120,204,395 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611119,701,226 - 119,706,557 (+)NCBINCBI36Build 36hg18NCBI36
Celera11117,354,721 - 117,360,805 (+)NCBICelera
Cytogenetic Map11q23.3NCBI
HuRef11116,135,872 - 116,145,388 (+)NCBIHuRef
CHM1_111120,083,295 - 120,091,845 (+)NCBICHM1_1
T2T-CHM13v2.011120,348,101 - 120,357,433 (+)NCBIT2T-CHM13v2.0
Tlcd5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39943,019,945 - 43,028,000 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl943,019,945 - 43,027,865 (-)EnsemblGRCm39 Ensembl
GRCm38943,108,650 - 43,116,693 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl943,108,650 - 43,116,570 (-)EnsemblGRCm38mm10GRCm38
MGSCv37942,916,736 - 42,924,653 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36942,859,648 - 42,867,565 (-)NCBIMGSCv36mm8
Celera940,361,657 - 40,369,549 (-)NCBICelera
Cytogenetic Map9A5.1NCBI
cM Map924.2NCBI
Tlcd5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8852,378,360 - 52,383,258 (-)NCBIGRCr8
mRatBN7.2843,481,388 - 43,486,288 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl843,479,016 - 43,486,290 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx848,979,724 - 48,984,583 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0847,258,407 - 47,263,266 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0845,126,024 - 45,130,883 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0847,399,122 - 47,404,018 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl847,396,741 - 47,404,010 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0845,869,918 - 45,874,814 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4846,112,492 - 46,117,388 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera843,072,618 - 43,077,522 (-)NCBICelera
Cytogenetic Map8q22NCBI
Tlcd5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541221,344,261 - 21,352,074 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541221,344,464 - 21,350,675 (+)NCBIChiLan1.0ChiLan1.0
TLCD5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29121,028,944 - 121,038,152 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111122,132,154 - 122,141,372 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011115,161,556 - 115,170,850 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111119,087,580 - 119,096,387 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11119,087,580 - 119,093,621 (+)Ensemblpanpan1.1panPan2
TLCD5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1513,673,059 - 13,681,139 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl513,675,878 - 13,681,287 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha513,724,350 - 13,734,173 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0513,615,662 - 13,625,518 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl513,620,192 - 13,623,167 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1513,753,107 - 13,762,930 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0513,657,092 - 13,666,922 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0513,696,310 - 13,706,352 (-)NCBIUU_Cfam_GSD_1.0
Tlcd5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947102,264,922 - 102,272,560 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365425,186,226 - 5,194,119 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365425,186,445 - 5,192,015 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLCD5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11111,733,315 - 111,740,345 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1111,733,838 - 111,741,860 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604314,319,576 - 14,327,725 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tlcd5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478415,684,202 - 15,690,188 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478415,682,422 - 15,688,976 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TLCD5
106 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 5 14 12 23 3 6 1

Sequence


Ensembl Acc Id: ENSSSCT00000060596   ⟹   ENSSSCP00000048072
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl947,464,905 - 47,472,764 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000091904   ⟹   ENSSSCP00000078743
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl947,466,876 - 47,470,522 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000097262   ⟹   ENSSSCP00000078514
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl947,466,876 - 47,472,764 (+)Ensembl
RefSeq Acc Id: XM_021062987   ⟹   XP_020918646
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1947,465,106 - 47,472,819 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021062988   ⟹   XP_020918647
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1947,464,840 - 47,472,819 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021062989   ⟹   XP_020918648
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1947,464,844 - 47,472,819 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021062990   ⟹   XP_020918649
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1947,464,896 - 47,472,819 (+)NCBI
Sequence:
RefSeq Acc Id: XP_020918647   ⟸   XM_021062988
- Peptide Label: isoform X2
- UniProtKB: A0A4X1VLL3 (UniProtKB/TrEMBL),   A0A287AVC4 (UniProtKB/TrEMBL),   A0A8D1KYJ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020918648   ⟸   XM_021062989
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020918649   ⟸   XM_021062990
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020918646   ⟸   XM_021062987
- Peptide Label: isoform X1
- UniProtKB: A0A4X1VKI7 (UniProtKB/TrEMBL),   A0A8W4FJN2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000048072   ⟸   ENSSSCT00000060596
Ensembl Acc Id: ENSSSCP00000078743   ⟸   ENSSSCT00000091904
Ensembl Acc Id: ENSSSCP00000078514   ⟸   ENSSSCT00000097262
Protein Domains
TLC


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000037406 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005000772 UniProtKB/TrEMBL
  ENSSSCG00015059919 UniProtKB/TrEMBL
  ENSSSCG00025013054 UniProtKB/TrEMBL
  ENSSSCG00030054290 UniProtKB/TrEMBL
  ENSSSCG00035049639 UniProtKB/TrEMBL
  ENSSSCG00040046333 UniProtKB/TrEMBL
  ENSSSCG00045017937 UniProtKB/TrEMBL
  ENSSSCG00050026506 UniProtKB/TrEMBL
  ENSSSCG00055029731 UniProtKB/TrEMBL
  ENSSSCG00060027339 UniProtKB/TrEMBL
  ENSSSCG00065052219 UniProtKB/TrEMBL
  ENSSSCG00070025060 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000060596 ENTREZGENE
  ENSSSCT00000060596.3 UniProtKB/TrEMBL
  ENSSSCT00000091904.1 UniProtKB/TrEMBL
  ENSSSCT00000097262 ENTREZGENE
  ENSSSCT00000097262.1 UniProtKB/TrEMBL
  ENSSSCT00005001044.1 UniProtKB/TrEMBL
  ENSSSCT00015080043.1 UniProtKB/TrEMBL
  ENSSSCT00025017307.1 UniProtKB/TrEMBL
  ENSSSCT00030075663.1 UniProtKB/TrEMBL
  ENSSSCT00035066169.1 UniProtKB/TrEMBL
  ENSSSCT00040062344.1 UniProtKB/TrEMBL
  ENSSSCT00045030544.1 UniProtKB/TrEMBL
  ENSSSCT00050035661.1 UniProtKB/TrEMBL
  ENSSSCT00055059115.1 UniProtKB/TrEMBL
  ENSSSCT00060037007.1 UniProtKB/TrEMBL
  ENSSSCT00065071532.1 UniProtKB/TrEMBL
  ENSSSCT00070050101.1 UniProtKB/TrEMBL
  ENSSSCT00070050102.1 UniProtKB/TrEMBL
InterPro TLC-dom UniProtKB/TrEMBL
  Tmem136 UniProtKB/TrEMBL
NCBI Gene TMEM136 ENTREZGENE
PANTHER PTHR31898 UniProtKB/TrEMBL
  TLC DOMAIN-CONTAINING PROTEIN 5 UniProtKB/TrEMBL
PROSITE TLC UniProtKB/TrEMBL
SMART TLC UniProtKB/TrEMBL
UniProt A0A287AVC4 ENTREZGENE
  A0A4X1VKI7 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1VLL3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1KYJ2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W4FIN3_PIG UniProtKB/TrEMBL
  A0A8W4FJN2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A287AVC4 UniProtKB/TrEMBL
VGNC ID VGNC:94014 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-05-07 TLCD5  TLC domain containing 5  TMEM136  transmembrane protein 136  Symbol and/or name change 5135510 APPROVED