MLYCD (malonyl-CoA decarboxylase) - Rat Genome Database

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Gene: MLYCD (malonyl-CoA decarboxylase) Sus scrofa
Analyze
Symbol: MLYCD
Name: malonyl-CoA decarboxylase
RGD ID: 14063204
Description: ENCODES a protein that exhibits malonyl-CoA decarboxylase activity (ortholog); INVOLVED IN acetyl-CoA biosynthetic process (ortholog); fatty acid oxidation (ortholog); regulation of fatty acid beta-oxidation (ortholog); PARTICIPATES IN malonic aciduria pathway; methylmalonic aciduria, cobalamin-related pathway; propanoate metabolic pathway; ASSOCIATED WITH Cardiac Fibrosis (ortholog); cardiomyopathy (ortholog); Cardiotoxicity (ortholog); FOUND IN peroxisome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: malonyl-CoA decarboxylase, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl64,681,664 - 4,698,661 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.164,683,386 - 4,698,698 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:15105298   PMID:16100246   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MLYCD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl64,681,664 - 4,698,661 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.164,683,386 - 4,698,698 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MLYCD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381683,899,115 - 83,927,031 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1683,899,115 - 83,951,445 (+)EnsemblGRCh38hg38GRCh38
GRCh371683,932,720 - 83,960,636 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361682,490,231 - 82,507,288 (+)NCBINCBI36Build 36hg18NCBI36
Build 341682,490,272 - 82,507,277NCBI
Celera1668,233,776 - 68,250,834 (+)NCBICelera
Cytogenetic Map16q23.3NCBI
HuRef1669,684,307 - 69,701,406 (+)NCBIHuRef
CHM1_11685,344,095 - 85,361,152 (+)NCBICHM1_1
T2T-CHM13v2.01689,964,788 - 89,992,706 (+)NCBIT2T-CHM13v2.0
Mlycd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398120,121,591 - 120,148,577 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8120,121,617 - 120,137,841 (+)EnsemblGRCm39 Ensembl
GRCm388119,394,852 - 119,421,838 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8119,394,878 - 119,411,102 (+)EnsemblGRCm38mm10GRCm38
MGSCv378121,918,792 - 121,934,988 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368122,280,869 - 122,297,065 (+)NCBIMGSCv36mm8
MGSCv364123,800,115 - 123,816,910 (+)NCBIMGSCv36mm8
Celera8123,611,072 - 123,627,694 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map867.64NCBI
Mlycd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81964,356,582 - 64,372,447 (+)NCBIGRCr8
mRatBN7.21947,447,931 - 47,463,794 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1947,447,970 - 47,463,793 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1954,242,309 - 54,258,174 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01954,922,657 - 54,938,880 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01957,137,162 - 57,153,264 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01952,032,950 - 52,048,773 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1952,032,886 - 52,048,753 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01962,781,490 - 62,797,313 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41949,637,193 - 49,653,016 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11949,642,073 - 49,657,896 (+)NCBI
Celera1946,707,681 - 46,723,504 (+)NCBICelera
Cytogenetic Map19q12NCBI
MLYCD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21893,643,962 - 93,661,512 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11699,562,880 - 99,579,831 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01664,520,860 - 64,537,955 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11683,912,793 - 83,929,856 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1683,912,793 - 83,929,162 (+)Ensemblpanpan1.1panPan2
MLYCD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1568,385,058 - 68,399,965 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl568,384,618 - 68,399,965 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha568,398,888 - 68,413,778 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0568,683,230 - 68,698,120 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl568,683,230 - 68,698,120 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1568,631,023 - 68,645,876 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0568,467,455 - 68,482,348 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0568,883,325 - 68,898,237 (-)NCBIUU_Cfam_GSD_1.0
Mlycd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934928,082,871 - 28,110,598 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366413,836,418 - 3,846,485 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MLYCD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1569,312,978 - 69,329,346 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl569,313,062 - 69,329,102 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660476,492,522 - 6,508,731 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mlycd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247463,604,773 - 3,619,775 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247463,604,773 - 3,619,790 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MLYCD
391 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 9 4 3 4 2 17 2 1
Below cutoff 1 1 6 1 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000060999   ⟹   ENSSSCP00000058067
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl64,681,664 - 4,698,661 (-)Ensembl
RefSeq Acc Id: XM_021093740   ⟹   XP_020949399
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.164,683,386 - 4,698,686 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021093741   ⟹   XP_020949400
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.164,683,386 - 4,698,698 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020949400   ⟸   XM_021093741
- Peptide Label: isoform X2
- UniProtKB: D2D0E6 (UniProtKB/TrEMBL),   A0A4X1T2L7 (UniProtKB/TrEMBL),   A0A480ID59 (UniProtKB/TrEMBL),   A0A480MT52 (UniProtKB/TrEMBL),   A0A8D0NUW8 (UniProtKB/TrEMBL),   A0A8D0ZXP9 (UniProtKB/TrEMBL),   A0A8D1RY17 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020949399   ⟸   XM_021093740
- Peptide Label: isoform X1
- UniProtKB: A0A480IDH9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000058067   ⟸   ENSSSCT00000060999
Protein Domains
Malonyl-CoA decarboxylase C-terminal   Malonyl-CoA decarboxylase N-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000031450 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015041237 UniProtKB/TrEMBL
  ENSSSCG00030062332 UniProtKB/TrEMBL
  ENSSSCG00035039544 UniProtKB/TrEMBL
  ENSSSCG00045026863 UniProtKB/TrEMBL
  ENSSSCG00055025596 UniProtKB/TrEMBL
  ENSSSCG00070005883 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000060999 ENTREZGENE
  ENSSSCT00000060999.2 UniProtKB/TrEMBL
  ENSSSCT00015054963.1 UniProtKB/TrEMBL
  ENSSSCT00030087183.1 UniProtKB/TrEMBL
  ENSSSCT00035052521.1 UniProtKB/TrEMBL
  ENSSSCT00045045723.1 UniProtKB/TrEMBL
  ENSSSCT00055050601.1 UniProtKB/TrEMBL
  ENSSSCT00070011207.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.140.90 UniProtKB/TrEMBL
  3.40.630.150 UniProtKB/TrEMBL
InterPro Malonyl_CoA_deC UniProtKB/TrEMBL
  Malonyl_CoA_deC_C UniProtKB/TrEMBL
  Malonyl_CoA_deC_C_sf UniProtKB/TrEMBL
  MCD_N UniProtKB/TrEMBL
  MCD_N_sf UniProtKB/TrEMBL
NCBI Gene MLYCD ENTREZGENE
PANTHER MALONYL-COA DECARBOXYLASE, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR28641 UniProtKB/TrEMBL
Pfam MCD UniProtKB/TrEMBL
  MCD_N UniProtKB/TrEMBL
UniProt A0A480ID59 ENTREZGENE, UniProtKB/TrEMBL
  A0A480IDH9 ENTREZGENE, UniProtKB/TrEMBL
  A0A480MT52 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1T2L7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0NUW8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0ZXP9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1RY17 ENTREZGENE, UniProtKB/TrEMBL
  D2D0E6 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:98129 ENTREZGENE