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Gene: POU2AF1 (POU class 2 homeobox associating factor 1) Sus scrofa

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Symbol:

POU2AF1

Name:

POU class 2 homeobox associating factor 1

RGD ID:

14028037

Description:

ENCODES a protein that exhibits DNA binding (inferred); POU domain binding (inferred); transcription coactivator activity (inferred); INVOLVED IN cellular response to virus (inferred); germinal center B cell differentiation (inferred); positive regulation of interleukin-6 production (inferred); ASSOCIATED WITH ataxia telangiectasia (ortholog); BH4-deficient hyperphenylalaninemia A (ortholog); Carney-Stratakis syndrome (ortholog); FOUND IN RNA polymerase II transcription regulator complex (inferred)

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

POU class 2 associating factor 1; POU domain class 2-associating factor 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	39,119,052 - 39,144,606 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	39,121,422 - 39,144,636 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	43,842,916 - 43,866,146 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

ataxia telangiectasia (ISO)

BH4-deficient hyperphenylalaninemia A (ISO)

Carney-Stratakis syndrome (ISO)

chromosome 11 partial duplication syndrome (ISO)

intellectual disability (ISO)

Pyruvate Dehydrogenase E2 Deficiency (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to virus (IEA)

germinal center B cell differentiation (IEA)

positive regulation of interleukin-6 production (IEA)

positive regulation of transcription by RNA polymerase II (IEA)

Cellular Component

RNA polymerase II transcription regulator complex (IEA)

Molecular Function

DNA binding (IEA)

POU domain binding (IEA)

protein binding (ISO)

transcription coactivator activity (IEA)

References

Additional References at PubMed

PMID:14681463	PMID:15679890	PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

POU2AF1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	39,119,052 - 39,144,606 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	39,121,422 - 39,144,636 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	43,842,916 - 43,866,146 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

POU2AF1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	111,352,255 - 111,379,275 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	111,352,255 - 111,455,630 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	111,222,980 - 111,250,000 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	110,728,190 - 110,755,626 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	110,728,191 - 110,755,627	NCBI
Celera	11	108,376,166 - 108,403,348 (-)	NCBI		Celera
Cytogenetic Map	11	q23.1	NCBI
HuRef	11	107,147,948 - 107,174,870 (-)	NCBI		HuRef
CHM1_1	11	111,106,115 - 111,133,306 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	111,362,447 - 111,389,410 (-)	NCBI		T2T-CHM13v2.0

Pou2af1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	51,124,990 - 51,151,379 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	51,125,008 - 51,151,380 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	51,213,690 - 51,240,079 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	51,213,708 - 51,240,080 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	51,021,795 - 51,048,184 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	50,965,920 - 50,992,309 (+)	NCBI		MGSCv36	mm8
Celera	9	48,500,772 - 48,527,193 (+)	NCBI		Celera
Cytogenetic Map	9	A5.3	NCBI
cM Map	9	27.95	NCBI

Pou2af1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	60,418,173 - 60,445,176 (+)	NCBI		GRCr8
mRatBN7.2	8	51,521,813 - 51,548,819 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	51,474,015 - 51,548,819 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	57,069,168 - 57,096,180 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	55,348,098 - 55,375,116 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	53,212,370 - 53,239,388 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	55,603,968 - 55,631,448 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	55,603,968 - 55,631,446 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	54,198,726 - 54,226,204 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	54,534,417 - 54,561,348 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	8	51,067,218 - 51,094,286 (+)	NCBI		Celera
Cytogenetic Map	8	q23	NCBI

Pou2af1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955412	13,131,168 - 13,156,128 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955412	13,131,229 - 13,167,150 (-)	NCBI	ChiLan1.0	ChiLan1.0

POU2AF1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	112,095,642 - 112,122,583 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	113,188,913 - 113,214,653 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	106,231,870 - 106,258,822 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	110,078,850 - 110,103,996 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	110,078,850 - 110,103,996 (-)	Ensembl	panpan1.1		panPan2

POU2AF1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	21,671,000 - 21,695,757 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	21,628,439 - 21,694,773 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	21,592,714 - 21,616,448 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	21,696,860 - 21,720,830 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	21,654,173 - 21,720,838 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	21,757,706 - 21,781,439 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	21,657,851 - 21,681,577 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	21,707,004 - 21,730,740 (+)	NCBI		UU_Cfam_GSD_1.0

Pou2af1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	93,650,582 - 93,675,350 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936612	3,032,015 - 3,054,966 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936612	3,032,015 - 3,055,015 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

POU2AF1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	102,692,305 - 102,719,066 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666043	23,255,548 - 23,280,949 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pou2af1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624784	6,455,927 - 6,479,624 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624784	6,455,984 - 6,479,555 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in POU2AF1
361 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
8	2	5	1	2	5	7	5	5	2	3

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001244060	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000070	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK234001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY609814	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BP156506	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FP565216	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01059480	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSSCT00000016380 ⟹ ENSSSCP00000015940

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	9	39,119,052 - 39,144,606 (-)	Ensembl

Ensembl Acc Id:

ENSSSCT00000077822 ⟹ ENSSSCP00000064773

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	9	39,119,012 - 39,125,993 (-)	Ensembl

RefSeq Acc Id:

NM_001244060 ⟹ NP_001230989

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	9	39,121,422 - 39,144,636 (-)	NCBI

Sequence:

show sequence

TTTAAAAAGCCGAGGAAACAGCCGCTGAGCAGGCAGTGGCTACACTGGAGGCAAGCACACCCAG
GTCTCACATTAAAGAAGCCAAACTGTCTGCTTCAAAGAGAAAAGGCAACATCCTGTCGCAGGCC
ATGCTCTGGCAAAAACCCGCAGCTCCAGAGCAGGCCCCGGCACCACCCCGGCCGTACCAGGGTG
TGCGCGTGAAGGAGCCGGTCAAAGAGCTGCTGCGGAGGAAACGAGGCCATGCCAGCAGCGGGGC
ACCTGTGGCACCAACCGCGGTGGTGCTGCCCCATCAGCCCCTGGCGACCTACACCACAGTGGGT
CCCTCCTGCCTCGACATGGAGGTCTCTGCTTCCACAGTGACGGAGGAGGGGGCGCTGTGCACCG
GCTGGCTCTCCCAGCCCGCCCCGGCCGCCCTCCAGCCCCTAGCCCCGTGGACGCCCTACACTGA
GTATGTGTCCCACGAGGCTGTCAGCTGCCCCTACTCAGCTGACATGTATGTGCAGCCCGTGTGT
CCCAGCTACACGGTGGTGGGGCCCTCCTCTGTGCTGACCTACGCCTCCCAGCCGCTCATCACCA
ATGTCACGACGAGAAGCGCCGCCACACCCACAGTGGGGCCCCAGCTGGAAGGCCCAGAGCACCA
GGCACCCCTCACCTATTTCCCGTGGCCTCAGCCCCTGTCCACGCTGCCCACTTCCACTCTGCAG
TACCAGCCTCCAGCCCCAGCCCTGCCTGGGCCGCAGTTTGTCCAGCTCCCCATCTCCATCCCTG
AGCCGGTCCTTCAGGACGTGGAAGACCCCAGGAGAACCATCAGCTCCCTGCTTCTGGAGGAAGA
GGATAGTGATACCTACTCGCTCAACCACACGCTTTCCGTGGAAGGCTTTTAAGGCTGGCTCCCA
CCTGAAAATCTTGTTCCCAGAAACTGGGATTTGAAAATGACCCTGAGGGAGTTCCCGTGTGGCT
CAGCACATTAAGGATTCGAGCTGTCACTGCTGTGGTACAGGTTCGATTCTTCACCTGGGAACTT
CTGCGTGCCATGGGCGAGGCCAAAAAAATAAAAATAAAAATGAGCCTGGGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001230989	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000015940
	ENSSSCP00000015940.3
	ENSSSCP00015006373.1
	ENSSSCP00025020873.1
	ENSSSCP00030046664.1
	ENSSSCP00035033795.1
	ENSSSCP00040032334.1
	ENSSSCP00045005807.1
	ENSSSCP00050014991.1
	ENSSSCP00055024649.1
	ENSSSCP00060033861.1
	ENSSSCP00065048552.1
	ENSSSCP00070014323.1

RefSeq Acc Id:

NP_001230989 ⟸ NM_001244060

- UniProtKB:

F1SV02 (UniProtKB/TrEMBL), A0A4X1TGP4 (UniProtKB/TrEMBL), A0A8D1GKP2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLWQKPAAPEQAPAPPRPYQGVRVKEPVKELLRRKRGHASSGAPVAPTAVVLPHQPLATYTTVG
PSCLDMEVSASTVTEEGALCTGWLSQPAPAALQPLAPWTPYTEYVSHEAVSCPYSADMYVQPVC
PSYTVVGPSSVLTYASQPLITNVTTRSAATPTVGPQLEGPEHQAPLTYFPWPQPLSTLPTSTLQ
YQPPAPALPGPQFVQLPISIPEPVLQDVEDPRRTISSLLLEEEDSDTYSLNHTLSVEGF

hide sequence

Ensembl Acc Id:

ENSSSCP00000015940 ⟸ ENSSSCT00000016380

Ensembl Acc Id:

ENSSSCP00000064773 ⟸ ENSSSCT00000077822

Protein Domains

OCA

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000015016	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00015012392	UniProtKB/TrEMBL
	ENSSSCG00025035761	UniProtKB/TrEMBL
	ENSSSCG00030072212	UniProtKB/TrEMBL
	ENSSSCG00035060788	UniProtKB/TrEMBL
	ENSSSCG00040055609	UniProtKB/TrEMBL
	ENSSSCG00045005163	UniProtKB/TrEMBL
	ENSSSCG00050026792	UniProtKB/TrEMBL
	ENSSSCG00055015722	UniProtKB/TrEMBL
	ENSSSCG00060057549	UniProtKB/TrEMBL
	ENSSSCG00065078348	UniProtKB/TrEMBL
	ENSSSCG00070008936	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000016380	ENTREZGENE
	ENSSSCT00000016380.5	UniProtKB/TrEMBL
	ENSSSCT00015016361.1	UniProtKB/TrEMBL
	ENSSSCT00025048741.1	UniProtKB/TrEMBL
	ENSSSCT00030101151.1	UniProtKB/TrEMBL
	ENSSSCT00035081623.1	UniProtKB/TrEMBL
	ENSSSCT00040075335.1	UniProtKB/TrEMBL
	ENSSSCT00045008574.1	UniProtKB/TrEMBL
	ENSSSCT00050036061.1	UniProtKB/TrEMBL
	ENSSSCT00055030958.1	UniProtKB/TrEMBL
	ENSSSCT00060078389.1	UniProtKB/TrEMBL
	ENSSSCT00065108564.1	UniProtKB/TrEMBL
	ENSSSCT00070017307.1	UniProtKB/TrEMBL
InterPro	OCA	UniProtKB/TrEMBL
	PD-C2-AF1	UniProtKB/TrEMBL
KEGG Report	ssc:100512063	UniProtKB/TrEMBL
NCBI Gene	POU2AF1	ENTREZGENE
PANTHER	POU DOMAIN CLASS 2-ASSOCIATING FACTOR 1	UniProtKB/TrEMBL
	POU DOMAIN CLASS 2-ASSOCIATING FACTOR 1	UniProtKB/TrEMBL
Pfam	PD-C2-AF1	UniProtKB/TrEMBL
PROSITE	OCA	UniProtKB/TrEMBL
UniProt	A0A4X1TGP4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D1GKP2	ENTREZGENE, UniProtKB/TrEMBL
	F1SV02	ENTREZGENE
UniProt Secondary	F1SV02	UniProtKB/TrEMBL
VGNC ID	VGNC:91671	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-03-26	POU2AF1	POU class 2 homeobox associating factor 1		POU class 2 associating factor 1	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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