MT-CO3 (mitochondrially encoded cytochrome c oxidase III) - Rat Genome Database

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Gene: MT-CO3 (mitochondrially encoded cytochrome c oxidase III) Sus scrofa
Analyze
Symbol: MT-CO3 (Ensembl: COX3)
Name: mitochondrially encoded cytochrome c oxidase III (Ensembl:cytochrome c oxidase subunit III)
RGD ID: 13988711
Description: ENCODES a protein that exhibits cytochrome-c oxidase activity (inferred); electron transfer activity (inferred); INVOLVED IN respiratory chain complex IV assembly (ortholog); ASSOCIATED WITH cerebellar ataxia (ortholog); cone-rod dystrophy (ortholog); cytochrome-c oxidase deficiency disease (ortholog); FOUND IN respiratory chain complex IV (ortholog); INTERACTS WITH malathion
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: COX3; cytochrome c oxidase subunit III
RGD Orthologs
Human
Mouse
Rat
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblMT9,800 - 10,583 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1MT9,800 - 10,583 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2MT9,800 - 10,583 (+)NCBISscrofa10.2Sscrofa10.2susScr3


1 to 20 of 23 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MT-CO3Pigcerebellar ataxia  ISOMT-CO3 (Homo sapiens)8554872ClinVar Annotator: match by term: Cerebellar ataxiaClinVarPMID:10590437 more ...
MT-CO3Pigcone-rod dystrophy  ISOMT-CO3 (Homo sapiens)8554872ClinVar Annotator: match by term: Rod-cone dystrophyClinVarPMID:10590437 more ...
MT-CO3Pigcytochrome-c oxidase deficiency disease  ISOMT-CO3 (Homo sapiens)8554872ClinVar Annotator: match by term: COX deficiencyClinVarPMID:12414820 more ...
MT-CO3Pigdilated cardiomyopathy  ISOMT-CO3 (Homo sapiens)8554872ClinVar Annotator: match by term: Primary dilated cardiomyopathyClinVarPMID:24088041 and PMID:26633545
MT-CO3Pigepilepsy  ISOMT-CO3 (Homo sapiens)8554872ClinVar Annotator: match by term: EpilepsyClinVarPMID:28027978
MT-CO3PigHypertelorism  ISOMT-CO3 (Homo sapiens)8554872ClinVar Annotator: match by term: HypertelorismClinVarPMID:10590437 more ...
MT-CO3PigKearns-Sayre syndrome  ISOMT-CO3 (Homo sapiens)8554872ClinVar Annotator: match by term: Kearns-Sayre syndromeClinVarPMID:20301382
MT-CO3Piglactic acidosis  ISOMT-CO3 (Homo sapiens)8554872ClinVar Annotator: match by term: Seizures and lactic acidosisClinVarPMID:12915481 and PMID:8739943
MT-CO3PigLeber congenital amaurosis  ISOMT-CO3 (Homo sapiens)8554872ClinVar Annotator: match by term: Leber's diseaseClinVarPMID:10590437 more ...
MT-CO3PigLeber hereditary optic neuropathy  ISOMT-CO3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10590437 more ...
MT-CO3PigLeigh disease  ISOMT-CO3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10590437 more ...
MT-CO3PigMELAS syndrome  ISOMT-CO3 (Homo sapiens)8554872ClinVar Annotator: match by term: MELAS syndromeClinVarPMID:15823923 more ...
MT-CO3Pigmitochondrial complex IV deficiency nuclear type 1  ISOMT-CO3 (Homo sapiens)8554872ClinVar Annotator: match by term: Mitochondrial complex IV deficiency and nuclear type 1ClinVarPMID:11063732 more ...
MT-CO3Pigmitochondrial complex V (ATP synthase) deficiency mitochondrial type 1  ISOMT-CO3 (Homo sapiens)8554872ClinVar Annotator: match by term: Mitochondrial complex v (atp synthase) deficiency and mitochondrial type 1ClinVarPMID:10590437 more ...
MT-CO3Pigmitochondrial metabolism disease  ISOMT-CO3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10590437 more ...
MT-CO3PigMitochondrial Myopathy, Infantile, Transient  ISOMT-CO3 (Homo sapiens)8554872ClinVar Annotator: match by term: Mitochondrial myopathy more ...ClinVarPMID:12414820
MT-CO3PigNARP syndrome  ISOMT-CO3 (Homo sapiens)8554872ClinVar Annotator: match by term: NARP syndromeClinVarPMID:10590437 more ...
MT-CO3Pignephrolithiasis  ISOMT-CO3 (Homo sapiens)8554872ClinVar Annotator: match by term: NephrolithiasisClinVarPMID:25741868
MT-CO3PigPearson syndrome  ISOMT-CO3 (Homo sapiens)8554872ClinVar Annotator: match by term: Pearson syndromeClinVar 
MT-CO3PigPremature Birth  ISOMT-CO3 (Homo sapiens)8554872ClinVar Annotator: match by term: Premature birthClinVarPMID:10590437 more ...
1 to 20 of 23 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MT-CO3Pigtemporal lobe epilepsy  ISOMT-CO3 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:17092649


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MT-CO3Pigmalathion affects expressionEXP 6480464Malathion affects the expression of COX3 mRNACTDPMID:17454254


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MT-CO3Pigaerobic electron transport chain involved_inIEAInterPro:IPR024791150520179 InterProGO_REF:0000002
MT-CO3Pigmitochondrial electron transport, cytochrome c to oxygen involved_inIBAPANTHER:PTN001685539 more ...150520179 GO_CentralGO_REF:0000033
MT-CO3Pigproton transmembrane transport involved_inIEAGO:0004129150520179 GOCGO_REF:0000108
MT-CO3Pigrespiratory chain complex IV assembly involved_inIEAUniProtKB:P00414 and ensembl:ENSP00000354982150520179 EnsemblGO_REF:0000107
MT-CO3Pigrespiratory chain complex IV assembly involved_inISSUniProtKB:P00414150520179 UniProtGO_REF:0000024
MT-CO3Pigrespiratory electron transport chain involved_inIEAInterPro:IPR013833150520179 InterProGO_REF:0000002

Cellular Component
1 to 10 of 10 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MT-CO3Pigmembrane located_inIEAInterPro:IPR000298 more ...150520179 InterProGO_REF:0000002
MT-CO3Pigmembrane located_inIEAUniProtKB-KW:KW-0472150520179 UniProtGO_REF:0000043
MT-CO3Pigmitochondrial inner membrane is_active_inIEARefSeq:ENSMUSP00000080997 and UniProtKB:P00416150520179 EnsemblGO_REF:0000107
MT-CO3Pigmitochondrial inner membrane located_inIEAUniProtKB-KW:KW-0999150520179 UniProtGO_REF:0000043
MT-CO3Pigmitochondrial inner membrane located_inIEAUniProtKB-SubCell:SL-0168150520179 UniProtGO_REF:0000044
MT-CO3Pigmitochondrial membrane located_inIEAUniProtKB:P00414 and ensembl:ENSP00000354982150520179 EnsemblGO_REF:0000107
MT-CO3Pigmitochondrion located_inIEAUniProtKB-KW:KW-0496150520179 UniProtGO_REF:0000043
MT-CO3Pigmitochondrion is_active_inIBAFB:FBgn0013676 more ...150520179 GO_CentralGO_REF:0000033
MT-CO3Pigrespiratory chain complex IV part_ofISSUniProtKB:P00414150520179 UniProtGO_REF:0000024
MT-CO3Pigrespiratory chain complex IV part_ofIEARefSeq:ENSMUSP00000080997 more ...150520179 EnsemblGO_REF:0000107
1 to 10 of 10 rows

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MT-CO3Pigcytochrome-c oxidase activity contributes_toIBAPANTHER:PTN000150044 more ...150520179 GO_CentralGO_REF:0000033
MT-CO3Pigcytochrome-c oxidase activity enablesIEAEC:7.1.1.9150520179 UniProtGO_REF:0000003
MT-CO3Pigcytochrome-c oxidase activity enablesIEAInterPro:IPR000298 more ...150520179 InterProGO_REF:0000002
MT-CO3Pigcytochrome-c oxidase activity enablesIEARHEA:11436150520179 RHEAGO_REF:0000116
MT-CO3Pigelectron transfer activity enablesIEAInterPro:IPR024791 and InterPro:IPR035973150520179 InterProGO_REF:0000002
MT-CO3Pigprotein binding enablesISOUniProtKB:P378409068941 PMID:12059041IntActPMID:12059041



MT-CO3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblMT9,800 - 10,583 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1MT9,800 - 10,583 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2MT9,800 - 10,583 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MT-CO3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38MT9,207 - 9,990 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblMT9,207 - 9,990 (+)EnsemblGRCh38hg38GRCh38
GRCh37MT9,207 - 9,990 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36MT9,208 - 9,988 (+)NCBINCBI36Build 36hg18NCBI36
mt-Co3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39MT8,607 - 9,390 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblMT8,607 - 9,390 (+)EnsemblGRCm39 Ensembl
GRCm38MT8,607 - 9,390 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblMT8,607 - 9,390 (+)EnsemblGRCm38mm10GRCm38
MGSCv37MT8,607 - 9,390 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Mt-co3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8MT8,599 - 9,382 (+)NCBIGRCr8
mRatBN7.2MT8,599 - 9,382 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT8,599 - 9,382 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT8,599 - 9,382 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT8,599 - 9,382 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT8,599 - 9,382 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT8,599 - 9,382 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT8,599 - 9,382 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT8,599 - 9,382 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT8,599 - 9,382 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT8,599 - 9,382 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT8,599 - 9,382 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblMT8,599 - 9,382 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0MT8,599 - 9,382 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblMT8,599 - 9,382 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0MT8,599 - 9,382 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4MT8,599 - 9,382 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic MapMT NCBI
MT-CO3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1MT8,644 - 9,427 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblMT8,644 - 9,427 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaMT8,644 - 9,427 (+)NCBIDog10K_Boxer_Tasha

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Variants in MT-CO3
9 total Variants



alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3


GenBank Nucleotide AF034253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSSCT00000019677   ⟹   ENSSSCP00000019141
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblMT9,800 - 10,583 (+)Ensembl
1 to 11 of 11 rows
Protein RefSeqs NP_008640 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD34191 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000019141
  ENSSSCP00000019141.1
  ENSSSCP00070052584.1
  ENSSSCP00085000008
  ENSSSCP00090000008
  ENSSSCP00105000008
  ENSSSCP00110000008
  ENSSSCP00115000008
  ENSSSCP00130000008
1 to 11 of 11 rows
Ensembl Acc Id: ENSSSCP00000019141   ⟸   ENSSSCT00000019677
Heme-copper oxidase subunit III family profile



1 to 40 of 54 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSSSCG00000018082 Ensembl, UniProtKB/Swiss-Prot
  ENSSSCG00070030642 UniProtKB/Swiss-Prot
  ENSSSCG00085000024 UniProtKB/Swiss-Prot
  ENSSSCG00090000024 UniProtKB/Swiss-Prot
  ENSSSCG00105000024 UniProtKB/Swiss-Prot
  ENSSSCG00110000024 UniProtKB/Swiss-Prot
  ENSSSCG00115000024 UniProtKB/Swiss-Prot
  ENSSSCG00130000024 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00000019677.1 UniProtKB/Swiss-Prot
  ENSSSCT00070061679.1 UniProtKB/Swiss-Prot
  ENSSSCT00085000024 UniProtKB/Swiss-Prot
  ENSSSCT00090000024 UniProtKB/Swiss-Prot
  ENSSSCT00105000024 UniProtKB/Swiss-Prot
  ENSSSCT00110000024 UniProtKB/Swiss-Prot
  ENSSSCT00115000024 UniProtKB/Swiss-Prot
  ENSSSCT00130000024 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  1.20.120.80 UniProtKB/Swiss-Prot
InterPro Cyt_c/ubiquinol_Oxase_su3 UniProtKB/Swiss-Prot
  Cyt_c_oxase_su3_dom UniProtKB/Swiss-Prot
  Cyt_c_oxidase-like_su3 UniProtKB/Swiss-Prot
  Cyt_c_oxidase_su3-like_sf UniProtKB/Swiss-Prot
  Cyt_c_oxidase_su3_a-hlx UniProtKB/Swiss-Prot
KEGG Report ssc:808507 UniProtKB/Swiss-Prot
NCBI Gene COX3 ENTREZGENE
PANTHER CYTOCHROME C OXIDASE SUBUNIT 3 UniProtKB/Swiss-Prot
  PTHR11403 UniProtKB/Swiss-Prot
Pfam COX3 UniProtKB/Swiss-Prot
PROSITE COX3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF81452 UniProtKB/Swiss-Prot
UniProt A0A076EDA2 ENTREZGENE
  A0A076EHR5 ENTREZGENE
  A0A076J9Y2 ENTREZGENE, UniProtKB/TrEMBL
  A0A1D8DAP4 ENTREZGENE, UniProtKB/TrEMBL
  A0A343RPD9 ENTREZGENE, UniProtKB/TrEMBL
  A0A343RPZ7 ENTREZGENE, UniProtKB/TrEMBL
  A9LFN2 ENTREZGENE, UniProtKB/TrEMBL
  A9LFS1 ENTREZGENE, UniProtKB/TrEMBL
  A9LG12 ENTREZGENE, UniProtKB/TrEMBL
  A9LG25 ENTREZGENE, UniProtKB/TrEMBL
1 to 40 of 54 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-05-18 MT-CO3  mitochondrially encoded cytochrome c oxidase III  COX3  cytochrome c oxidase subunit III  Symbol and/or name change 19259463 PROVISIONAL