MTPAP (mitochondrial poly(A) polymerase) - Rat Genome Database

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Gene: MTPAP (mitochondrial poly(A) polymerase) Sus scrofa
Analyze
Symbol: MTPAP
Name: mitochondrial poly(A) polymerase
RGD ID: 13874478
Description: ENCODES a protein that exhibits ATP binding (inferred); identical protein binding (inferred); magnesium ion binding (inferred); INVOLVED IN histone mRNA catabolic process (inferred); mitochondrial RNA 3'-end processing (inferred); RNA metabolic process (inferred); ASSOCIATED WITH fundus dystrophy (ortholog); genetic disease (ortholog); melanoma (ortholog); FOUND IN intracellular membrane-bounded organelle (inferred); mitochondrion (inferred); nucleoplasm (inferred); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: mitochondrial poly(A) RNA polymerase; poly(A) RNA polymerase, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1040,764,396 - 40,789,061 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11040,764,098 - 40,869,608 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21045,197,646 - 45,225,482 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MTPAPPigfundus dystrophy  ISOMTPAP (Homo sapiens)8554872ClinVar Annotator: match by term: Retinal dystrophyClinVarPMID:25741868
MTPAPPiggenetic disease  ISOMTPAP (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 more ...
MTPAPPigspastic ataxia  ISOMTPAP (Homo sapiens)8554872ClinVar Annotator: match by term: Spastic ataxiaClinVarPMID:25741868
MTPAPPigspastic ataxia 4  ISOMTPAP (Homo sapiens)8554872ClinVar more ...ClinVarPMID:20970105 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MTPAPPigmelanoma  ISOMTPAP (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:22535842
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MTPAPPigspastic ataxia 4  ISOMTPAP (Homo sapiens)7240710 OMIM 


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MTPAPPigdeoxynivalenol increases expressionEXP 6480464deoxynivalenol results in increased expression of MTPAP mRNACTDPMID:35307453


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MTPAPPighistone mRNA catabolic process involved_inIEAUniProtKB:Q9NVV4 and ensembl:ENSP00000263063150520179 EnsemblGO_REF:0000107
MTPAPPigmitochondrial RNA 3'-end processing involved_inIEAUniProtKB:Q9NVV4 and ensembl:ENSP00000263063150520179 EnsemblGO_REF:0000107
MTPAPPigRNA 3'-end processing involved_inIBAFB:FBgn0024360 more ...150520179 GO_CentralGO_REF:0000033
MTPAPPigRNA metabolic process involved_inIEAARBA:ARBA00028985150520179 UniProtGO_REF:0000117

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MTPAPPigintracellular membrane-bounded organelle located_inIEAUniProtKB:Q9NVV4 and ensembl:ENSP00000263063150520179 EnsemblGO_REF:0000107
MTPAPPigmitochondrion located_inIEAUniProtKB:Q9NVV4 and ensembl:ENSP00000263063150520179 EnsemblGO_REF:0000107
MTPAPPigmitochondrion is_active_inIBAPANTHER:PTN000263477 and UniProtKB:Q9NVV4150520179 GO_CentralGO_REF:0000033
MTPAPPignucleoplasm located_inIEAUniProtKB:Q9NVV4 and ensembl:ENSP00000263063150520179 EnsemblGO_REF:0000107

Molecular Function
1 to 11 of 11 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MTPAPPigATP binding enablesIEAUniProtKB:Q9NVV4 and ensembl:ENSP00000263063150520179 EnsemblGO_REF:0000107
MTPAPPigidentical protein binding enablesIEAUniProtKB:Q9NVV4 and ensembl:ENSP00000263063150520179 EnsemblGO_REF:0000107
MTPAPPigmagnesium ion binding enablesIEAUniProtKB:Q9NVV4 and ensembl:ENSP00000263063150520179 EnsemblGO_REF:0000107
MTPAPPigmanganese ion binding enablesIEAUniProtKB:Q9NVV4 and ensembl:ENSP00000263063150520179 EnsemblGO_REF:0000107
MTPAPPigpoly(A) RNA polymerase activity enablesIEAUniProtKB:Q9NVV4 and ensembl:ENSP00000263063150520179 EnsemblGO_REF:0000107
MTPAPPigpoly(A) RNA polymerase activity enablesIBAFB:FBgn0024360 more ...150520179 GO_CentralGO_REF:0000033
MTPAPPigprotein binding enablesISOUniProtKB:Q131379068941 PMID:33961781IntActPMID:33961781
MTPAPPigprotein binding enablesISOUniProtKB:Q13137 more ...9068941 PMID:21903422IntActPMID:21903422
MTPAPPigprotein homodimerization activity enablesIEAUniProtKB:Q9NVV4 and ensembl:ENSP00000263063150520179 EnsemblGO_REF:0000107
MTPAPPigtransferase activity enablesIEAUniProtKB-KW:KW-0808150520179 UniProtGO_REF:0000043
MTPAPPigUTP binding enablesIEAUniProtKB:Q9NVV4 and ensembl:ENSP00000263063150520179 EnsemblGO_REF:0000107
1 to 11 of 11 rows

PMID:14681463   PMID:22297614   PMID:30032202  



MTPAP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1040,764,396 - 40,789,061 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11040,764,098 - 40,869,608 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21045,197,646 - 45,225,482 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MTPAP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381030,309,801 - 30,349,278 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1030,309,801 - 30,374,448 (-)EnsemblGRCh38hg38GRCh38
GRCh371030,598,730 - 30,638,207 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361030,641,765 - 30,678,254 (-)NCBINCBI36Build 36hg18NCBI36
Build 341030,641,764 - 30,678,254NCBI
Celera1030,363,675 - 30,403,196 (-)NCBICelera
Cytogenetic Map10p11.23NCBI
HuRef1030,317,607 - 30,357,218 (-)NCBIHuRef
CHM1_11030,598,696 - 30,638,239 (-)NCBICHM1_1
T2T-CHM13v2.01030,340,827 - 30,380,279 (-)NCBIT2T-CHM13v2.0
Mtpap
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39184,375,573 - 4,399,888 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl184,375,592 - 4,397,330 (+)EnsemblGRCm39 Ensembl
GRCm38184,375,589 - 4,399,888 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl184,375,592 - 4,397,330 (+)EnsemblGRCm38mm10GRCm38
MGSCv37184,375,590 - 4,397,328 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36184,375,590 - 4,396,782 (+)NCBIMGSCv36mm8
Celera184,420,341 - 4,442,079 (+)NCBICelera
Cytogenetic Map18A1NCBI
cM Map182.77NCBI
Mtpap
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81758,015,979 - 58,036,735 (-)NCBIGRCr8
mRatBN7.21753,320,739 - 53,341,500 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1753,320,741 - 53,341,538 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1756,487,928 - 56,508,696 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01760,490,865 - 60,511,635 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01754,652,729 - 54,673,519 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01756,046,507 - 56,068,185 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1756,046,509 - 56,068,125 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01754,083,463 - 54,105,399 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41761,847,984 - 61,868,867 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11761,859,420 - 61,879,734 (-)NCBI
Celera1749,316,835 - 49,337,431 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
Mtpap
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542921,767,547 - 21,794,885 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542921,768,011 - 21,792,481 (+)NCBIChiLan1.0ChiLan1.0
MTPAP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2842,973,311 - 43,020,922 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11042,978,638 - 43,026,256 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01030,463,414 - 30,500,245 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11030,818,591 - 30,854,542 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1030,818,599 - 30,854,542 (-)Ensemblpanpan1.1panPan2
MTPAP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1216,666,742 - 16,695,753 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl216,666,749 - 16,695,709 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha214,162,942 - 14,191,932 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0214,907,486 - 14,936,502 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl214,907,486 - 14,936,473 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1214,352,326 - 14,381,322 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0214,238,649 - 14,267,606 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0214,511,673 - 14,540,814 (-)NCBIUU_Cfam_GSD_1.0
Mtpap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093449,285,880 - 9,314,897 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366133,836,308 - 3,866,542 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366133,836,461 - 3,865,240 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTPAP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1929,918,227 - 29,966,806 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl929,919,008 - 29,951,006 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605135,995,452 - 36,027,820 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mtpap
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248052,651,121 - 2,672,899 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248052,651,464 - 2,727,894 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in MTPAP
4015 total Variants



alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3



Ensembl Acc Id: ENSSSCT00000012060   ⟹   ENSSSCP00000011752
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1040,764,396 - 40,789,061 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000048465   ⟹   ENSSSCP00000054344
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1040,764,396 - 40,793,398 (+)Ensembl
RefSeq Acc Id: NM_001317082   ⟹   NP_001304011
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11040,764,417 - 40,789,023 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001299270
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11040,764,098 - 40,797,964 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002336108
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11040,764,098 - 40,869,608 (+)NCBI
Sequence:
1 to 10 of 10 rows
Protein RefSeqs NP_001304011 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ADU33129 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000011752
  ENSSSCP00000011752.4
  ENSSSCP00015032351.1
  ENSSSCP00035016085.1
  ENSSSCP00040012504.1
  ENSSSCP00045018932.1
  ENSSSCP00060033233.1
  ENSSSCP00065023126.1
1 to 10 of 10 rows
RefSeq Acc Id: NP_001304011   ⟸   NM_001317082
- UniProtKB: E7BXW8 (UniProtKB/TrEMBL),   A0A8D1HJ06 (UniProtKB/TrEMBL),   F1RWE3 (UniProtKB/TrEMBL),   A0A8D1DW20 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000054344   ⟸   ENSSSCT00000048465
Ensembl Acc Id: ENSSSCP00000011752   ⟸   ENSSSCT00000012060


1 to 36 of 36 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSSSCG00000011018 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015059841 UniProtKB/TrEMBL
  ENSSSCG00035030335 UniProtKB/TrEMBL
  ENSSSCG00040022292 UniProtKB/TrEMBL
  ENSSSCG00045016112 UniProtKB/TrEMBL
  ENSSSCG00060056450 UniProtKB/TrEMBL
  ENSSSCG00065038907 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000012060 ENTREZGENE
  ENSSSCT00000012060.5 UniProtKB/TrEMBL
  ENSSSCT00015080035.1 UniProtKB/TrEMBL
  ENSSSCT00035040195.1 UniProtKB/TrEMBL
  ENSSSCT00040029902.1 UniProtKB/TrEMBL
  ENSSSCT00045027407.1 UniProtKB/TrEMBL
  ENSSSCT00060076891.1 UniProtKB/TrEMBL
  ENSSSCT00065053191.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1410.10 UniProtKB/TrEMBL
  3.30.460.10 UniProtKB/TrEMBL
InterPro IPR041252 UniProtKB/TrEMBL
  MTPAP-like_central UniProtKB/TrEMBL
  NT_sf UniProtKB/TrEMBL
  PAP_assoc UniProtKB/TrEMBL
KEGG Report ssc:100517235 UniProtKB/TrEMBL
NCBI Gene MTPAP ENTREZGENE
PANTHER POLY A POLYMERASE CID PAP -RELATED UniProtKB/TrEMBL
  POLY(A) RNA POLYMERASE, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam MTPAP-like_central UniProtKB/TrEMBL
  PAP_assoc UniProtKB/TrEMBL
  PF17797 UniProtKB/TrEMBL
Superfamily-SCOP PAP/OAS1 substrate-binding domain UniProtKB/TrEMBL
  SSF81301 UniProtKB/TrEMBL
UniProt A0A8D1DW20 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1HJ06 ENTREZGENE, UniProtKB/TrEMBL
  E7BXW8 ENTREZGENE, UniProtKB/TrEMBL
  F1RWE3 ENTREZGENE
UniProt Secondary F1RWE3 UniProtKB/TrEMBL
VGNC ID VGNC:96676 ENTREZGENE
1 to 36 of 36 rows