Cd59<sup>em1Ask</sup> (CD59 molecule; CRISPR/Cas9 induced mutant1, Ask) - Rat Genome Database

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Gene: Cd59em1Ask (CD59 molecule; CRISPR/Cas9 induced mutant1, Ask) Rattus norvegicus
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Symbol: Cd59em1Ask
Name: CD59 molecule; CRISPR/Cas9 induced mutant1, Ask
RGD ID: 13792720
Description: The CRISPR/Cas9 genome editing system was used to generate Cd59 mutation in the Sprague Dawley embryos. The CRISPR/Cas9 targeting exon 3 of the rat Cd59 created a 11 bp-deletion (TGCAAAACAAA) in exon 3. No protein expression was detected in the blood smear of homozygous mutants.
ASSOCIATED WITH decreased erythrocyte cell number; increased red blood cell distribution width; increased susceptibility to type III hypersensitivity reaction; ASSOCIATED WITH neuromyelitis optica
Type: allele  of Cd59b  
Previously known as: Cd59^[em1Ask]
Is Marker For: Strains:   SD-Cd59em1Ask-/-  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position: No map positions available.



  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
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Original Reference(s)
Cd59em1AskRatneuromyelitis optica severityIMP 13792592 RGD 


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Reference Title
Reference Citation
1. Marked central nervous system pathology in CD59 knockout rats following passive transfer of Neuromyelitis optica immunoglobulin G. Yao X and Verkman AS, Acta Neuropathol Commun. 2017 Feb 17;5(1):15. doi: 10.1186/s40478-017-0417-9.


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The following Strains have been annotated to Cd59em1Ask
SD-Cd59em1Ask-/-    










Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-09-24 Cd59em1Ask  CD59 molecule; CRISPR/Cas9 induced mutant1, Ask  Cd59em1Ask  CD59 molecule; CRISPR/Cas9 induced mutant1, Ask  Symbol changed 629549 APPROVED
2018-09-24 Cd59em1Ask  CD59 molecule; CRISPR/Cas9 induced mutant1, Ask  Cd59em1Ask-/-  CD59 molecule; CRISPR/Cas9 induced mutant1, Ask  Symbol changed 629549 APPROVED