Oprl1<sup>m1Hubr</sup> (opioid related nociceptin receptor 1; ENU induced mutant1, Hubr) - Rat Genome Database

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Gene: Oprl1m1Hubr (opioid related nociceptin receptor 1; ENU induced mutant1, Hubr) Rattus norvegicus
Symbol: Oprl1m1Hubr
Name: opioid related nociceptin receptor 1; ENU induced mutant1, Hubr
RGD ID: 13792571
Description: The original mutation was created by target-selected ENU-induced mutagenesis in a Brown Norway background.Then they were subsequently backcrossed on a Wistar (Crl:WI) background. A C to G transversion at position 3657 in the oprl1 gene (ENSRNOG00000016768), resulting into a premature stop codon (TAC>TAG) in the third exon.
ASSOCIATED WITH decreased chemical nociceptive threshold; decreased mechanical nociceptive threshold; enhanced conditioned place preference behavior
Type: allele  of Oprl1  
Previously known as: Oprl1^[m1Hubr]
Is Marker For: Strains:   WI-Oprl1m1Hubr+/-   WI-Oprl1m1Hubr-/-  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


References - curated
# Reference Title Reference Citation
1. Visceral hypersensitivity in female but not in male serotonin transporter knockout rats. Galligan JJ, etal., Neurogastroenterol Motil. 2013 Jun;25(6):e373-81. doi: 10.1111/nmo.12133. Epub 2013 Apr 17.
2. Complete knockout of the nociceptin/orphanin FQ receptor in the rat does not induce compensatory changes in mu, delta and kappa opioid receptors. Homberg JR, etal., Neuroscience. 2009 Sep 29;163(1):308-15. doi: 10.1016/j.neuroscience.2009.06.021. Epub 2009 Jun 12.
3. Acute and subchronic antinociceptive effects of nociceptin/orphanin FQ receptor agonists infused by intrathecal route in rats. Micheli L, etal., Eur J Pharmacol. 2015 May 5;754:73-81. doi: 10.1016/j.ejphar.2015.02.020. Epub 2015 Feb 19.
4. Nociceptin/orphanin FQ receptor knockout rats: in vitro and in vivo studies. Rizzi A, etal., Neuropharmacology. 2011 Mar;60(4):572-9. doi: 10.1016/j.neuropharm.2010.12.010. Epub 2010 Dec 22.
5. Pharmacological blockade or genetic knockout of the NOP receptor potentiates the rewarding effect of morphine in rats. Rutten K, etal., Drug Alcohol Depend. 2011 Apr 1;114(2-3):253-6. doi: 10.1016/j.drugalcdep.2010.10.004. Epub 2010 Nov 20.


Related Rat Strains
The following Strains have been annotated to Oprl1m1Hubr



Nucleotide Sequences

Additional Information

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-05-17 Oprl1m1Hubr  opioid related nociceptin receptor 1; ENU induced mutant1, Hubr  Oprl1m1Hubr  opioid related nociceptin receptor 1; ZFN induced mutant1, Hubr  Name changed 629549 APPROVED
2019-02-18 Oprl1m1Hubr  opioid related nociceptin receptor 1; ZFN induced mutant1, Hubr  Oprl1m1Hubr    Name changed 629549 APPROVED