Ly49i7 (Ly49 inhibitory receptor 7) - Rat Genome Database

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Gene: Ly49i7 (Ly49 inhibitory receptor 7) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ly49i7
Name: Ly49 inhibitory receptor 7
RGD ID: 1359302
Description: Predicted to enable signaling receptor activity. Predicted to be involved in cell adhesion. Predicted to be located in plasma membrane. Predicted to be active in cell surface; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: immunoreceptor Ly49i7; killer cell lectin-like receptor 5-like; LOC100911272; T-cell surface glycoprotein YE1/48-like
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84166,584,725 - 166,604,575 (-)NCBIGRCr8
mRatBN7.24164,853,287 - 164,871,902 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4164,853,574 - 164,867,333 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4171,133,835 - 171,147,597 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04166,916,852 - 166,930,614 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04165,550,900 - 165,564,662 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04162,711,534 - 162,731,831 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4162,712,869 - 162,726,628 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl4165,347,864 - 165,361,623 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04227,908,142 - 227,926,568 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44168,794,389 - 168,808,148 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14169,039,324 - 169,053,084 (-)NCBI
Celera4153,463,235 - 153,476,994 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ly49i7Rat1,2-dimethylhydrazine multiple interactionsEXP 6480464[APC protein affects the susceptibility to 1 and 2-Dimethylhydrazine] which results in decreased expression of LY49I7 mRNACTDPMID:27840820
Ly49i7Rat17beta-estradiol multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of LY49I7 mRNACTDPMID:32741896
Ly49i7Rat17beta-estradiol 3-benzoate multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of LY49I7 mRNACTDPMID:32741896
Ly49i7Ratamphetamine increases expressionEXP 6480464Amphetamine results in increased expression of LY49I7 mRNACTDPMID:30779732
Ly49i7Rattestosterone multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of LY49I7 mRNACTDPMID:32741896
Ly49i7Rattrichloroethene decreases methylationEXP 6480464Trichloroethylene results in decreased methylation of LY49I7 geneCTDPMID:27618143


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ly49i7Ratcell adhesion involved_inIEAUniProtKB-KW:KW-01301600115GO_REF:0000043UniProtGO_REF:0000043

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ly49i7Ratcell surface is_active_inIBAMGI:101901 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ly49i7Ratmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Ly49i7Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Ly49i7Ratplasma membrane located_inIEAARBA:ARBA000278011600115GO_REF:0000117UniProtGO_REF:0000117

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ly49i7Ratcarbohydrate binding enablesIEAUniProtKB-KW:KW-04301600115GO_REF:0000043UniProtGO_REF:0000043
Ly49i7Ratsignaling receptor activity enablesIBAMGI:101907 and PANTHER:PTN0005143361600115GO_REF:0000033GO_CentralGO_REF:0000033


#
Reference Title
Reference Citation
1. The genes and gene organization of the Ly49 region of the rat natural killer cell gene complex. Nylenna O, etal., Eur J Immunol 2005 Jan;35(1):261-72.
2. GOA pipeline RGD automated data pipeline


.

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Variants in Ly49i7
218 total Variants

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:16
Interacting mature miRNAs:16
Transcripts:ENSRNOT00000073877, ENSRNOT00000075161
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 34 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat

1 to 10 of 34 rows
D4Won25  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.04214,033,324 - 214,033,464NCBIRnor5.0
Rnor_5.04227,874,513 - 227,874,709NCBIRnor5.0
Rnor_5.04213,987,142 - 213,987,338NCBIRnor5.0
Rnor_5.04227,920,596 - 227,920,736NCBIRnor5.0
RGSC_v3.44168,760,490 - 168,760,685UniSTSRGSC3.4
RGSC_v3.44168,806,573 - 168,806,712UniSTSRGSC3.4
Celera4153,475,419 - 153,475,558UniSTS
Celera4153,429,336 - 153,429,531UniSTS
Cytogenetic Map4q42UniSTS




alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
5 5 22 18 14 3 6 3 6 35 19 10 8 23 11



Ensembl Acc Id: ENSRNOT00000073877   ⟹   ENSRNOP00000065392
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4162,712,869 - 162,726,628 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000088908   ⟹   ENSRNOP00000075483
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4164,853,574 - 164,867,333 (-)Ensembl
Rnor_6.0 Ensembl4165,347,864 - 165,361,623 (-)Ensembl
RefSeq Acc Id: NM_001009500   ⟹   NP_001009500
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84166,585,010 - 166,598,823 (-)NCBI
mRatBN7.24164,853,572 - 164,867,385 (-)NCBI
Rnor_6.04162,712,869 - 162,726,628 (-)NCBI
Rnor_5.04227,908,142 - 227,926,568 (-)NCBI
RGSC_v3.44168,794,389 - 168,808,148 (-)RGD
Celera4153,463,235 - 153,476,994 (-)RGD
Sequence:
RefSeq Acc Id: XM_039108040   ⟹   XP_038963968
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84166,584,725 - 166,604,575 (-)NCBI
mRatBN7.24164,853,287 - 164,871,902 (-)NCBI
RefSeq Acc Id: XM_039108041   ⟹   XP_038963969
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84166,584,725 - 166,604,575 (-)NCBI
mRatBN7.24164,853,287 - 164,871,902 (-)NCBI
Protein RefSeqs NP_001009500 (Get FASTA)   NCBI Sequence Viewer  
  XP_038963968 (Get FASTA)   NCBI Sequence Viewer  
  XP_038963969 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAV74346 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075483
  ENSRNOP00000075483.1
RefSeq Acc Id: NP_001009500   ⟸   NM_001009500
- UniProtKB: Q5MPP5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000065392   ⟸   ENSRNOT00000073877
RefSeq Acc Id: XP_038963969   ⟸   XM_039108041
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038963968   ⟸   XM_039108040
- Peptide Label: isoform X1
- UniProtKB: Q5MPP5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000075483   ⟸   ENSRNOT00000088908
C-type lectin

Name Modeler Protein Id AA Range Protein Structure
AF-Q5MPP5-F1-model_v2 AlphaFold Q5MPP5 1-272 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 27 of 27 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-42733 BioCyc
Ensembl Genes ENSRNOG00000048253 Ensembl
  ENSRNOG00000057069 Ensembl
  ENSRNOG00000062621 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000088908 ENTREZGENE
  ENSRNOT00000088908.2 UniProtKB/TrEMBL
Gene3D-CATH 3.10.100.10 UniProtKB/TrEMBL
InterPro C-type_lectin UniProtKB/TrEMBL
  C-type_lectin-like UniProtKB/TrEMBL
  C-type_lectin_fold UniProtKB/TrEMBL
  Ly49 UniProtKB/TrEMBL
  Mouse_KLRs UniProtKB/TrEMBL
  NKR-like_CTLD UniProtKB/TrEMBL
KEGG Report rno:494210 UniProtKB/TrEMBL
NCBI Gene 494210 ENTREZGENE
PANTHER KILLER CELL LECTIN-LIKE RECEPTOR 2 UniProtKB/TrEMBL
  KILLER CELL LECTIN-LIKE RECEPTOR, SUBFAMILY A, MEMBER 17 UniProtKB/TrEMBL
Pfam Lectin_C UniProtKB/TrEMBL
  Ly49 UniProtKB/TrEMBL
PhenoGen Ly49i7 PhenoGen
PROSITE C_TYPE_LECTIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000048253 RatGTEx
  ENSRNOG00000057069 RatGTEx
  ENSRNOG00000062621 RatGTEx
SMART CLECT UniProtKB/TrEMBL
Superfamily-SCOP C-type_lectin_fold UniProtKB/TrEMBL
UniProt Q5MPP5 ENTREZGENE, UniProtKB/TrEMBL
1 to 27 of 27 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-04-22 Ly49i7  Ly49 inhibitory receptor 7  Ly49i7  immunoreceptor Ly49i7  Name changed 629549 APPROVED
2021-03-09 Ly49i7  immunoreceptor Ly49i7  LOC100911272  killer cell lectin-like receptor 5-like  Data merged from RGD:6493929 737654 PROVISIONAL
2012-07-05 LOC100911272  killer cell lectin-like receptor 5-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-07-29 Ly49i7  immunoreceptor Ly49i7      Symbol and Name status set to provisional 70820 PROVISIONAL