Zfp868 (zinc finger protein 868) - Rat Genome Database

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Gene: Zfp868 (zinc finger protein 868) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Zfp868
Name: zinc finger protein 868
RGD ID: 1359299
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC494340; MGC105514; MGC72612; similar to expressed sequence AI449175; uncharacterized protein LOC494340
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81619,796,576 - 19,810,608 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1619,796,576 - 19,810,652 (+)EnsemblGRCr8
mRatBN7.21619,762,667 - 19,777,148 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1619,762,659 - 19,776,690 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1619,794,859 - 19,808,961 (+)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01620,943,198 - 20,957,234 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01619,847,843 - 19,861,945 (+)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1619,939,918 - 19,953,954 (+)NCBI
Lyon_Normotensive1619,812,902 - 19,826,938 (+)NCBI
Lyon_Hypertensive1619,806,855 - 19,820,891 (+)NCBI
F344_StmMcwi1619,944,504 - 19,958,552 (+)NCBI
Rnor_6.01621,510,793 - 21,525,290 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1621,518,873 - 21,524,286 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.01621,424,551 - 21,438,840 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41620,251,613 - 20,265,573 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1619,956,670 - 19,970,630 (+)NCBICelera
RGSC_v3.11620,251,610 - 20,265,571 (+)NCBI
Cytogenetic Map16p14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA,IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Genomics

Variants

.
Variants in Zfp868
93 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:61
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000015635
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549842Bp248Blood pressure QTL 2480.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1638712345387123Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133425095Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139568015Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16423421253708481Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161574800625801629Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16474422249744222Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16126734272Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126734272Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16435482249354822Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)1638712345387123Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16423421249757901Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421266955197Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)161627818427244292Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139568015Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338679049757901Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338679026128267Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126734272Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161773081872536785Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)161590580260905802Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683908652786090Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16330168348301683Rat

Markers in Region
RH137522  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21619,771,831 - 19,772,040 (+)MAPPERmRatBN7.2
Rnor_6.01621,519,979 - 21,520,187NCBIRnor6.0
Rnor_5.01621,433,978 - 21,434,186UniSTSRnor5.0
RGSC_v3.41620,260,716 - 20,260,924UniSTSRGSC3.4
Celera1619,965,773 - 19,965,981UniSTS
Cytogenetic Map16p14UniSTS
RH130501  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21619,776,456 - 19,776,637 (+)MAPPERmRatBN7.2
Rnor_6.01621,524,602 - 21,524,782NCBIRnor6.0
Rnor_5.01621,438,601 - 21,438,781UniSTSRnor5.0
RGSC_v3.41620,265,339 - 20,265,519UniSTSRGSC3.4
Celera1619,970,396 - 19,970,576UniSTS
RH 3.4 Map16240.82UniSTS
Cytogenetic Map16p14UniSTS
UniSTS:235912  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21619,776,253 - 19,776,558 (+)MAPPERmRatBN7.2
Rnor_6.01621,524,399 - 21,524,703NCBIRnor6.0
Rnor_5.01621,438,398 - 21,438,702UniSTSRnor5.0
RGSC_v3.41620,265,136 - 20,265,440UniSTSRGSC3.4
Celera1619,970,193 - 19,970,497UniSTS
Cytogenetic Map16p14UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
274 156 730 1591 4048 1007 1723 133 870 487 852 156 5381 2588 447 3961 38 1389 741 908 160 158

Sequence


Ensembl Acc Id: ENSRNOT00000015635   ⟹   ENSRNOP00000015635
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1619,796,576 - 19,810,652 (+)Ensembl
mRatBN7.2 Ensembl1619,762,673 - 19,776,682 (+)Ensembl
Rnor_6.0 Ensembl1621,518,873 - 21,524,286 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116139   ⟹   ENSRNOP00000076683
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1619,762,659 - 19,776,690 (+)Ensembl
RefSeq Acc Id: NM_001009538   ⟹   NP_001009538
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81619,796,576 - 19,810,608 (+)NCBI
mRatBN7.21619,762,667 - 19,776,700 (+)NCBI
Dahl_SR_JrHsd1619,939,918 - 19,953,954 (+)NCBI
Lyon_Normotensive1619,812,902 - 19,826,938 (+)NCBI
Lyon_Hypertensive1619,806,855 - 19,820,891 (+)NCBI
F344_StmMcwi1619,944,504 - 19,958,552 (+)NCBI
Rnor_6.01621,510,876 - 21,524,836 (+)NCBI
Rnor_5.01621,424,551 - 21,438,840 (+)NCBI
RGSC_v3.41620,251,613 - 20,265,573 (+)RGD
Celera1619,956,670 - 19,970,630 (+)RGD
Sequence:
RefSeq Acc Id: NM_001395045   ⟹   NP_001381974
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81619,796,576 - 19,810,608 (+)NCBI
mRatBN7.21619,762,667 - 19,776,700 (+)NCBI
Dahl_SR_JrHsd1619,939,918 - 19,953,954 (+)NCBI
Lyon_Normotensive1619,812,902 - 19,826,938 (+)NCBI
Lyon_Hypertensive1619,806,855 - 19,820,891 (+)NCBI
F344_StmMcwi1619,944,504 - 19,958,552 (+)NCBI
RefSeq Acc Id: XM_006252916   ⟹   XP_006252978
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81619,796,718 - 19,810,599 (+)NCBI
mRatBN7.21619,762,806 - 19,777,148 (+)NCBI
Rnor_6.01621,510,947 - 21,525,290 (+)NCBI
Rnor_5.01621,424,551 - 21,438,840 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006252917   ⟹   XP_006252979
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81619,796,718 - 19,810,599 (+)NCBI
mRatBN7.21619,762,806 - 19,777,148 (+)NCBI
Rnor_6.01621,510,947 - 21,525,290 (+)NCBI
Rnor_5.01621,424,551 - 21,438,840 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001009538   ⟸   NM_001009538
- UniProtKB: Q6P6Q8 (UniProtKB/TrEMBL),   F1LPG7 (UniProtKB/TrEMBL),   A0A9K3Y6P8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252978   ⟸   XM_006252916
- Peptide Label: isoform X1
- UniProtKB: Q6P6Q8 (UniProtKB/TrEMBL),   F1LPG7 (UniProtKB/TrEMBL),   A0A9K3Y6P8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252979   ⟸   XM_006252917
- Peptide Label: isoform X1
- UniProtKB: Q6P6Q8 (UniProtKB/TrEMBL),   F1LPG7 (UniProtKB/TrEMBL),   A0A9K3Y6P8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015635   ⟸   ENSRNOT00000015635
Ensembl Acc Id: ENSRNOP00000076683   ⟸   ENSRNOT00000116139
RefSeq Acc Id: NP_001381974   ⟸   NM_001395045
- UniProtKB: F1LPG7 (UniProtKB/TrEMBL),   A0A9K3Y6P8 (UniProtKB/TrEMBL),   Q6P6Q8 (UniProtKB/TrEMBL)
Protein Domains
C2H2-type   KRAB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P6Q8-F1-model_v2 AlphaFold Q6P6Q8 1-423 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359299 AgrOrtholog
BioCyc Gene G2FUF-11731 BioCyc
Ensembl Genes ENSRNOG00000028919 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015635 ENTREZGENE
  ENSRNOT00000015635.7 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5599629 IMAGE-MGC_LOAD
  IMAGE:7125789 IMAGE-MGC_LOAD
InterPro KRAB_dom_sf UniProtKB/TrEMBL
  Krueppel-associated_box UniProtKB/TrEMBL
  Znf_C2H2-type UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:494340 UniProtKB/TrEMBL
MGC_CLONE MGC:105514 IMAGE-MGC_LOAD
  MGC:72612 IMAGE-MGC_LOAD
NCBI Gene 494340 ENTREZGENE
PANTHER RIKEN CDNA 6720489N17 GENE-RELATED UniProtKB/TrEMBL
  ZNF44 PROTEIN UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
  zf-C2H2_6 UniProtKB/TrEMBL
PhenoGen Zfp868 PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028919 RatGTEx
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP Krueppel-associated_box UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A0A9K3Y6P8 ENTREZGENE, UniProtKB/TrEMBL
  F1LPG7 ENTREZGENE
  Q6P6Q8 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1LPG7 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-01-13 Zfp868  zinc finger protein 868  MGC72612  similar to expressed sequence AI449175  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 MGC72612  similar to expressed sequence AI449175      Symbol and Name status set to provisional 70820 PROVISIONAL