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Gene: TRPC2 (transient receptor potential cation channel subfamily C member 2 (pseudogene)) Homo sapiens

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Symbol:

TRPC2

Name:

transient receptor potential cation channel subfamily C member 2 (pseudogene)

RGD ID:

1350987

HGNC Page

HGNC:12334

Description:

Predicted to enable diacylglycerol binding activity; inositol 1,4,5 trisphosphate binding activity; and store-operated calcium channel activity. Predicted to act upstream of or within several processes, including female courtship behavior; inter-male aggressive behavior; and mating behavior, sex discrimination. Predicted to be located in dendrite membrane and endomembrane system.

Type:

pseudo (Ensembl: transcribed_unprocessed_pseudogene)

RefSeq Status:

VALIDATED

Previously known as:

transient receptor potential cation channel subfamily C member 2, pseudogene

RGD Orthologs

Mouse

Rat

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	3,626,460 - 3,637,559 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	3,616,679 - 3,637,549 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38.p14 Ensembl	11	3,626,438 - 3,637,677 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	3,647,690 - 3,658,789 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	3,604,290 - 3,615,365 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	3,604,289 - 3,615,365	NCBI
Celera	11	3,659,826 - 3,663,093 (+)	NCBI		Celera
Cytogenetic Map	11	p15.4	NCBI
HuRef	11	3,384,984 - 3,396,073 (+)	NCBI		HuRef
CHM1_1	11	3,646,765 - 3,657,866 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	3,671,928 - 3,682,997 (+)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

4,4'-diaminodiphenylmethane (ISO)

ammonium chloride (ISO)

amphetamine (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (ISO)

cadmium dichloride (ISO)

carbachol (ISO)

chlorpyrifos (ISO)

cisplatin (EXP)

coumarin (ISO)

cypermethrin (ISO)

decabromodiphenyl ether (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (ISO)

oxaliplatin (ISO)

panobinostat (EXP)

phenobarbital (ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

rotenone (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

succimer (ISO)

thioacetamide (ISO)

topotecan (ISO)

trichloroethene (ISO)

valproic acid (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acrosome reaction (ISO)

aggressive behavior (ISO)

calcium ion transport (ISO)

female courtship behavior (ISO)

inter-male aggressive behavior (ISO)

mating behavior, sex discrimination (ISO)

negative regulation of male mating behavior (ISO)

positive regulation of cytosolic calcium ion concentration (ISO)

regulation of gene expression (ISO)

response to pheromone (ISO)

territorial aggressive behavior (ISO)

Cellular Component

dendrite membrane (ISO)

endomembrane system (ISO)

plasma membrane (ISO)

Molecular Function

diacylglycerol binding (ISO)

inositol 1,4,5 trisphosphate binding (ISO)

protein binding (ISO)

store-operated calcium channel activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:7568191	PMID:11290752	PMID:12032305	PMID:12601176	PMID:12631698	PMID:14505576	PMID:14699131	PMID:16382100	PMID:17217050	PMID:20210993	PMID:24756702

Genomics

Comparative Map Data

TRPC2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	3,626,460 - 3,637,559 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	3,616,679 - 3,637,549 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38.p14 Ensembl	11	3,626,438 - 3,637,677 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	3,647,690 - 3,658,789 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	3,604,290 - 3,615,365 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	3,604,289 - 3,615,365	NCBI
Celera	11	3,659,826 - 3,663,093 (+)	NCBI		Celera
Cytogenetic Map	11	p15.4	NCBI
HuRef	11	3,384,984 - 3,396,073 (+)	NCBI		HuRef
CHM1_1	11	3,646,765 - 3,657,866 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	3,671,928 - 3,682,997 (+)	NCBI		T2T-CHM13v2.0

Trpc2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	101,732,323 - 101,746,071 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	101,732,323 - 101,745,603 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	102,083,116 - 102,096,864 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	102,083,116 - 102,096,396 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	109,214,227 - 109,244,930 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	101,949,701 - 101,970,155 (+)	NCBI		MGSCv36	mm8
Celera	7	102,440,894 - 102,463,475 (+)	NCBI		Celera
Cytogenetic Map	7	E2	NCBI
cM Map	7	54.71	NCBI

Trpc2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	165,871,991 - 165,885,339 (+)	NCBI		GRCr8
mRatBN7.2	1	156,460,009 - 156,473,039 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	156,440,305 - 156,473,073 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	164,437,596 - 164,450,988 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	171,617,684 - 171,631,076 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	164,494,996 - 164,508,394 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	167,180,103 - 167,192,456 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	167,169,442 - 167,192,801 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	173,368,155 - 173,381,696 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	159,542,801 - 159,576,294 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	159,642,649 - 159,655,999 (+)	NCBI
Celera	1	154,528,993 - 154,541,346 (+)	NCBI		Celera
Cytogenetic Map	1	q32	NCBI

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	991
Count of miRNA genes:	518
Interacting mature miRNAs:	575
Transcripts:	ENST00000399582, ENST00000451043, ENST00000526541
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCh38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
597453421	GWAS1549495_H	small vessel stroke QTL GWAS1549495 (human)		0.000001	small vessel stroke		11	3630648	3630649	Human
1558691	SCL8_H	Serum cholesterol level QTL 8 (human)	1.2		Lipid level	HDL cholesterol	11	1	5227071	Human
1559107	SCL32_H	Serum cholesterol level QTL 32 (human)	3.27		Lipid level	LDL cholesterol	11	2892430	28892430	Human
1559113	SCL31_H	Serum cholesterol level QTL 31 (human)	3.72		Lipid level	LDL cholesterol	11	2892430	28892430	Human

Markers in Region

PMC152292P2

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	11	3,642,574 - 3,642,717	UniSTS	GRCh37
Build 36	11	3,599,150 - 3,599,293	RGD	NCBI36
Cytogenetic Map	11	p15.4-p15.3	UniSTS
HuRef	11	3,379,868 - 3,380,011	UniSTS

PMC152292P3

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	11	3,658,422 - 3,658,680	UniSTS	GRCh37
Build 36	11	3,614,998 - 3,615,256	RGD	NCBI36
Celera	11	3,662,726 - 3,662,984	RGD
Cytogenetic Map	11	p15.4-p15.3	UniSTS
HuRef	11	3,395,706 - 3,395,964	UniSTS

PMC21939P1

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	11	3,647,723 - 3,647,954	UniSTS	GRCh37
Build 36	11	3,604,299 - 3,604,530	RGD	NCBI36
Cytogenetic Map	11	p15.4-p15.3	UniSTS
HuRef	11	3,385,017 - 3,385,248	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	entire extraembryonic component	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system
1200	2207	2725	2106	4082	1603	2004	3	544	1402	390	2057	6262	5724	10	3043	705	1536	1368	156

Sequence

Nucleotide Sequences


RefSeq Transcripts	NR_002720	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AA423920	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB231779	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC060812	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY231383	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY231395	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068267	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X89067	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENST00000451043

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	11	3,616,679 - 3,637,549 (+)	Ensembl

Ensembl Acc Id:

ENST00000526541

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	11	3,626,448 - 3,637,676 (+)	Ensembl

Ensembl Acc Id:

ENST00000688797

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	11	3,626,454 - 3,637,672 (+)	Ensembl

Ensembl Acc Id:

ENST00000689523

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	11	3,626,439 - 3,637,672 (+)	Ensembl

Ensembl Acc Id:

ENST00000696867

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	11	3,626,439 - 3,637,672 (+)	Ensembl

Ensembl Acc Id:

ENST00000696868

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	11	3,626,454 - 3,637,672 (+)	Ensembl

Ensembl Acc Id:

ENST00000744238

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	11	3,626,438 - 3,637,677 (+)	Ensembl

Ensembl Acc Id:

ENST00000744239

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	11	3,626,447 - 3,637,677 (+)	Ensembl

Ensembl Acc Id:

ENST00000744240

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	11	3,634,316 - 3,637,677 (+)	Ensembl

Ensembl Acc Id:

ENST00000744241

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	11	3,634,934 - 3,637,677 (+)	Ensembl

RefSeq Acc Id:

NR_002720

RefSeq Status:

VALIDATED

Type:

NON-CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	11	3,626,460 - 3,637,559 (+)	NCBI
GRCh37	11	3,647,690 - 3,658,789 (+)	NCBI
Build 36	11	3,604,290 - 3,615,365 (+)	NCBI Archive
Celera	11	3,659,826 - 3,663,093 (+)	RGD
HuRef	11	3,384,984 - 3,396,073 (+)	NCBI
CHM1_1	11	3,646,765 - 3,657,866 (+)	NCBI
T2T-CHM13v2.0	11	3,671,928 - 3,682,997 (+)	NCBI

Sequence:

show sequence

ATGGTCGTCCTGTCCCTGTACCTGGCAGCCTTCGCACTGCGCCTCCTCCTGGCTGGGCTTGCCC
CCATGCACTGCCGGGACGCCTCCCAAGCGGCTGCCTGCCACTATTTCACCATGGCTGAATGAAG
CGAGTGGCACACCGAGGATCCCCAGTTCTTGGCTGAGGTGCTCTTCACTGCCACCAGCATGCTC
AGCTTCACCCGCCTGGCCTACATTCTGCCGGCCCACGAGTCGCTGGGCACTCTGCAGATTTCCA
TTGGCAAGATGATTGAAGACATGATCCGTTTCAATGAGACGTTTCAGTTTCTGTTCTGGACCAT
GTTCGGTATGGAAGAGCACAGCGTGGTGGACGTGCCTCAGTTTCTGGTGCCCGAGTTTGCAGGC
CGGGCCCTCTATGGCATCTTTACCATCATCATGGTCATTGTGCTGCTCAACATGCTCATTGCTA
TGATCACCAACTCCTTCCAGAAGATTGAGGATGATGCTGACGTGGAGTGGACGTTTGCTCGCTC
CAAGCTGTATCTGTTCTACTTCTGAGAGGGCCTGACACTGCCTGTGCCCTTCAACATCCTGCCC
TCCTCGAAGGCTGTCTTCTACCTTCTCAGGAGAATTTGCCAGTTCATTTGCTGTTGCTGTTCCT
GCTGCAAAACCAAGAAGCCAGACTATCCCCCGATCCCTACTTTTGCCAATCCCAGGGCAGGGGC
TGTGCCTGGGGAGGGAGAGCGTGGATCCTACCGCCTTCACGTCATCAAGGCCCTGGTACAGCGC
TACACAGAGACTGCCCGGCGAGAATTCGAGGAGACCCGGCGGAAAGATCTGGGCAACAGACTCA
CAGAGCTGACCAAGACCATATCTCGACTGCAAAGCGAGGTAGCCGGTGTGCGGTGAACTCTGGC
AGAGGGAGGGACGCCCCGGCCTCCCGACGGTGCCAGCGTCCTCAGTCACTACATCACTCAAGTG
CACAACAGCTTCCAGAACCTGGGGCCTCCCATCCCTGAGACCCCAGAGCTGACAGGGCCTGGGA
TTGTGAGGACCCAGGAATCATCAGGAACCGGGCTTCAGGACACTGGAGGGGTGAGGACTCTGGC
TTCCGGAGAGTCTGGCCCCTGCTCCCCAGCTCATGTGCTAGTTCATAGGGAGCAGGAAGCAGAG
GGGGCTGGGGACCTGCCCCAGGGGGAGGATTCGGGGACTGAGAGGAGGTCCTGATACAGTG

hide sequence

Protein Sequences


GenBank Protein	BAE46900	(Get FASTA)	NCBI Sequence Viewer

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:12334	AgrOrtholog
COSMIC	TRPC2	COSMIC
Ensembl Genes	ENSG00000182048	Ensembl
	ENSG00000290962	Ensembl, ENTREZGENE
Ensembl Transcript	ENST00000526541	ENTREZGENE
GTEx	ENSG00000182048	GTEx
	ENSG00000290962	GTEx
HGNC ID	HGNC:12334	ENTREZGENE
Human Proteome Map	TRPC2	Human Proteome Map
NCBI Gene	7221	ENTREZGENE
PharmGKB	PA37007	PharmGKB

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-01-16	TRPC2	transient receptor potential cation channel subfamily C member 2 (pseudogene)		transient receptor potential cation channel subfamily C member 2, pseudogene	Symbol and/or name change	5135510	APPROVED
2016-02-02	TRPC2	transient receptor potential cation channel subfamily C member 2, pseudogene		transient receptor potential cation channel, subfamily C, member 2, pseudogene	Symbol and/or name change	5135510	APPROVED
2011-07-27	TRPC2	transient receptor potential cation channel, subfamily C, member 2, pseudogene	TRPC2	transient receptor potential cation channel, subfamily C, member 2 (pseudogene)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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