TRIM74 (tripartite motif containing 74) - Rat Genome Database

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Advanced Search (OLGA)
Gene: TRIM74 (tripartite motif containing 74) Homo sapiens
Analyze
No known orthologs.
Symbol: TRIM74
Name: tripartite motif containing 74
RGD ID: 1350983
HGNC Page HGNC:17453
Description: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response. Located in cytosol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC45440; TRIM50C; tripartite motif-containing 50C; tripartite motif-containing 74; tripartite motif-containing protein 50C; tripartite motif-containing protein 74
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38772,954,868 - 72,969,681 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl772,959,485 - 72,969,466 (-)EnsemblGRCh38hg38GRCh38
GRCh37772,430,016 - 72,439,997 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36772,067,952 - 72,077,933 (-)NCBINCBI36Build 36hg18NCBI36
Build 34771,874,666 - 71,884,648NCBI
Cytogenetic Map7q11.23NCBI
HuRef768,614,029 - 68,623,821 (-)NCBIHuRef
CHM1_1772,519,507 - 72,529,488 (-)NCBICHM1_1
T2T-CHM13v2.0774,183,097 - 74,197,887 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2771,762,838 - 71,772,819NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
cytosol  (IDA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:12853948   PMID:18398435   PMID:19549727   PMID:21873635   PMID:22493164   PMID:22939624   PMID:23105109   PMID:24952745   PMID:25416956   PMID:26186194   PMID:26196062  
PMID:28514442   PMID:32296183   PMID:32814053   PMID:33961781  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7q11.22-21.11(chr7:71225344-81735657)x1 copy number loss See cases [RCV000050709] Chr7:71225344..81735657 [GRCh38]
Chr7:70690330..81364973 [GRCh37]
Chr7:70328266..81202909 [NCBI36]
Chr7:7q11.22-21.11		 pathogenic
GRCh38/hg38 7q11.23(chr7:72930548-74869255)x1 copy number loss See cases [RCV000050996] Chr7:72930548..74869255 [GRCh38]
Chr7:72401086..74285345 [GRCh37]
Chr7:72039022..73923281 [NCBI36]
Chr7:7q11.23		 pathogenic
GRCh38/hg38 7q11.21-21.11(chr7:64560824-79186156)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052318]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052318]|See cases [RCV000052318] Chr7:64560824..79186156 [GRCh38]
Chr7:64021202..78815472 [GRCh37]
Chr7:63658637..78653408 [NCBI36]
Chr7:7q11.21-21.11		 pathogenic
GRCh38/hg38 7q11.22-11.23(chr7:68668307-73710276)x1 copy number loss See cases [RCV000052321] Chr7:68668307..73710276 [GRCh38]
Chr7:68133294..72806397 [GRCh37]
Chr7:67771230..72762542 [NCBI36]
Chr7:7q11.22-11.23		 pathogenic
GRCh38/hg38 7q11.22-11.23(chr7:72649515-75361855)x3 copy number gain See cases [RCV000051965] Chr7:72649515..75361855 [GRCh38]
Chr7:72196405..74991125 [GRCh37]
Chr7:71752436..74829061 [NCBI36]
Chr7:7q11.22-11.23		 pathogenic
GRCh38/hg38 7q11.23(chr7:72768821-74869255)x3 copy number gain See cases [RCV000051966] Chr7:72768821..74869255 [GRCh38]
Chr7:72233835..74285345 [GRCh37]
Chr7:71871771..73923281 [NCBI36]
Chr7:7q11.23		 pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q11.22-11.23(chr7:69382353-77823832)x1 copy number loss See cases [RCV000054111] Chr7:69382353..77823832 [GRCh38]
Chr7:68847339..77453149 [GRCh37]
Chr7:68485275..77291085 [NCBI36]
Chr7:7q11.22-11.23		 pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q11.22-11.23(chr7:71461127-73614730)x1 copy number loss See cases [RCV000135816] Chr7:71461127..73614730 [GRCh38]
Chr7:70926112..72806397 [GRCh37]
Chr7:70564048..72666996 [NCBI36]
Chr7:7q11.22-11.23		 pathogenic|likely pathogenic
GRCh38/hg38 7q11.23(chr7:72938064-74779028)x3 copy number gain See cases [RCV000136287] Chr7:72938064..74779028 [GRCh38]
Chr7:72408602..74193374 [GRCh37]
Chr7:72046538..73831310 [NCBI36]
Chr7:7q11.23		 pathogenic
GRCh38/hg38 7q11.21-11.23(chr7:62977085-75415352)x3 copy number gain See cases [RCV000142242] Chr7:62977085..75415352 [GRCh38]
Chr7:62437463..75044630 [GRCh37]
Chr7:62074898..74882566 [NCBI36]
Chr7:7q11.21-11.23		 pathogenic
GRCh38/hg38 7q11.21-11.23(chr7:62736364-75432710)x1 copy number loss See cases [RCV000142528] Chr7:62736364..75432710 [GRCh38]
Chr7:62196742..75061986 [GRCh37]
Chr7:61834177..74899922 [NCBI36]
Chr7:7q11.21-11.23		 pathogenic
GRCh38/hg38 7q11.22-11.23(chr7:71478043-73444574)x1 copy number loss See cases [RCV000143344] Chr7:71478043..73444574 [GRCh38]
Chr7:70943028..72806397 [GRCh37]
Chr7:70580964..72496840 [NCBI36]
Chr7:7q11.22-11.23		 uncertain significance
GRCh38/hg38 7q11.22-21.11(chr7:72179092-79164071) copy number gain See cases [RCV000143454] Chr7:72179092..79164071 [GRCh38]
Chr7:71644077..78793387 [GRCh37]
Chr7:71282013..78631323 [NCBI36]
Chr7:7q11.22-21.11		 likely pathogenic
GRCh37/hg19 7q11.22-11.23(chr7:71968212-74133332)x3 copy number gain See cases [RCV000240527] Chr7:71968212..74133332 [GRCh37]
Chr7:7q11.22-11.23		 pathogenic
TMEM106B-BRAF fusion deletion Pleomorphic xanthoastrocytoma [RCV000454357] Chr7:12258147..140494267 [GRCh37]
Chr7:7p21.3-q34		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
NC_000007.13:g.(20954043_21001537)_(114528369_114556605)inv inversion Childhood apraxia of speech [RCV000234948] Chr7:21001537..114528369 [GRCh37]
Chr7:7p15.3-q31.1		 pathogenic
GRCh37/hg19 7q11.23(chr7:72305671-74196360)x1 copy number loss not provided [RCV000746789] Chr7:72305671..74196360 [GRCh37]
Chr7:7q11.23		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
Single allele duplication Neurodevelopmental disorder [RCV000787457] Chr7:72364526..73780265 [GRCh37]
Chr7:7q11.23		 likely pathogenic
GRCh37/hg19 7q11.22-11.23(chr7:68977230-73939510)x1 copy number loss not provided [RCV001260005] Chr7:68977230..73939510 [GRCh37]
Chr7:7q11.22-11.23		 pathogenic
Single allele complex Ring chromosome 7 [RCV002280646] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7q11.23(chr7:72403117-76709600)x1 copy number loss not provided [RCV001258798] Chr7:72403117..76709600 [GRCh37]
Chr7:7q11.23		 pathogenic
GRCh37/hg19 7q11.22-11.23(chr7:71847968-73391310) copy number loss Williams syndrome [RCV001352633] Chr7:71847968..73391310 [GRCh37]
Chr7:7q11.22-11.23		 likely pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:56604613-96692931)x1 copy number loss See cases [RCV002287832] Chr7:56604613..96692931 [GRCh37]
Chr7:7p22.3-q36.3		 uncertain significance
GRCh37/hg19 7q11.21-11.23(chr7:66776724-74629034)x3 copy number gain not specified [RCV003986715] Chr7:66776724..74629034 [GRCh37]
Chr7:7q11.21-11.23		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:520
Count of miRNA genes:238
Interacting mature miRNAs:250
Transcripts:ENST00000285805, ENST00000395244
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
597351547GWAS1447621_HQT interval QTL GWAS1447621 (human)0.000002QT intervalQT interval (CMO:0000235)77295559172955592Human

Markers in Region
GDB:4585495  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37772,434,035 - 72,434,120UniSTSGRCh37
GRCh37775,030,786 - 75,030,871UniSTSGRCh37
Build 36772,071,971 - 72,072,056RGDNCBI36
Cytogenetic Map7q11.23UniSTS
CRA_TCAGchr7v2774,363,850 - 74,363,935UniSTS
CRA_TCAGchr7v2771,766,857 - 71,766,942UniSTS
STS-N62712  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7q11.23UniSTS
GeneMap99-GB4 RH Map7424.51UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
2403 4816 5471 4385 9760 3387 4583 7 1191 3437 874 4455 13788 12327 100 7370 1648 3414 3173 339

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001317815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_198853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011516187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011516189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011516190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017012197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047420350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047420352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047420353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047420354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047420355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047420356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054358173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054358174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054358175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054358176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054358177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054358178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054358179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054358180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054358181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001744731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001744732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001744733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001744734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001744735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001744736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001744737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001744739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001744740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001744741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001744742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001744744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001744745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001744749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001744750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001744751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002956438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002956439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002956440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002956441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002956442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002956443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002956444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002956445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002956446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002956447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002956448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002956449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002956450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC005488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC211476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF498999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC033871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000285805   ⟹   ENSP00000285805
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl772,959,485 - 72,969,466 (-)Ensembl
Ensembl Acc Id: ENST00000395244   ⟹   ENSP00000378665
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl772,959,485 - 72,966,953 (-)Ensembl
Ensembl Acc Id: ENST00000423834
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl772,998,490 - 73,005,922 (-)Ensembl
Ensembl Acc Id: ENST00000428423
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl772,997,059 - 73,005,918 (-)Ensembl
Ensembl Acc Id: ENST00000436857
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl772,969,696 - 73,005,721 (-)Ensembl
Ensembl Acc Id: ENST00000448173
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl772,998,484 - 73,005,915 (-)Ensembl
Ensembl Acc Id: ENST00000569650
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl772,998,493 - 73,005,785 (-)Ensembl
Ensembl Acc Id: ENST00000608210
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl772,998,027 - 73,003,730 (-)Ensembl
RefSeq Acc Id: NM_001317815   ⟹   NP_001304744
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38772,959,485 - 72,966,953 (-)NCBI
CHM1_1772,519,507 - 72,526,975 (-)NCBI
T2T-CHM13v2.0774,187,710 - 74,195,178 (-)NCBI
Sequence:
RefSeq Acc Id: NM_198853   ⟹   NP_942150
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38772,959,485 - 72,969,466 (-)NCBI
GRCh37772,430,016 - 72,439,997 (-)RGD
Build 36772,067,952 - 72,077,933 (-)NCBI Archive
HuRef768,614,030 - 68,623,822 (+)RGD
CHM1_1772,519,507 - 72,529,488 (-)NCBI
T2T-CHM13v2.0774,187,710 - 74,197,691 (-)NCBI
CRA_TCAGchr7v2771,762,838 - 71,772,819 (-)RGD
Sequence:
RefSeq Acc Id: XM_011516187   ⟹   XP_011514489
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38772,959,485 - 72,969,681 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011516189   ⟹   XP_011514491
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38772,959,485 - 72,966,953 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011516190   ⟹   XP_011514492
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38772,954,868 - 72,969,630 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047420350   ⟹   XP_047276306
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38772,959,485 - 72,969,466 (-)NCBI
RefSeq Acc Id: XM_047420352   ⟹   XP_047276308
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38772,954,868 - 72,969,466 (-)NCBI
RefSeq Acc Id: XM_047420353   ⟹   XP_047276309
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38772,954,868 - 72,966,953 (-)NCBI
RefSeq Acc Id: XM_047420354   ⟹   XP_047276310
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38772,954,868 - 72,969,672 (-)NCBI
RefSeq Acc Id: XM_047420355   ⟹   XP_047276311
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38772,954,868 - 72,966,953 (-)NCBI
RefSeq Acc Id: XM_047420356   ⟹   XP_047276312
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38772,959,485 - 72,969,672 (-)NCBI
RefSeq Acc Id: XM_054358173   ⟹   XP_054214148
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0774,183,097 - 74,197,691 (-)NCBI
RefSeq Acc Id: XM_054358174   ⟹   XP_054214149
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0774,183,097 - 74,195,178 (-)NCBI
RefSeq Acc Id: XM_054358175   ⟹   XP_054214150
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0774,183,097 - 74,197,887 (-)NCBI
RefSeq Acc Id: XM_054358176   ⟹   XP_054214151
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0774,187,710 - 74,195,178 (-)NCBI
RefSeq Acc Id: XM_054358177   ⟹   XP_054214152
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0774,183,097 - 74,197,691 (-)NCBI
RefSeq Acc Id: XM_054358178   ⟹   XP_054214153
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0774,183,097 - 74,197,882 (-)NCBI
RefSeq Acc Id: XM_054358179   ⟹   XP_054214154
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0774,183,097 - 74,195,178 (-)NCBI
RefSeq Acc Id: XM_054358180   ⟹   XP_054214155
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0774,188,390 - 74,197,691 (-)NCBI
RefSeq Acc Id: XM_054358181   ⟹   XP_054214156
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0774,183,097 - 74,195,178 (-)NCBI
RefSeq Acc Id: NP_942150   ⟸   NM_198853
- UniProtKB: Q86UV6 (UniProtKB/Swiss-Prot),   B7WP46 (UniProtKB/Swiss-Prot),   I3L0H3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011514492   ⟸   XM_011516190
- Peptide Label: isoform X2
- UniProtKB: J3KQW6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011514491   ⟸   XM_011516189
- Peptide Label: isoform X1
- UniProtKB: I3L0H3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011514489   ⟸   XM_011516187
- Peptide Label: isoform X4
- UniProtKB: Q86UV6 (UniProtKB/Swiss-Prot),   B7WP46 (UniProtKB/Swiss-Prot),   I3L0H3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001304744   ⟸   NM_001317815
- UniProtKB: Q86UV6 (UniProtKB/Swiss-Prot),   B7WP46 (UniProtKB/Swiss-Prot),   I3L0H3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000285805   ⟸   ENST00000285805
Ensembl Acc Id: ENSP00000378665   ⟸   ENST00000395244
RefSeq Acc Id: XP_047276310   ⟸   XM_047420354
- Peptide Label: isoform X3
RefSeq Acc Id: XP_047276308   ⟸   XM_047420352
- Peptide Label: isoform X2
- UniProtKB: J3KQW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047276311   ⟸   XM_047420355
- Peptide Label: isoform X3
RefSeq Acc Id: XP_047276309   ⟸   XM_047420353
- Peptide Label: isoform X2
- UniProtKB: J3KQW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047276312   ⟸   XM_047420356
- Peptide Label: isoform X5
- UniProtKB: C9JQH3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047276306   ⟸   XM_047420350
- Peptide Label: isoform X1
- UniProtKB: I3L0H3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054214150   ⟸   XM_054358175
- Peptide Label: isoform X6
- UniProtKB: J3KQW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054214153   ⟸   XM_054358178
- Peptide Label: isoform X2
- UniProtKB: J3KQW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054214152   ⟸   XM_054358177
- Peptide Label: isoform X2
- UniProtKB: J3KQW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054214148   ⟸   XM_054358173
- Peptide Label: isoform X6
- UniProtKB: J3KQW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054214156   ⟸   XM_054358181
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054214154   ⟸   XM_054358179
- Peptide Label: isoform X2
- UniProtKB: J3KQW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054214149   ⟸   XM_054358174
- Peptide Label: isoform X6
- UniProtKB: J3KQW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054214151   ⟸   XM_054358176
- Peptide Label: isoform X1
- UniProtKB: I3L0H3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054214155   ⟸   XM_054358180
- Peptide Label: isoform X7

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q86UV6-F1-model_v2 AlphaFold Q86UV6 1-250 view protein structure

Promoters
RGD ID:7210751
Promoter ID:EPDNEW_H11121
Type:initiation region
Name:TRIM74_1
Description:tripartite motif containing 74
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38772,966,973 - 72,967,033EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:17453 AgrOrtholog
COSMIC TRIM74 COSMIC
Ensembl Genes ENSG00000155428 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSG00000174353 Ensembl
Ensembl Transcript ENST00000285805 ENTREZGENE
  ENST00000285805.3 UniProtKB/Swiss-Prot
  ENST00000395244 ENTREZGENE
  ENST00000395244.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.40.10 UniProtKB/Swiss-Prot
  Classic Zinc Finger UniProtKB/Swiss-Prot
GTEx ENSG00000155428 GTEx
  ENSG00000174353 GTEx
HGNC ID HGNC:17453 ENTREZGENE
Human Proteome Map TRIM74 Human Proteome Map
InterPro TRIM/RBCC UniProtKB/Swiss-Prot
  Znf-RING_LisH UniProtKB/Swiss-Prot
  Znf_B-box UniProtKB/Swiss-Prot
  Znf_RING UniProtKB/Swiss-Prot
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot
  Znf_RING_CS UniProtKB/Swiss-Prot
KEGG Report hsa:378108 UniProtKB/Swiss-Prot
NCBI Gene TRIM74 ENTREZGENE
OMIM 612550 OMIM
PANTHER E3 UBIQUITIN-PROTEIN LIGASE TRIM UniProtKB/Swiss-Prot
  E3 UBIQUITIN-PROTEIN LIGASE TRIM50-RELATED UniProtKB/Swiss-Prot
Pfam zf-B_box UniProtKB/Swiss-Prot
  zf-RING_UBOX UniProtKB/Swiss-Prot
PharmGKB PA38454 PharmGKB
PROSITE ZF_BBOX UniProtKB/Swiss-Prot
  ZF_RING_1 UniProtKB/Swiss-Prot
  ZF_RING_2 UniProtKB/Swiss-Prot
SMART BBOX UniProtKB/Swiss-Prot
  RING UniProtKB/Swiss-Prot
Superfamily-SCOP B-box zinc-binding domain UniProtKB/Swiss-Prot
  RING/U-box UniProtKB/Swiss-Prot
UniProt B7WP46 ENTREZGENE
  C9JQH3 ENTREZGENE
  I3L0H3 ENTREZGENE
  J3KQW6 ENTREZGENE
  Q86UV6 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B7WP46 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 TRIM74  tripartite motif containing 74  TRIM74  tripartite motif-containing 74  Symbol and/or name change 5135510 APPROVED