OR10AG1 (olfactory receptor family 10 subfamily AG member 1) - Rat Genome Database

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Advanced Search (OLGA)
Gene: OR10AG1 (olfactory receptor family 10 subfamily AG member 1) Homo sapiens
Analyze
Symbol: OR10AG1
Name: olfactory receptor family 10 subfamily AG member 1
RGD ID: 1350024
HGNC Page HGNC:19607
Description: Predicted to enable olfactory receptor activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in membrane. Predicted to be active in plasma membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: olfactory receptor 10AG1; olfactory receptor OR11-160; olfactory receptor, family 10, subfamily AG, member 1; OR11-160
RGD Orthologs
Mouse
Rat
Dog
Pig
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381155,965,755 - 55,969,945 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1155,965,755 - 55,969,945 (-)EnsemblGRCh38hg38GRCh38
GRCh371155,733,231 - 55,737,421 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361155,491,610 - 55,492,515 (-)NCBINCBI36Build 36hg18NCBI36
Build 341155,491,609 - 55,492,515NCBI
Celera1153,075,208 - 53,076,113 (-)NCBICelera
Cytogenetic Map11q12.1NCBI
HuRef1152,064,025 - 52,064,930 (-)NCBIHuRef
CHM1_11155,600,594 - 55,601,499 (-)NCBICHM1_1
T2T-CHM13v2.01155,904,078 - 55,908,266 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14983052   PMID:21873635   PMID:32296183  


Genomics

Comparative Map Data
OR10AG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381155,965,755 - 55,969,945 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1155,965,755 - 55,969,945 (-)EnsemblGRCh38hg38GRCh38
GRCh371155,733,231 - 55,737,421 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361155,491,610 - 55,492,515 (-)NCBINCBI36Build 36hg18NCBI36
Build 341155,491,609 - 55,492,515NCBI
Celera1153,075,208 - 53,076,113 (-)NCBICelera
Cytogenetic Map11q12.1NCBI
HuRef1152,064,025 - 52,064,930 (-)NCBIHuRef
CHM1_11155,600,594 - 55,601,499 (-)NCBICHM1_1
T2T-CHM13v2.01155,904,078 - 55,908,266 (-)NCBIT2T-CHM13v2.0
Or10ag2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39287,248,394 - 87,249,365 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl287,246,979 - 87,253,555 (+)EnsemblGRCm39 Ensembl
GRCm38287,418,050 - 87,419,021 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl287,416,635 - 87,423,211 (+)EnsemblGRCm38mm10GRCm38
MGSCv37287,258,207 - 87,259,178 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36287,218,889 - 87,219,860 (+)NCBIMGSCv36mm8
Celera289,021,941 - 89,022,912 (+)NCBICelera
Cytogenetic Map2DNCBI
cM Map249.86NCBI
Or10ag2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8393,220,038 - 93,221,009 (+)NCBIGRCr8
mRatBN7.2372,763,750 - 72,764,721 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl372,762,194 - 72,765,238 (+)NCBImRatBN7.2 Ensembl
mRatBN7.2 Ensembl372,762,194 - 72,765,238 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx376,115,504 - 76,116,475 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0384,714,070 - 84,715,041 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0382,588,248 - 82,589,219 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0375,437,833 - 75,438,804 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl375,437,833 - 75,438,804 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0382,156,575 - 82,157,546 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4371,056,189 - 71,057,160 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1370,952,560 - 70,953,532 (+)NCBI
Celera372,065,614 - 72,066,585 (+)NCBICelera
Cytogenetic Map3q24NCBI
OR10AG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11839,894,988 - 39,895,938 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1839,895,033 - 39,895,938 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1839,419,559 - 39,420,509 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01840,584,435 - 40,585,385 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1840,584,480 - 40,585,385 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11840,194,753 - 40,195,703 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01839,757,125 - 39,758,075 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01840,343,314 - 40,344,264 (+)NCBIUU_Cfam_GSD_1.0
LOC110258257
(Sus scrofa - pig)		 No map positions available.

Variants

.
Variants in OR10AG1
16 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q11-12.1(chr11:55319519-56212930)x3 copy number gain See cases [RCV000050318] Chr11:55319519..56212930 [GRCh38]
Chr11:55086995..55980406 [GRCh37]
Chr11:54843571..55736982 [NCBI36]
Chr11:11q11-12.1		 benign
GRCh38/hg38 11q11-12.1(chr11:55445689-57114783)x1 copy number loss See cases [RCV000050913] Chr11:55445689..57114783 [GRCh38]
Chr11:55213165..56882257 [GRCh37]
Chr11:54969741..56638833 [NCBI36]
Chr11:11q11-12.1		 benign
NM_001005491.1(OR10AG1):c.173C>T (p.Ser58Phe) single nucleotide variant Malignant melanoma [RCV000069469] Chr11:55968291 [GRCh38]
Chr11:55735767 [GRCh37]
Chr11:55492343 [NCBI36]
Chr11:11q12.1		 not provided
NM_001005491.1(OR10AG1):c.257T>A (p.Phe86Tyr) single nucleotide variant Malignant melanoma [RCV000062275] Chr11:55968207 [GRCh38]
Chr11:55735683 [GRCh37]
Chr11:55492259 [NCBI36]
Chr11:11q12.1		 not provided
NM_001005491.1(OR10AG1):c.4G>A (p.Glu2Lys) single nucleotide variant Malignant melanoma [RCV000062276] Chr11:55968460 [GRCh38]
Chr11:55735936 [GRCh37]
Chr11:55492512 [NCBI36]
Chr11:11q12.1		 not provided
GRCh38/hg38 11q11-12.1(chr11:55265785-56230226)x3 copy number gain See cases [RCV000134403] Chr11:55265785..56230226 [GRCh38]
Chr11:55033261..55997702 [GRCh37]
Chr11:54789837..55754278 [NCBI36]
Chr11:11q11-12.1		 benign
GRCh38/hg38 11q12.1(chr11:55936260-56048836)x1 copy number loss See cases [RCV000135871] Chr11:55936260..56048836 [GRCh38]
Chr11:55703736..55816312 [GRCh37]
Chr11:55460312..55572888 [NCBI36]
Chr11:11q12.1		 benign
GRCh38/hg38 11q11-12.1(chr11:55316535-57539457)x3 copy number gain See cases [RCV000141200] Chr11:55316535..57539457 [GRCh38]
Chr11:55084011..57306930 [GRCh37]
Chr11:54840587..57063506 [NCBI36]
Chr11:11q11-12.1		 uncertain significance
GRCh38/hg38 11q11-12.1(chr11:55319519-58998777)x3 copy number gain See cases [RCV000142757] Chr11:55319519..58998777 [GRCh38]
Chr11:55086995..58766250 [GRCh37]
Chr11:54843571..58522826 [NCBI36]
Chr11:11q11-12.1		 pathogenic
GRCh38/hg38 11q11-12.1(chr11:55319519-56212930)x3 copy number gain See cases [RCV000148269] Chr11:55319519..56212930 [GRCh38]
Chr11:55086995..55980406 [GRCh37]
Chr11:54843571..55736982 [NCBI36]
Chr11:11q11-12.1		 benign
GRCh37/hg19 11q11-12.1(chr11:55033164-55980347)x3 copy number gain See cases [RCV000448938] Chr11:55033164..55980347 [GRCh37]
Chr11:11q11-12.1		 benign
GRCh37/hg19 11q11-12.1(chr11:55029738-55980347)x3 copy number gain See cases [RCV000448359] Chr11:55029738..55980347 [GRCh37]
Chr11:11q11-12.1		 benign
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p11.12-q12.1(chr11:51183548-56977098)x3 copy number gain See cases [RCV000512524] Chr11:51183548..56977098 [GRCh37]
Chr11:11p11.12-q12.1		 uncertain significance
GRCh37/hg19 11p11.12-q12.1(chr11:49313405-59008426)x3 copy number gain not provided [RCV000683370] Chr11:49313405..59008426 [GRCh37]
Chr11:11p11.12-q12.1		 uncertain significance
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11q11-12.1(chr11:54794237-56003589)x3 copy number gain not provided [RCV000737530] Chr11:54794237..56003589 [GRCh37]
Chr11:11q11-12.1		 benign
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11q11-12.1(chr11:55685767-55823576)x1 copy number loss not provided [RCV000737533] Chr11:55685767..55823576 [GRCh37]
Chr11:11q11-12.1		 benign
Single allele duplication not provided [RCV000844966] Chr11:55033164..57518726 [GRCh37]
Chr11:11q11-12.1		 not provided
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3		 pathogenic
GRCh37/hg19 11p11.12-q12.1(chr11:51164494-56879839)x3 copy number gain not provided [RCV001827812] Chr11:51164494..56879839 [GRCh37]
Chr11:11p11.12-q12.1		 uncertain significance
GRCh37/hg19 11p11.2-q12.2(chr11:51581311-54891247)x3 copy number gain See cases [RCV002286338] Chr11:51581311..54891247 [GRCh37]
Chr11:11p11.2-q12.2		 pathogenic
GRCh37/hg19 11p13-q25(chr11:32799481-134938470)x3 copy number gain MISSED ABORTION [RCV002282973] Chr11:32799481..134938470 [GRCh37]
Chr11:11p13-q25		 pathogenic
NM_001005491.2(OR10AG1):c.572A>G (p.Asp191Gly) single nucleotide variant not specified [RCV004152100] Chr11:55967952 [GRCh38]
Chr11:55735428 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_001005491.2(OR10AG1):c.578C>T (p.Pro193Leu) single nucleotide variant not specified [RCV004224220] Chr11:55967946 [GRCh38]
Chr11:55735422 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_001005491.2(OR10AG1):c.245T>C (p.Ile82Thr) single nucleotide variant not specified [RCV004171468] Chr11:55968279 [GRCh38]
Chr11:55735755 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_001005491.2(OR10AG1):c.895A>G (p.Ile299Val) single nucleotide variant not specified [RCV004129775] Chr11:55967629 [GRCh38]
Chr11:55735105 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_001005491.2(OR10AG1):c.301G>A (p.Gly101Arg) single nucleotide variant not specified [RCV004136115] Chr11:55968223 [GRCh38]
Chr11:55735699 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_001005491.2(OR10AG1):c.824C>T (p.Pro275Leu) single nucleotide variant not specified [RCV004232658] Chr11:55967700 [GRCh38]
Chr11:55735176 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_001005491.2(OR10AG1):c.855T>G (p.Ile285Met) single nucleotide variant not specified [RCV004224933] Chr11:55967669 [GRCh38]
Chr11:55735145 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_001005491.2(OR10AG1):c.111G>A (p.Met37Ile) single nucleotide variant not specified [RCV004107709] Chr11:55968413 [GRCh38]
Chr11:55735889 [GRCh37]
Chr11:11q12.1		 likely benign
NM_001005491.2(OR10AG1):c.448A>G (p.Lys150Glu) single nucleotide variant not specified [RCV004349972] Chr11:55968076 [GRCh38]
Chr11:55735552 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_001005491.2(OR10AG1):c.728G>C (p.Arg243Thr) single nucleotide variant not specified [RCV004348023] Chr11:55967796 [GRCh38]
Chr11:55735272 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_001005491.2(OR10AG1):c.830A>G (p.Gln277Arg) single nucleotide variant not specified [RCV004334739] Chr11:55967694 [GRCh38]
Chr11:55735170 [GRCh37]
Chr11:11q12.1		 uncertain significance
GRCh37/hg19 11p11.12-q13.1(chr11:50398499-63924462)x3 copy number gain not specified [RCV003986918] Chr11:50398499..63924462 [GRCh37]
Chr11:11p11.12-q13.1		 likely pathogenic
NM_001005491.2(OR10AG1):c.928G>A (p.Val310Met) single nucleotide variant not specified [RCV004499370] Chr11:55967596 [GRCh38]
Chr11:55735072 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_001005491.2(OR10AG1):c.144G>A (p.Met48Ile) single nucleotide variant not specified [RCV004655232] Chr11:55968380 [GRCh38]
Chr11:55735856 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_001005491.2(OR10AG1):c.524T>G (p.Phe175Cys) single nucleotide variant not specified [RCV004646179] Chr11:55968000 [GRCh38]
Chr11:55735476 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_001005491.2(OR10AG1):c.484A>G (p.Ile162Val) single nucleotide variant not specified [RCV004499369] Chr11:55968040 [GRCh38]
Chr11:55735516 [GRCh37]
Chr11:11q12.1		 uncertain significance
GRCh37/hg19 11q11-12.1(chr11:54697347-56021284)x3 copy number gain not provided [RCV000737528] Chr11:54697347..56021284 [GRCh37]
Chr11:11q11-12.1		 benign
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:53
Interacting mature miRNAs:54
Transcripts:ENST00000312345
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
5 27 24 17 82 12 28 8 20 5 60 75 67 1 30 14 151 17 3

Sequence


Ensembl Acc Id: ENST00000312345   ⟹   ENSP00000311477
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1155,967,499 - 55,968,514 (-)Ensembl
Ensembl Acc Id: ENST00000641071   ⟹   ENSP00000493281
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1155,965,755 - 55,969,945 (-)Ensembl
RefSeq Acc Id: NM_001005491   ⟹   NP_001005491
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381155,965,755 - 55,969,945 (-)NCBI
GRCh371155,735,034 - 55,735,939 (-)RGD
Build 361155,491,610 - 55,492,515 (-)NCBI Archive
Celera1153,075,208 - 53,076,113 (-)RGD
HuRef1152,064,025 - 52,064,930 (-)RGD
CHM1_11155,600,594 - 55,601,499 (-)NCBI
T2T-CHM13v2.01155,904,078 - 55,908,266 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001005491   ⟸   NM_001005491
- UniProtKB: Q8NH19 (UniProtKB/Swiss-Prot),   Q6IEU3 (UniProtKB/Swiss-Prot),   B2RNH4 (UniProtKB/Swiss-Prot),   A0A2U3TZR9 (UniProtKB/TrEMBL),   A0A126GVM8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000311477   ⟸   ENST00000312345
Ensembl Acc Id: ENSP00000493281   ⟸   ENST00000641071
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8NH19-F1-model_v2 AlphaFold Q8NH19 1-301 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:19607 AgrOrtholog
COSMIC OR10AG1 COSMIC
Ensembl Genes ENSG00000174970 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000312345.4 UniProtKB/Swiss-Prot
  ENST00000641071 ENTREZGENE
  ENST00000641071.2 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000174970 GTEx
HGNC ID HGNC:19607 ENTREZGENE
Human Proteome Map OR10AG1 Human Proteome Map
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:282770 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 282770 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OLFACTORY RECEPTOR 10AG1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134929321 PharmGKB
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A126GVM8 ENTREZGENE, UniProtKB/TrEMBL
  A0A2U3TZR9 ENTREZGENE, UniProtKB/TrEMBL
  B2RNH4 ENTREZGENE
  O10AG_HUMAN UniProtKB/Swiss-Prot
  Q6IEU3 ENTREZGENE
  Q8NH19 ENTREZGENE
UniProt Secondary B2RNH4 UniProtKB/Swiss-Prot
  Q6IEU3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-15 OR10AG1  olfactory receptor family 10 subfamily AG member 1  OR10AG1  olfactory receptor, family 10, subfamily AG, member 1  Symbol and/or name change 5135510 APPROVED