WFDC8 (WAP four-disulfide core domain 8) - Rat Genome Database

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Gene: WFDC8 (WAP four-disulfide core domain 8) Homo sapiens
Analyze
Symbol: WFDC8
Name: WAP four-disulfide core domain 8
RGD ID: 1347537
HGNC Page HGNC:16163
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of peptidase activity. Predicted to be located in extracellular region.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: C20orf170; dJ461P17.1; epididymis secretory protein Li 292; HEL-S-292; protease inhibitor WAP8; putative protease inhibitor WAP8; testicular secretory protein Li 68; WAP four-disulfide core domain protein 8; WAP motif protein 1; WAP8
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382045,551,152 - 45,579,284 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2045,551,153 - 45,579,326 (-)EnsemblGRCh38hg38GRCh38
GRCh372044,179,791 - 44,207,923 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362043,613,205 - 43,641,379 (-)NCBINCBI36Build 36hg18NCBI36
Build 342043,613,204 - 43,641,379NCBI
Celera2040,888,320 - 40,916,496 (-)NCBICelera
Cytogenetic Map20q13.12NCBI
HuRef2040,921,269 - 40,949,426 (-)NCBIHuRef
CHM1_12044,082,355 - 44,110,529 (-)NCBICHM1_1
T2T-CHM13v2.02047,287,009 - 47,315,139 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
Additional References at PubMed
PMID:11780052   PMID:12206714   PMID:15950183   PMID:21536719   PMID:23292442   PMID:23314748   PMID:33961781  


Genomics

Comparative Map Data
WFDC8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382045,551,152 - 45,579,284 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2045,551,153 - 45,579,326 (-)EnsemblGRCh38hg38GRCh38
GRCh372044,179,791 - 44,207,923 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362043,613,205 - 43,641,379 (-)NCBINCBI36Build 36hg18NCBI36
Build 342043,613,204 - 43,641,379NCBI
Celera2040,888,320 - 40,916,496 (-)NCBICelera
Cytogenetic Map20q13.12NCBI
HuRef2040,921,269 - 40,949,426 (-)NCBIHuRef
CHM1_12044,082,355 - 44,110,529 (-)NCBICHM1_1
T2T-CHM13v2.02047,287,009 - 47,315,139 (-)NCBIT2T-CHM13v2.0
Wfdc8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392164,438,378 - 164,455,545 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2164,438,378 - 164,455,546 (-)EnsemblGRCm39 Ensembl
GRCm382164,596,458 - 164,613,626 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2164,596,458 - 164,613,626 (-)EnsemblGRCm38mm10GRCm38
MGSCv372164,422,713 - 164,439,126 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362164,287,663 - 164,304,831 (-)NCBIMGSCv36mm8
Celera2170,533,878 - 170,550,009 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map285.22NCBI
Wfdc8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83173,742,844 - 173,759,188 (-)NCBIGRCr8
mRatBN7.23153,323,503 - 153,339,849 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3153,324,413 - 153,339,842 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3157,136,373 - 157,145,564 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03165,635,334 - 165,644,529 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03163,378,963 - 163,388,156 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03161,058,217 - 161,067,358 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3161,058,217 - 161,067,358 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03167,236,337 - 167,245,727 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43155,621,234 - 155,630,837 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3151,935,618 - 151,944,730 (-)NCBICelera
Cytogenetic Map3q42NCBI
Wfdc8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495544511,666,987 - 11,682,180 (+)NCBIChiLan1.0ChiLan1.0
WFDC8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22151,290,558 - 51,318,067 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12051,283,667 - 51,311,176 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02041,888,066 - 41,915,619 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12042,977,183 - 43,004,718 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2042,978,055 - 42,990,413 (-)Ensemblpanpan1.1panPan2
WFDC8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12432,813,432 - 32,829,108 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2432,814,662 - 32,823,340 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.02433,524,392 - 33,539,732 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12432,785,490 - 32,800,760 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02432,901,186 - 32,916,477 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02433,445,521 - 33,460,785 (-)NCBIUU_Cfam_GSD_1.0
Wfdc8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640191,914,351 - 191,929,038 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365147,367,994 - 7,381,900 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WFDC8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1747,862,615 - 47,876,464 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11747,863,302 - 47,877,267 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21753,509,346 - 53,528,378 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WFDC8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1218,261,347 - 18,287,264 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl218,275,771 - 18,286,403 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605066,902,665 - 66,928,486 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wfdc8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247908,860,940 - 8,868,261 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247908,859,310 - 8,868,261 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in WFDC8
13 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 20q13.12-13.33(chr20:44787704-64277321)x3 copy number gain See cases [RCV000053035] Chr20:44787704..64277321 [GRCh38]
Chr20:43416345..62908674 [GRCh37]
Chr20:42849759..62379118 [NCBI36]
Chr20:20q13.12-13.33		 pathogenic
GRCh38/hg38 20p13-q13.33(chr20:99557-64277321)x3 copy number gain See cases [RCV000135859] Chr20:99557..64277321 [GRCh38]
Chr20:80198..62908674 [GRCh37]
Chr20:28198..62379118 [NCBI36]
Chr20:20p13-q13.33		 pathogenic
GRCh38/hg38 20q11.22-13.12(chr20:35237946-47631818)x1 copy number loss See cases [RCV000140816] Chr20:35237946..47631818 [GRCh38]
Chr20:33825749..46260562 [GRCh37]
Chr20:33289165..45693969 [NCBI36]
Chr20:20q11.22-13.12		 pathogenic
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555)x3 copy number gain See cases [RCV000510832] Chr20:61569..62915555 [GRCh37]
Chr20:20p13-q13.33		 pathogenic
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555) copy number gain See cases [RCV000512450] Chr20:61569..62915555 [GRCh37]
Chr20:20p13-q13.33		 pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62961294)x3 copy number gain not provided [RCV000741059] Chr20:63244..62961294 [GRCh37]
Chr20:20p13-q13.33		 pathogenic
GRCh37/hg19 20q13.12(chr20:44197259-44207251)x1 copy number loss not provided [RCV000741231] Chr20:44197259..44207251 [GRCh37]
Chr20:20q13.12		 benign
GRCh37/hg19 20p13-q13.33(chr20:63244-62912463)x3 copy number gain not provided [RCV000741057] Chr20:63244..62912463 [GRCh37]
Chr20:20p13-q13.33		 pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62948788)x3 copy number gain not provided [RCV000741058] Chr20:63244..62948788 [GRCh37]
Chr20:20p13-q13.33		 pathogenic
NM_130896.3(WFDC8):c.712G>C (p.Asp238His) single nucleotide variant not specified [RCV004324649] Chr20:45552040 [GRCh38]
Chr20:44180679 [GRCh37]
Chr20:20q13.12		 uncertain significance
Single allele deletion Focal-onset seizure [RCV001004039] Chr20:34980430..46806549 [GRCh37]
Chr20:20q11.23-13.13		 likely pathogenic
GRCh37/hg19 20q13.12-13.13(chr20:42985044-48599046)x1 copy number loss Developmental and epileptic encephalopathy, 26 [RCV001801198] Chr20:42985044..48599046 [GRCh37]
Chr20:20q13.12-13.13		 pathogenic
NC_000020.10:g.(?_42223339)_(44638757_?)del deletion Combined immunodeficiency due to STK4 deficiency [RCV003109483] Chr20:42223339..44638757 [GRCh37]
Chr20:20q13.12		 pathogenic
NM_130896.3(WFDC8):c.547G>C (p.Glu183Gln) single nucleotide variant not specified [RCV004207263] Chr20:45553175 [GRCh38]
Chr20:44181814 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_130896.3(WFDC8):c.322G>A (p.Ala108Thr) single nucleotide variant not specified [RCV004171455] Chr20:45555824 [GRCh38]
Chr20:44184463 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_130896.3(WFDC8):c.572C>T (p.Ala191Val) single nucleotide variant not specified [RCV004235464] Chr20:45553150 [GRCh38]
Chr20:44181789 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_130896.3(WFDC8):c.29A>G (p.His10Arg) single nucleotide variant not specified [RCV004226702] Chr20:45562217 [GRCh38]
Chr20:44190856 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_130896.3(WFDC8):c.329G>A (p.Arg110His) single nucleotide variant not specified [RCV004199955] Chr20:45555817 [GRCh38]
Chr20:44184456 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_130896.3(WFDC8):c.515A>G (p.Asp172Gly) single nucleotide variant not specified [RCV004088085] Chr20:45553207 [GRCh38]
Chr20:44181846 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_130896.3(WFDC8):c.721C>T (p.Arg241Cys) single nucleotide variant not specified [RCV004244445] Chr20:45552031 [GRCh38]
Chr20:44180670 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_130896.3(WFDC8):c.722G>A (p.Arg241His) single nucleotide variant not specified [RCV004230554] Chr20:45552030 [GRCh38]
Chr20:44180669 [GRCh37]
Chr20:20q13.12		 likely benign
NM_130896.3(WFDC8):c.333G>T (p.Trp111Cys) single nucleotide variant not specified [RCV004105499] Chr20:45555813 [GRCh38]
Chr20:44184452 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_130896.3(WFDC8):c.338T>G (p.Phe113Cys) single nucleotide variant not specified [RCV004265355] Chr20:45555808 [GRCh38]
Chr20:44184447 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_130896.3(WFDC8):c.14G>T (p.Arg5Leu) single nucleotide variant not specified [RCV004480908] Chr20:45579234 [GRCh38]
Chr20:44207873 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_130896.3(WFDC8):c.607C>T (p.Arg203Cys) single nucleotide variant not specified [RCV004480909] Chr20:45552145 [GRCh38]
Chr20:44180784 [GRCh37]
Chr20:20q13.12		 uncertain significance
NC_000020.10:g.(?_42223339)_(45362473_?)del deletion Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency [RCV004579451] Chr20:42223339..45362473 [GRCh37]
Chr20:20q13.12		 pathogenic
NM_130896.3(WFDC8):c.365C>T (p.Pro122Leu) single nucleotide variant not specified [RCV004678443] Chr20:45555781 [GRCh38]
Chr20:44184420 [GRCh37]
Chr20:20q13.12		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:332
Count of miRNA genes:288
Interacting mature miRNAs:303
Transcripts:ENST00000289953, ENST00000357199
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300007BP29_HBlood pressure QTL 29 (human)Blood pressurehypertension susceptibility203653600562536005Human

Markers in Region
WFDC8__4902  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372044,179,624 - 44,180,250UniSTSGRCh37
Build 362043,613,038 - 43,613,664RGDNCBI36
Celera2040,888,153 - 40,888,779RGD
HuRef2040,921,102 - 40,921,728UniSTS
D8S2279  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map21q22.12UniSTS
Cytogenetic Map15q13UniSTS
Cytogenetic Map9q32UniSTS
Cytogenetic Map15q22.3UniSTS
Cytogenetic Map17p12UniSTS
Cytogenetic Map21q21.3UniSTS
Cytogenetic Map3p22-p21.3UniSTS
Cytogenetic Map1q21.1UniSTS
Cytogenetic Map2q24.2UniSTS
Cytogenetic Map17q24.2UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map3p25.3UniSTS
Cytogenetic Map20q13.3UniSTS
Cytogenetic Map2q31.1UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map3p14.1UniSTS
Cytogenetic Map2q37.3UniSTS
Cytogenetic Map7p14.1UniSTS
Cytogenetic Map2q22.3UniSTS
Cytogenetic Map15q13.2UniSTS
Cytogenetic Map12q24.1UniSTS
Cytogenetic Map7p15.2UniSTS
Cytogenetic Map5q31.2UniSTS
Cytogenetic Map2p25.2UniSTS
Cytogenetic Map3p24.3UniSTS
Cytogenetic Map17q25.3UniSTS
Cytogenetic Map15q22.31UniSTS
Cytogenetic Map5q14UniSTS
Cytogenetic Map5q31UniSTS
Cytogenetic Map1p36.32UniSTS
Cytogenetic Map1q42.12UniSTS
Cytogenetic Map7q21.11UniSTS
Cytogenetic Map9q34.2UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map22q13.33UniSTS
Cytogenetic Map8q22.3UniSTS
Cytogenetic Map6p21.1-p12UniSTS
Cytogenetic Map1p36.13UniSTS
Cytogenetic Map7q36.3UniSTS
Cytogenetic Map2p25.1UniSTS
Cytogenetic Map7p21.3UniSTS
Cytogenetic Map4q12UniSTS
Cytogenetic Map22q11.22UniSTS
Cytogenetic Map11p13UniSTS
Cytogenetic Map1q12UniSTS
Cytogenetic Map8p23UniSTS
Cytogenetic Map11q13.2-q13.3UniSTS
Cytogenetic Map13q14.1-q14.3UniSTS
Cytogenetic Map3q22-q24UniSTS
Cytogenetic Map3q13.1-q13.2UniSTS
Cytogenetic Map16q24UniSTS
Cytogenetic Map5q23.3-q31.1UniSTS
Cytogenetic Map8p21.3UniSTS
Cytogenetic Map14q32.3UniSTS
Cytogenetic Map7q11.23UniSTS
Cytogenetic Map7q32UniSTS
Cytogenetic Map14q32.33UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map9q34.3UniSTS
Cytogenetic Map1p32.3UniSTS
Cytogenetic Map17q11UniSTS
Cytogenetic Map17p13.1-p12UniSTS
Cytogenetic Map18q21.33UniSTS
Cytogenetic Map19p13.12UniSTS
Cytogenetic Map5q14.1UniSTS
Cytogenetic Map14q24.3UniSTS
Cytogenetic Map1q21-q23UniSTS
Cytogenetic MapXp11.23UniSTS
Cytogenetic Map4q21.1UniSTS
Cytogenetic Map12q13.13UniSTS
Cytogenetic Map14q23.3UniSTS
Cytogenetic Map17p12-p11.2UniSTS
Cytogenetic Map6p21.1UniSTS
Cytogenetic Map1q24UniSTS
Cytogenetic Map1q43UniSTS
Cytogenetic Map9q34.13UniSTS
Cytogenetic Map19q13.4UniSTS
Cytogenetic Map2q32UniSTS
Cytogenetic MapXp22.2UniSTS
Cytogenetic Map19p13.11UniSTS
Cytogenetic Map2q33UniSTS
Cytogenetic Map10p13UniSTS
Cytogenetic Map2q11.2UniSTS
Cytogenetic Map3q27UniSTS
Cytogenetic Map17q25.1UniSTS
Cytogenetic Map4p16.1UniSTS
Cytogenetic Map14q22.3UniSTS
Cytogenetic Map10q23-q24UniSTS
Cytogenetic Map2q37.1UniSTS
Cytogenetic Map17q12UniSTS
Cytogenetic Map14q31-q32UniSTS
Cytogenetic Map5p15.33UniSTS
Cytogenetic Map1q23.2UniSTS
Cytogenetic Map16q24.3UniSTS
Cytogenetic Map4p14UniSTS
Cytogenetic Map2q32.3UniSTS
Cytogenetic Map15q21.1UniSTS
Cytogenetic Map4q32.2UniSTS
Cytogenetic Map10q23UniSTS
Cytogenetic Map5q14.2UniSTS
Cytogenetic Map4q32.1UniSTS
Cytogenetic Map1q25.1UniSTS
Cytogenetic Map11q14.1UniSTS
Cytogenetic Map4p16.3UniSTS
Cytogenetic Map1p34.2UniSTS
Cytogenetic Map11q23.1UniSTS
Cytogenetic Map3p21.1UniSTS
Cytogenetic Map16q22.2UniSTS
Cytogenetic Map14q32.31UniSTS
Cytogenetic Map16q11.2UniSTS
Cytogenetic Map6q22UniSTS
Cytogenetic Map10p15.3UniSTS
Cytogenetic Map11q23UniSTS
Cytogenetic Map22q13.2UniSTS
Cytogenetic Map12q12UniSTS
Cytogenetic Map19q13.42UniSTS
Cytogenetic Map19q13.11UniSTS
Cytogenetic Map12q24.31UniSTS
Cytogenetic Map15q15UniSTS
Cytogenetic Map2q33.1UniSTS
Cytogenetic Map22q12.3UniSTS
Cytogenetic Map20q11UniSTS
Cytogenetic Map22q11.23UniSTS
Cytogenetic Map17q25UniSTS
Cytogenetic Map1p13.3UniSTS
Cytogenetic Map3p22.1UniSTS
Cytogenetic Map8q22.1UniSTS
Cytogenetic Map16q22.1UniSTS
Cytogenetic Map18p11.31UniSTS
Cytogenetic Map19p12UniSTS
Cytogenetic Map11q13.1UniSTS
Cytogenetic Map19p13.3UniSTS
Cytogenetic Map2p22.1UniSTS
Cytogenetic Map16p13.3UniSTS
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Cytogenetic Map13q11-q12UniSTS
Cytogenetic Map6p12.3-p11.2UniSTS
Cytogenetic Map6q16.1-q16.3UniSTS
Cytogenetic Map22q11UniSTS
Cytogenetic Map7q31.2UniSTS
Cytogenetic Map10q21.3UniSTS
Cytogenetic Map3q25.2UniSTS
Cytogenetic Map3p21.1-p14.3UniSTS
Cytogenetic Map6p12.1UniSTS
Cytogenetic Map3q23-q24UniSTS
Cytogenetic Map3q12UniSTS
Cytogenetic Map7q11.1UniSTS
Cytogenetic Map3q22.3UniSTS
Cytogenetic Map7q21.3UniSTS
Cytogenetic Map4q31.1UniSTS
Cytogenetic Map22q12-q13UniSTS
Cytogenetic Map4q23UniSTS
Cytogenetic MapXp22.12UniSTS
Cytogenetic Map6q16.1UniSTS
Cytogenetic Map13q14.13UniSTS
Cytogenetic Map18q21.3UniSTS
Cytogenetic Map9q33.2UniSTS
Cytogenetic Map11q21UniSTS
Cytogenetic Map8q12UniSTS
Cytogenetic Map4q28-q32UniSTS
Cytogenetic Map17q24.3UniSTS
Cytogenetic Map6p23UniSTS
Cytogenetic Map8p11UniSTS
Cytogenetic Map5q34UniSTS
Cytogenetic Map1q24.3UniSTS
Cytogenetic Map9q33.1UniSTS
Cytogenetic Map1q23.3UniSTS
Cytogenetic Map2p16.2UniSTS
Cytogenetic Map9q22.31UniSTS
Cytogenetic Map9p24.3UniSTS
Cytogenetic Map7q35UniSTS
Cytogenetic Map1p36.2UniSTS
Cytogenetic Map11q22.3UniSTS
Cytogenetic Map16p12UniSTS
Cytogenetic Map1q22-q23UniSTS
Cytogenetic Map13q22.1UniSTS
Cytogenetic Map2q12.2UniSTS
Cytogenetic Map8p12UniSTS
Cytogenetic Map4q21UniSTS
Cytogenetic Map13q12.2UniSTS
Cytogenetic Map9q31-q33UniSTS
Cytogenetic Map6p24.1UniSTS
Cytogenetic Map1q23UniSTS
Cytogenetic Map11q12-q13UniSTS
Cytogenetic Map11q13.3UniSTS
Cytogenetic Map11q24.2UniSTS
Cytogenetic Map11q12.1UniSTS
Cytogenetic Map3p26UniSTS
Cytogenetic Map5q13UniSTS
Cytogenetic Map8p21UniSTS
Cytogenetic Map19q13.1-q13.2UniSTS
Cytogenetic Map1p33-p32UniSTS
Cytogenetic Map7q36.2UniSTS
Cytogenetic Map4q32.3UniSTS
Cytogenetic Map16p13.2UniSTS
Cytogenetic Map14q32UniSTS
Cytogenetic Map10q11.23UniSTS
Cytogenetic Map10q26.1UniSTS
Cytogenetic Map9q32-q33.3UniSTS
Cytogenetic Map9q22.1-q22.2UniSTS
Cytogenetic Map3q26.1-q26.2UniSTS
Cytogenetic Map5q31-q34UniSTS
Cytogenetic Map9q33-q34UniSTS
Cytogenetic Map5q11.2-q13.2UniSTS
Cytogenetic Map13q32UniSTS
Cytogenetic Map9q22.32UniSTS
Cytogenetic Map1p36.3UniSTS
Cytogenetic Map1p36.3-p36.2UniSTS
Cytogenetic Map4q28.1UniSTS
Cytogenetic Map5q22UniSTS
Cytogenetic Map12p11.21UniSTS
Cytogenetic MapXq13.3UniSTS
Cytogenetic Map9q31.3UniSTS
Cytogenetic Map3p26.3UniSTS
Cytogenetic Map2q11.1UniSTS
Cytogenetic Map21q11.2UniSTS
Cytogenetic Map18q21.32UniSTS
Cytogenetic Map15q26.2UniSTS
Cytogenetic Map12q24.23UniSTS
Cytogenetic Map10q25.3UniSTS
Cytogenetic Map20q11.23UniSTS
Cytogenetic Map20p12.1UniSTS
Cytogenetic Map2q31.1-q31.2UniSTS
Cytogenetic MapXp22.31UniSTS
Cytogenetic MapXp21.3UniSTS
Cytogenetic Map5q33.3UniSTS
Cytogenetic Map4q28.2UniSTS
Cytogenetic Map3p14.2UniSTS
Cytogenetic Map3q24UniSTS
Cytogenetic Map2q13UniSTS
Cytogenetic Map20q13.2UniSTS
Cytogenetic Map14q11.2-q12UniSTS
Cytogenetic Map3p24UniSTS
Cytogenetic Map12q23.3UniSTS
Cytogenetic Map11q24.3UniSTS
Cytogenetic Map11q14.3UniSTS
Cytogenetic Map10q25.2UniSTS
Cytogenetic Map3q25.1UniSTS
Cytogenetic Map8q13UniSTS
Cytogenetic Map1p22.2UniSTS
Cytogenetic Map3p22.3UniSTS
Cytogenetic Map18q11.1UniSTS
Cytogenetic Map8q23.3UniSTS
Cytogenetic Map15q24UniSTS
Cytogenetic Map11cen-q12UniSTS
Cytogenetic Map11q25UniSTS
Cytogenetic Map3p22.2UniSTS
Cytogenetic MapXp21.1UniSTS
Cytogenetic Map7q36UniSTS
Cytogenetic Map7p14.3UniSTS
Cytogenetic Map12q21UniSTS
Cytogenetic Map7p15UniSTS
Cytogenetic Map7q22-q31UniSTS
Cytogenetic Map11q22UniSTS
Cytogenetic Map5p15.3UniSTS
Cytogenetic Map20q13.3-qterUniSTS
Cytogenetic Map1p35-p34UniSTS
Cytogenetic Map4p13-p12UniSTS
Cytogenetic Map10q21-q22UniSTS
Cytogenetic Map4q22UniSTS
Cytogenetic Map7p13-p11.1UniSTS
Cytogenetic Map9q31-q34UniSTS
Cytogenetic Map7q21.1-q22UniSTS
Cytogenetic Map15q26.1UniSTS
Cytogenetic Map3q13.13-q13.2UniSTS
Cytogenetic MapXp22.13UniSTS
Cytogenetic Map13q12.12UniSTS
Cytogenetic Map13q14.2UniSTS
Cytogenetic Map12qUniSTS
Cytogenetic Map1pUniSTS
Cytogenetic Map16pUniSTS
Cytogenetic Map15qUniSTS
Cytogenetic Map7qUniSTS
Cytogenetic Map2qUniSTS
Cytogenetic Map5q13.1UniSTS
Cytogenetic Map11p14.1UniSTS
Cytogenetic Map4q32UniSTS
Cytogenetic Map2p22UniSTS
Cytogenetic Map5q14.3UniSTS
Cytogenetic Map10p12.1UniSTS
Cytogenetic Map5q23.2UniSTS
Cytogenetic Map2p24.1UniSTS
Cytogenetic Map8q24.13UniSTS
Cytogenetic Map12p13.32UniSTS
Cytogenetic Map9p21.1UniSTS
Cytogenetic Map9q34.2-q34.3UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
377 565 563 336 1639 910 1211 3 139 332 55 761 1497 1307 49 1114 348 1074 1025 96

Sequence


Ensembl Acc Id: ENST00000289953   ⟹   ENSP00000289953
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2045,551,762 - 45,579,284 (-)Ensembl
Ensembl Acc Id: ENST00000357199   ⟹   ENSP00000361735
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2045,551,153 - 45,579,326 (-)Ensembl
RefSeq Acc Id: NM_130896   ⟹   NP_570966
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382045,551,762 - 45,579,284 (-)NCBI
GRCh372044,179,791 - 44,207,989 (-)NCBI
Build 362043,613,815 - 43,641,379 (-)NCBI Archive
Celera2040,888,320 - 40,916,496 (-)RGD
HuRef2040,921,269 - 40,949,426 (-)RGD
CHM1_12044,082,962 - 44,110,529 (-)NCBI
T2T-CHM13v2.02047,287,616 - 47,315,139 (-)NCBI
Sequence:
RefSeq Acc Id: NM_181510   ⟹   NP_852611
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382045,551,152 - 45,579,284 (-)NCBI
GRCh372044,179,791 - 44,207,989 (-)NCBI
Build 362043,613,205 - 43,641,379 (-)NCBI Archive
Celera2040,888,320 - 40,916,496 (-)RGD
HuRef2040,921,269 - 40,949,426 (-)RGD
CHM1_12044,082,355 - 44,110,529 (-)NCBI
T2T-CHM13v2.02047,287,009 - 47,315,139 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017028119   ⟹   XP_016883608
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382045,552,089 - 45,579,284 (-)NCBI
Sequence:
RefSeq Acc Id: XM_054324197   ⟹   XP_054180172
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.02047,287,943 - 47,315,139 (-)NCBI
RefSeq Acc Id: NP_852611   ⟸   NM_181510
- Peptide Label: precursor
- UniProtKB: Q5TDV2 (UniProtKB/Swiss-Prot),   E1P623 (UniProtKB/Swiss-Prot),   Q96A34 (UniProtKB/Swiss-Prot),   Q8IUA0 (UniProtKB/Swiss-Prot),   A0A140VK68 (UniProtKB/TrEMBL),   A0A0K0K1J0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_570966   ⟸   NM_130896
- Peptide Label: precursor
- UniProtKB: Q5TDV2 (UniProtKB/Swiss-Prot),   E1P623 (UniProtKB/Swiss-Prot),   Q96A34 (UniProtKB/Swiss-Prot),   Q8IUA0 (UniProtKB/Swiss-Prot),   A0A140VK68 (UniProtKB/TrEMBL),   A0A0K0K1J0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016883608   ⟸   XM_017028119
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSP00000289953   ⟸   ENST00000289953
Ensembl Acc Id: ENSP00000361735   ⟸   ENST00000357199
RefSeq Acc Id: XP_054180172   ⟸   XM_054324197
- Peptide Label: isoform X1
Protein Domains
BPTI/Kunitz inhibitor   WAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8IUA0-F1-model_v2 AlphaFold Q8IUA0 1-241 view protein structure

Promoters
RGD ID:13207085
Promoter ID:EPDNEW_H27123
Type:initiation region
Name:WFDC8_1
Description:WAP four-disulfide core domain 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382045,579,283 - 45,579,343EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:16163 AgrOrtholog
COSMIC WFDC8 COSMIC
Ensembl Genes ENSG00000158901 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000289953 ENTREZGENE
  ENST00000289953.3 UniProtKB/Swiss-Prot
  ENST00000357199 ENTREZGENE
  ENST00000357199.8 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.410.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.75.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000158901 GTEx
HGNC ID HGNC:16163 ENTREZGENE
Human Proteome Map WFDC8 Human Proteome Map
InterPro Elafin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kunitz_BPTI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kunitz_BPTI_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prtase_inh_Kunz-CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WFDC8/12/15B-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:90199 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 90199 ENTREZGENE
PANTHER PTHR47769 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Kunitz_BPTI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA25713 PharmGKB
PRINTS 4DISULPHCORE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BASICPTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BPTI_KUNITZ_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BPTI_KUNITZ_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00131 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57256 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57362 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0K0K1J0 ENTREZGENE, UniProtKB/TrEMBL
  A0A140VK68 ENTREZGENE, UniProtKB/TrEMBL
  E1P623 ENTREZGENE
  Q5TDV2 ENTREZGENE
  Q8IUA0 ENTREZGENE
  Q96A34 ENTREZGENE
  WFDC8_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary E1P623 UniProtKB/Swiss-Prot
  Q5TDV2 UniProtKB/Swiss-Prot
  Q96A34 UniProtKB/Swiss-Prot