Wfdc8 (WAP four-disulfide core domain 8)

Gene: Wfdc8 (WAP four-disulfide core domain 8) Ictidomys tridecemlineatus

Analyze

Symbol:

Wfdc8

Name:

WAP four-disulfide core domain 8

RGD ID:

12644096

Description:

ENCODES a protein that exhibits serine-type endopeptidase inhibitor activity (inferred); ASSOCIATED WITH focal epilepsy (ortholog); genetic disease (ortholog); T-Cell Immunodeficiency, Recurrent Infections, and Autoimmunity with or without Cardiac Malformations (ortholog); FOUND IN extracellular region (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

WAP four-disulfide core domain protein 8

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	191,914,351 - 191,929,038 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936514	7,367,994 - 7,381,900 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

focal epilepsy (ISO)

genetic disease (ISO)

T-Cell Immunodeficiency, Recurrent Infections, and Autoimmunity with or without Cardiac Malformations (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

extracellular region (IEA)

Molecular Function

serine-type endopeptidase inhibitor activity (IEA)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Wfdc8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	191,914,351 - 191,929,038 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936514	7,367,994 - 7,381,900 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

WFDC8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	45,551,152 - 45,579,284 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	45,551,153 - 45,579,326 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	44,179,791 - 44,207,923 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	43,613,205 - 43,641,379 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	43,613,204 - 43,641,379	NCBI
Celera	20	40,888,320 - 40,916,496 (-)	NCBI		Celera
Cytogenetic Map	20	q13.12	NCBI
HuRef	20	40,921,269 - 40,949,426 (-)	NCBI		HuRef
CHM1_1	20	44,082,355 - 44,110,529 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	20	47,287,009 - 47,315,139 (-)	NCBI		T2T-CHM13v2.0

Wfdc8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	164,438,378 - 164,455,545 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	164,438,378 - 164,455,546 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	164,596,458 - 164,613,626 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	164,596,458 - 164,613,626 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	164,422,713 - 164,439,126 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	164,287,663 - 164,304,831 (-)	NCBI		MGSCv36	mm8
Celera	2	170,533,878 - 170,550,009 (-)	NCBI		Celera
Cytogenetic Map	2	H3	NCBI
cM Map	2	85.22	NCBI

Wfdc8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	173,742,844 - 173,759,188 (-)	NCBI		GRCr8
mRatBN7.2	3	153,323,503 - 153,339,849 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	153,324,413 - 153,339,842 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	157,136,373 - 157,145,564 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	165,635,334 - 165,644,529 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	163,378,963 - 163,388,156 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	161,058,217 - 161,067,358 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	161,058,217 - 161,067,358 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	167,236,337 - 167,245,727 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	155,621,234 - 155,630,837 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	151,935,618 - 151,944,730 (-)	NCBI		Celera
Cytogenetic Map	3	q42	NCBI

Wfdc8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955445	11,666,987 - 11,682,180 (+)	NCBI	ChiLan1.0	ChiLan1.0

WFDC8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	51,290,558 - 51,318,067 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	51,283,667 - 51,311,176 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	41,888,066 - 41,915,619 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	42,977,183 - 43,004,718 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	42,978,055 - 42,990,413 (-)	Ensembl	panpan1.1		panPan2

WFDC8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	32,813,432 - 32,829,108 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	32,814,662 - 32,823,340 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
ROS_Cfam_1.0	24	33,524,392 - 33,539,732 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	24	32,785,490 - 32,800,760 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	32,901,186 - 32,916,477 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	33,445,521 - 33,460,785 (-)	NCBI		UU_Cfam_GSD_1.0

WFDC8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	47,862,615 - 47,876,464 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	47,863,302 - 47,877,267 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	53,509,346 - 53,528,378 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

WFDC8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	18,261,347 - 18,287,264 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	18,275,771 - 18,286,403 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	66,902,665 - 66,928,486 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Wfdc8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624790	8,860,940 - 8,868,261 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624790	8,859,310 - 8,868,261 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005325382	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010003700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_005325382 ⟹ XP_005325439

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024408640	191,914,351 - 191,929,038 (+)	NCBI
SpeTri2.0	NW_004936514	7,367,994 - 7,381,900 (+)	NCBI

Sequence:

show sequence

ATGCAGCAGATCACACTATGCCACTGGGATGAAGAGGTTGTGAACAAGCTCTCAACCACGAAAA
CAGGACCTGGGATTGGGCGTTCTCCAAGTGGGGGAGCACTCCTTTCAAGTGCAAAATGCTTCTC
AGTTTACTACAAGGAGAAACTTCTGCCATCTGGAAAGTCTGGGCCAAAAGAACTAAGGGGTTCT
GGGGGATCCCCGGGAAGGCTCCTCTGCACACTTTGTGCCTCCTCTGGATCATGCCTCACACGGA
TCCCTCTTCTCTCACACATCTGCCCTTCTCTCCACAGCCCCGCCTTCTCTTGGAGGAATGTAGC
TCTCCTGCTGCTTCTCCCTCTCTCTTTGGAGCAGACTTCTGCATCGCAGTCCAACAAGATCAAA
GTGAAACCTGGAGAGTGCCCCAGAGAGCGGCTCTTCTGTGACGTCATGAGGCCGGATTTATGCA
AATCGGATTTCAACTGCCCAGATTACATGAAGTGCTGCACTTTTGCCTGTGGGAGGAAGTGCAT
GGATCCATATGAAGAACCCTGCATGCTACCCTTTAAAGAAGGAGACTGCAGGATGAGACTGCAG
CGTTGGTATTATGACTTTAAAAAACAGGAGTGTAGAACCTTTATCTATCATGGCTGCCAAGGGA
ACGCCAACAACTTCCTCAGGCTGGATGACTGCAAGAAGGCCTGCATGTTAATTGTCAAGAAAGG
ACAGTGCCCACTCTTCCCTTACACCTCTCGAATGGAGTGTCCAAAGCCATGTAAGAATGACATG
GATTGCCTGATGACAGAAAAATGCTGTGACTCCAGGTGTGGTTTTGTTTGTGCCAACCTCTGGC
AAGTCAAACCAGGTTTTTGCCCACGTATGCCTCAGATGTGTAAAAAGATTAGTAAACCAATGTG
CCTTCAGGATAGCGATTGCCCAGAGGGGGAGAAGTGCTGTTCACGCTGTGGACTGATGTGCTTG
GCACCCTGGAAATGA

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Protein Sequences


Protein RefSeqs	XP_005325439	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000009157.3
GenBank Protein	KAG3263554	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005325439 ⟸ XM_005325382

- UniProtKB:

I3MF15 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MQQITLCHWDEEVVNKLSTTKTGPGIGRSPSGGALLSSAKCFSVYYKEKLLPSGKSGPKELRGS
GGSPGRLLCTLCASSGSCLTRIPLLSHICPSLHSPAFSWRNVALLLLLPLSLEQTSASQSNKIK
VKPGECPRERLFCDVMRPDLCKSDFNCPDYMKCCTFACGRKCMDPYEEPCMLPFKEGDCRMRLQ
RWYYDFKKQECRTFIYHGCQGNANNFLRLDDCKKACMLIVKKGQCPLFPYTSRMECPKPCKNDM
DCLMTEKCCDSRCGFVCANLWQVKPGFCPRMPQMCKKISKPMCLQDSDCPEGEKCCSRCGLMCL
APWK

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Protein Domains

BPTI/Kunitz inhibitor WAP

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000010208	UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000010207.3	UniProtKB/TrEMBL
Gene3D-CATH	4.10.410.10	UniProtKB/TrEMBL
	4.10.75.10	UniProtKB/TrEMBL
InterPro	Elafin-like_sf	UniProtKB/TrEMBL
	Kunitz_BPTI	UniProtKB/TrEMBL
	Kunitz_BPTI_sf	UniProtKB/TrEMBL
	Prtase_inh_Kunz-CS	UniProtKB/TrEMBL
	WAP_dom	UniProtKB/TrEMBL
	WFDC8/12/15B-like	UniProtKB/TrEMBL
NCBI Gene	Wfdc8	ENTREZGENE
PANTHER	PTHR47769	UniProtKB/TrEMBL
	WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 8	UniProtKB/TrEMBL
Pfam	Kunitz_BPTI	UniProtKB/TrEMBL
	WAP	UniProtKB/TrEMBL
PRINTS	4DISULPHCORE	UniProtKB/TrEMBL
	BASICPTASE	UniProtKB/TrEMBL
PROSITE	BPTI_KUNITZ_1	UniProtKB/TrEMBL
	BPTI_KUNITZ_2	UniProtKB/TrEMBL
	WAP	UniProtKB/TrEMBL
SMART	SM00131	UniProtKB/TrEMBL
	WAP	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57256	UniProtKB/TrEMBL
	SSF57362	UniProtKB/TrEMBL
UniProt	I3MF15	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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