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Gene: Mmrn2 (multimerin 2) Mus musculus

Analyze

Symbol:

Mmrn2

Name:

multimerin 2

RGD ID:

1322934

MGI Page

MGI

Description:

Predicted to enable receptor ligand activity. Predicted to be an extracellular matrix structural constituent. Involved in cell migration involved in sprouting angiogenesis; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; and positive regulation of defense response to bacterium. Located in basement membrane. Is expressed in several structures, including cardiovascular system; early conceptus; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human MMRN2 (multimerin 2).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

AA986839; elastin microfibril interfacer 3; Emi; Emilin3; ENDOGL; EndoGly; EndoGlyx-1; ENDOGLYX1; MGC41271; multimerin-2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MMRN2 (multimerin 2)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Mmrn2 (multimerin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mmrn2 (multimerin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MMRN2 (multimerin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MMRN2 (multimerin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mmrn2 (multimerin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MMRN2 (multimerin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MMRN2 (multimerin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mmrn2 (multimerin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Mmrn2 (multimerin 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	MMRN2 (multimerin 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mmrn2b (multimerin 2b)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	mmrn2a (multimerin 2a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	mmrn2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	34,097,461 - 34,126,244 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	34,097,422 - 34,126,244 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	34,375,504 - 34,404,287 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	34,375,465 - 34,404,287 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	35,188,690 - 35,217,473 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	33,204,621 - 33,232,834 (+)	NCBI		MGSCv36	mm8
Celera	14	30,641,747 - 30,669,702 (+)	NCBI		Celera
Cytogenetic Map	14	B	NCBI
cM Map	14	20.81	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

juvenile polyposis syndrome (ISO)

PTEN hamartoma tumor syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (EXP)

1,2-dimethylhydrazine (EXP)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dinitrotoluene (ISO)

4,4'-sulfonyldiphenol (EXP)

4-hydroxyphenyl retinamide (EXP)

aflatoxin B1 (ISO)

alpha-Zearalanol (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (ISO)

benzo[a]pyrene (EXP,ISO)

benzo[b]fluoranthene (EXP)

bisphenol A (EXP)

bisphenol F (EXP)

carbon nanotube (EXP)

chloroprene (EXP)

chlorpyrifos (EXP)

chrysene (EXP)

decabromodiphenyl ether (ISO)

dibenz[a,h]anthracene (EXP)

dimethylselenide (ISO)

ethanol (EXP)

folic acid (ISO)

furan (ISO)

lipopolysaccharide (EXP,ISO)

mitomycin C (EXP)

N-methyl-4-phenylpyridinium (EXP)

oxaliplatin (ISO)

ozone (EXP,ISO)

paracetamol (ISO)

perfluorooctanoic acid (ISO)

potassium dichromate (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sulforaphane (ISO)

tetraphene (EXP)

titanium dioxide (ISO)

topotecan (ISO)

triclosan (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

angiogenesis (ISO)

cell adhesion (NAS)

cell migration involved in sprouting angiogenesis (IMP)

negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis (IDA,ISO)

negative regulation of cell migration (ISO)

negative regulation of cell migration involved in sprouting angiogenesis (IBA,IEA,ISO)

negative regulation of cell population proliferation (IDA,ISO)

negative regulation of vascular endothelial growth factor receptor signaling pathway (IBA,IEA,ISO)

positive regulation of defense response to bacterium (IDA)

positive regulation of epithelial tube formation (ISO)

positive regulation of morphogenesis of an epithelium (ISO)

signal transduction (IEA)

Cellular Component

basement membrane (IDA)

collagen-containing extracellular matrix (HDA,ISO)

extracellular matrix (TAS)

extracellular space (ISO,ISS)

multimerin complex (ISS)

Molecular Function

extracellular matrix structural constituent (RCA)

protein binding (IPI)

receptor ligand activity (IEA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal retina blood vessel morphology (IAGP)

abnormal tumor vascularization (IAGP)

increased vascular permeability (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8889548	PMID:10349636	PMID:11042159	PMID:11076861	PMID:11217851	PMID:12221002	PMID:12477932	PMID:14610273	PMID:14996434	PMID:15489334	PMID:16141072	PMID:16141073
PMID:17988845	PMID:18411305	PMID:18757743	PMID:21267068	PMID:21873635	PMID:22020326	PMID:22159717	PMID:25745997	PMID:28526753	PMID:31422156	PMID:32291340	PMID:32325033
PMID:37196079

Genomics

Comparative Map Data

Mmrn2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	34,097,461 - 34,126,244 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	34,097,422 - 34,126,244 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	34,375,504 - 34,404,287 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	34,375,465 - 34,404,287 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	35,188,690 - 35,217,473 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	33,204,621 - 33,232,834 (+)	NCBI		MGSCv36	mm8
Celera	14	30,641,747 - 30,669,702 (+)	NCBI		Celera
Cytogenetic Map	14	B	NCBI
cM Map	14	20.81	NCBI

MMRN2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	86,935,540 - 86,957,615 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	86,935,540 - 86,969,481 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	88,695,297 - 88,717,372 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	88,685,576 - 88,707,352 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	88,685,575 - 88,707,352	NCBI
Celera	10	82,698,335 - 82,720,425 (-)	NCBI		Celera
Cytogenetic Map	10	q23.2	NCBI
HuRef	10	82,549,122 - 82,571,213 (-)	NCBI		HuRef
CHM1_1	10	88,977,037 - 88,999,158 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	10	87,819,295 - 87,841,328 (-)	NCBI		T2T-CHM13v2.0

Mmrn2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	9,712,181 - 9,733,653 (+)	NCBI		GRCr8
mRatBN7.2	16	9,705,925 - 9,727,405 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	9,705,892 - 9,727,405 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	9,726,090 - 9,747,526 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	10,870,804 - 10,892,240 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	9,721,171 - 9,742,604 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	10,727,552 - 10,749,303 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	10,727,571 - 10,749,382 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	9,055,337 - 9,075,346 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	10,031,365 - 10,052,169 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	10,031,524 - 10,051,725 (+)	NCBI
Celera	16	5,489,507 - 5,510,959 (-)	NCBI		Celera
Cytogenetic Map	16	p15	NCBI

Mmrn2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955510	5,945,043 - 5,958,352 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955510	5,943,126 - 5,957,679 (-)	NCBI	ChiLan1.0	ChiLan1.0

MMRN2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	98,930,555 - 98,966,505 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	98,935,874 - 98,971,822 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	83,363,696 - 83,396,966 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	86,920,521 - 86,956,333 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	86,920,521 - 86,942,777 (-)	Ensembl	panpan1.1		panPan2

MMRN2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	34,577,072 - 34,604,521 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	34,589,597 - 34,605,576 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	34,580,472 - 34,595,946 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	34,949,417 - 34,964,896 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	34,950,035 - 34,964,843 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	34,795,071 - 34,810,534 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	34,964,039 - 34,979,464 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	35,469,876 - 35,485,332 (-)	NCBI		UU_Cfam_GSD_1.0

Mmrn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	43,912,229 - 43,930,881 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936804	22,533 - 39,540 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936804	22,609 - 39,974 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MMRN2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	87,896,074 - 87,916,342 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	87,891,585 - 87,916,327 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	95,292,539 - 95,308,417 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MMRN2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	44,913,403 - 44,934,430 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	44,913,455 - 44,935,112 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	5,020,595 - 5,042,314 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mmrn2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624841	197,547 - 210,132 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624841	196,708 - 212,499 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Mmrn2
1165 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	320
Count of miRNA genes:	240
Interacting mature miRNAs:	268
Transcripts:	ENSMUST00000111908
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1357589	Kdnw2_m	kidney weight 2 (mouse)			Not determined		14	20887473	121269804	Mouse
27226748	Femd8_m	femur midshaft diameter 8, 10 week (mouse)					14	13769273	46737457	Mouse
1357527	Epfpq1_m	epididymal fat percentage QTL 1 (mouse)			Not determined		14	21062450	71885801	Mouse
27226744	Metcl6_m	metatarsal-calcaneal length 6, 5 week (mouse)					14	30321957	52937457	Mouse
27226775	Tibl7_m	tibia length 7, 5 week (mouse)					14	30321957	48837457	Mouse
27226774	Tibl15_m	tibia length 15, 10 week (mouse)					14	30321957	87937436	Mouse
4142485	Modor2_m	modifier of ocular retardation 2 (mouse)			Not determined		14	24926248	58179769	Mouse
27226737	Metcl12_m	metatarsal-calcaneal length 12, 10 week (mouse)					14	33221957	59437449	Mouse
1301372	Sluc13_m	susceptibility to lung cancer 13 (mouse)			Not determined		14	18827604	52827726	Mouse
14696688	Rfq2_m	rearing frequency QTL 2, males (mouse)					14	33721957	35721957	Mouse
4141550	Dbm3_m	diabetes modifier 3 (mouse)			Not determined			5143473	39143596	Mouse
1300544	Hypn_m	hyperinsulinemia (mouse)			Not determined		14	15160616	49160765	Mouse
1301991	Wta3_m	weight adult 3 (mouse)			Not determined		14	3887473	37887650	Mouse
1300998	Cia17_m	collagen induced arthritis 17 (mouse)			Not determined		14	30335250	64335381	Mouse
4141864	Mrdq4_m	modifier of retinal degeneration QTL 4 (mouse)			Not determined			9923245	48765082	Mouse
10043886	Cia49_m	collagen induced arthritis QTL 49 (mouse)			Not determined		14	29996994	63997133	Mouse
1300779	Dyscalc4_m	dystrophic cardiac calcinosis 4 (mouse)			Not determined		14	12212871	46213007	Mouse
27226727	Tibl21_m	tibia length 21, 16 week (mouse)					14	34121957	52937457	Mouse
14746973	Manh76_m	mandible shape 76 (mouse)					14	22287217	56287217	Mouse
1300909	Ath13_m	atherosclerosis 13 (mouse)			Not determined		14	30335250	64335381	Mouse
27226752	Femd4_m	femur midshaft diameter 4, 5 week (mouse)					14	13769273	47237457	Mouse
13506929	Recrq10_m	recombination rate in male meiosis QTL 10 (mouse)					14	27921957	61137449	Mouse

Markers in Region

AA986839

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	14	34,403,601 - 34,403,714	UniSTS	GRCm38
MGSCv37	14	35,216,787 - 35,216,900	UniSTS	GRCm37
Celera	14	30,669,016 - 30,669,129	UniSTS
Cytogenetic Map	14	B	UniSTS
Whitehead/MRC_RH	14	301.79	UniSTS

UniSTS:237166

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	14	34,402,988 - 34,403,227	UniSTS	GRCm38
MGSCv37	14	35,216,174 - 35,216,413	UniSTS	GRCm37
Celera	14	30,668,403 - 30,668,642	UniSTS
Cytogenetic Map	14	B	UniSTS

UniSTS:237167

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	14	34,404,060 - 34,404,268	UniSTS	GRCm38
MGSCv37	14	35,217,246 - 35,217,454	UniSTS	GRCm37
Celera	14	30,669,475 - 30,669,683	UniSTS
Cytogenetic Map	14	B	UniSTS

PMC262405P1

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	14	34,375,848 - 34,376,338	UniSTS	GRCm38
MGSCv37	14	35,189,034 - 35,189,524	UniSTS	GRCm37
Celera	14	30,642,091 - 30,642,581	UniSTS
Cytogenetic Map	14	B	UniSTS
Cytogenetic Map	14	B-C	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_153127	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC160930	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK077884	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK078470	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK134285	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC034871	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC145845	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466573	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSMUST00000111908 ⟹ ENSMUSP00000107539

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	14	34,097,422 - 34,126,244 (+)	Ensembl
GRCm38.p6 Ensembl	14	34,375,465 - 34,404,287 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000227130 ⟹ ENSMUSP00000153972

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	14	34,097,678 - 34,119,885 (+)	Ensembl
GRCm38.p6 Ensembl	14	34,375,721 - 34,397,928 (+)	Ensembl

RefSeq Acc Id:

NM_153127 ⟹ NP_694767

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	14	34,097,461 - 34,126,244 (+)	NCBI
GRCm38	14	34,375,504 - 34,404,287 (+)	ENTREZGENE
MGSCv37	14	35,188,690 - 35,217,473 (+)	RGD
Celera	14	30,641,747 - 30,669,702 (+)	RGD
cM Map	14		ENTREZGENE

Sequence:

show sequence

TTTGTTGTCCTCGTGTTTTCTTTTCTTTCTGACATTTCGCTTGAAGACCACATCACCAGCAAAT
TTGAGAGTCACTTGTAAGGCTGAGCATCAGCACAGGAGCCCCTCACCATGATCCCGACACTGCT
GCTGGGCTTTGGGGTGTACCTGAGCTGGGGACTGCTAGGGTCCTGGGCACAGGACCCCGGTACC
AAGTTCTCCCATCTCAATAGGCCCGGCATGCCTGAAGGCTGGAGACTAGGGGCTGAGGATACCA
GCAGAGACCCCATCAGACGGAACTGGTGTCCTTACCAGAAGTCCAGGCTAGTCACCTTTGTAGC
TGCTTGCAAAACAGAGAAATTCCTGGTCCATTCACAGCAGCCATGTCCACAGGGAGCCCCTGAC
TGCCAGGGAGTCAGAGTCATGTATCGAGTGGCCCAGAAGCCAGTGTACCAGGTCCAGCAGAAGG
TGCTGATCTCTGTGGACTGGCGGTGCTGCCCAGGGTTCCAGGGACCAGACTGCCAGGACCACAA
TCCCACAGCAAACCCTGAGCCCACAGAGCCAAGTGGTAAACTCCAGGAGACTTGGGACTCGATG
GATGGCTTTGAACTTGGTCACCCTGTCCCAGAGTTTAATGAGATTAAGGTGCCACAAGAACAAC
AGGAAAACCTGCTTCAAAATCTCCAGAATGATGCCCAGTCAGTAGAAGATGGCTTTCCAGGCTC
TTGGGAAGCCCCACCCAGCAACCTCACAGATGAGATGACAGAAGCCAATCTAACAGAATTCGAG
TTTCCTGGCAGGACATCAGAGCACCTGCTGCAGCCCCATATTGATGCATTCCTGAAAGCACACT
TCAGTCCCATCTGGAAGAACTTCAACGACAGCTTGCACAGCCTCTCCCAGGCCATCAGAAACTT
GTCTCTTGATGTGGAGGCCAATCACCAGGCCATCAAGATGATCCAGGAGGGCACAGTGGCTAGG
GCTGACTTCCAAGAGCTTGGTGCCAAGTTTGAGGCCAAGGTCCAGCAGAATAGCCAGAGACTGG
GCCAACTGTGGCAGGATGTGGAGGACCAGCTGCATGCCCAGCGCCGATCGGTGCATCATGCCCT
CTCTGATGTCCAGGCTGAGGTGAGCACCAAGTTAAAGCAGCTTGTCAAGGCTCAGGAACTTCCA
GGGGCCAATGGCAGCCTGGTGATGGCATCTGCAGCAGCGGCAGCAAGGCCAGAGCCAGAGAGCC
TGCAGGCCAGGCTAGGGCAGCTGCAGAGAAACCTCTCTGCTCTGCACATGGTCACTAGCCAGAG
GGAGGAGGAGTTGCAGAGCACCCTCAAGAACATGGACAGCGTCCTGAAGCAGCACGCCGAAGAG
ATCAAAGAGCTCTATTCTGAATCGGATGAGACCTTCGACCAGATCAGCAAGGTAGAGAGGCAGG
TGGAGGAGCTGCTGGTGAACCACACCGGGCTTCGAGAGCTGCGGGTGATCCTAATGGAAAAGTC
CCTGATCATGGAGGAGAACAAAGAGGAGATAGAGCGGCAACTGTTGGAACTCAACCTTACCCTG
CAGCATCTGCATGCGGGTCATGCAGACCTCATTAAGTATGTCAAGGACTGCAACTGCCAAAGGG
TCAACTCTGACGTGGATGTCGCTCCGGAGGGCCACAGGGATGTCATGCACACCCTAGAAGAGAC
CCAAGTGAGCCTGGACGAACAGCACCAGCTAGACGGTTCTTCTTTGCAGGCCCTGCAAAGCACT
GTAGATGCCATGTCTTCAGCAATGGATGCCTATAGAGGAGAGGGTGAACGGGCCCGGGCTGAAA
GGGCACGGATACGGAGCCAACTGCGGGCTCTGGATCATGCTGTGGAAGCGCTGAAGACAGCGGC
GAATGGAACCCGCAAAGAGATACGCCTACTGCACGGCTCCTTCACAGCCCTGCTGGAGGATGCC
CTGCGACATCAGGCCGTGCTAGCTGCACTCTTCGGGGAGGAGATGATAGACGAGATGTCAGAGG
AGGCCCCTCGCCCTCTGCCACTGGATTATGAGCAGATCCGCCTAGCCCTGCAGGACGCGGCCAG
TGGGCTACAGGAACAGGCGATTGGTTGGGAGGACTTGGCCACCCGGGTGGAGGCATTGGAGAAG
GCCGCAGGTGGCTTTGTGGAGCAGCACCCACAGTTGGCAGAGGGACTTGAGCCCAGCCACGACT
CTGGGAGAGAGGAGGAAGCCATGACTTTGGCGGAGCTGGAGCAGGAGATTCGGCGCCTGAGTTC
TGATGTCAAGCAGATTGGGCAGTGCTGTGAGGCCTCCTGGGCTGCCTCCCTCAATAGCTCCCTT
GAAGACCTACACAGCATGCTCTTGGACACCCAGCACGGCCTGAGACAGCACCGGCAGCTCTTCC
ACAACCTCTTCCAGAACTTCCAAGGTCTGGTGGCAAGCAACATCAGCCTAGACTTGGGGAAGCT
GCAGGCCATGTTGAGTAAGAAAGATAAGAAGCAACCGAGAGGCCCAGGAGAATCCCGGAAGAGG
GATAAGAAGCAAGTGGTGATGTCTACAGATGCACACGCCAAAGGTCTGGAGCTCTGGGAGACAG
GCTCCCCTGTGGCCTTCTATGCCGGTTCTTCAGAAGGGGCCACTGCTCTGCAGATGGTGAAGTT
CAACACCACATCCATCAATGTGGGCAGCAGCTACTTTCCTGAACATGGCTACTTCCGAGCTCCC
AAACGTGGCGTCTACTTGTTTGCTGTGAGCATTACATTTGGCCCAGGCCCAGGAATGGGGCAGC
TGGTATTTGAAGGTCATCACCGGGTTCCAGTCTACAGTACGGAACAGAGGGGCGGGAGCACAGC
CACCACTTTTGCTATGGTAGAGCTACAAAAGGGTGAGAGAGCGTGGTTTGAGTTAATCCAAGGG
TCAGCAACCAAAGGGAGCCAACCAGGCACTGCATTTGGGGGCTTCCTGATGTTCAAGACCTGAA
CCCTGGGCTCGGCTCAGCTTGTATCAGACATGGTAGATCCGCCTGCTGCTCTTAGACTGAGGCT
CTGGCCAGCAAAGGCTGGAGAACATCTAGTGGCCTAGCTCTTCCCTGGACACCTTCTGCAAAGA
CCCTGCGGCCAGCAGCACGTACCTTCTTCTGGACACACAGGTTGGGGAGGCCAGAATACTGCTC
TCTGGACTGGGCCGGGGCCTGGAGTGGGAGCTGGGATTTCCATGCCTTCCCCAATGGCACGGCT
CGGCTTGTCTCTGAGACACTTCCTCAGTTCTACAGCTTTTCTTTTTCTCTCCCTTGTGGTTGGA
AACTTGTACACTTACGCCTTTTTCGGTTTCCACTTTTCTGTGTTAGAAAGTCACTGTTTCTCAG
AAGGAATGTCTACAGTGATGGGTTTGCCATGCAGAAAGGTCCCAGATTCTCTTTCCAATGTCTC
AAAAAAAAAAAAAAAAAAAAAAAAAAGAAGAAGAAGAAGAAAATGAAGATTTTTTTTTTACCCC
CCCCCCCCCCATGAAACTGGAAACAGGTCTCCAATTACTACAGAAAAGCTAATCAAAAACAGTC
TTTCTAGTTTCAGAAGGGAGCCAACACATGGTTGAATTAGCCCTGGGTCCAGTCTCCAGCACTG
TGCACACCTATGGTCTCAGCATATGGAGTAAGCATGAAGTTCAGAGCTATCCTCAGCTTCATAA
CAAGTTCAAGGCTAGCCTGGGATATGGGAGACCCTGTCTCAAAACAGCAAAAGAAGTTACATTA
ACTCCCAGCCACACTTTGTCTTTGTTTATTTAATTTTAATATCACGCCCTGCTTCACTCTGTAA
AGGCCAACATATCAAATAGGGACAATGTTGTGCATGGCCTTCACCCTTCTTATTCATCTATCAA
GACTGTGCCAACCCCAGCATCTCTAAGGAAGGGAAGGAGGGAAATTAAACCCTACTGGTAGTGA
CCGACTTTGGAATAAAGTGATACTCTCCAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_694767	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	A6H6E2	(Get FASTA)	NCBI Sequence Viewer
	AAH34871	(Get FASTA)	NCBI Sequence Viewer
	AAI45846	(Get FASTA)	NCBI Sequence Viewer
	BAC37291	(Get FASTA)	NCBI Sequence Viewer
	EDL24878	(Get FASTA)	NCBI Sequence Viewer
	EDL24879	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000107539
	ENSMUSP00000107539.2
	ENSMUSP00000153972.2

RefSeq Acc Id:	NP_694767 ⟸ NM_153127
- Peptide Label:	precursor
- UniProtKB:	Q8BJX4 (UniProtKB/Swiss-Prot), Q8K1Z7 (UniProtKB/Swiss-Prot), A6H6E2 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MIPTLLLGFGVYLSWGLLGSWAQDPGTKFSHLNRPGMPEGWRLGAEDTSRDPIRRNWCPYQKSR LVTFVAACKTEKFLVHSQQPCPQGAPDCQGVRVMYRVAQKPVYQVQQKVLISVDWRCCPGFQGP DCQDHNPTANPEPTEPSGKLQETWDSMDGFELGHPVPEFNEIKVPQEQQENLLQNLQNDAQSVE DGFPGSWEAPPSNLTDEMTEANLTEFEFPGRTSEHLLQPHIDAFLKAHFSPIWKNFNDSLHSLS QAIRNLSLDVEANHQAIKMIQEGTVARADFQELGAKFEAKVQQNSQRLGQLWQDVEDQLHAQRR SVHHALSDVQAEVSTKLKQLVKAQELPGANGSLVMASAAAAARPEPESLQARLGQLQRNLSALH MVTSQREEELQSTLKNMDSVLKQHAEEIKELYSESDETFDQISKVERQVEELLVNHTGLRELRV ILMEKSLIMEENKEEIERQLLELNLTLQHLHAGHADLIKYVKDCNCQRVNSDVDVAPEGHRDVM HTLEETQVSLDEQHQLDGSSLQALQSTVDAMSSAMDAYRGEGERARAERARIRSQLRALDHAVE ALKTAANGTRKEIRLLHGSFTALLEDALRHQAVLAALFGEEMIDEMSEEAPRPLPLDYEQIRLA LQDAASGLQEQAIGWEDLATRVEALEKAAGGFVEQHPQLAEGLEPSHDSGREEEAMTLAELEQE IRRLSSDVKQIGQCCEASWAASLNSSLEDLHSMLLDTQHGLRQHRQLFHNLFQNFQGLVASNIS LDLGKLQAMLSKKDKKQPRGPGESRKRDKKQVVMSTDAHAKGLELWETGSPVAFYAGSSEGATA LQMVKFNTTSINVGSSYFPEHGYFRAPKRGVYLFAVSITFGPGPGMGQLVFEGHHRVPVYSTEQ RGGSTATTFAMVELQKGERAWFELIQGSATKGSQPGTAFGGFLMFKT hide sequence

Ensembl Acc Id:

ENSMUSP00000107539 ⟸ ENSMUST00000111908

Ensembl Acc Id:

ENSMUSP00000153972 ⟸ ENSMUST00000227130

Protein Domains

C1q EMI

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A6H6E2-F1-model_v2	AlphaFold	A6H6E2	1-943	view protein structure

Promoters

RGD ID:

8681934

Promoter ID:

EPDNEW_M18998

Type:

initiation region

Name:

Mmrn2_1

Description:

Mus musculus multimerin 2 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	14	34,375,534 - 34,375,594	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:2385618	AgrOrtholog
Ensembl Genes	ENSMUSG00000041445	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000111908	ENTREZGENE
	ENSMUST00000111908.3	UniProtKB/Swiss-Prot
	ENSMUST00000227130.2	UniProtKB/TrEMBL
Gene3D-CATH	2.60.120.40	UniProtKB/Swiss-Prot
InterPro	C1q_dom	UniProtKB/Swiss-Prot
	Collagen/C1q_domain	UniProtKB/Swiss-Prot
	EMI_domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tumour_necrosis_fac-like_dom	UniProtKB/Swiss-Prot
KEGG Report	mmu:105450	UniProtKB/Swiss-Prot
MGD	MGI:2385618	ENTREZGENE
NCBI Gene	105450	ENTREZGENE
PANTHER	EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER	UniProtKB/Swiss-Prot
	MULTIMERIN-2	UniProtKB/Swiss-Prot
Pfam	C1q	UniProtKB/Swiss-Prot
	EMI	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Mmrn2	PhenoGen
PROSITE	C1Q	UniProtKB/Swiss-Prot
	EMI	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	C1Q	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF49842	UniProtKB/Swiss-Prot
UniProt	A0A2I3BPZ4_MOUSE	UniProtKB/TrEMBL
	A6H6E2	ENTREZGENE, UniProtKB/Swiss-Prot
	Q8BJX4	ENTREZGENE
	Q8K1Z7	ENTREZGENE
UniProt Secondary	Q8BJX4	UniProtKB/Swiss-Prot
	Q8K1Z7	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Mammalian Phenotype