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Gene: Serpine3 (serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3) Mus musculus

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Symbol:

Serpine3

Name:

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3

RGD ID:

1321460

MGI Page

MGI

Description:

Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be active in extracellular space. Orthologous to human SERPINE3 (serpin family E member 3).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

E130113E03Rik; serpin E3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SERPINE3 (serpin family E member 3)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Rattus norvegicus (Norway rat):	Serpine3 (serpin family E member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Serpine3 (serpin family E member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SERPINE3 (serpin family E member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SERPINE3 (serpin family E member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Serpine3 (serpin family E member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SERPINE3 (serpin family E member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SERPINE3 (serpin family E member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Serpine3 (serpin family E member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Serpine3 (serpin family E member 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	SERPINE3 (serpin family E member 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	serpine3 (serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn53F	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Drosophila melanogaster (fruit fly):	CG43366	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Drosophila melanogaster (fruit fly):	Spn31A	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	serpine3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	62,900,743 - 62,929,692 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	62,901,116 - 62,929,692 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	62,663,298 - 62,692,243 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	62,663,667 - 62,692,243 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	63,282,504 - 63,311,080 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	61,617,777 - 61,647,749 (+)	NCBI		MGSCv36	mm8
Celera	14	60,422,453 - 60,450,997 (+)	NCBI		Celera
Cytogenetic Map	14	D1	NCBI
cM Map	14	33.23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Serpine3	Mouse	chromosome 13q14 deletion syndrome		ISO	SERPINE3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Chromosome 13q14 deletion syndrome	ClinVar
Serpine3	Mouse	intellectual disability		ISO	SERPINE3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Intellectual disability	ClinVar
Serpine3	Mouse	Wilson disease		ISO	SERPINE3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Wilson disease	ClinVar	PMID:28492532

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Serpine3	Mouse	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	ISO	Serpine3 (Rattus norvegicus)	6480464	Tetrachlorodibenzodioxin results in decreased expression of SERPINE3 mRNA	CTD	PMID:33387578
Serpine3	Mouse	acrylamide	decreases expression	ISO	Serpine3 (Rattus norvegicus)	6480464	Acrylamide results in decreased expression of SERPINE3 mRNA	CTD	PMID:28959563
Serpine3	Mouse	aristolochic acid A	increases expression	ISO	SERPINE3 (Homo sapiens)	6480464	aristolochic acid I results in increased expression of SERPINE3 mRNA	CTD	PMID:33212167
Serpine3	Mouse	bisphenol A	decreases expression	ISO	Serpine3 (Rattus norvegicus)	6480464	bisphenol A results in decreased expression of SERPINE3 mRNA	CTD	PMID:25181051
Serpine3	Mouse	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of SERPINE3 mRNA	CTD	PMID:32156529
Serpine3	Mouse	cadmium atom	multiple interactions	ISO	SERPINE3 (Homo sapiens)	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SERPINE3 mRNA	CTD	PMID:35301059
Serpine3	Mouse	cadmium dichloride	multiple interactions	ISO	SERPINE3 (Homo sapiens)	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SERPINE3 mRNA	CTD	PMID:35301059
Serpine3	Mouse	cisplatin	decreases expression	ISO	SERPINE3 (Homo sapiens)	6480464	Cisplatin results in decreased expression of SERPINE3 mRNA	CTD	PMID:27392435
Serpine3	Mouse	cisplatin	multiple interactions	ISO	SERPINE3 (Homo sapiens)	6480464	[Cisplatin co-treated with jinfukang] results in decreased expression of SERPINE3 mRNA	CTD	PMID:27392435
Serpine3	Mouse	epoxiconazole	increases expression	EXP		6480464	epoxiconazole results in increased expression of SERPINE3 mRNA	CTD	PMID:35436446
Serpine3	Mouse	ethylparaben	decreases expression	ISO	SERPINE3 (Homo sapiens)	6480464	ethyl-p-hydroxybenzoate results in decreased expression of SERPINE3 mRNA	CTD	PMID:37690743
Serpine3	Mouse	Monobutylphthalate	decreases expression	ISO	Serpine3 (Rattus norvegicus)	6480464	monobutyl phthalate results in decreased expression of SERPINE3 mRNA	CTD	PMID:29162477
Serpine3	Mouse	paracetamol	decreases expression	ISO	SERPINE3 (Homo sapiens)	6480464	Acetaminophen results in decreased expression of SERPINE3 mRNA	CTD	PMID:26690555
Serpine3	Mouse	titanium dioxide	decreases expression	EXP		6480464	titanium dioxide results in decreased expression of SERPINE3 mRNA	CTD	PMID:29264374
Serpine3	Mouse	trichloroethene	decreases expression	ISO	Serpine3 (Rattus norvegicus)	6480464	Trichloroethylene results in decreased expression of SERPINE3 mRNA	CTD	PMID:33387578
Serpine3	Mouse	triclosan	increases expression	ISO	SERPINE3 (Homo sapiens)	6480464	Triclosan results in increased expression of SERPINE3 mRNA	CTD	PMID:30510588
Serpine3	Mouse	triptonide	increases expression	EXP		6480464	triptonide results in increased expression of SERPINE3 mRNA	CTD	PMID:33045310
Serpine3	Mouse	valproic acid	increases methylation	ISO	SERPINE3 (Homo sapiens)	6480464	Valproic Acid results in increased methylation of SERPINE3 gene	CTD	PMID:29154799

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Serpine3	Mouse	extracellular space	is_active_in	IBA	PANTHER:PTN000156123 more ...	2290270		GO_Central	GO_REF:0000033

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Serpine3	Mouse	serine-type endopeptidase inhibitor activity	enables	IBA	PANTHER:PTN000156127 more ...	2290270		GO_Central	GO_REF:0000033

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Serpine3	Mouse	abnormal auditory brainstem response		IEA		5509061		MGI

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

PMID:10349636	PMID:11042159	PMID:11076861	PMID:11217851	PMID:12466851	PMID:12904583	PMID:16141072	PMID:16141073	PMID:21873635	PMID:24172014	PMID:35727138

Serpine3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	62,900,743 - 62,929,692 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	62,901,116 - 62,929,692 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	62,663,298 - 62,692,243 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	62,663,667 - 62,692,243 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	63,282,504 - 63,311,080 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	61,617,777 - 61,647,749 (+)	NCBI		MGSCv36	mm8
Celera	14	60,422,453 - 60,450,997 (+)	NCBI		Celera
Cytogenetic Map	14	D1	NCBI
cM Map	14	33.23	NCBI

SERPINE3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	13	51,339,691 - 51,364,735 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	13	51,335,773 - 51,364,735 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	13	51,913,827 - 51,938,871 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	13	50,813,169 - 50,834,240 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	13	32,964,335 - 32,985,406 (+)	NCBI		Celera
Cytogenetic Map	13	q14.3	NCBI
HuRef	13	32,704,249 - 32,725,482 (+)	NCBI		HuRef
CHM1_1	13	51,882,676 - 51,903,771 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	13	50,554,612 - 50,579,655 (+)	NCBI		T2T-CHM13v2.0

Serpine3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	41,084,819 - 41,109,006 (+)	NCBI		GRCr8
mRatBN7.2	15	36,908,816 - 36,931,825 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	36,907,131 - 36,933,150 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	15	45,827,983 - 45,855,952 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	45,834,302 - 45,858,335 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	49,600,587 - 49,622,250 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	41,917,864 - 41,942,032 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	15	36,588,819 - 36,616,791 (+)	NCBI		Celera
Cytogenetic Map	15	p12	NCBI

Serpine3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955431	4,694,654 - 4,727,080 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955431	4,694,654 - 4,727,080 (+)	NCBI	ChiLan1.0	ChiLan1.0

SERPINE3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	14	52,778,733 - 52,799,929 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	13	51,416,083 - 51,443,938 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	13	32,475,429 - 32,496,700 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	13	51,220,434 - 51,244,077 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	13	51,220,735 - 51,241,791 (+)	Ensembl	panpan1.1		panPan2

SERPINE3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	22	637,600 - 666,028 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	22	636,466 - 663,695 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	22	670,052 - 697,870 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	22	618,307 - 646,209 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	22	621,442 - 644,221 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	22	539,560 - 567,633 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	22	588,743 - 616,809 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	22	607,030 - 635,107 (-)	NCBI		UU_Cfam_GSD_1.0

Serpine3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	160,683,068 - 160,711,309 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936565	4,168,895 - 4,197,662 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936565	4,167,734 - 4,198,573 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SERPINE3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	11	16,466,475 - 16,500,541 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	11	16,465,521 - 16,500,580 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	11	16,805,221 - 16,839,092 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SERPINE3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	3	29,227,812 - 29,251,219 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	3	29,228,049 - 29,249,397 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666057	14,575,894 - 14,597,429 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Serpine3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624748	2,833,748 - 2,860,303 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Serpine3
1076 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	39
Count of miRNA genes:	36
Interacting mature miRNAs:	39
Transcripts:	ENSMUST00000171692
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1357589	Kdnw2_m	kidney weight 2 (mouse)			Not determined		14	20887473	121269804	Mouse
1300625	Cosz2_m	cocaine seizure 2 (mouse)			Not determined		14	35045797	68785736	Mouse
1301777	Bglq15_m	body growth late QTL 15 (mouse)			Not determined		14	42962416	76962593	Mouse
1301489	Lbm10_m	lean body mass 10 (mouse)			Not determined		14	53761296	87761529	Mouse
1357527	Epfpq1_m	epididymal fat percentage QTL 1 (mouse)			Not determined		14	21062450	71885801	Mouse
1301424	Skull21_m	skull morphology 21 (mouse)			Not determined		14	42962416	76962593	Mouse
4142364	Pbwg18_m	postnatal body weight growth 18 (mouse)			Not determined		14	52281984	86282125	Mouse
4141400	Nilac8_m	nicotine induced locomotor activity 8 (mouse)			Not determined		14	43065847	77066045	Mouse
10043889	Cia52_m	collagen induced arthritis QTL 52 (mouse)			Not determined		14	56082381	90082509	Mouse
27226774	Tibl15_m	tibia length 15, 10 week (mouse)					14	30321957	87937436	Mouse
1301562	Hwq1_m	heart weight quantitative locus 1 (mouse)			Not determined		14	56546745	90546941	Mouse
1357565	wrmod1_m	wobbler modifier 1 (mouse)			Not determined		14	58179640	101859473	Mouse
1300666	Fembm2_m	femoral bone morphometry 2 (mouse)			Not determined		14	62397460	96397680	Mouse
4142419	Tgq26_m	triglyceride QTL 26 (mouse)			Not determined			40337319	74337319	Mouse
1300605	El5_m	epilepsy 5 (mouse)			Not determined		14	49455425	83455556	Mouse
11039527	Ccc2_m	colitis susceptibility in the Collaborative Cross 2 (mouse)					14	59918612	94138217	Mouse
1301091	Bbaa21_m	B.burgdorferi-associated arthritis 21 (mouse)			Not determined		14	43065847	77066045	Mouse
12880432	Fgf23lq3_m	FGF23 serum level QTL 3 (mouse)					14	53937440	87937440	Mouse
1300998	Cia17_m	collagen induced arthritis 17 (mouse)			Not determined		14	30335250	64335381	Mouse
10043887	Cia50_m	collagen induced arthritis QTL 50 (mouse)			Not determined		14	37430185	71430320	Mouse
1300805	Mors3_m	modifier of obesity related sterility 3 (mouse)			Not determined		14	43037270	77037418	Mouse
10043886	Cia49_m	collagen induced arthritis QTL 49 (mouse)			Not determined		14	29996994	63997133	Mouse
1300909	Ath13_m	atherosclerosis 13 (mouse)			Not determined		14	30335250	64335381	Mouse

AI480962

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	14	62,690,601 - 62,690,744	UniSTS	GRCm38
MGSCv37	14	63,309,438 - 63,309,581	UniSTS	GRCm37
Celera	14	60,449,355 - 60,449,498	UniSTS
Cytogenetic Map	14	D1	UniSTS
Cytogenetic Map	14	C3	UniSTS
Whitehead/MRC_RH	14	694.37	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	NM_001199945	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017316054	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AK053602	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CT572983	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSMUST00000171692 ⟹ ENSMUSP00000125769

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	14	62,901,116 - 62,929,692 (+)	Ensembl
GRCm38.p6 Ensembl	14	62,663,667 - 62,692,243 (+)	Ensembl

RefSeq Acc Id:

NM_001199945 ⟹ NP_001186874

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	14	62,901,116 - 62,929,692 (+)	NCBI
GRCm38	14	62,663,667 - 62,692,243 (+)	NCBI
Celera	14	60,422,453 - 60,450,997 (+)	ENTREZGENE
cM Map	14		ENTREZGENE

Sequence:

show sequence

GGCACAAGAACAGAATCAAACAAGGAAACTACCATTTGATTAAAGAGTCGGTGTCCAGTCTCCATGCTGCCTCTCCTGCAGGTCACCTTCTTTCTTCTCTCCTCCTGCTTCTCAGCAGGAGGGGGCAG
CCCCCTCAGTGAAGGCCTGTGGCTGCTGAAGACTGAGTTTGCCCTCCACCTTTACCGGAGTGCAGCAGCAGAGAGAAACGGGACAAACTTCGTCATCTCACCGGCCAGTGTGTCCCTCTCCCTGGAGA
TCCTGCAGTTTGGAGCCAGGGGCAACACCGGCTGGCAGCTGGCTGGGGCCCTCGGCTATACAGTGCAAGACCCAAGAGTGAAAGAATTCCTGCATGCTGTTTATACCACACGGCACAACTCCAGTCAA
GGTGTCGGAATGGAGCTGGCCTGCACCCTGTTCATGCAAACCGGAACATCCCTGTCTCCCTGCTTTGTGGAGCAGGTCTCCCGGTGGGCCAACAGCAGTCTGGAGGCAGCTGACTTCAGCGAGCCTAA
CAGCACTACCACGGAGGCCTCCAAAGTCACATCCAGACAGAGCACAGGTGAAGGCCCAGATAGCCCGTTGTGGGGCCGGGCCGATGCCCTGTCTACTCAGCTCTCCATCATGAGCACCATGACTTTCC
AAAGTACCTGGCAGAAGAGATTCTCTGTGGTCCTGCAGCCCCTGCCTTTCACCCATGCCCATGGTCTTGTACTTCAAGTCCCAGCGATGCACCAAGTGGCAGAGGTCAGCTATGGCCAGTTCCAGGAT
GCTGCAGGCCATGAGATAGCTGTTCTAGAGCTGTTGTACCTGGGAAGGGTGGCCAGTTTGCTCCTGGTGCTTCCCCAAGACAAGGGCACTCCTCTGGACCACATTGAACCACACCTCACTGCCAGAGT
CCTCCACCTCTGGACCACAAGGCTGAAGAGAGCCAGAATGGATGTGTTTCTCCCCAGGTTTAAGATCCAAAATCAATTTGACGTAAAAAGCATTTTAAGATCGTGGGGTATCACTGATCTTTTTGACC
CACTCAAAGCTAACTTGAAAGGAATTTCAGGCCAAGATGGCTTTTACGTTTCTCAACTAACCCACAAGGCCAAGATGGAGCTTTCAGAGGAGGGTACCAGGTCCTCTGCAGCCACAGCGGTGCTGCTG
CTGAGGAGGTCTCGGACCTCTGCTTTTAAAGCAGATCGGCCCTTCATCTTTCTTCTGAGAGAACACAGCACAGGGTTTGTCTTCAGTATCGGAAGAGTTTCAAATCCCCTTGACTAAAATAGCAGACC
TCAAGAATGTTTTCTCTATGTATGCTTTCCTTCATAAATATTTACAATTTCTTTTAAGAGTATGTGATTTCCAAATATTATTAATCTAAAAATAATTCAATTAAAAAAATAATTTAAAGGGT

hide sequence

RefSeq Acc Id:

XM_017316054 ⟹ XP_017171543

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	14	62,900,743 - 62,927,176 (+)	NCBI
GRCm38	14	62,663,298 - 62,689,727 (+)	NCBI

Sequence:

show sequence

AGGAGGAGGAGAGAGGCACTAGGTACCTGGCACCCAGCAAAAACCCAGAGTTATCTCGGAATTCTTCAAAGTCATAAAGGGCTAGATGGAGGGTTCCTTGCTGGTACAACCAGGTCACAAGCCTTAGA
AGGCTTGATGGGCATGGCTGGCTCTGTCCCCGAGGCATACTCTGCTCTCATCTGGGCTTTGCTGCCTACAGCTGAGATGCTTCTCCTGGCTCCCTGCAGAACGTCCAGGCTCCAGGAATTTGGACGGA
GTGGTAGAGACATCGCCGGCAGAGACGGCAATTACCAGCTTCCTCCCTGGGATGTCTTGTGATTCGGGGCACATTCTGCTCCTACTCTTTTAAAAAGGGCAGCATGTTGATGCTCAAGGCACAAGAAC
AGAATCAAACAAGGAAACTACCATTTGATTAAAGAGTCGGTGTCCAGTCTCCATGCTGCCTCTCCTGCAGGTCACCTTCTTTCTTCTCTCCTCCTGCTTCTCAGCAGGAGGGGGCAGCCCCCTCAGTG
AAGGCCTGTGGCTGCTGAAGACTGAGTTTGCCCTCCACCTTTACCGGAGTGCAGCAGCAGAGAGAAACGGGACAAACTTCGTCATCTCACCGGCCAGTGTGTCCCTCTCCCTGGAGATCCTGCAGTTT
GGAGCCAGGGGCAACACCGGCTGGCAGCTGGCTGGGGCCCTCGGCTATACAGTGCAAGACCCAAGAGTGAAAGAATTCCTGCATGCTGTTTATACCACACGGCACAACTCCAGTCAAGGTGTCGGAAT
GGAGCTGGCCTGCACCCTGTTCATGCAAACCGGAACATCCCTGTCTCCCTGCTTTGTGGAGCAGGTCTCCCGGTGGGCCAACAGCAGTCTGGAGGCAGCTGACTTCAGCGAGCCTAACAGCACTACCA
CGGAGGCCTCCAAAGTCACATCCAGACAGAGCACAGGTGAAGGCCCAGATAGCCCGTTGTGGGGCCGGGCCGATGCCCTGTCTACTCAGCTCTCCATCATGAGCACCATGACTTTCCAAAGTACCTGG
CAGAAGAGATTCTCTGTGGTCCTGCAGCCCCTGCCTTTCACCCATGCCCATGGTCTTGTACTTCAAGTCCCAGCGATGCACCAAGTGGCAGAGGTCAGCTATGGCCAGTTCCAGGATGCTGCAGGCCA
TGAGATAGCTGTTCTAGAGCTGTTGTACCTGGGAAGGGTGGCCAGTTTGCTCCTGGTGCTTCCCCAAGACAAGGGCACTCCTCTGGACCACATTGAACCACACCTCACTGCCAGAGTCCTCCACCTCT
GGACCACAAGGCTGAAGAGAGCCAGAATGGATGTGTTTCTCCCCAGGTTTAAGATCCAAAATCAATTTGACGTAAAAAGCATTTTAAGATCGTGGGGTATCACTGATCTTTTTGACCCACTCAAAGCT
AACTTGAAAGGAATTTCAGGCCAAGATGGCTTTTACGTTTCTCAACTAACCCACAAGGCCAAGATGGAGCTTTCAGAGGAGGGTACCAGGTCCTCTGCAGCCACAGCGGTGCTGCTGCTGAGGAGGTC
TCGGACCTCTGCTTTTAAAGCAGATCGGCCCTTCATCTTTCTTCTGAGAGAACACAGCACAGGTACTGACTTTTTAAAAAAAAAACTGGATTCAGACATTTATGTCCATCTCTAACAATTTACGTTTA
T

hide sequence


Protein RefSeqs	NP_001186874	(Get FASTA)	NCBI Sequence Viewer
	XP_017171543	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000125769
	ENSMUSP00000125769.2

RefSeq Acc Id:	NP_001186874 ⟸ NM_001199945
- Peptide Label:	precursor
- UniProtKB:	E9Q6A2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLPLLQVTFFLLSSCFSAGGGSPLSEGLWLLKTEFALHLYRSAAAERNGTNFVISPASVSLSLEILQFGARGNTGWQLAGALGYTVQDPRVKEFLHAVYTTRHNSSQGVGMELACTLFMQTGTSLSPC FVEQVSRWANSSLEAADFSEPNSTTTEASKVTSRQSTGEGPDSPLWGRADALSTQLSIMSTMTFQSTWQKRFSVVLQPLPFTHAHGLVLQVPAMHQVAEVSYGQFQDAAGHEIAVLELLYLGRVASLL LVLPQDKGTPLDHIEPHLTARVLHLWTTRLKRARMDVFLPRFKIQNQFDVKSILRSWGITDLFDPLKANLKGISGQDGFYVSQLTHKAKMELSEEGTRSSAATAVLLLRRSRTSAFKADRPFIFLLRE HSTGFVFSIGRVSNPLD hide sequence

RefSeq Acc Id:

XP_017171543 ⟸ XM_017316054

- Peptide Label:

isoform X1

- Sequence:

show sequence

MLPLLQVTFFLLSSCFSAGGGSPLSEGLWLLKTEFALHLYRSAAAERNGTNFVISPASVSLSLE
ILQFGARGNTGWQLAGALGYTVQDPRVKEFLHAVYTTRHNSSQGVGMELACTLFMQTGTSLSPCFVEQVSRWANSSLEAADFSEPNSTTTEASKVTSRQSTGEGPDSPLWGRADALSTQLSIMSTMTF
QSTWQKRFSVVLQPLPFTHAHGLVLQVPAMHQVAEVSYGQFQDAAGHEIAVLELLYLGRVASLLLVLPQDKGTPLDHIEPHLTARVLHLWTTRLKRARMDVFLPRFKIQNQFDVKSILRSWGITDLFD
PLKANLKGISGQDGFYVSQLTHKAKMELSEEGTRSSAATAVLLLRRSRTSAFKADRPFIFLLREHSTGTDFLKKKLDSDIYVHL

hide sequence

Ensembl Acc Id:

ENSMUSP00000125769 ⟸ ENSMUST00000171692

Protein Domains

SERPIN

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-E9Q6A2-F1-model_v2	AlphaFold	E9Q6A2	1-401	view protein structure

RGD ID:

8682666

Promoter ID:

EPDNEW_M19363

Type:

single initiation site

Name:

Serpine3_1

Description:

Mus musculus serpin peptidase inhibitor, clade E (nexin, plasminogenactivator inhibitor type 1), member 3 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	14	62,663,670 - 62,663,730	EPDNEW

Database	Acc Id	Source(s)
Ensembl Genes	ENSMUSG00000091155	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000171692	ENTREZGENE
	ENSMUST00000171692.2	UniProtKB/TrEMBL
Gene3D-CATH	2.30.39.10	UniProtKB/TrEMBL
	3.30.497.10	UniProtKB/TrEMBL
InterPro	Protease_inhib_I4_serpin	UniProtKB/TrEMBL
	Protease_inhib_I4_serpin_CS	UniProtKB/TrEMBL
	Sepin_dom	UniProtKB/TrEMBL
	Serpin_sf	UniProtKB/TrEMBL
	Serpin_sf_1	UniProtKB/TrEMBL
	Serpin_sf_2	UniProtKB/TrEMBL
KEGG Report	mmu:319433	UniProtKB/TrEMBL
MGD	MGI:2442020	ENTREZGENE
NCBI Gene	319433	ENTREZGENE
PANTHER	Prot_inh_serpin	UniProtKB/TrEMBL
	PTHR11461:SF129	UniProtKB/TrEMBL
Pfam	Serpin	UniProtKB/TrEMBL
PhenoGen	Serpine3	PhenoGen
PROSITE	SERPIN	UniProtKB/TrEMBL
SMART	SERPIN	UniProtKB/TrEMBL
Superfamily-SCOP	Prot_inh_serpin	UniProtKB/TrEMBL
UniProt	E9Q6A2	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

Imported Disease Annotations - ClinVar

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Imported Disease Annotations - ClinVar

Mammalian Phenotype