Serpine3 (serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3) - Rat Genome Database

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Gene: Serpine3 (serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3) Mus musculus
Analyze
Symbol: Serpine3
Name: serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3
RGD ID: 1321460
MGI Page MGI
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be active in extracellular space. Orthologous to human SERPINE3 (serpin family E member 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E130113E03Rik; serpin E3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391462,900,743 - 62,929,692 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1462,901,116 - 62,929,692 (+)EnsemblGRCm39 Ensembl
GRCm381462,663,298 - 62,692,243 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1462,663,667 - 62,692,243 (+)EnsemblGRCm38mm10GRCm38
MGSCv371463,282,504 - 63,311,080 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361461,617,777 - 61,647,749 (+)NCBIMGSCv36mm8
Celera1460,422,453 - 60,450,997 (+)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1433.23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12904583   PMID:16141072   PMID:16141073   PMID:21873635   PMID:24172014   PMID:35727138  


Genomics

Comparative Map Data
Serpine3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391462,900,743 - 62,929,692 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1462,901,116 - 62,929,692 (+)EnsemblGRCm39 Ensembl
GRCm381462,663,298 - 62,692,243 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1462,663,667 - 62,692,243 (+)EnsemblGRCm38mm10GRCm38
MGSCv371463,282,504 - 63,311,080 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361461,617,777 - 61,647,749 (+)NCBIMGSCv36mm8
Celera1460,422,453 - 60,450,997 (+)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1433.23NCBI
SERPINE3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381351,339,691 - 51,364,735 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1351,335,773 - 51,364,735 (+)EnsemblGRCh38hg38GRCh38
GRCh371351,913,827 - 51,938,871 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361350,813,169 - 50,834,240 (+)NCBINCBI36Build 36hg18NCBI36
Celera1332,964,335 - 32,985,406 (+)NCBICelera
Cytogenetic Map13q14.3NCBI
HuRef1332,704,249 - 32,725,482 (+)NCBIHuRef
CHM1_11351,882,676 - 51,903,771 (+)NCBICHM1_1
T2T-CHM13v2.01350,554,612 - 50,579,655 (+)NCBIT2T-CHM13v2.0
Serpine3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81541,084,819 - 41,109,006 (+)NCBIGRCr8
mRatBN7.21536,908,816 - 36,931,825 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1536,907,131 - 36,933,150 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01545,827,983 - 45,855,952 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1545,834,302 - 45,858,335 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01549,600,587 - 49,622,250 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41541,917,864 - 41,942,032 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1536,588,819 - 36,616,791 (+)NCBICelera
Cytogenetic Map15p12NCBI
Serpine3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554314,694,654 - 4,727,080 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554314,694,654 - 4,727,080 (+)NCBIChiLan1.0ChiLan1.0
SERPINE3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21452,778,733 - 52,799,929 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11351,416,083 - 51,443,938 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01332,475,429 - 32,496,700 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11351,220,434 - 51,244,077 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1351,220,735 - 51,241,791 (+)Ensemblpanpan1.1panPan2
SERPINE3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.122637,600 - 666,028 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl22636,466 - 663,695 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha22670,052 - 697,870 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.022618,307 - 646,209 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl22621,442 - 644,221 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.122539,560 - 567,633 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.022588,743 - 616,809 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.022607,030 - 635,107 (-)NCBIUU_Cfam_GSD_1.0
Serpine3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945160,683,068 - 160,711,309 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365654,168,895 - 4,197,662 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365654,167,734 - 4,198,573 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERPINE3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1116,466,475 - 16,500,541 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11116,465,521 - 16,500,580 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21116,805,221 - 16,839,092 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SERPINE3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1329,227,812 - 29,251,219 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl329,228,049 - 29,249,397 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605714,575,894 - 14,597,429 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Serpine3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247482,833,748 - 2,860,303 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Serpine3
1076 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:36
Interacting mature miRNAs:39
Transcripts:ENSMUST00000171692
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
10043886Cia49_mcollagen induced arthritis QTL 49 (mouse)Not determined142999699463997133Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
1300909Ath13_matherosclerosis 13 (mouse)Not determined143033525064335381Mouse
1300998Cia17_mcollagen induced arthritis 17 (mouse)Not determined143033525064335381Mouse
1300625Cosz2_mcocaine seizure 2 (mouse)Not determined143504579768785736Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143743018571430320Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144303727077037418Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144306584777066045Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144945542583455556Mouse
4142364Pbwg18_mpostnatal body weight growth 18 (mouse)Not determined145228198486282125Mouse
1301489Lbm10_mlean body mass 10 (mouse)Not determined145376129687761529Mouse
12880432Fgf23lq3_mFGF23 serum level QTL 3 (mouse)145393744087937440Mouse
10043889Cia52_mcollagen induced arthritis QTL 52 (mouse)Not determined145608238190082509Mouse
1301562Hwq1_mheart weight quantitative locus 1 (mouse)Not determined145654674590546941Mouse
1357565wrmod1_mwobbler modifier 1 (mouse)Not determined1458179640101859473Mouse
11039527Ccc2_mcolitis susceptibility in the Collaborative Cross 2 (mouse)145991861294138217Mouse
1300666Fembm2_mfemoral bone morphometry 2 (mouse)Not determined146239746096397680Mouse

Markers in Region
AI480962  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381462,690,601 - 62,690,744UniSTSGRCm38
MGSCv371463,309,438 - 63,309,581UniSTSGRCm37
Celera1460,449,355 - 60,449,498UniSTS
Cytogenetic Map14D1UniSTS
Cytogenetic Map14C3UniSTS
Whitehead/MRC_RH14694.37UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000171692   ⟹   ENSMUSP00000125769
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1462,901,116 - 62,929,692 (+)Ensembl
GRCm38.p6 Ensembl1462,663,667 - 62,692,243 (+)Ensembl
RefSeq Acc Id: NM_001199945   ⟹   NP_001186874
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391462,901,116 - 62,929,692 (+)NCBI
GRCm381462,663,667 - 62,692,243 (+)NCBI
Celera1460,422,453 - 60,450,997 (+)ENTREZGENE
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017316054   ⟹   XP_017171543
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391462,900,743 - 62,927,176 (+)NCBI
GRCm381462,663,298 - 62,689,727 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001186874 (Get FASTA)   NCBI Sequence Viewer  
  XP_017171543 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000125769
  ENSMUSP00000125769.2
Reference Protein Sequences
RefSeq Acc Id: NP_001186874   ⟸   NM_001199945
- Peptide Label: precursor
- UniProtKB: E9Q6A2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017171543   ⟸   XM_017316054
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000125769   ⟸   ENSMUST00000171692
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9Q6A2-F1-model_v2 AlphaFold E9Q6A2 1-401 view protein structure

Promoters
RGD ID:8682666
Promoter ID:EPDNEW_M19363
Type:single initiation site
Name:Serpine3_1
Description:Mus musculus serpin peptidase inhibitor, clade E (nexin, plasminogenactivator inhibitor type 1), member 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381462,663,670 - 62,663,730EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2442020 AgrOrtholog
Ensembl Genes ENSMUSG00000091155 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000171692 ENTREZGENE
  ENSMUST00000171692.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/TrEMBL
InterPro Protease_inhib_I4_serpin UniProtKB/TrEMBL
  Protease_inhib_I4_serpin_CS UniProtKB/TrEMBL
  Sepin_dom UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/TrEMBL
KEGG Report mmu:319433 UniProtKB/TrEMBL
MGD MGI:2442020 ENTREZGENE
NCBI Gene 319433 ENTREZGENE
PANTHER Prot_inh_serpin UniProtKB/TrEMBL
  PTHR11461:SF129 UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
PhenoGen Serpine3 PhenoGen
PROSITE SERPIN UniProtKB/TrEMBL
SMART SERPIN UniProtKB/TrEMBL
Superfamily-SCOP Prot_inh_serpin UniProtKB/TrEMBL
UniProt E9Q6A2 ENTREZGENE, UniProtKB/TrEMBL