SERPINE3 (serpin family E member 3) - Rat Genome Database

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Gene: SERPINE3 (serpin family E member 3) Chlorocebus sabaeus
Analyze
Symbol: SERPINE3
Name: serpin family E member 3
RGD ID: 18709729
Description: ENCODES a protein that exhibits serine-type endopeptidase inhibitor activity (inferred); ASSOCIATED WITH chromosome 13q14 deletion syndrome (ortholog); genetic disease (ortholog); intellectual disability (ortholog); FOUND IN extracellular space (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: serpin E3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1329,227,812 - 29,251,219 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl329,228,049 - 29,249,397 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605714,575,894 - 14,597,429 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
SERPINE3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1329,227,812 - 29,251,219 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl329,228,049 - 29,249,397 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605714,575,894 - 14,597,429 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
SERPINE3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381351,339,691 - 51,364,735 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1351,335,773 - 51,364,735 (+)EnsemblGRCh38hg38GRCh38
GRCh371351,913,827 - 51,938,871 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361350,813,169 - 50,834,240 (+)NCBINCBI36Build 36hg18NCBI36
Celera1332,964,335 - 32,985,406 (+)NCBICelera
Cytogenetic Map13q14.3NCBI
HuRef1332,704,249 - 32,725,482 (+)NCBIHuRef
CHM1_11351,882,676 - 51,903,771 (+)NCBICHM1_1
T2T-CHM13v2.01350,554,612 - 50,579,655 (+)NCBIT2T-CHM13v2.0
Serpine3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391462,900,743 - 62,929,692 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1462,901,116 - 62,929,692 (+)EnsemblGRCm39 Ensembl
GRCm381462,663,298 - 62,692,243 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1462,663,667 - 62,692,243 (+)EnsemblGRCm38mm10GRCm38
MGSCv371463,282,504 - 63,311,080 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361461,617,777 - 61,647,749 (+)NCBIMGSCv36mm8
Celera1460,422,453 - 60,450,997 (+)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1433.23NCBI
Serpine3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81541,084,819 - 41,109,006 (+)NCBIGRCr8
mRatBN7.21536,908,816 - 36,931,825 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1536,907,131 - 36,933,150 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01545,827,983 - 45,855,952 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1545,834,302 - 45,858,335 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01549,600,587 - 49,622,250 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41541,917,864 - 41,942,032 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1536,588,819 - 36,616,791 (+)NCBICelera
Cytogenetic Map15p12NCBI
Serpine3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554314,694,654 - 4,727,080 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554314,694,654 - 4,727,080 (+)NCBIChiLan1.0ChiLan1.0
SERPINE3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21452,778,733 - 52,799,929 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11351,416,083 - 51,443,938 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01332,475,429 - 32,496,700 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11351,220,434 - 51,244,077 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1351,220,735 - 51,241,791 (+)Ensemblpanpan1.1panPan2
SERPINE3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.122637,600 - 666,028 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl22636,466 - 663,695 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha22670,052 - 697,870 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.022618,307 - 646,209 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl22621,442 - 644,221 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.122539,560 - 567,633 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.022588,743 - 616,809 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.022607,030 - 635,107 (-)NCBIUU_Cfam_GSD_1.0
Serpine3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945160,683,068 - 160,711,309 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365654,168,895 - 4,197,662 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365654,167,734 - 4,198,573 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERPINE3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1116,466,475 - 16,500,541 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11116,465,521 - 16,500,580 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21116,805,221 - 16,839,092 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Serpine3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247482,833,748 - 2,860,303 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 36 20 60
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000015791   ⟹   ENSCSAP00000013720
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl329,228,049 - 29,249,397 (+)Ensembl
RefSeq Acc Id: XM_007960443   ⟹   XP_007958634
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1329,227,989 - 29,251,219 (+)NCBI
Vero_WHO_p1.0NW_02366605714,575,894 - 14,597,429 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007958634 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000013720.1
Reference Protein Sequences
RefSeq Acc Id: XP_007958634   ⟸   XM_007960443
- UniProtKB: A0A0D9RYN1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000013720   ⟸   ENSCSAT00000015791


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000017696 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000015791.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/TrEMBL
InterPro Serpin_CS UniProtKB/TrEMBL
  Serpin_dom UniProtKB/TrEMBL
  Serpin_E3 UniProtKB/TrEMBL
  Serpin_fam UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/TrEMBL
NCBI Gene SERPINE3 ENTREZGENE
PANTHER PTHR11461 UniProtKB/TrEMBL
  SERPIN E3 UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
PROSITE SERPIN UniProtKB/TrEMBL
SMART SERPIN UniProtKB/TrEMBL
Superfamily-SCOP SSF56574 UniProtKB/TrEMBL
UniProt A0A0D9RYN1 ENTREZGENE, UniProtKB/TrEMBL