Cavin4 (caveolae associated 4) - Rat Genome Database

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Gene: Cavin4 (caveolae associated 4) Mus musculus
Analyze
Symbol: Cavin4
Name: caveolae associated 4
RGD ID: 1321277
MGI Page MGI
Description: Predicted to enable GTPase activator activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in Z disc; caveola; and sarcoplasm. Is expressed in cardiovascular system; lung; and skeletal muscle. Orthologous to human CAVIN4 (caveolae associated protein 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2310039E09Rik; caveolae-associated protein 4; cavin 4; MGC107637; Mur; Murc; muscle-restricted coiled-coil protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39448,663,514 - 48,673,492 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl448,663,514 - 48,673,502 (+)EnsemblGRCm39 Ensembl
GRCm38448,663,514 - 48,673,492 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl448,663,514 - 48,673,502 (+)EnsemblGRCm38mm10GRCm38
MGSCv37448,676,386 - 48,686,364 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36448,684,657 - 48,694,593 (+)NCBIMGSCv36mm8
Celera448,687,179 - 48,697,159 (+)NCBICelera
Cytogenetic Map4B1NCBI
cM Map426.23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
caveola  (IBA,IDA,ISO)
cytoplasm  (IBA,ISO)
cytosol  (IEA)
plasma membrane  (IDA,ISO)
sarcolemma  (IEA)
sarcoplasm  (IDA)
Z disc  (IDA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:18332105   PMID:18508909   PMID:19546242   PMID:21873635  
PMID:24013648   PMID:24567387   PMID:26497963   PMID:27171814   PMID:27546070   PMID:28433630   PMID:31364493   PMID:32098917   PMID:34633413  


Genomics

Comparative Map Data
Cavin4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39448,663,514 - 48,673,492 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl448,663,514 - 48,673,502 (+)EnsemblGRCm39 Ensembl
GRCm38448,663,514 - 48,673,492 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl448,663,514 - 48,673,502 (+)EnsemblGRCm38mm10GRCm38
MGSCv37448,676,386 - 48,686,364 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36448,684,657 - 48,694,593 (+)NCBIMGSCv36mm8
Celera448,687,179 - 48,697,159 (+)NCBICelera
Cytogenetic Map4B1NCBI
cM Map426.23NCBI
CAVIN4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389100,576,867 - 100,588,389 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9100,578,079 - 100,588,389 (+)EnsemblGRCh38hg38GRCh38
GRCh379103,340,361 - 103,350,671 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369102,380,157 - 102,390,001 (+)NCBINCBI36Build 36hg18NCBI36
Celera973,853,560 - 73,863,400 (+)NCBICelera
Cytogenetic Map9q31.1NCBI
HuRef972,939,042 - 72,949,352 (+)NCBIHuRef
CHM1_19103,486,816 - 103,497,108 (+)NCBICHM1_1
T2T-CHM13v2.09112,748,569 - 112,760,082 (+)NCBIT2T-CHM13v2.0
Cavin4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8567,792,171 - 67,893,094 (+)NCBIGRCr8
mRatBN7.2562,996,906 - 63,007,677 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl562,996,865 - 63,007,678 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx564,974,561 - 64,982,412 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0566,793,881 - 66,801,733 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0566,763,332 - 66,771,181 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0564,413,005 - 64,420,849 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl564,412,895 - 64,423,725 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0568,926,895 - 68,934,739 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4565,357,777 - 65,365,621 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1565,362,889 - 65,370,734 (+)NCBI
Celera564,592,108 - 64,599,951 (-)NCBICelera
Cytogenetic Map5q22NCBI
Cavin4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541925,181,438 - 25,188,632 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541925,181,395 - 25,188,951 (-)NCBIChiLan1.0ChiLan1.0
CAVIN4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21138,772,797 - 38,783,514 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1938,775,169 - 38,785,886 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0971,788,601 - 71,799,310 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1999,785,397 - 99,796,121 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl999,785,397 - 99,796,114 (+)Ensemblpanpan1.1panPan2
CAVIN4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11157,452,229 - 57,462,933 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1157,452,347 - 57,460,463 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1155,895,496 - 55,906,219 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01158,579,567 - 58,590,283 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1158,580,742 - 58,590,219 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11157,077,571 - 57,088,014 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01157,103,190 - 57,113,636 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01157,802,519 - 57,812,964 (+)NCBIUU_Cfam_GSD_1.0
Cavin4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947172,320,785 - 172,330,229 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365248,868,721 - 8,876,019 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365248,868,295 - 8,882,398 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAVIN4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1242,308,977 - 242,320,047 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11242,310,017 - 242,319,977 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21270,670,749 - 270,680,300 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CAVIN4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11238,852,824 - 38,863,132 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1238,853,613 - 38,861,918 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660353,691,234 - 3,701,578 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cavin4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624825441,987 - 452,926 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cavin4
366 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:237
Count of miRNA genes:190
Interacting mature miRNAs:215
Transcripts:ENSMUST00000030033
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301203Alcp8_malcohol preference locus 8 (mouse)Not determined41739516051395290Mouse
1301586Stheal3_msoft tissue heal 3 (mouse)Not determined42865844262658566Mouse
11532714Sluc43_msusceptibility to lung cancer 43 (mouse)446642108123127211Mouse
39128211Lwq22_mliver weight QTL 22 (mouse)41789261688982216Mouse
25314308Mlh1fc1_mMLH1 foci count 1 (mouse)44850000076918237Mouse
1301786Bpq3_mblood pressure QTL 3 (mouse)Not determined44240224076402381Mouse
4141555Nbwa2_mNZB and NZW autoimmunity 2 (mouse)Not determined41789251551892635Mouse
10412178Habiir2_mhyperoxic acute lung injury imprinted region 2 (mouse)Not determined43945212663283678Mouse
1300574Im2_mimmunoregulatory 2 (mouse)Not determined42807768262077816Mouse
4142318Lyr2_mlymphoma resistance 2 (mouse)Not determined1401045763283678Mouse
1301697Sluc18_msusceptibility to lung cancer 18 (mouse)Not determined42237344856373612Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138342753Mouse
1357453Kidq4_mkidney weight QTL 4 (mouse)Not determined41789261688982216Mouse
1558794Agnm1_mautoimmune glomerulonephritis in MRL 1 (mouse)Not determined44633264655755867Mouse
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117072206Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
1357877Synch1_msynechia 1 (mouse)Not determined42870992562710107Mouse
10449022Aanq1_maristolochic acid nephrotoxicity QTL 1 (mouse)44660382680603826Mouse
1300977Mopkd1_mmodifier of polycystic kidney disease progression 1 (mouse)Not determined43655083970550967Mouse
1301237Alcp7_malcohol preference locus 7 (mouse)Not determined41739516051395290Mouse
1301941Mmtg1_mmodifier of mammary tumor growth 1 (mouse)Not determined44565844283099157Mouse
4141911W6q15_mweight 6 weeks QTL 15 (mouse)Not determined1789261688982216Mouse
1302075Bdln6_mbody length 6 (mouse)Not determined42237344856373612Mouse
12879977Bod2_mbone length and organs 2 (mouse)44628353180283678Mouse
1301437Scon1_msucrose consumption 1 (mouse)Not determined42237344856373612Mouse
10043880Adip23_madiposity 23 (mouse)Not determined44628353180283678Mouse
1300769Pcyts2_mplasmacytoma susceptibility 2 (mouse)Not determined42211194456112145Mouse
1301792Hdlq10_mHDL QTL 10 (mouse)Not determined43585970769859853Mouse
1558948Ath8_matherosclerosis 8 (mouse)Not determined445658442105156995Mouse
1301990Arvm1_mautoimmune renal vasculitis 1 (mouse)Not determined42933264663332776Mouse
1300966Pabr2_mplasma apolipoprotein B (human) regulator 2 (mouse)Not determined446332646105801860Mouse
1302116Bbaa1_mB.burgdorferi-associated arthritis 1 (mouse)Not determined43825093072251078Mouse
1302058Hrtfm3_mheart failure modifier 3 (mouse)Not determined42211194456112145Mouse
26884449Sklq2_mskull length QTL 2, 5 week (mouse)436700000128993793Mouse
27226724Tibw2_mtibia width 2, proximal, 10 week (mouse)443000000108357197Mouse
13432176Actres1_mactivity response to ethanol/saline 1 (mouse)44758712850387128Mouse
13432179Acq1_mactivity chamber QTL 1 (mouse)44708712850187128Mouse
11532688Mh_mmodifier of hemostasis (mouse)44830477582304775Mouse

Markers in Region
AW457727  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38448,662,276 - 48,662,417UniSTSGRCm38
MGSCv37448,675,148 - 48,675,289UniSTSGRCm37
Celera448,685,941 - 48,686,082UniSTS
Cytogenetic Map4B2UniSTS
Whitehead/MRC_RH4766.52UniSTS
UniSTS:234919  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38448,662,548 - 48,662,686UniSTSGRCm38
MGSCv37448,675,420 - 48,675,558UniSTSGRCm37
Celera448,686,213 - 48,686,351UniSTS
Cytogenetic Map4B2UniSTS
Murc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4B2UniSTS
cM Map426.23UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000030033   ⟹   ENSMUSP00000030033
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl448,663,514 - 48,673,502 (+)Ensembl
GRCm38.p6 Ensembl448,663,514 - 48,673,502 (+)Ensembl
RefSeq Acc Id: NM_026509   ⟹   NP_080785
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39448,663,514 - 48,673,492 (+)NCBI
GRCm38448,663,514 - 48,673,492 (+)ENTREZGENE
MGSCv37448,676,386 - 48,686,364 (+)RGD
Celera448,687,179 - 48,697,159 (+)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_080785   ⟸   NM_026509
- UniProtKB: Q9CV87 (UniProtKB/Swiss-Prot),   Q5FW67 (UniProtKB/Swiss-Prot),   B1PRL4 (UniProtKB/Swiss-Prot),   Q9D728 (UniProtKB/Swiss-Prot),   A2AMM0 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000030033   ⟸   ENSMUST00000030033

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A2AMM0-F1-model_v2 AlphaFold A2AMM0 1-362 view protein structure

Promoters
RGD ID:6883404
Promoter ID:EPDNEW_M5153
Type:initiation region
Name:Cavin4_1
Description:Mus musculus caveolae associated 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38448,663,554 - 48,663,614EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1915266 AgrOrtholog
Ensembl Genes ENSMUSG00000028348 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000030033 ENTREZGENE
  ENSMUST00000030033.5 UniProtKB/Swiss-Prot
InterPro Cavin_fam UniProtKB/Swiss-Prot
KEGG Report mmu:68016 UniProtKB/Swiss-Prot
MGD MGI:1915266 ENTREZGENE
NCBI Gene 68016 ENTREZGENE
PANTHER PTHR15240 UniProtKB/Swiss-Prot
  PTHR15240:SF4 UniProtKB/Swiss-Prot
Pfam PTRF_SDPR UniProtKB/Swiss-Prot
PhenoGen Cavin4 PhenoGen
UniProt A2AMM0 ENTREZGENE
  B1PRL4 ENTREZGENE
  CAVN4_MOUSE UniProtKB/Swiss-Prot
  Q5FW67 ENTREZGENE
  Q9CV87 ENTREZGENE
  Q9D728 ENTREZGENE
UniProt Secondary B1PRL4 UniProtKB/Swiss-Prot
  Q5FW67 UniProtKB/Swiss-Prot
  Q9CV87 UniProtKB/Swiss-Prot
  Q9D728 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-05-23 Cavin4  caveolae associated 4  Murc  muscle-related coiled-coil protein  Symbol and/or name change 5135510 APPROVED