Fam174a (family with sequence similarity 174, member A) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Fam174a (family with sequence similarity 174, member A) Mus musculus
Analyze
Symbol: Fam174a
Name: family with sequence similarity 174, member A
RGD ID: 1320605
MGI Page MGI
Description: Predicted to be located in membrane. Orthologous to human FAM174A (family with sequence similarity 174 member A).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2310044D20Rik; Fam174; membrane protein FAM174A; Naa6; Tmem157; transmembrane protein 157
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39195,241,353 - 95,263,009 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl195,241,348 - 95,263,009 (+)EnsemblGRCm39 Ensembl
GRCm38195,313,628 - 95,335,284 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl195,313,623 - 95,335,284 (+)EnsemblGRCm38mm10GRCm38
MGSCv37197,210,205 - 97,231,861 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36197,144,150 - 97,165,471 (+)NCBIMGSCv36mm8
Celera198,172,416 - 98,194,072 (+)NCBICelera
Cytogenetic Map1DNCBI
cM Map147.76NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:21267068  


Genomics

Comparative Map Data
Fam174a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39195,241,353 - 95,263,009 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl195,241,348 - 95,263,009 (+)EnsemblGRCm39 Ensembl
GRCm38195,313,628 - 95,335,284 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl195,313,623 - 95,335,284 (+)EnsemblGRCm38mm10GRCm38
MGSCv37197,210,205 - 97,231,861 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36197,144,150 - 97,165,471 (+)NCBIMGSCv36mm8
Celera198,172,416 - 98,194,072 (+)NCBICelera
Cytogenetic Map1DNCBI
cM Map147.76NCBI
FAM174A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385100,535,374 - 100,586,741 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5100,535,338 - 100,586,741 (+)EnsemblGRCh38hg38GRCh38
GRCh37599,871,078 - 99,922,445 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36599,899,023 - 99,950,339 (+)NCBINCBI36Build 36hg18NCBI36
Celera595,818,712 - 95,870,036 (+)NCBICelera
Cytogenetic Map5q21.1NCBI
HuRef595,054,071 - 95,105,396 (+)NCBIHuRef
CHM1_1599,303,131 - 99,354,447 (+)NCBICHM1_1
T2T-CHM13v2.05101,043,697 - 101,095,060 (+)NCBIT2T-CHM13v2.0
Fam174a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89103,190,144 - 103,208,419 (+)NCBIGRCr8
mRatBN7.2995,742,815 - 95,761,083 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl995,742,927 - 95,761,081 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9104,167,440 - 104,185,594 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09109,295,426 - 109,313,580 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09107,638,792 - 107,656,946 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09102,862,761 - 102,881,046 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9102,862,890 - 102,881,038 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09102,475,439 - 102,493,703 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4994,575,773 - 94,593,929 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1994,785,252 - 94,803,406 (+)NCBI
Celera993,215,983 - 93,234,139 (+)NCBICelera
Cytogenetic Map9q36NCBI
Fam174a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541812,877,982 - 12,911,864 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541812,877,465 - 12,912,096 (-)NCBIChiLan1.0ChiLan1.0
FAM174A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2495,786,824 - 95,838,530 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1593,940,472 - 93,992,177 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0595,863,985 - 95,915,633 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15101,533,818 - 101,585,468 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5101,533,818 - 101,585,468 (+)Ensemblpanpan1.1panPan2
FAM174A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.139,974,049 - 10,009,405 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl39,986,930 - 10,009,244 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha311,317,501 - 11,353,058 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.039,866,584 - 9,902,093 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl39,879,467 - 9,901,755 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.139,805,499 - 9,841,180 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.039,827,750 - 9,863,476 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.039,981,515 - 10,023,349 (-)NCBIUU_Cfam_GSD_1.0
Fam174a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213165,387,008 - 165,434,757 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365233,572,913 - 3,620,252 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365233,572,959 - 3,620,127 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAM174A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2106,555,289 - 106,583,694 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12106,555,242 - 106,581,912 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22110,536,597 - 110,563,200 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FAM174A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1234,056,450 - 4,100,550 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl234,056,430 - 4,100,600 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603610,292,124 - 10,336,239 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fam174a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474318,960,960 - 18,997,925 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474318,961,538 - 18,997,110 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:358
Count of miRNA genes:248
Interacting mature miRNAs:287
Transcripts:ENSMUST00000059975
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
15039333Nmrs1_mNAFLD-associated magnetic resonance shift 1 (mouse)189786512123786512Mouse
27095901Scvln8_msacral vertebrae length 2, 10 week (mouse)194127725172027567Mouse
10045976Tir6_mtrypanosome infection response 6 (mouse)Not determined193536855120529678Mouse
1357847Jckm2_mjuvenile cystic kidney modifier 2 (mouse)Not determined174991977133290937Mouse
4141627Bwq7_mbody weight, QTL 7 (mouse)Not determined192940909124497796Mouse
4142394Mssq1_mmandible size and shape QTL 1 (mouse)Not determined73615692107615830Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
1558928Mord2_mmodifier of retinal degeneration 2 (mouse)Not determined177123115110536075Mouse
12879491Hfnq1_mhair follicle number QTL 1 (mouse)193310310123636759Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
14697706Stsl3a_mSalmonella typhimurium susceptibility locus 3a (mouse)17747663795827725Mouse
12790991Aath1_maortic arch atherosclerosis 1 (mouse)186483929120483929Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139132808126445310Mouse
10412238Alpq5_malcohol preference QTL 5 (mouse)Not determined182832635116832635Mouse
1302146Cocrb1_mcocaine related behavior 1 (mouse)Not determined170133533104139557Mouse
1357760Synch3_msynechia 3 (mouse)Not determined192901442126901550Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
4141347Reb1_mrepetitive behavior 1 (mouse)Not determined91468266100413667Mouse
12791004Aath7_maortic arch atherosclerosis 7 (mouse)182832635116832635Mouse
4141725Wbcq4_mwhite blood cell quantitative locus 4 (mouse)Not determined179858683113858791Mouse
12050069Nabq1_mnasal bone morphology QTL 1 (mouse)179858683113858791Mouse
1300976Bmd19_mbone mineral density 19 (mouse)Not determined173266214108838414Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74516235148715579Mouse
27095928Pglq6_mpelvic girdle length QTL 6, 10 week (mouse)175976637148775742Mouse
27095931Pglq1_mpelvic girdle length QTL 1, 5 week (mouse)175976637128527737Mouse
13452395Leusq2_mleucocytosis susceptibility QTL 2 (mouse)180245593126386517Mouse
1301748Abbp1_mA/J and C57BL/6 blood pressure 1 (mouse)Not determined162946755120529678Mouse
1301304Hrq3_mheart rate quantitative locus 3 (mouse)Not determined173615692107615830Mouse
1357439Popoa_mpremature ovulation and primary oocyte arrest (mouse)Not determined182643189135615379Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173755175147125370Mouse
4141329Mleu1_mmyeloid leukemia survival 1 (mouse)Not determined89786512123786512Mouse
11667074Led2_mlate embryonic death 2 (mouse)185696027117195081Mouse
27095918Ulnl1_mulna length 1, 5 week (mouse)167339159129727737Mouse
27095913Scvln2_msacral vertebrae length 2, 5 week (mouse)194127725148775742Mouse
1301350Nidd4k_mNidd4 on KK-A (mouse)Not determined782291982147125370Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000059975   ⟹   ENSMUSP00000057670
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl195,241,348 - 95,263,009 (+)Ensembl
GRCm38.p6 Ensembl195,313,623 - 95,335,284 (+)Ensembl
Ensembl Acc Id: ENSMUST00000186780   ⟹   ENSMUSP00000139943
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl195,241,353 - 95,255,670 (+)Ensembl
GRCm38.p6 Ensembl195,313,628 - 95,327,945 (+)Ensembl
RefSeq Acc Id: NM_026321   ⟹   NP_080597
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39195,241,353 - 95,263,009 (+)NCBI
GRCm38195,313,628 - 95,335,284 (+)ENTREZGENE
MGSCv37197,210,205 - 97,231,861 (+)RGD
Celera198,172,416 - 98,194,072 (+)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_080597   ⟸   NM_026321
- Peptide Label: precursor
- UniProtKB: Q9D6W5 (UniProtKB/Swiss-Prot),   Q9D238 (UniProtKB/Swiss-Prot),   Q8VDR1 (UniProtKB/Swiss-Prot),   Q8CC46 (UniProtKB/Swiss-Prot),   Q3UF92 (UniProtKB/Swiss-Prot),   Q9D6Z3 (UniProtKB/Swiss-Prot),   Q9D3L0 (UniProtKB/Swiss-Prot),   C9K0Z9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000057670   ⟸   ENSMUST00000059975
Ensembl Acc Id: ENSMUSP00000139943   ⟸   ENSMUST00000186780

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9D3L0-F1-model_v2 AlphaFold Q9D3L0 1-190 view protein structure

Promoters
RGD ID:6874590
Promoter ID:EPDNEW_M746
Type:initiation region
Name:Fam174a_1
Description:Mus musculus family with sequence similarity 174, member A ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38195,313,693 - 95,313,753EPDNEW
RGD ID:6818629
Promoter ID:MM_KWN:1726
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_026321,   UC007CEX.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36197,209,996 - 97,210,677 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1914948 AgrOrtholog
Ensembl Genes ENSMUSG00000051185 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000059975 ENTREZGENE
  ENSMUST00000059975.8 UniProtKB/Swiss-Prot
  ENSMUST00000186780.2 UniProtKB/Swiss-Prot
InterPro DUF1180 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:67698 UniProtKB/Swiss-Prot
MGD MGI:1914948 ENTREZGENE
NCBI Gene 67698 ENTREZGENE
PANTHER MEMBRANE PROTEIN FAM174A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR28607 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF1180 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fam174a PhenoGen
UniProt C9K0Z9 ENTREZGENE, UniProtKB/TrEMBL
  F174A_MOUSE UniProtKB/Swiss-Prot
  Q3UF92 ENTREZGENE
  Q8CC46 ENTREZGENE
  Q8VDR1 ENTREZGENE
  Q9D238 ENTREZGENE
  Q9D3L0 ENTREZGENE
  Q9D6W5 ENTREZGENE
  Q9D6Z3 ENTREZGENE
UniProt Secondary Q3UF92 UniProtKB/Swiss-Prot
  Q8CC46 UniProtKB/Swiss-Prot
  Q8VDR1 UniProtKB/Swiss-Prot
  Q9D238 UniProtKB/Swiss-Prot
  Q9D6W5 UniProtKB/Swiss-Prot
  Q9D6Z3 UniProtKB/Swiss-Prot