Kcnk16 (potassium channel, subfamily K, member 16) - Rat Genome Database

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Gene: Kcnk16 (potassium channel, subfamily K, member 16) Mus musculus
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Symbol: Kcnk16
Name: potassium channel, subfamily K, member 16
RGD ID: 1319411
MGI Page MGI
Description: Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to act upstream of or within potassium ion transport. Predicted to be active in plasma membrane. Orthologous to human KCNK16 (potassium two pore domain channel subfamily K member 16).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4731413G05Rik; TAL; TALK; TALK-1; TALK1
RGD Orthologs
Human
Rat
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm19465  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391420,311,443 - 20,319,337 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1420,311,444 - 20,319,267 (-)EnsemblGRCm39 Ensembl
GRCm381420,261,375 - 20,269,269 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1420,261,376 - 20,269,199 (-)EnsemblGRCm38mm10GRCm38
MGSCv371421,081,978 - 21,088,384 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361419,051,308 - 19,057,714 (-)NCBIMGSCv36mm8
Celera1416,643,909 - 16,650,315 (-)NCBICelera
Cytogenetic Map14A3NCBI
cM Map1411.49NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11125038   PMID:11217851   PMID:12466851   PMID:12724142   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21677750   PMID:21873635  
PMID:26239056   PMID:28403169   PMID:28928238   PMID:29402588   PMID:31543264   PMID:38206814   PMID:38355793   PMID:38700926  


Genomics

Comparative Map Data
Kcnk16
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391420,311,443 - 20,319,337 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1420,311,444 - 20,319,267 (-)EnsemblGRCm39 Ensembl
GRCm381420,261,375 - 20,269,269 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1420,261,376 - 20,269,199 (-)EnsemblGRCm38mm10GRCm38
MGSCv371421,081,978 - 21,088,384 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361419,051,308 - 19,057,714 (-)NCBIMGSCv36mm8
Celera1416,643,909 - 16,650,315 (-)NCBICelera
Cytogenetic Map14A3NCBI
cM Map1411.49NCBI
KCNK16
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38639,314,570 - 39,322,968 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl639,314,698 - 39,322,968 (-)EnsemblGRCh38hg38GRCh38
GRCh37639,282,474 - 39,290,744 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36639,390,460 - 39,398,294 (-)NCBINCBI36Build 36hg18NCBI36
Build 34639,390,459 - 39,398,294NCBI
Celera640,835,738 - 40,843,594 (-)NCBICelera
Cytogenetic Map6p21.2NCBI
HuRef639,000,935 - 39,008,791 (-)NCBIHuRef
CHM1_1639,285,120 - 39,292,976 (-)NCBICHM1_1
T2T-CHM13v2.0639,139,109 - 39,147,515 (-)NCBIT2T-CHM13v2.0
Kcnk16
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8154,069,495 - 4,098,836 (+)NCBIGRCr8
mRatBN7.2154,042,506 - 4,049,652 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl154,042,506 - 4,049,652 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx154,052,610 - 4,059,749 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0155,439,032 - 5,446,172 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0154,051,427 - 4,058,567 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0154,474,732 - 4,482,196 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl154,475,051 - 4,482,194 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0158,574,694 - 8,582,657 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4154,287,010 - 4,294,153 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera15547,096 - 554,173 (-)NCBICelera
Cytogenetic Map15p16NCBI
KCNK16
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2553,811,177 - 53,819,445 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1649,680,775 - 49,689,043 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0638,903,546 - 38,911,814 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1640,214,325 - 40,222,171 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl640,214,325 - 40,222,171 (-)Ensemblpanpan1.1panPan2
Kcnk16
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494643,627,366 - 43,633,167 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647620,327,086 - 20,332,752 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647620,327,086 - 20,332,752 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNK16
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl734,727,793 - 34,734,771 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1734,727,771 - 34,734,790 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2739,812,306 - 39,817,139 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNK16
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11732,815,592 - 32,823,313 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604439,318,493 - 39,325,976 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnk16
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475421,195,440 - 21,200,885 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnk16
295 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:178
Count of miRNA genes:149
Interacting mature miRNAs:165
Transcripts:ENSMUST00000024155
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141550Dbm3_mdiabetes modifier 3 (mouse)Not determined514347339143596Mouse
27226748Femd8_mfemur midshaft diameter 8, 10 week (mouse)141376927346737457Mouse
1300544Hypn_mhyperinsulinemia (mouse)Not determined141516061649160765Mouse
1301991Wta3_mweight adult 3 (mouse)Not determined14388747337887650Mouse
4141864Mrdq4_mmodifier of retinal degeneration QTL 4 (mouse)Not determined992324548765082Mouse
11532711Sluc40_msusceptibility to lung cancer 40 (mouse)14127379943Mouse
1300779Dyscalc4_mdystrophic cardiac calcinosis 4 (mouse)Not determined141221287146213007Mouse
10412071Ssen3_msuseptibility to Sendai virus 3 (mouse)Not determined14126987934Mouse
4141265Appd2_mAPP associated premature death 2 (mouse)Not determined14594555230114862Mouse
27226752Femd4_mfemur midshaft diameter 4, 5 week (mouse)141376927347237457Mouse
1301372Sluc13_msusceptibility to lung cancer 13 (mouse)Not determined141882760452827726Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000024155   ⟹   ENSMUSP00000024155
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1420,312,824 - 20,319,267 (-)Ensembl
GRCm38.p6 Ensembl1420,262,756 - 20,269,199 (-)Ensembl
Ensembl Acc Id: ENSMUST00000225596   ⟹   ENSMUSP00000153256
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1420,311,444 - 20,317,484 (-)Ensembl
GRCm38.p6 Ensembl1420,261,376 - 20,267,416 (-)Ensembl
RefSeq Acc Id: NM_029006   ⟹   NP_083282
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391420,311,443 - 20,319,337 (-)NCBI
GRCm381420,261,375 - 20,269,269 (-)NCBI
MGSCv371421,081,978 - 21,088,384 (-)RGD
Celera1416,643,909 - 16,650,315 (-)RGD
cM Map14 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_083282 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL01527 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000024155
  ENSMUSP00000024155.8
  ENSMUSP00000153256.2
RefSeq Acc Id: NP_083282   ⟸   NM_029006
- UniProtKB: G5E845 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000153256   ⟸   ENSMUST00000225596
Ensembl Acc Id: ENSMUSP00000024155   ⟸   ENSMUST00000024155
Protein Domains
Potassium channel

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G5E845-F1-model_v2 AlphaFold G5E845 1-292 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1921821 AgrOrtholog
Ensembl Genes ENSMUSG00000023387 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000024155 ENTREZGENE
  ENSMUST00000024155.9 UniProtKB/TrEMBL
  ENSMUST00000225596.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
InterPro 2pore_dom_K_chnl UniProtKB/TrEMBL
  2pore_dom_K_chnl_TASK UniProtKB/TrEMBL
  Ion_trans_2 UniProtKB/TrEMBL
KEGG Report mmu:74571 UniProtKB/TrEMBL
MGD MGI:1921821 ENTREZGENE
NCBI Gene 74571 ENTREZGENE
PANTHER POTASSIUM CHANNEL SUBFAMILY K MEMBER 16 UniProtKB/TrEMBL
  PTHR11003 UniProtKB/TrEMBL
Pfam Ion_trans_2 UniProtKB/TrEMBL
PhenoGen Kcnk16 PhenoGen
PIRSF K_channel_subfamily_K_type UniProtKB/TrEMBL
PRINTS 2POREKCHANEL UniProtKB/TrEMBL
  TASKCHANNEL UniProtKB/TrEMBL
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A286YDH8_MOUSE UniProtKB/TrEMBL
  G5E845 ENTREZGENE, UniProtKB/TrEMBL