KCNK16 (potassium two pore domain channel subfamily K member 16) - Rat Genome Database

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Gene: KCNK16 (potassium two pore domain channel subfamily K member 16) Homo sapiens
Analyze
Symbol: KCNK16
Name: potassium two pore domain channel subfamily K member 16
RGD ID: 1319410
HGNC Page HGNC:14464
Description: Enables potassium channel activity. Acts upstream of or within potassium ion transport. Predicted to be located in membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 2P domain potassium channel Talk-1; K2p16.1; MGC133123; pancreatic potassium channel Talk-1; potassium channel subfamily K member 16; potassium channel, subfamily K, member 16; potassium channel, two pore domain subfamily K, member 16; TALK-1; TALK1; TWIK-related alkaline pH-activated K(+) channel 1
RGD Orthologs
Mouse
Rat
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38639,314,570 - 39,322,968 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl639,314,698 - 39,322,968 (-)EnsemblGRCh38hg38GRCh38
GRCh37639,282,474 - 39,290,744 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36639,390,460 - 39,398,294 (-)NCBINCBI36Build 36hg18NCBI36
Build 34639,390,459 - 39,398,294NCBI
Celera640,835,738 - 40,843,594 (-)NCBICelera
Cytogenetic Map6p21.2NCBI
HuRef639,000,935 - 39,008,791 (-)NCBIHuRef
CHM1_1639,285,120 - 39,292,976 (-)NCBICHM1_1
T2T-CHM13v2.0639,139,109 - 39,147,515 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11256078   PMID:11263999   PMID:12477932   PMID:12724142   PMID:14574404   PMID:16382106   PMID:18516069   PMID:21873635   PMID:22158537   PMID:24509480   PMID:25416956   PMID:26186194  
PMID:26239056   PMID:28403169   PMID:28514442   PMID:28928238   PMID:30021884   PMID:33961781   PMID:36724073  


Genomics

Comparative Map Data
KCNK16
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38639,314,570 - 39,322,968 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl639,314,698 - 39,322,968 (-)EnsemblGRCh38hg38GRCh38
GRCh37639,282,474 - 39,290,744 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36639,390,460 - 39,398,294 (-)NCBINCBI36Build 36hg18NCBI36
Build 34639,390,459 - 39,398,294NCBI
Celera640,835,738 - 40,843,594 (-)NCBICelera
Cytogenetic Map6p21.2NCBI
HuRef639,000,935 - 39,008,791 (-)NCBIHuRef
CHM1_1639,285,120 - 39,292,976 (-)NCBICHM1_1
T2T-CHM13v2.0639,139,109 - 39,147,515 (-)NCBIT2T-CHM13v2.0
Kcnk16
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391420,311,443 - 20,319,337 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1420,311,444 - 20,319,267 (-)EnsemblGRCm39 Ensembl
GRCm381420,261,375 - 20,269,269 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1420,261,376 - 20,269,199 (-)EnsemblGRCm38mm10GRCm38
MGSCv371421,081,978 - 21,088,384 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361419,051,308 - 19,057,714 (-)NCBIMGSCv36mm8
Celera1416,643,909 - 16,650,315 (-)NCBICelera
Cytogenetic Map14A3NCBI
cM Map1411.49NCBI
Kcnk16
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8154,069,495 - 4,098,836 (+)NCBIGRCr8
mRatBN7.2154,042,506 - 4,049,652 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl154,042,506 - 4,049,652 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx154,052,610 - 4,059,749 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0155,439,032 - 5,446,172 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0154,051,427 - 4,058,567 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0154,474,732 - 4,482,196 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl154,475,051 - 4,482,194 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0158,574,694 - 8,582,657 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4154,287,010 - 4,294,153 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera15547,096 - 554,173 (-)NCBICelera
Cytogenetic Map15p16NCBI
KCNK16
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2553,811,177 - 53,819,445 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1649,680,775 - 49,689,043 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0638,903,546 - 38,911,814 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1640,214,325 - 40,222,171 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl640,214,325 - 40,222,171 (-)Ensemblpanpan1.1panPan2
Kcnk16
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494643,627,366 - 43,633,167 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647620,327,086 - 20,332,752 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647620,327,086 - 20,332,752 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNK16
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl734,727,793 - 34,734,771 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1734,727,771 - 34,734,790 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2739,812,306 - 39,817,139 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNK16
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11732,815,592 - 32,823,313 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604439,318,493 - 39,325,976 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnk16
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475421,195,440 - 21,200,885 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KCNK16
23 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6p21.2-21.1(chr6:37777369-45653843)x1 copy number loss See cases [RCV000052181] Chr6:37777369..45653843 [GRCh38]
Chr6:37745145..45621580 [GRCh37]
Chr6:37853123..45729558 [NCBI36]
Chr6:6p21.2-21.1		 pathogenic
NM_001135106.1(KCNK16):c.689C>T (p.Ser230Leu) single nucleotide variant Malignant melanoma [RCV000061427] Chr6:39316415 [GRCh38]
Chr6:39284191 [GRCh37]
Chr6:39392169 [NCBI36]
Chr6:6p21.2		 not provided
GRCh38/hg38 6p21.2(chr6:39127448-40287232)x3 copy number gain See cases [RCV000134152] Chr6:39127448..40287232 [GRCh38]
Chr6:39095224..40254971 [GRCh37]
Chr6:39203202..40362949 [NCBI36]
Chr6:6p21.2		 likely benign|uncertain significance
GRCh38/hg38 6p21.2(chr6:39302297-39429561)x3 copy number gain See cases [RCV000136511] Chr6:39302297..39429561 [GRCh38]
Chr6:39270073..39397337 [GRCh37]
Chr6:39378051..39505315 [NCBI36]
Chr6:6p21.2		 benign
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
NM_001135106.2(KCNK16):c.65T>A (p.Val22Asp) single nucleotide variant Inborn genetic diseases [RCV003273028] Chr6:39322476 [GRCh38]
Chr6:39290252 [GRCh37]
Chr6:6p21.2		 uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367) copy number gain not provided [RCV000767714] Chr6:29455465..81447367 [GRCh37]
Chr6:6p22.1-q14.1		 pathogenic
GRCh37/hg19 6p21.2(chr6:39201170-39473868)x3 copy number gain not provided [RCV000847835] Chr6:39201170..39473868 [GRCh37]
Chr6:6p21.2		 uncertain significance
NM_001135106.2(KCNK16):c.149A>T (p.Glu50Val) single nucleotide variant Inborn genetic diseases [RCV003251003] Chr6:39322392 [GRCh38]
Chr6:39290168 [GRCh37]
Chr6:6p21.2		 uncertain significance
NM_031460.4(KCNK17):c.61A>G (p.Ser21Gly) single nucleotide variant not provided [RCV001637785] Chr6:39314260 [GRCh38]
Chr6:39282036 [GRCh37]
Chr6:6p21.2		 benign
NM_001135106.2(KCNK16):c.272G>A (p.Ser91Asn) single nucleotide variant Inborn genetic diseases [RCV003293819] Chr6:39319075 [GRCh38]
Chr6:39286851 [GRCh37]
Chr6:6p21.2		 uncertain significance
GRCh37/hg19 6p21.2(chr6:39069267-39301460)x3 copy number gain not provided [RCV001258728] Chr6:39069267..39301460 [GRCh37]
Chr6:6p21.2		 uncertain significance
NM_001135106.2(KCNK16):c.566T>C (p.Met189Thr) single nucleotide variant Inborn genetic diseases [RCV003261402] Chr6:39316877 [GRCh38]
Chr6:39284653 [GRCh37]
Chr6:6p21.2		 uncertain significance
NM_001135106.2(KCNK16):c.253G>A (p.Gly85Ser) single nucleotide variant Inborn genetic diseases [RCV002689350] Chr6:39319094 [GRCh38]
Chr6:39286870 [GRCh37]
Chr6:6p21.2		 uncertain significance
NM_001135106.2(KCNK16):c.647G>A (p.Gly216Glu) single nucleotide variant Inborn genetic diseases [RCV002797506] Chr6:39316796 [GRCh38]
Chr6:39284572 [GRCh37]
Chr6:6p21.2		 uncertain significance
NM_001135106.2(KCNK16):c.476A>C (p.Asp159Ala) single nucleotide variant Inborn genetic diseases [RCV002977631] Chr6:39317805 [GRCh38]
Chr6:39285581 [GRCh37]
Chr6:6p21.2		 uncertain significance
NM_001135106.2(KCNK16):c.38G>A (p.Arg13Gln) single nucleotide variant Inborn genetic diseases [RCV002768057] Chr6:39322503 [GRCh38]
Chr6:39290279 [GRCh37]
Chr6:6p21.2		 uncertain significance
NM_001135106.2(KCNK16):c.40G>T (p.Val14Leu) single nucleotide variant Inborn genetic diseases [RCV002898247] Chr6:39322501 [GRCh38]
Chr6:39290277 [GRCh37]
Chr6:6p21.2		 uncertain significance
NM_001135106.2(KCNK16):c.485G>A (p.Arg162Lys) single nucleotide variant Inborn genetic diseases [RCV003208785] Chr6:39317796 [GRCh38]
Chr6:39285572 [GRCh37]
Chr6:6p21.2		 uncertain significance
NM_001135106.2(KCNK16):c.450T>G (p.His150Gln) single nucleotide variant Inborn genetic diseases [RCV003204899] Chr6:39317831 [GRCh38]
Chr6:39285607 [GRCh37]
Chr6:6p21.2		 uncertain significance
NM_001135106.2(KCNK16):c.366G>T (p.Gln122His) single nucleotide variant Inborn genetic diseases [RCV003191068] Chr6:39317915 [GRCh38]
Chr6:39285691 [GRCh37]
Chr6:6p21.2		 uncertain significance
NM_001135106.2(KCNK16):c.158G>A (p.Arg53His) single nucleotide variant Inborn genetic diseases [RCV003309497] Chr6:39322383 [GRCh38]
Chr6:39290159 [GRCh37]
Chr6:6p21.2		 uncertain significance
NM_001135106.2(KCNK16):c.436G>A (p.Gly146Arg) single nucleotide variant Inborn genetic diseases [RCV003342049] Chr6:39317845 [GRCh38]
Chr6:39285621 [GRCh37]
Chr6:6p21.2		 uncertain significance
NM_001135106.2(KCNK16):c.326T>G (p.Ile109Arg) single nucleotide variant Inborn genetic diseases [RCV003383798] Chr6:39319021 [GRCh38]
Chr6:39286797 [GRCh37]
Chr6:6p21.2		 uncertain significance
GRCh37/hg19 6p21.31-21.1(chr6:35562152-42003452)x1 copy number loss not provided [RCV003485510] Chr6:35562152..42003452 [GRCh37]
Chr6:6p21.31-21.1		 pathogenic
GRCh37/hg19 6p21.2(chr6:39054113-40272338)x3 copy number gain not provided [RCV003484641] Chr6:39054113..40272338 [GRCh37]
Chr6:6p21.2		 uncertain significance
NM_001135105.2(KCNK16):c.*84C>T single nucleotide variant not provided [RCV003431841] Chr6:39315040 [GRCh38]
Chr6:39282816 [GRCh37]
Chr6:6p21.2		 likely benign
NM_032115.4(KCNK16):c.803-175C>T single nucleotide variant not provided [RCV003428844] Chr6:39315304 [GRCh38]
Chr6:39283080 [GRCh37]
Chr6:6p21.2		 likely benign
NM_001135106.2(KCNK16):c.817G>A (p.Val273Ile) single nucleotide variant not provided [RCV003428845] Chr6:39316287 [GRCh38]
Chr6:39284063 [GRCh37]
Chr6:6p21.2		 likely benign
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1475
Count of miRNA genes:629
Interacting mature miRNAs:726
Transcripts:ENST00000373227, ENST00000373229, ENST00000425054, ENST00000437525, ENST00000507712
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 1
Medium 7 1 22
Low 112 9 200 2 1 2 14 243 1
Below cutoff 743 845 685 98 223 76 588 383 1378 21 542 839 22 185 398 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001135105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001135106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001135107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001363784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_032115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017011346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054356512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF358909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL136087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY253145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY253146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY253147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC111860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP387644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA843225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU978943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FB764117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000373227   ⟹   ENSP00000362324
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl639,315,002 - 39,322,540 (-)Ensembl
RefSeq Acc Id: ENST00000373229   ⟹   ENSP00000362326
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl639,314,698 - 39,322,554 (-)Ensembl
RefSeq Acc Id: ENST00000425054   ⟹   ENSP00000391498
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl639,314,821 - 39,322,540 (-)Ensembl
RefSeq Acc Id: ENST00000437525   ⟹   ENSP00000415375
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl639,316,171 - 39,322,702 (-)Ensembl
RefSeq Acc Id: ENST00000507712   ⟹   ENSP00000423842
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl639,314,948 - 39,322,968 (-)Ensembl
RefSeq Acc Id: NM_001135105   ⟹   NP_001128577
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38639,314,698 - 39,322,702 (-)NCBI
GRCh37639,282,474 - 39,290,330 (-)RGD
Celera640,835,738 - 40,843,594 (-)RGD
HuRef639,000,935 - 39,008,791 (-)RGD
CHM1_1639,285,120 - 39,292,976 (-)NCBI
T2T-CHM13v2.0639,139,241 - 39,147,249 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001135106   ⟹   NP_001128578
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38639,316,171 - 39,322,702 (-)NCBI
GRCh37639,282,474 - 39,290,330 (-)RGD
Celera640,835,738 - 40,843,594 (-)RGD
HuRef639,000,935 - 39,008,791 (-)RGD
CHM1_1639,286,593 - 39,292,976 (-)NCBI
T2T-CHM13v2.0639,140,714 - 39,147,249 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001135107   ⟹   NP_001128579
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38639,314,698 - 39,322,702 (-)NCBI
GRCh37639,282,474 - 39,290,330 (-)RGD
Celera640,835,738 - 40,843,594 (-)RGD
HuRef639,000,935 - 39,008,791 (-)RGD
CHM1_1639,285,120 - 39,292,976 (-)NCBI
T2T-CHM13v2.0639,139,241 - 39,147,249 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001363784   ⟹   NP_001350713
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38639,314,698 - 39,322,968 (-)NCBI
T2T-CHM13v2.0639,139,241 - 39,147,515 (-)NCBI
Sequence:
RefSeq Acc Id: NM_032115   ⟹   NP_115491
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38639,314,698 - 39,322,702 (-)NCBI
GRCh37639,282,474 - 39,290,330 (-)RGD
Build 36639,390,460 - 39,398,294 (-)NCBI Archive
Celera640,835,738 - 40,843,594 (-)RGD
HuRef639,000,935 - 39,008,791 (-)RGD
CHM1_1639,285,120 - 39,292,976 (-)NCBI
T2T-CHM13v2.0639,139,241 - 39,147,249 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017011346   ⟹   XP_016866835
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38639,314,570 - 39,322,702 (-)NCBI
Sequence:
RefSeq Acc Id: XM_054356512   ⟹   XP_054212487
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0639,139,109 - 39,147,249 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_115491   ⟸   NM_032115
- Peptide Label: isoform 2
- UniProtKB: Q6X6Z5 (UniProtKB/Swiss-Prot),   Q6X6Z4 (UniProtKB/Swiss-Prot),   Q6X6Z3 (UniProtKB/Swiss-Prot),   Q5TCF3 (UniProtKB/Swiss-Prot),   Q2M2N9 (UniProtKB/Swiss-Prot),   B5TJL9 (UniProtKB/Swiss-Prot),   Q9H591 (UniProtKB/Swiss-Prot),   Q96T55 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001128577   ⟸   NM_001135105
- Peptide Label: isoform 1
- UniProtKB: Q96T55 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001128579   ⟸   NM_001135107
- Peptide Label: isoform 4
- UniProtKB: Q96T55 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001128578   ⟸   NM_001135106
- Peptide Label: isoform 3
- UniProtKB: Q96T55 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016866835   ⟸   XM_017011346
- Peptide Label: isoform X1
- UniProtKB: Q96T55 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001350713   ⟸   NM_001363784
- Peptide Label: isoform 5
- UniProtKB: D6RC57 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSP00000391498   ⟸   ENST00000425054
RefSeq Acc Id: ENSP00000362324   ⟸   ENST00000373227
RefSeq Acc Id: ENSP00000362326   ⟸   ENST00000373229
RefSeq Acc Id: ENSP00000423842   ⟸   ENST00000507712
RefSeq Acc Id: ENSP00000415375   ⟸   ENST00000437525
RefSeq Acc Id: XP_054212487   ⟸   XM_054356512
- Peptide Label: isoform X1
Protein Domains
Potassium channel

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q96T55-F1-model_v2 AlphaFold Q96T55 1-309 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:14464 AgrOrtholog
COSMIC KCNK16 COSMIC
Ensembl Genes ENSG00000095981 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000373227 ENTREZGENE
  ENST00000373227.8 UniProtKB/Swiss-Prot
  ENST00000373229 ENTREZGENE
  ENST00000373229.9 UniProtKB/Swiss-Prot
  ENST00000425054 ENTREZGENE
  ENST00000425054.6 UniProtKB/Swiss-Prot
  ENST00000437525 ENTREZGENE
  ENST00000437525.3 UniProtKB/Swiss-Prot
  ENST00000507712 ENTREZGENE
  ENST00000507712.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000095981 GTEx
HGNC ID HGNC:14464 ENTREZGENE
Human Proteome Map KCNK16 Human Proteome Map
InterPro 2pore_dom_K_chnl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2pore_dom_K_chnl_TASK UniProtKB/Swiss-Prot
  K_chnl_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:83795 UniProtKB/Swiss-Prot
NCBI Gene 83795 ENTREZGENE
OMIM 607369 OMIM
PANTHER POTASSIUM CHANNEL SUBFAMILY K MEMBER 16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11003 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ion_trans_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA30057 PharmGKB
PRINTS 2POREKCHANEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TASKCHANNEL UniProtKB/Swiss-Prot
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B5TJL9 ENTREZGENE
  D6RC57 ENTREZGENE, UniProtKB/TrEMBL
  KCNKG_HUMAN UniProtKB/Swiss-Prot
  Q2M2N9 ENTREZGENE
  Q5TCF3 ENTREZGENE
  Q6X6Z3 ENTREZGENE
  Q6X6Z4 ENTREZGENE
  Q6X6Z5 ENTREZGENE
  Q96T55 ENTREZGENE
  Q9H591 ENTREZGENE
UniProt Secondary B5TJL9 UniProtKB/Swiss-Prot
  Q2M2N9 UniProtKB/Swiss-Prot
  Q5TCF3 UniProtKB/Swiss-Prot
  Q6X6Z3 UniProtKB/Swiss-Prot
  Q6X6Z4 UniProtKB/Swiss-Prot
  Q6X6Z5 UniProtKB/Swiss-Prot
  Q9H591 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-10 KCNK16  potassium two pore domain channel subfamily K member 16  KCNK16  potassium channel, two pore domain subfamily K, member 16  Symbol and/or name change 5135510 APPROVED
2015-01-20 KCNK16  potassium channel, two pore domain subfamily K, member 16  KCNK16  potassium channel, subfamily K, member 16  Symbol and/or name change 5135510 APPROVED