Wdr5b (WD repeat domain 5B) - Rat Genome Database

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Gene: Wdr5b (WD repeat domain 5B) Mus musculus
Analyze
Symbol: Wdr5b
Name: WD repeat domain 5B
RGD ID: 1318415
MGI Page MGI
Description: Predicted to enable histone binding activity. Predicted to be part of Set1C/COMPASS complex. Orthologous to human WDR5B (WD repeat domain 5B).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 2310009C03Rik; AI606931; WD repeat-containing protein 5B
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391635,861,560 - 35,863,344 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1635,861,560 - 35,864,298 (+)EnsemblGRCm39 Ensembl
GRCm381636,041,190 - 36,042,974 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1636,041,190 - 36,043,928 (+)EnsemblGRCm38mm10GRCm38
MGSCv371636,041,276 - 36,043,060 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361635,960,937 - 35,962,721 (+)NCBIMGSCv36mm8
Celera1636,521,798 - 36,523,582 (+)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1625.43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:17041588   PMID:21677750   PMID:21873635  


Genomics

Comparative Map Data
Wdr5b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391635,861,560 - 35,863,344 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1635,861,560 - 35,864,298 (+)EnsemblGRCm39 Ensembl
GRCm381636,041,190 - 36,042,974 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1636,041,190 - 36,043,928 (+)EnsemblGRCm38mm10GRCm38
MGSCv371636,041,276 - 36,043,060 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361635,960,937 - 35,962,721 (+)NCBIMGSCv36mm8
Celera1636,521,798 - 36,523,582 (+)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1625.43NCBI
WDR5B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383122,411,846 - 122,416,062 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3122,411,846 - 122,416,062 (-)EnsemblGRCh38hg38GRCh38
GRCh373122,130,693 - 122,134,909 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363123,613,390 - 123,617,572 (-)NCBINCBI36Build 36hg18NCBI36
Build 343123,613,389 - 123,617,572NCBI
Celera3120,540,328 - 120,544,510 (-)NCBICelera
Cytogenetic Map3q21.1NCBI
HuRef3119,504,011 - 119,508,193 (-)NCBIHuRef
CHM1_13122,094,185 - 122,098,367 (-)NCBICHM1_1
T2T-CHM13v2.03125,131,401 - 125,135,617 (-)NCBIT2T-CHM13v2.0
Wdr5b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81178,216,266 - 78,218,125 (-)NCBIGRCr8
mRatBN7.21164,710,945 - 64,712,804 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1164,710,355 - 64,712,807 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1173,536,288 - 73,538,147 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01166,198,550 - 66,200,409 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01165,229,798 - 65,231,657 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01167,645,959 - 67,647,818 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1167,645,965 - 67,647,818 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01170,733,436 - 70,735,295 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41166,546,008 - 66,547,867 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11166,603,598 - 66,605,456 (-)NCBI
Celera1164,176,936 - 64,178,795 (-)NCBICelera
Cytogenetic Map11q22NCBI
Wdr5b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542721,698,917 - 21,699,888 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542721,698,766 - 21,700,390 (-)NCBIChiLan1.0ChiLan1.0
WDR5B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22120,357,926 - 120,361,745 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13120,360,418 - 120,366,525 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03119,503,001 - 119,506,814 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13126,408,696 - 126,412,482 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3126,410,902 - 126,411,894 (-)Ensemblpanpan1.1panPan2
WDR5B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13325,554,218 - 25,557,025 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3325,555,419 - 25,556,408 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3325,578,548 - 25,581,379 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03325,789,314 - 25,792,140 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3325,789,314 - 25,792,105 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13325,586,303 - 25,589,137 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03325,629,685 - 25,632,491 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03326,187,207 - 26,190,033 (-)NCBIUU_Cfam_GSD_1.0
Wdr5b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602128,787,032 - 128,794,125 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365368,728,735 - 8,730,367 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365368,727,881 - 8,731,067 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WDR5B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13138,109,848 - 138,113,646 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113138,109,758 - 138,113,638 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213147,720,711 - 147,723,427 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WDR5B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12258,444,586 - 58,446,316 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2258,445,149 - 58,446,141 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041107,895,882 - 107,899,147 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wdr5b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624912764,076 - 766,647 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624912762,893 - 766,690 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Wdr5b
47 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:184
Count of miRNA genes:149
Interacting mature miRNAs:171
Transcripts:ENSMUST00000042203
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11059560Lmr12b_mleishmaniasis resistance 12b (mouse)162879281362792952Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
1301841Lrnx9_mlearning-contextual 9 (mouse)Not determined161222536046225471Mouse
1302096Aod1a_mautoimmune ovarian dysgenesis 1a (mouse)Not determined163544664392573008Mouse
4141179Ipng3_mimprinted postnatal growth 3 (mouse)Not determined2277525257594076Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16431786444520363Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16381786464620363Mouse
11049571Lmr12c_mleishmaniasis resistance 12c (mouse)162879281362792952Mouse
1301086Lprm5_mlymphoproliferation modifier 5 (mouse)Not determined161184882445848923Mouse
27226768Tibl9_mtibia length 9, 5 week (mouse)16331786451420363Mouse
11059559Lmr12a_mleishmaniasis resistance 12a (mouse)162879281362792952Mouse
1301443Mopkd2_mmodifier of polycystic kidney disease progression 2 (mouse)Not determined16464631438646414Mouse
10043978Obq35_mobesity QTL 35 (mouse)Not determined16988163143881631Mouse
25671380Hrsq2_mhost response to SARS QTL 2, titer (mouse)163140250136540273Mouse
4142187Arrd3_mage-related retinal degeneration 3 (mouse)Not determined3252290965466552Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16654297965466552Mouse
1357517Bwtn1_mbody weight at necropsy 1 (mouse)Not determined162001932985600826Mouse
1300943Skts9_mskin tumor susceptibility 9 (mouse)Not determined16577525239775440Mouse
1301070Cypr1_mcytokine production 1 (mouse)Not determined163231279566312933Mouse
1300915Lmr12_mleishmaniasis resistance 12 (mouse)Not determined162879281362792952Mouse
1300656Bgeq15_mbody growth early QTL 15 (mouse)Not determined16577525239775440Mouse
4142236Pstc4_mperiosteal circumference 4 (mouse)Not determined161552290949523112Mouse
1300534Bmd15_mbone mineral density 15 (mouse)Not determined162193838355938574Mouse
11251724Ewc6_methanol withdrawal and consumption 6 (mouse)16822605242226052Mouse
1300987Skull23_mskull morphology 23 (mouse)Not determined16577525239775440Mouse
1301945Skl7_mskeletal size (tail length) 7 (mouse)Not determined16577525239775440Mouse
10045614Rapop6_mradiation-induced apoptosis 6 (mouse)Not determined161480292148803032Mouse
15092062Egrme4_mearly growth rate, maternal effect 4 (mouse)162521866444220250Mouse
27095908Scvln7_msacral vertebrae length 2, 5 week (mouse)16331786439820362Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16331786464620363Mouse

Markers in Region
AI606931  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381636,042,736 - 36,042,826UniSTSGRCm38
MGSCv371636,042,822 - 36,042,912UniSTSGRCm37
Celera1636,523,344 - 36,523,434UniSTS
Cytogenetic Map16B3UniSTS
Whitehead/MRC_RH16346.3UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000042203   ⟹   ENSMUSP00000040852
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1635,861,560 - 35,864,298 (+)Ensembl
GRCm38.p6 Ensembl1636,041,190 - 36,043,928 (+)Ensembl
RefSeq Acc Id: NM_027113   ⟹   NP_081389
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391635,861,560 - 35,863,344 (+)NCBI
GRCm381636,041,190 - 36,042,974 (+)ENTREZGENE
MGSCv371636,041,276 - 36,043,060 (+)RGD
Celera1636,521,798 - 36,523,582 (+)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_081389   ⟸   NM_027113
- UniProtKB: Q9D7H2 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000040852   ⟸   ENSMUST00000042203

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9D7H2-F1-model_v2 AlphaFold Q9D7H2 1-328 view protein structure

Promoters
RGD ID:6827625
Promoter ID:MM_KWN:20891
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_027113
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361636,040,556 - 36,042,852 (+)MPROMDB
RGD ID:8686098
Promoter ID:EPDNEW_M21080
Type:initiation region
Name:Wdr5b_1
Description:Mus musculus WD repeat domain 5B , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381636,041,286 - 36,041,346EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1916794 AgrOrtholog
Ensembl Genes ENSMUSG00000034379 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000042203 ENTREZGENE
  ENSMUST00000042203.10 UniProtKB/Swiss-Prot
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot
InterPro G-protein_beta_WD-40_rep UniProtKB/Swiss-Prot
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot
  WD40_repeat UniProtKB/Swiss-Prot
  WD40_repeat_CS UniProtKB/Swiss-Prot
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot
KEGG Report mmu:69544 UniProtKB/Swiss-Prot
MGD MGI:1916794 ENTREZGENE
NCBI Gene 69544 ENTREZGENE
PANTHER WD REPEAT-CONTAINING PROTEIN 5B UniProtKB/Swiss-Prot
  WD40 REPEAT PROTEIN UniProtKB/Swiss-Prot
Pfam WD40 UniProtKB/Swiss-Prot
PhenoGen Wdr5b PhenoGen
PIRSF GN-bd_beta UniProtKB/Swiss-Prot
PRINTS GPROTEINBRPT UniProtKB/Swiss-Prot
PROSITE WD_REPEATS_1 UniProtKB/Swiss-Prot
  WD_REPEATS_2 UniProtKB/Swiss-Prot
  WD_REPEATS_REGION UniProtKB/Swiss-Prot
SMART WD40 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot
UniProt Q9D7H2 ENTREZGENE, UniProtKB/Swiss-Prot