WDR5B (WD repeat domain 5B) - Rat Genome Database

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Gene: WDR5B (WD repeat domain 5B) Canis lupus familiaris
Analyze
Symbol: WDR5B
Name: WD repeat domain 5B
RGD ID: 12360802
Description: ENCODES a protein that exhibits dynein complex binding (inferred); microtubule plus-end binding (inferred); INVOLVED IN establishment of mitotic spindle orientation (inferred); microtubule organizing center organization (inferred); nuclear migration (inferred); ASSOCIATED WITH alkaptonuria (ortholog); familial hypocalciuric hypercalcemia (ortholog); genetic disease (ortholog); FOUND IN cytoplasmic microtubule (inferred); kinetochore (inferred); microtubule associated complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: WD repeat-containing protein 5B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13325,554,218 - 25,557,025 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3325,555,419 - 25,556,408 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3325,578,548 - 25,581,379 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03325,789,314 - 25,792,140 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3325,789,314 - 25,792,105 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13325,586,303 - 25,589,137 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03325,629,685 - 25,632,491 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03326,187,207 - 26,190,033 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
WDR5B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13325,554,218 - 25,557,025 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3325,555,419 - 25,556,408 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3325,578,548 - 25,581,379 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03325,789,314 - 25,792,140 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3325,789,314 - 25,792,105 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13325,586,303 - 25,589,137 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03325,629,685 - 25,632,491 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03326,187,207 - 26,190,033 (-)NCBIUU_Cfam_GSD_1.0
WDR5B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383122,411,846 - 122,416,062 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3122,411,846 - 122,416,062 (-)EnsemblGRCh38hg38GRCh38
GRCh373122,130,693 - 122,134,909 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363123,613,390 - 123,617,572 (-)NCBINCBI36Build 36hg18NCBI36
Build 343123,613,389 - 123,617,572NCBI
Celera3120,540,328 - 120,544,510 (-)NCBICelera
Cytogenetic Map3q21.1NCBI
HuRef3119,504,011 - 119,508,193 (-)NCBIHuRef
CHM1_13122,094,185 - 122,098,367 (-)NCBICHM1_1
T2T-CHM13v2.03125,131,401 - 125,135,617 (-)NCBIT2T-CHM13v2.0
Wdr5b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391635,861,560 - 35,863,344 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1635,861,560 - 35,864,298 (+)EnsemblGRCm39 Ensembl
GRCm381636,041,190 - 36,042,974 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1636,041,190 - 36,043,928 (+)EnsemblGRCm38mm10GRCm38
MGSCv371636,041,276 - 36,043,060 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361635,960,937 - 35,962,721 (+)NCBIMGSCv36mm8
Celera1636,521,798 - 36,523,582 (+)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1625.43NCBI
Wdr5b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81178,216,266 - 78,218,125 (-)NCBIGRCr8
mRatBN7.21164,710,945 - 64,712,804 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1164,710,355 - 64,712,807 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1173,536,288 - 73,538,147 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01166,198,550 - 66,200,409 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01165,229,798 - 65,231,657 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01167,645,959 - 67,647,818 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1167,645,965 - 67,647,818 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01170,733,436 - 70,735,295 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41166,546,008 - 66,547,867 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11166,603,598 - 66,605,456 (-)NCBI
Celera1164,176,936 - 64,178,795 (-)NCBICelera
Cytogenetic Map11q22NCBI
Wdr5b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542721,698,917 - 21,699,888 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542721,698,766 - 21,700,390 (-)NCBIChiLan1.0ChiLan1.0
WDR5B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22120,357,926 - 120,361,745 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13120,360,418 - 120,366,525 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03119,503,001 - 119,506,814 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13126,408,696 - 126,412,482 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3126,410,902 - 126,411,894 (-)Ensemblpanpan1.1panPan2
Wdr5b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602128,787,032 - 128,794,125 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365368,728,735 - 8,730,367 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365368,727,881 - 8,731,067 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WDR5B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13138,109,848 - 138,113,646 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113138,109,758 - 138,113,638 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213147,720,711 - 147,723,427 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WDR5B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12258,444,586 - 58,446,316 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2258,445,149 - 58,446,141 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041107,895,882 - 107,899,147 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wdr5b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624912764,076 - 766,647 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624912762,893 - 766,690 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in WDR5B
50 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 16 6 6 9 10 4
Low 1 5 6 6 6 6 3 8 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022414051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022414052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022414053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038445126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038445127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038445128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038519380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038519381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038519382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038583007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038583008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038583009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038647395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038647396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038647397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSCAFT00000018893   ⟹   ENSCAFP00000017508
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3325,555,419 - 25,556,408 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845041589   ⟹   ENSCAFP00845032610
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3325,789,314 - 25,792,105 (-)Ensembl
RefSeq Acc Id: XM_022414051   ⟹   XP_022269759
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13325,554,218 - 25,557,010 (-)NCBI
Dog10K_Boxer_Tasha3325,578,548 - 25,581,361 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022414052   ⟹   XP_022269760
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13325,554,218 - 25,557,025 (-)NCBI
Dog10K_Boxer_Tasha3325,578,548 - 25,581,353 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022414053   ⟹   XP_022269761
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13325,554,218 - 25,557,023 (-)NCBI
Dog10K_Boxer_Tasha3325,578,548 - 25,581,379 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038445126   ⟹   XP_038301054
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03325,789,314 - 25,792,140 (-)NCBI
RefSeq Acc Id: XM_038445127   ⟹   XP_038301055
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03325,789,314 - 25,792,123 (-)NCBI
RefSeq Acc Id: XM_038445128   ⟹   XP_038301056
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03325,789,314 - 25,792,116 (-)NCBI
RefSeq Acc Id: XM_038519380   ⟹   XP_038375308
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13325,586,303 - 25,589,137 (-)NCBI
RefSeq Acc Id: XM_038519381   ⟹   XP_038375309
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13325,586,303 - 25,589,120 (-)NCBI
RefSeq Acc Id: XM_038519382   ⟹   XP_038375310
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13325,586,303 - 25,589,112 (-)NCBI
RefSeq Acc Id: XM_038583007   ⟹   XP_038438935
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03326,187,207 - 26,190,033 (-)NCBI
RefSeq Acc Id: XM_038583008   ⟹   XP_038438936
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03326,187,207 - 26,190,015 (-)NCBI
RefSeq Acc Id: XM_038583009   ⟹   XP_038438937
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03326,187,207 - 26,190,007 (-)NCBI
RefSeq Acc Id: XM_038647395   ⟹   XP_038503323
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03325,629,685 - 25,632,491 (-)NCBI
RefSeq Acc Id: XM_038647396   ⟹   XP_038503324
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03325,629,685 - 25,632,474 (-)NCBI
RefSeq Acc Id: XM_038647397   ⟹   XP_038503325
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03325,629,685 - 25,632,465 (-)NCBI
RefSeq Acc Id: XP_022269760   ⟸   XM_022414052
- Peptide Label: isoform X2
- UniProtKB: A0A8P0SGW2 (UniProtKB/TrEMBL),   A0A8C0N497 (UniProtKB/TrEMBL),   A0A8C0TKM5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022269761   ⟸   XM_022414053
- Peptide Label: isoform X2
- UniProtKB: A0A8P0SGW2 (UniProtKB/TrEMBL),   A0A8C0N497 (UniProtKB/TrEMBL),   A0A8C0TKM5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022269759   ⟸   XM_022414051
- Peptide Label: isoform X2
- UniProtKB: A0A8P0SGW2 (UniProtKB/TrEMBL),   A0A8C0N497 (UniProtKB/TrEMBL),   A0A8C0TKM5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000017508   ⟸   ENSCAFT00000018893
RefSeq Acc Id: XP_038375308   ⟸   XM_038519380
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038375309   ⟸   XM_038519381
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038375310   ⟸   XM_038519382
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038503323   ⟸   XM_038647395
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038503324   ⟸   XM_038647396
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038503325   ⟸   XM_038647397
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038301054   ⟸   XM_038445126
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JXM7 (UniProtKB/TrEMBL),   A0A8I3PJE9 (UniProtKB/TrEMBL),   A0A8C0N497 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038301055   ⟸   XM_038445127
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JXM7 (UniProtKB/TrEMBL),   A0A8I3PJE9 (UniProtKB/TrEMBL),   A0A8C0N497 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038301056   ⟸   XM_038445128
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JXM7 (UniProtKB/TrEMBL),   A0A8I3PJE9 (UniProtKB/TrEMBL),   A0A8C0N497 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038438935   ⟸   XM_038583007
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JXM7 (UniProtKB/TrEMBL),   A0A8C0N497 (UniProtKB/TrEMBL),   A0A8I3PJE9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038438936   ⟸   XM_038583008
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JXM7 (UniProtKB/TrEMBL),   A0A8C0N497 (UniProtKB/TrEMBL),   A0A8I3PJE9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038438937   ⟸   XM_038583009
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JXM7 (UniProtKB/TrEMBL),   A0A8C0N497 (UniProtKB/TrEMBL),   A0A8I3PJE9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845032610   ⟸   ENSCAFT00845041589


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000011894 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030013144 UniProtKB/TrEMBL
  ENSCAFG00040022324 UniProtKB/TrEMBL
  ENSCAFG00845023565 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000018893.2 UniProtKB/TrEMBL
  ENSCAFT00030024289.1 UniProtKB/TrEMBL
  ENSCAFT00040041450.1 UniProtKB/TrEMBL
  ENSCAFT00845041589 ENTREZGENE
  ENSCAFT00845041589.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
InterPro G-protein_beta_WD-40_rep UniProtKB/TrEMBL
  Gprotein_B UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
NCBI Gene WDR5B ENTREZGENE
PANTHER F-BOX_WD REPEAT-CONTAINING PROTEIN 11 UniProtKB/TrEMBL
  WD REPEAT-CONTAINING PROTEIN 5B UniProtKB/TrEMBL
  WD REPEAT-CONTAINING PROTEIN POP1 UniProtKB/TrEMBL
  WD REPEAT-CONTAINING PROTEIN POP1 UniProtKB/TrEMBL
  WD40 REPEAT PROTEIN UniProtKB/TrEMBL
Pfam WD40 UniProtKB/TrEMBL
PIRSF GN-bd_beta UniProtKB/TrEMBL
PRINTS GPROTEINB UniProtKB/TrEMBL
  GPROTEINBRPT UniProtKB/TrEMBL
PROSITE WD_REPEATS_1 UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/TrEMBL
UniProt A0A8C0JXM7 ENTREZGENE
  A0A8C0N497 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TKM5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PJE9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SGW2 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:48377 ENTREZGENE