MOB3C (MOB kinase activator 3C) - Rat Genome Database

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Gene: MOB3C (MOB kinase activator 3C) Homo sapiens
Analyze
Symbol: MOB3C
Name: MOB kinase activator 3C
RGD ID: 1317238
HGNC Page HGNC:29800
Description: Predicted to enable protein kinase activator activity. Predicted to be involved in signal transduction. Predicted to be active in cytoplasm and nucleus.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: MGC26743; mob1 homolog 2C; MOB1, Mps One Binder kinase activator-like 2C; MOB1E; MOBKL2C; mps one binder kinase activator-like 2C
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38146,607,719 - 46,616,811 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl146,607,719 - 46,616,811 (-)EnsemblGRCh38hg38GRCh38
GRCh37147,073,391 - 47,082,483 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36146,845,974 - 46,855,150 (-)NCBINCBI36Build 36hg18NCBI36
Celera145,360,739 - 45,369,899 (-)NCBICelera
Cytogenetic Map1p33NCBI
HuRef145,188,892 - 45,198,048 (-)NCBIHuRef
CHM1_1147,190,398 - 47,199,558 (-)NCBICHM1_1
T2T-CHM13v2.0146,484,946 - 46,494,037 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
nucleus  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:12477932   PMID:14702039   PMID:15489334   PMID:19739119   PMID:21832049   PMID:21873635   PMID:25416956   PMID:27503909   PMID:28514442   PMID:28700943   PMID:29117863  
PMID:29892012   PMID:32296183   PMID:33961781   PMID:37536630  


Genomics

Comparative Map Data
MOB3C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38146,607,719 - 46,616,811 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl146,607,719 - 46,616,811 (-)EnsemblGRCh38hg38GRCh38
GRCh37147,073,391 - 47,082,483 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36146,845,974 - 46,855,150 (-)NCBINCBI36Build 36hg18NCBI36
Celera145,360,739 - 45,369,899 (-)NCBICelera
Cytogenetic Map1p33NCBI
HuRef145,188,892 - 45,198,048 (-)NCBIHuRef
CHM1_1147,190,398 - 47,199,558 (-)NCBICHM1_1
T2T-CHM13v2.0146,484,946 - 46,494,037 (-)NCBIT2T-CHM13v2.0
Mob3c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394115,675,962 - 115,693,382 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4115,685,289 - 115,693,382 (+)EnsemblGRCm39 Ensembl
GRCm384115,827,886 - 115,836,185 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4115,828,092 - 115,836,185 (+)EnsemblGRCm38mm10GRCm38
MGSCv374115,500,697 - 115,508,788 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364115,326,024 - 115,334,115 (+)NCBIMGSCv36mm8
Celera4114,567,806 - 114,575,903 (+)NCBICelera
Cytogenetic Map4D1NCBI
cM Map453.06NCBI
Mob3c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85134,542,929 - 134,552,017 (+)NCBIGRCr8
mRatBN7.25129,306,255 - 129,315,264 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5129,306,569 - 129,315,256 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5131,923,667 - 131,932,327 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05133,678,537 - 133,687,197 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05133,700,689 - 133,709,351 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05134,679,850 - 134,687,899 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5134,679,713 - 134,688,963 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05138,464,329 - 138,472,344 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45136,088,611 - 136,095,078 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15136,097,478 - 136,100,593 (+)NCBI
Celera5127,838,087 - 127,844,534 (+)NCBICelera
Cytogenetic Map5q35NCBI
Mob3c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546411,662,566 - 11,705,495 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546411,697,952 - 11,705,495 (+)NCBIChiLan1.0ChiLan1.0
MOB3C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21180,192,061 - 180,201,238 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11179,333,682 - 179,342,844 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0145,910,230 - 45,919,403 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1147,265,759 - 47,274,922 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl147,265,759 - 47,273,112 (-)Ensemblpanpan1.1panPan2
MOB3C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11513,844,325 - 13,854,298 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1513,844,571 - 13,852,409 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1513,965,124 - 13,974,996 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01513,995,164 - 14,005,004 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1513,995,673 - 14,005,002 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11513,796,387 - 13,806,242 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01513,865,019 - 13,874,853 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01513,934,276 - 13,944,137 (+)NCBIUU_Cfam_GSD_1.0
Mob3c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505861,791,429 - 61,798,383 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647427,612,991 - 27,623,422 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647427,613,084 - 27,623,105 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MOB3C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6164,875,674 - 164,887,492 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16164,874,591 - 164,884,327 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26152,367,863 - 152,373,163 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MOB3C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12086,192,259 - 86,201,161 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2086,195,467 - 86,199,243 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603330,791,062 - 30,820,325 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mob3c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249062,485,706 - 2,493,120 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249062,485,694 - 2,494,733 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MOB3C
26 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p34.3-33(chr1:39479787-47688131)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051817]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051817]|See cases [RCV000051817] Chr1:39479787..47688131 [GRCh38]
Chr1:39945459..48153803 [GRCh37]
Chr1:39718046..47926390 [NCBI36]
Chr1:1p34.3-33		 pathogenic
GRCh37/hg19 1p36.12-12(chr1:20608823-120546301)x3 copy number loss not provided [RCV000762767] Chr1:20608823..120546301 [GRCh37]
Chr1:1p36.12-12		 likely benign
GRCh37/hg19 1p34.1-33(chr1:46747177-47280720)x3 copy number gain See cases [RCV000449344] Chr1:46747177..47280720 [GRCh37]
Chr1:1p34.1-33		 uncertain significance
GRCh37/hg19 1p34.1-32.3(chr1:45303358-52157856)x1 copy number loss See cases [RCV000448358] Chr1:45303358..52157856 [GRCh37]
Chr1:1p34.1-32.3		 likely pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p34.1-33(chr1:46541307-47088882)x3 copy number gain See cases [RCV000511609] Chr1:46541307..47088882 [GRCh37]
Chr1:1p34.1-33		 uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p34.1-33(chr1:46372688-47188150)x3 copy number gain not provided [RCV000736482] Chr1:46372688..47188150 [GRCh37]
Chr1:1p34.1-33		 uncertain significance
GRCh37/hg19 1p36.22-21.1(chr1:103343285-103455144)x3 copy number gain Global developmental delay [RCV000787285] Chr1:103343285..103455144 [GRCh37]
Chr1:1p36.22-21.1		 uncertain significance
GRCh37/hg19 1p34.1-33(chr1:46768408-47174149)x3 copy number gain See cases [RCV001007440] Chr1:46768408..47174149 [GRCh37]
Chr1:1p34.1-33		 uncertain significance
GRCh37/hg19 1p35.1-33(chr1:33285582-47891811) copy number gain not specified [RCV002052781] Chr1:33285582..47891811 [GRCh37]
Chr1:1p35.1-33		 pathogenic
GRCh37/hg19 1p34.1-32.3(chr1:45303358-52157856) copy number loss not specified [RCV002053281] Chr1:45303358..52157856 [GRCh37]
Chr1:1p34.1-32.3		 likely pathogenic
NM_201403.3(MOB3C):c.-50-1647G>C single nucleotide variant not specified [RCV004238384] Chr1:46615018 [GRCh38]
Chr1:47080690 [GRCh37]
Chr1:1p33		 uncertain significance
NM_201403.3(MOB3C):c.459G>T (p.Lys153Asn) single nucleotide variant not specified [RCV004104736] Chr1:46610164 [GRCh38]
Chr1:47075836 [GRCh37]
Chr1:1p33		 uncertain significance
NM_201403.3(MOB3C):c.79C>T (p.Arg27Cys) single nucleotide variant not specified [RCV004116320] Chr1:46613243 [GRCh38]
Chr1:47078915 [GRCh37]
Chr1:1p33		 uncertain significance
NM_201403.3(MOB3C):c.376G>A (p.Glu126Lys) single nucleotide variant not specified [RCV004144380] Chr1:46612946 [GRCh38]
Chr1:47078618 [GRCh37]
Chr1:1p33		 uncertain significance
NM_201403.3(MOB3C):c.207C>G (p.Asn69Lys) single nucleotide variant not specified [RCV004231550] Chr1:46613115 [GRCh38]
Chr1:47078787 [GRCh37]
Chr1:1p33		 uncertain significance
NM_201403.3(MOB3C):c.28G>C (p.Ala10Pro) single nucleotide variant not specified [RCV004208851] Chr1:46613294 [GRCh38]
Chr1:47078966 [GRCh37]
Chr1:1p33		 uncertain significance
NM_201403.3(MOB3C):c.605G>A (p.Arg202Gln) single nucleotide variant not specified [RCV004091032] Chr1:46610018 [GRCh38]
Chr1:47075690 [GRCh37]
Chr1:1p33		 uncertain significance
NM_201403.3(MOB3C):c.367G>C (p.Asp123His) single nucleotide variant not specified [RCV004069647] Chr1:46612955 [GRCh38]
Chr1:47078627 [GRCh37]
Chr1:1p33		 uncertain significance
NM_201403.3(MOB3C):c.187C>T (p.His63Tyr) single nucleotide variant not specified [RCV004250777] Chr1:46613135 [GRCh38]
Chr1:47078807 [GRCh37]
Chr1:1p33		 uncertain significance
NM_201403.3(MOB3C):c.78G>C (p.Gln26His) single nucleotide variant not specified [RCV004279106] Chr1:46613244 [GRCh38]
Chr1:47078916 [GRCh37]
Chr1:1p33		 uncertain significance
NM_201403.3(MOB3C):c.77A>C (p.Gln26Pro) single nucleotide variant not specified [RCV004279105] Chr1:46613245 [GRCh38]
Chr1:47078917 [GRCh37]
Chr1:1p33		 uncertain significance
NM_201403.3(MOB3C):c.289G>C (p.Glu97Gln) single nucleotide variant not specified [RCV004259861] Chr1:46613033 [GRCh38]
Chr1:47078705 [GRCh37]
Chr1:1p33		 uncertain significance
NM_201403.3(MOB3C):c.58C>T (p.Arg20Cys) single nucleotide variant not specified [RCV004335011] Chr1:46613264 [GRCh38]
Chr1:47078936 [GRCh37]
Chr1:1p33		 uncertain significance
NM_201403.3(MOB3C):c.641T>A (p.Ile214Asn) single nucleotide variant not specified [RCV004349691] Chr1:46609665 [GRCh38]
Chr1:47075337 [GRCh37]
Chr1:1p33		 uncertain significance
NM_201403.3(MOB3C):c.394G>A (p.Glu132Lys) single nucleotide variant not specified [RCV004362915] Chr1:46612928 [GRCh38]
Chr1:47078600 [GRCh37]
Chr1:1p33		 uncertain significance
Single allele inversion Bilateral polymicrogyria [RCV003459046] Chr1:33246132..61045156 [GRCh38]
Chr1:1p35.1-31.3		 likely pathogenic
NM_201403.3(MOB3C):c.604C>T (p.Arg202Trp) single nucleotide variant not specified [RCV004484588] Chr1:46610019 [GRCh38]
Chr1:47075691 [GRCh37]
Chr1:1p33		 uncertain significance
NM_201403.3(MOB3C):c.112C>T (p.Leu38Phe) single nucleotide variant not specified [RCV004482169] Chr1:46613210 [GRCh38]
Chr1:47078882 [GRCh37]
Chr1:1p33		 uncertain significance
NM_201403.3(MOB3C):c.347G>A (p.Arg116His) single nucleotide variant not specified [RCV004482331] Chr1:46612975 [GRCh38]
Chr1:47078647 [GRCh37]
Chr1:1p33		 uncertain significance
NM_201403.3(MOB3C):c.638G>A (p.Arg213Gln) single nucleotide variant not specified [RCV004484646] Chr1:46609668 [GRCh38]
Chr1:47075340 [GRCh37]
Chr1:1p33		 uncertain significance
NM_201403.3(MOB3C):c.368A>G (p.Asp123Gly) single nucleotide variant not specified [RCV004484396] Chr1:46612954 [GRCh38]
Chr1:47078626 [GRCh37]
Chr1:1p33		 uncertain significance
NM_201403.3(MOB3C):c.469C>T (p.Arg157Cys) single nucleotide variant not specified [RCV004484494] Chr1:46610154 [GRCh38]
Chr1:47075826 [GRCh37]
Chr1:1p33		 uncertain significance
NM_201403.3(MOB3C):c.526A>G (p.Met176Val) single nucleotide variant not specified [RCV004484527] Chr1:46610097 [GRCh38]
Chr1:47075769 [GRCh37]
Chr1:1p33		 uncertain significance
NM_201403.3(MOB3C):c.578T>G (p.Ile193Ser) single nucleotide variant not specified [RCV004484553] Chr1:46610045 [GRCh38]
Chr1:47075717 [GRCh37]
Chr1:1p33		 uncertain significance
NM_201403.3(MOB3C):c.220A>G (p.Ile74Val) single nucleotide variant not specified [RCV004482274] Chr1:46613102 [GRCh38]
Chr1:47078774 [GRCh37]
Chr1:1p33		 uncertain significance
NM_201403.3(MOB3C):c.366G>T (p.Met122Ile) single nucleotide variant not specified [RCV004482360] Chr1:46612956 [GRCh38]
Chr1:47078628 [GRCh37]
Chr1:1p33		 uncertain significance
NM_201403.3(MOB3C):c.479G>A (p.Arg160Gln) single nucleotide variant not specified [RCV004643276] Chr1:46610144 [GRCh38]
Chr1:47075816 [GRCh37]
Chr1:1p33		 uncertain significance
NM_201403.3(MOB3C):c.244T>C (p.Cys82Arg) single nucleotide variant not specified [RCV004629042] Chr1:46613078 [GRCh38]
Chr1:47078750 [GRCh37]
Chr1:1p33		 uncertain significance
NM_201403.3(MOB3C):c.523A>C (p.Ser175Arg) single nucleotide variant not specified [RCV004643277] Chr1:46610100 [GRCh38]
Chr1:47075772 [GRCh37]
Chr1:1p33		 uncertain significance
NM_201403.3(MOB3C):c.521T>A (p.Leu174His) single nucleotide variant not specified [RCV004629043] Chr1:46610102 [GRCh38]
Chr1:47075774 [GRCh37]
Chr1:1p33		 uncertain significance
NM_201403.3(MOB3C):c.22G>C (p.Val8Leu) single nucleotide variant not specified [RCV004482021] Chr1:46613300 [GRCh38]
Chr1:47078972 [GRCh37]
Chr1:1p33		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3216
Count of miRNA genes:739
Interacting mature miRNAs:874
Transcripts:ENST00000271139, ENST00000319928, ENST00000371940, ENST00000477318
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2314561GLUCO47_HGlucose level QTL 47 (human)1.1Glucose level14477336070773360Human
406944249GWAS593225_Hpyruvate measurement QTL GWAS593225 (human)3e-08pyruvate measurementblood pyruvate level (CMO:0002422)14661640746616408Human
407194172GWAS843148_Habdominal fat cell number QTL GWAS843148 (human)0.000008abdominal fat cell number14661500746615008Human
406954829GWAS603805_Hchronic kidney disease QTL GWAS603805 (human)5e-08chronic kidney disease14661500646615007Human
406959884GWAS608860_Hhypertension QTL GWAS608860 (human)0.0000005hypertension14661500646615007Human

Markers in Region
RH81054  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37147,073,428 - 47,073,677UniSTSGRCh37
Build 36146,846,015 - 46,846,264RGDNCBI36
Celera145,360,780 - 45,361,029RGD
Cytogenetic Map1p33UniSTS
HuRef145,188,933 - 45,189,182UniSTS
GeneMap99-GB4 RH Map1144.5UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1204 2432 2788 2245 4942 1723 2345 3 622 1946 464 2268 7278 6451 52 3708 847 1730 1612 170

Sequence


Ensembl Acc Id: ENST00000271139   ⟹   ENSP00000271139
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl146,607,719 - 46,615,133 (-)Ensembl
Ensembl Acc Id: ENST00000319928   ⟹   ENSP00000315113
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl146,607,719 - 46,616,811 (-)Ensembl
Ensembl Acc Id: ENST00000371940   ⟹   ENSP00000361008
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl146,607,725 - 46,616,465 (-)Ensembl
Ensembl Acc Id: ENST00000477318
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl146,610,002 - 46,616,884 (-)Ensembl
RefSeq Acc Id: NM_145279   ⟹   NP_660322
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38146,607,719 - 46,615,133 (-)NCBI
GRCh37147,073,387 - 47,082,563 (-)RGD
Build 36146,845,974 - 46,853,392 (-)NCBI Archive
Celera145,360,739 - 45,369,899 (-)RGD
HuRef145,188,892 - 45,198,048 (-)ENTREZGENE
CHM1_1147,190,398 - 47,197,800 (-)NCBI
T2T-CHM13v2.0146,484,946 - 46,492,359 (-)NCBI
Sequence:
RefSeq Acc Id: NM_201403   ⟹   NP_958805
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38146,607,719 - 46,616,811 (-)NCBI
GRCh37147,073,387 - 47,082,563 (-)RGD
Build 36146,845,974 - 46,855,150 (-)NCBI Archive
Celera145,360,739 - 45,369,899 (-)RGD
HuRef145,188,892 - 45,198,048 (-)ENTREZGENE
CHM1_1147,190,398 - 47,199,558 (-)NCBI
T2T-CHM13v2.0146,484,946 - 46,494,037 (-)NCBI
Sequence:
RefSeq Acc Id: NP_958805   ⟸   NM_201403
- UniProtKB: Q8NAZ2 (UniProtKB/Swiss-Prot),   Q5TC11 (UniProtKB/Swiss-Prot),   Q5TC10 (UniProtKB/Swiss-Prot),   Q0VA98 (UniProtKB/Swiss-Prot),   D3DQ22 (UniProtKB/Swiss-Prot),   Q8NF28 (UniProtKB/Swiss-Prot),   Q70IA8 (UniProtKB/Swiss-Prot),   X6R3L3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_660322   ⟸   NM_145279
- UniProtKB: Q8NAZ2 (UniProtKB/Swiss-Prot),   Q70IA8 (UniProtKB/Swiss-Prot),   Q5TC11 (UniProtKB/Swiss-Prot),   Q5TC10 (UniProtKB/Swiss-Prot),   Q0VA98 (UniProtKB/Swiss-Prot),   D3DQ22 (UniProtKB/Swiss-Prot),   Q8NF28 (UniProtKB/Swiss-Prot),   X6R3L3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000361008   ⟸   ENST00000371940
Ensembl Acc Id: ENSP00000271139   ⟸   ENST00000271139
Ensembl Acc Id: ENSP00000315113   ⟸   ENST00000319928

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q70IA8-F1-model_v2 AlphaFold Q70IA8 1-216 view protein structure

Promoters
RGD ID:6855436
Promoter ID:EPDNEW_H883
Type:multiple initiation site
Name:MOB3C_2
Description:MOB kinase activator 3C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H884  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38146,613,782 - 46,613,842EPDNEW
RGD ID:6855438
Promoter ID:EPDNEW_H884
Type:initiation region
Name:MOB3C_1
Description:MOB kinase activator 3C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H883  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38146,616,811 - 46,616,871EPDNEW
RGD ID:6785263
Promoter ID:HG_KWN:2578
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000371940,   NM_145279,   NM_201403,   OTTHUMT00000021927
Position:
Human AssemblyChrPosition (strand)Source
Build 36146,851,741 - 46,855,127 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:29800 AgrOrtholog
COSMIC MOB3C COSMIC
Ensembl Genes ENSG00000142961 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000271139 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000271139.13 UniProtKB/Swiss-Prot
  ENST00000319928 ENTREZGENE
  ENST00000319928.9 UniProtKB/Swiss-Prot
  ENST00000371940.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.140.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000142961 GTEx
HGNC ID HGNC:29800 ENTREZGENE
Human Proteome Map MOB3C Human Proteome Map
InterPro MOB_kinase_act_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MOB_kinase_act_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:148932 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 148932 ENTREZGENE
OMIM 620804 OMIM
PANTHER MOB KINASE ACTIVATOR 3C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR22599 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Mob1_phocein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134928770 PharmGKB
SMART Mob1_phocein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF101152 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3DQ22 ENTREZGENE
  MOB3C_HUMAN UniProtKB/Swiss-Prot
  Q0VA98 ENTREZGENE
  Q5TC10 ENTREZGENE
  Q5TC11 ENTREZGENE
  Q70IA8 ENTREZGENE
  Q8NAZ2 ENTREZGENE
  Q8NF28 ENTREZGENE
  X6R3L3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary D3DQ22 UniProtKB/Swiss-Prot
  Q0VA98 UniProtKB/Swiss-Prot
  Q5TC10 UniProtKB/Swiss-Prot
  Q5TC11 UniProtKB/Swiss-Prot
  Q8NAZ2 UniProtKB/Swiss-Prot
  Q8NF28 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-10-04 MOB3C  MOB kinase activator 3C  MOBKL2C  MOB1, Mps One Binder kinase activator-like 2C (yeast)  Symbol and/or name change 5135510 APPROVED